Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise

International Journal of Sport Nutrition

Volumn 9, Issue 2, 1999, Pages 166-180

  Svensson, Michael ^a,b   Malm, Christer ^a   Tonkonogi, Michail ^a,b   Ekblom, Bjǒrn ^a   Sjödin, Bertil ^a   Sahlin, Kent ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SWEDISH SCHOOL OF SPORT AND HEALTH SCIENCES   (Sweden)

Author keywords

Antioxidants; Mitochondria; Reactive oxygen species; Skeletal muscle; Training; Ubiquinone 10

Indexed keywords

ADENINE NUCLEOTIDE; HYPOXANTHINE; UBIDECARENONE; URIC ACID;

ADULT; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; EXERCISE; HUMAN; HUMAN EXPERIMENT; LIPID PEROXIDATION; MALE; MITOCHONDRIAL RESPIRATION; MUSCLE METABOLISM; NORMAL HUMAN; PURINE METABOLISM; SPORTS MEDICINE; TRAINING;

EID: 0033060419     PISSN: 10501606     EISSN: None     Source Type: Journal    
DOI: 10.1123/ijsn.9.2.166     Document Type: Article

References (49)

1. Åberg, F., Y. Zhang., E.L. Appekkvist, and G. Dallner. Effect of clofibrate, phathalates and probucol on ubiquinone levels. Chem, Biol. Interact. 91:1-14, 1994.
2. Alp, P., E. Newsholme, and V. Zamit. Activities of citrate synthase and NADP+- linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates. Biochem, J. 154:689-700, 1976.
3. Balsom, P.D., K. Söderlund, B. Sjödin, and B. Ekblom. Skeletal muscle metabolism during short duration high intensity exercise: Influence of creatine supplementation. Acta Physiol. Scand. 154(3):303-310, 1995.
4. Bergström, J. Muscle electrolytes in man, Scand. J. Clin, Lab. Invest. 68(SuppL): 1-110, 1962.
5. Beyer, R.E., P.G. Morales-Corral, B.J. Ramp, K.R. Kreitman, M.J. Falzon, S.Y. Rhee, T.W. Kuhn, M. Stein, M.J. Rosenwasser, and K.J. Cartwright. Elevation of tissue Q (ubiquinone) and cytochrome c concentrations by endurance exercise in the rat. Arch. Biochem. Biophys. 234(2):323-329, 1984.
6. Beyer, R.E., K. Nordenbrand, and L, Ernster. The function of coenzyme Q in free radical production and as an antioxidant. Chim, Scripta. 27:145-153, 1987.
7. Boveris, A., E. Cadenas, and A.O. Stoppani. Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. J, Biochem. 156(2):435-444, 1976.
8. 2max, and lipid peroxidation in trained cyclists. Int. J. Span Nuir. 1:353-365, 1991.
9. Crane, F.L., I.L. Sun, R.A. Crowe, F.J. Alcain, and H. Löw. Coenzyme Q10, plasma membrane oxidase and growth control. Molec. Aspects Med. 15(Suppl.):1-11, 1994.
10. Edlund, P.O. Determination of coenzyme Q10, alpha-tocopherol and cholesterol in biological samples by coupled column liquid chromatography with coulometric and ultraviolet detection. J. Chrom. 425:87-97, 1988.
11. Ernster, L, Ubiquinol as a biological antioxidant: A review. In Oxidative Processes and Antioxidants. R. Paoletti, B. Samuelsson, A.L. Catapano, and A. Poli (Eds.). New York: Raven Press, 1994, pp. 185-198.
12. Fitch, C.D., and K. Folkers. Coenzyme Q and the stability of biological membranes. Biochem, Biophys. Res. Comm, 26:128-131, 1967.
13. Folkers, K., S. Vadhanavikit, and S. Mortensen. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc. Natl. Acad. Sci. 82:901-904, 1985.
14. Forsmark-Andree, P., G. Dallner, and L. Ernster. Endogenous ubiquinol prevents protein modification accompanying lipid peroxidation in beef heart submitochondrial particles. Free Rad. Biol. Med. 19(6):749-757, 1995.
15. Greenberg, S., and W.H. Frishman. Co-enzyme Q10: A new drug for cardiovascular disease. J. Clin. Pharmacol. 30:596-608, 1990.
16. Grossi, G., A.M. Bargossi, P.L. Fiorella, and S. Piazzi. Improved high-performance Liquid Chromatographic method for determination of coenzyme Q10 in plasma. J. Chrom, 593:217-226, 1992.
17. Hanaki, Y., S. Sugiyama, T. Ozawa, and M. Ohno. Coenzyme Q10 and coronary artery disease. Clin. Invest. 71:112-115, 1993.
18. Hellsten, Y. Xanthine dehydrogenase and purine metabolism in man, with special reference to exercise. Acta Physiol. Scand. 151(Suppl.):621, 1994.
19. Hellsten, Y., B. Ekblom, and B. Sjödin. The metabolic relation between hypoxanthine and uric acid in man following maximal short-distance running. Acta Physiol. Scand. 137:341-345, 1989.
20. Hellsten, Y., B, Norman, P.D. Balsom, and B. Sjödin. Decreased resting levels of adenine nucleotides in human skeletal muscle after high-intensity training. J. AppL Physiol. 74(5):2523-2528, 1993.
21. Jacobs, I., O. Bar-Or, J. Karlsson, R. Dotan, P. Tesch, P. Kaiser, and O. Inbar. Changes in muscle metabolite in females with 30-s exhaustive exercise. Med. Sci. Sports Exerc. 14:457-460, 1982.
22. Jansson, E., G.A. Dudley, B. Norman, and P.A. Tesch. ATP and IMP in single human muscle fibres after high intensity exercise. Clin. Physiol. 7:337-345, 1987.
23. Johansen, K., H. Theorell, J. Karlsson, B. Diamant, and K. Folkers. Coenzyme Q10, alpha tocopherol and free cholesterol in HDL and LDL fractions. Ann. Med. 23:649-656, 1991.
24. Kamei, M., T. Fujita, T. Kanbe, K. Sasaki, K. Oshiba, S. Otani, I. Matsui-Yuasa, and S. Morisawa. The distribution and contents of ubiquinone in foods. Int. J. Vit. Nutr. Res. 56:57-63, 1986.
25. Karlsson, J., S. Gunnes, and B. Semb. Muscle fibres, ubiquinone and exercise capacity in effort angina. MoL Cell. Biochem. 179:179-184, 1996.
26. Karlsson, J., L. Lijun, C. Sylvén, and E. Jansson. Muscle ubiquinone in healthy physically active males, mol. Cell. Biochem. 156:169-172, 1996.
27. Karlsson, J., and B. Saltin. Lactate, ATP, and CP in working muscles during exhaustive exercise in man. J. Appl. Physiol. 29:598-602, 1970.
28. Kishorchandra, G., L. Rothfuss, J. Lang, and L. Packer. Effects of exercise training on tissue vitamin E and ubiquinone content. J. Appl. Physiol. 63(4): 1638-1641, 1987.
29. Kitamura, N., A. Yaamaguchi, M. Otaki, O. Sawatani, T. Minoji, H. Tamura, and M. Atobe. Myocardial tissue level of coenzyme Q10 in patients with cardiac failure. In Biomedical and Clinical Aspects of Coenzyme Q (Vol. 4), K. Folkers and Y. Yamamura (Eds.). Amsterdam: Elsevier Science, 1984, pp. 243-252.
30. Kooij, A. A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase. Histochem. 26:889-915, 1994.
31. Koshkin, V. V. Formation of hydrogen peroxide in mitochondria of skeletal muscles. Biochem. 49(11), 1632-1635, 1984.
32. Laaksonen, R., K. Jokelainen, T. Sahi, M.J. Tikkanen, and J.J. Himberg. Decreases in serum ubiquinone concentration do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin. Pharmacol. Ther. 57:62-66, 1995.
33. Laaksonen, R., A. Riihimäki, J. Laitila, K. Mårtensson, M.J. Tikkanen, and J.J. Himberg. Serum and muscle tissue ubiquinone levels in healthy subjects. J. Lab. Clin. Med. 125(5):517-520, 1994.
34. Lucker, P.W., N. Wetzelsberger, G. Hennings, and D. Rehn. Pharmacokinetics of coenzyme ubidecarenone in healthy volunteers. In Biomedical and Clinical Aspects of Coenzyme Q (Vol. 4), K. Folkers and Y. Yamamura (Eds.). Amsterdam: Elsevier Science, 1984, pp. 143-151.
35. Malm, C., M. Svensson, B. Ekblom, and B. Sjödin. Effects of ubiquinone-10 supplementation and high intensity training on physical performance. Acta Physiol. Scand. 161:379-384, 1997.
36. Malm, C., M. Svensson, B. Sjöberg, B. Ekblom, and B. Sjodin. Supplementation with ubiquinone-10 causes cell damage during intense exercise. Acta Physiol. Scand. 157:511-512, 1996.
37. Mohr, D., V.W. Bowry, and R. Stocker. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low density lipoprotein to initiation of lipid peroxidauon. Biochim. Biophys. Acta 1126:247-254, 1992.
38. Mukai, K., S. Kikuchi, and S. Urano. Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution. Biochim, Biophys. Acta 1035:77-82, 1990.
39. Nishino, T. The conversion of xanthine dehydrogenase to xanthine oxidase and the role of the enzyme in reperfusion injury. J. Biochem. 116:1-6, 1994.
40. Noack, H., U. Kube, and W. Augustin, Relations between tocopherol depletion and coenzy me Q during lipid peroxidation in rat liver mitochondria. Free Rad. Res. 20(6):375-386, 1994.
41. Öhrvall, M., S. Tengblad. B. Ekstrand, A. Siegbahn, and B. Vessby. Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. Atherosclerosis 108:103-110, 1994.
42. Okamoto, T., T. Matsuya, Y. Fukanaga, T. Kishi, and T. Yamagami. Human serum ubiquinol-10 levels and relations to serum lipids. Int. J. Vit. Nutr. Res. 59:288-292, 1989.
43. Schnurr, K., M. Hell wing, B. Seidemann, P. Jungblut, H. Kuhn, S.M. Rapoport, and T. Scbewe. Oxygenation of biomembranes by mammalian lipoxygenases: The role of ubiquinone. Free Rad. Biol. Med. 20:(1):11-21, 1996.
44. Stocker, R., V, W. Bowry, and B. Frei. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc. Natl. Acad. Sci. 88:1646-1650, 1991.
45. Stoyanovsky, D.A., A.N. Osipov, P.J. Quinn, and E. Kagan. Ubiquinone-dependent recycling of vitamin E radicals by Superoxide. Arch. Biochem. Biophys. 323(2): 343-351, 1995.
46. Tonkonogi, M., and K. Sahlin. Rate of oxidative phosphorylation in isolated mitochondria from human skeletal muscle: Effect of training status. Acta Physiol. Scand. 161:345-353, 1997.
47. Weber, C., T. Sejersgård-Jakobsen, S.A. Mortensen, G. Paulsen, and G. Holmer. Antioxidative effect of dietary coenzyme Q10 in human blood plasma. Int. J. Vit. Nutr. Res. 64:311-315, 1994.
48. Weston, S.B., S. Zhou, R.P. Weatherby. and S.J. Robson. Does exogenous coenzyme Q10 affect aerobic capacity in endurance athletes? Int. J. Sport Nutr. 7:197-206, 1997.
49. Wibom, R., A. Lundin, and E. Hultman. A sensitive method for measuring ATP-formation in rat muscle mitochondria. Scand. J. Clin. Lab. Invest. 50:143-152, 1990.