Coenzyme Q10 reverses pathological phenotype and reduces apoptosis in familial CoQ10 deficiency

Neurology

Volumn 57, Issue 3, 2001, Pages 515-518

  Di Giovanni, S ^a   Mirabella, M ^a   Spinazzola, A ^a   Crociani, P ^b   Silvestri, G ^a   Broccolini, A ^a   Tonali, P ^a   Di Mauro, S ^c   Servidei, Serenella ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^c Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; MITOCHONDRIAL ENZYME; UBIDECARENONE; UBIQUINONE; DRUG DERIVATIVE;

ADOLESCENT; APOPTOSIS; ARTICLE; CASE REPORT; CELL PROLIFERATION; COENZYME Q DEFICIENCY; CONTROLLED STUDY; ENZYME DEFICIENCY; ENZYME REPLACEMENT; ENZYME THERAPY; EXERCISE TOLERANCE; FAMILIAL DISEASE; HUMAN; IMMUNOHISTOCHEMISTRY; LIPID STORAGE; MALE; MUSCLE BIOPSY; MUSCLE FIBRIL; NICK END LABELING; PATHOLOGICAL ANATOMY; PHENOTYPE; PRIORITY JOURNAL; SCHOOL CHILD; SEIZURE; CHILD; ELECTRON MICROSCOPY; MUSCLE; MUSCLE DISEASE; PATHOLOGY; PRESCHOOL CHILD; ULTRASTRUCTURE;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; MUSCLES; MUSCULAR DISEASES; PHENOTYPE; UBIQUINONE;

EID: 0035859689     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.57.3.515     Document Type: Article

References (10)

1. 10 deficiency in familial mitochondrial encephalomyopathy
2. 10 deficiency
3. 10 deficiency
4. Apoptosis and ROS detoxification enzymes correlate with cytochrome C oxidase deficiency in mitochondrial encephalomyopathies
5. 10 deficiency
6. 10 deficiency
7. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP, and AtUCP
8. Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common site
9. Coenzyme Q can in some circumstances block apoptosis, and this effect is mediated through mitochondria
10. The role of mitochondria in the pathogenesis of neurodegenerative diseases