메뉴 건너뛰기




Volumn 38, Issue 5, 2005, Pages 509-517

Functional analysis of naturally occurring mutations in the open reading frame of CCR5 in HIV-infected Chinese patients and healthy controls

Author keywords

CCR5 polymorphism; Coreceptor function; Disease progression; Expression and conformation; HIV infection

Indexed keywords

ARGININE; CHEMOKINE RECEPTOR CCR5; GLUTAMINE;

EID: 20244365650     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.qai.0000151004.19128.4a     Document Type: Article
Times cited : (9)

References (62)
  • 1
    • 15844389650 scopus 로고    scopus 로고
    • HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    • Dragic T, Litwin V, Allaway GP, et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature. 1996;381:667-673.
    • (1996) Nature , vol.381 , pp. 667-673
    • Dragic, T.1    Litwin, V.2    Allaway, G.P.3
  • 2
    • 15844419153 scopus 로고    scopus 로고
    • Identification of a major co-receptor for primary isolates of HIV-1
    • Deng H, Liu R, Ellmeier W, et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature. 1996;381:661-666.
    • (1996) Nature , vol.381 , pp. 661-666
    • Deng, H.1    Liu, R.2    Ellmeier, W.3
  • 3
    • 0030018156 scopus 로고    scopus 로고
    • CC CKR5: A RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1
    • Alkhatib G, Combadiere C, Broder CC, et al. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science. 1996;272:1955-1958.
    • (1996) Science , vol.272 , pp. 1955-1958
    • Alkhatib, G.1    Combadiere, C.2    Broder, C.C.3
  • 4
    • 1842293926 scopus 로고    scopus 로고
    • A new SIV co-receptor, STRL33
    • Alkhatib G, Liao F, Berger EA, et al. A new SIV co-receptor, STRL33. Nature. 1997;388:238.
    • (1997) Nature , vol.388 , pp. 238
    • Alkhatib, G.1    Liao, F.2    Berger, E.A.3
  • 5
    • 0037213286 scopus 로고    scopus 로고
    • CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5
    • Raja A, Venturi M, Kwong P, et al. CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5. J Virol. 2003;77:713-718.
    • (2003) J Virol , vol.77 , pp. 713-718
    • Raja, A.1    Venturi, M.2    Kwong, P.3
  • 7
    • 0030037398 scopus 로고    scopus 로고
    • HIV receptors and the pathogenesis of AIDS
    • Weiss RA. HIV receptors and the pathogenesis of AIDS. Science. 1996; 272:1885-1886.
    • (1996) Science , vol.272 , pp. 1885-1886
    • Weiss, R.A.1
  • 8
    • 0031025113 scopus 로고    scopus 로고
    • Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor
    • Cheng-Mayer C, Liu R, Landau NR, et al. Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor. J Virol. 1997;71:1657-1661.
    • (1997) J Virol , vol.71 , pp. 1657-1661
    • Cheng-Mayer, C.1    Liu, R.2    Landau, N.R.3
  • 9
    • 0031008794 scopus 로고    scopus 로고
    • STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1
    • Liao F, Alkhatib G, Peden KW, et al. STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med. 1997;185:2015-2023.
    • (1997) J Exp Med , vol.185 , pp. 2015-2023
    • Liao, F.1    Alkhatib, G.2    Peden, K.W.3
  • 10
    • 19244380883 scopus 로고    scopus 로고
    • CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
    • He J, Chen Y, Farzan M, et al. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature. 1997;385:645-649.
    • (1997) Nature , vol.385 , pp. 645-649
    • He, J.1    Chen, Y.2    Farzan, M.3
  • 11
    • 0033942753 scopus 로고    scopus 로고
    • CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor
    • Lee S, Tiffany HL, King L, et al. CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor. J Virol. 2000;74: 6946-6952.
    • (2000) J Virol , vol.74 , pp. 6946-6952
    • Lee, S.1    Tiffany, H.L.2    King, L.3
  • 12
    • 0030604727 scopus 로고    scopus 로고
    • A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
    • Doranz BJ, Rucker J, Yi Y, et al. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell. 1996;85:1149-1158.
    • (1996) Cell , vol.85 , pp. 1149-1158
    • Doranz, B.J.1    Rucker, J.2    Yi, Y.3
  • 13
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    • Feng Y, Broder CC, Kennedy PE, et al. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 1996;272:872-877.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.C.2    Kennedy, P.E.3
  • 14
    • 0029984987 scopus 로고    scopus 로고
    • Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages
    • Alkhatib G, Broder CC, Berger EA. Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages. J Virol. 1996;70:5487-5494.
    • (1996) J Virol , vol.70 , pp. 5487-5494
    • Alkhatib, G.1    Broder, C.C.2    Berger, E.A.3
  • 15
    • 0030447722 scopus 로고    scopus 로고
    • Multiple extracellular elements of CCR5 and HTV-1 entry: Dissociation from response to chemokines
    • Atchison RE, Gosling J, Monteclaro FS, et al. Multiple extracellular elements of CCR5 and HTV-1 entry: dissociation from response to chemokines. Science. 1996;274:1924-1926.
    • (1996) Science , vol.274 , pp. 1924-1926
    • Atchison, R.E.1    Gosling, J.2    Monteclaro, F.S.3
  • 16
    • 1842371216 scopus 로고    scopus 로고
    • Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains
    • Edinger AL, Amedee A, Miller K, et al. Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains. Proc Natl Acad Sci USA. 1997;94:4005-4010.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4005-4010
    • Edinger, A.L.1    Amedee, A.2    Miller, K.3
  • 17
    • 12644288298 scopus 로고    scopus 로고
    • Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains
    • Lu Z, Berson JF, Chen Y, et al. Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains. Proc Natl Acad Sci USA. 1997;94:6426-6431.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6426-6431
    • Lu, Z.1    Berson, J.F.2    Chen, Y.3
  • 18
    • 0031298109 scopus 로고    scopus 로고
    • HIV entry and tropism: The chemokine receptor connection
    • Berger EA. HIV entry and tropism: the chemokine receptor connection. AIDS. 1997;11(Suppl A):S3-S16.
    • (1997) AIDS , vol.11 , Issue.SUPPL. A
    • Berger, E.A.1
  • 20
    • 0033516460 scopus 로고    scopus 로고
    • Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity
    • Blanpain C, Lee B, Vakili J, et al. Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity. J Biol Chem. 1999;274:18902-18908.
    • (1999) J Biol Chem , vol.274 , pp. 18902-18908
    • Blanpain, C.1    Lee, B.2    Vakili, J.3
  • 21
    • 0032837669 scopus 로고    scopus 로고
    • Genetics of HIV-1 infection: Chemokine receptor CCR5 polymorphism and its consequences
    • Carrington M, Dean M, Martin MP, et al. Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences. Hum Mol Genet. 1999;8:1939-1945.
    • (1999) Hum Mol Genet , vol.8 , pp. 1939-1945
    • Carrington, M.1    Dean, M.2    Martin, M.P.3
  • 22
    • 0030861238 scopus 로고    scopus 로고
    • Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1
    • Doranz BJ, Lu ZH, Rucker J, et al. Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1. J Virol. 1997;71:6305-6314.
    • (1997) J Virol , vol.71 , pp. 6305-6314
    • Doranz, B.J.1    Lu, Z.H.2    Rucker, J.3
  • 23
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    • Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 1996;86:367-377.
    • (1996) Cell , vol.86 , pp. 367-377
    • Liu, R.1    Paxton, W.A.2    Choe, S.3
  • 24
    • 0029890173 scopus 로고    scopus 로고
    • Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES
    • Combadiere C, Ahuja SK, Tiffany HL, et al. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES. J Leukoc Biol. 1996;60:147-152.
    • (1996) J Leukoc Biol , vol.60 , pp. 147-152
    • Combadiere, C.1    Ahuja, S.K.2    Tiffany, H.L.3
  • 25
    • 3943075742 scopus 로고    scopus 로고
    • Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese
    • Zhao XY, Lee SS, Wong KH, et al. Effects of single nucleotide polymorphisms in the RANTES promoter region in healthy and HIV-infected indigenous Chinese. Eur J Immunogenet. 2004;31:179-183.
    • (2004) Eur J Immunogenet , vol.31 , pp. 179-183
    • Zhao, X.Y.1    Lee, S.S.2    Wong, K.H.3
  • 26
    • 0037032906 scopus 로고    scopus 로고
    • Polymorphisms of CCR5 gene in a southern Chinese population and their effects on disease progression in HIV infections
    • Zheng BJ, Zhao XY, Zhu NS, et al. Polymorphisms of CCR5 gene in a southern Chinese population and their effects on disease progression in HIV infections. AIDS. 2002;16:2480-2482.
    • (2002) AIDS , vol.16 , pp. 2480-2482
    • Zheng, B.J.1    Zhao, X.Y.2    Zhu, N.S.3
  • 27
    • 17044452367 scopus 로고    scopus 로고
    • HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene
    • Quillent C, Oberlin E, Braun J, et al. HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene. Lancet. 1998;351:14-18.
    • (1998) Lancet , vol.351 , pp. 14-18
    • Quillent, C.1    Oberlin, E.2    Braun, J.3
  • 28
    • 0031455968 scopus 로고    scopus 로고
    • Novel alleles of the chemokine-receptor gene CCR5
    • Carrington M, Kissner T, Gerrard B, et al. Novel alleles of the chemokine-receptor gene CCR5. Am J Hum Genet. 1997;61:1261-1267.
    • (1997) Am J Hum Genet , vol.61 , pp. 1261-1267
    • Carrington, M.1    Kissner, T.2    Gerrard, B.3
  • 29
    • 19244384846 scopus 로고    scopus 로고
    • Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: Impact on the epidemiology of the HIV-1 pandemic
    • Gonzalez E, Dhanda R, Bamshad M, et al. Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: impact on the epidemiology of the HIV-1 pandemic. Proc Natl Acad Sci USA. 2001; 98:5199-5204.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5199-5204
    • Gonzalez, E.1    Dhanda, R.2    Bamshad, M.3
  • 30
    • 0037435775 scopus 로고    scopus 로고
    • Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: The protection varies with duration of infection
    • Mulherin SA, O'Brien TR, Ioannidis JP, et al. Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection. AIDS. 2003;17:377-387.
    • (2003) AIDS , vol.17 , pp. 377-387
    • Mulherin, S.A.1    O'Brien, T.R.2    Ioannidis, J.P.3
  • 31
    • 0030861904 scopus 로고    scopus 로고
    • Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study
    • Smith MW, Dean M, Carrington M, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science. 1997; 277:959-965.
    • (1997) Science , vol.277 , pp. 959-965
    • Smith, M.W.1    Dean, M.2    Carrington, M.3
  • 32
    • 0030961374 scopus 로고    scopus 로고
    • The extent of genetic variation in the CCR5 gene
    • Ansari-Lari MA, Liu XM, Metzker ML, et al. The extent of genetic variation in the CCR5 gene. Nat Genet. 1997;16:221-222.
    • (1997) Nat Genet , vol.16 , pp. 221-222
    • Ansari-Lari, M.A.1    Liu, X.M.2    Metzker, M.L.3
  • 33
    • 0034827756 scopus 로고    scopus 로고
    • Polymorphism of CCR5 affecting HIV disease progression in the Japanese population
    • Kageyama S, Mimaya J, Yamada K, et al. Polymorphism of CCR5 affecting HIV disease progression in the Japanese population. AIDS Res Hum Retroviruses. 2001;17:991-995.
    • (2001) AIDS Res Hum Retroviruses , vol.17 , pp. 991-995
    • Kageyama, S.1    Mimaya, J.2    Yamada, K.3
  • 34
    • 0033520930 scopus 로고    scopus 로고
    • Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein
    • Blanpain C, Doranz BJ, Vakili J, et al. Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein. J Biol Chem. 1999; 274:34719-34727.
    • (1999) J Biol Chem , vol.274 , pp. 34719-34727
    • Blanpain, C.1    Doranz, B.J.2    Vakili, J.3
  • 35
    • 0033032134 scopus 로고    scopus 로고
    • A longitudinal study of neutralizing antibodies and disease progression in HIV-1-infected subjects
    • Cecilia D, Kleeberger C, Munoz A, et al. A longitudinal study of neutralizing antibodies and disease progression in HIV-1-infected subjects. J Infect Dis. 1999;179:1365-1374.
    • (1999) J Infect Dis , vol.179 , pp. 1365-1374
    • Cecilia, D.1    Kleeberger, C.2    Munoz, A.3
  • 36
    • 0032728755 scopus 로고    scopus 로고
    • A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants
    • Kostrikis LG, Neumann AU, Thomson B, et al. A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants. J Virol. 1999;73:10264-10271.
    • (1999) J Virol , vol.73 , pp. 10264-10271
    • Kostrikis, L.G.1    Neumann, A.U.2    Thomson, B.3
  • 37
    • 43749109393 scopus 로고    scopus 로고
    • Vaccinia-based reporter gene cell-fusion assay to quantitate functional interactions of HIV envelope glycoprotein with receptors
    • Coligan JE, ed. New York: John Wiley & Sons
    • Dey BBE. Vaccinia-based reporter gene cell-fusion assay to quantitate functional interactions of HIV envelope glycoprotein with receptors. In: Coligan JE, ed. Current Protocols in Immunology. New York: John Wiley & Sons; 2003:12.10.20-12.10.03.
    • (2003) Current Protocols in Immunology
    • Dey, B.B.E.1
  • 38
    • 0033525590 scopus 로고    scopus 로고
    • Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry
    • Farzan M, Mirzabekov T, Kolchinsky P, et al. Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry. Cell. 1999;96:667-676.
    • (1999) Cell , vol.96 , pp. 667-676
    • Farzan, M.1    Mirzabekov, T.2    Kolchinsky, P.3
  • 39
    • 0025318790 scopus 로고
    • A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells
    • Morgenstern JP, Land H. A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells. Nucleic Acids Res. 1990;18:1068-1107.
    • (1990) Nucleic Acids Res , vol.18 , pp. 1068-1107
    • Morgenstern, J.P.1    Land, H.2
  • 40
    • 0035437877 scopus 로고    scopus 로고
    • RANTES and MIP-1beta mRNA expression in human peripheral blood mononuclear cells: Transcript quantification using NASBA technology
    • Romano JW, Shurtliff RN, Lee EM, et al. RANTES and MIP-1beta mRNA expression in human peripheral blood mononuclear cells: transcript quantification using NASBA technology. J Immunol Methods. 2001;255:115-124.
    • (2001) J Immunol Methods , vol.255 , pp. 115-124
    • Romano, J.W.1    Shurtliff, R.N.2    Lee, E.M.3
  • 41
    • 4143116692 scopus 로고    scopus 로고
    • A novel CCR5 mutation selectively affects immunoreactivity and fusogenic property of the HIV co-receptor
    • Zhao XY, Lee SS, Wong KH, et al. A novel CCR5 mutation selectively affects immunoreactivity and fusogenic property of the HIV co-receptor. AIDS. 2004;18:1729-1732.
    • (2004) AIDS , vol.18 , pp. 1729-1732
    • Zhao, X.Y.1    Lee, S.S.2    Wong, K.H.3
  • 42
    • 0000233999 scopus 로고
    • Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase
    • Fuerst TR, Niles EG, Studier FW, et al. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc Natl Acad Sci USA. 1986;83:8122-8126.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 8122-8126
    • Fuerst, T.R.1    Niles, E.G.2    Studier, F.W.3
  • 43
    • 0036168676 scopus 로고    scopus 로고
    • Safety and immunogenicity of ALVAC vCP1452 and recombinant gp160 in newly human immunodeficiency virus type 1-infected patients treated with prolonged highly active antiretroviral therapy
    • Jin X, Ramanathan M, Jr, Barsoum S, et al. Safety and immunogenicity of ALVAC vCP1452 and recombinant gp160 in newly human immunodeficiency virus type 1-infected patients treated with prolonged highly active antiretroviral therapy. J Virol. 2002;76:2206-2216.
    • (2002) J Virol , vol.76 , pp. 2206-2216
    • Jin, X.1    Ramanathan Jr., M.2    Barsoum, S.3
  • 44
    • 0032171247 scopus 로고    scopus 로고
    • Specificity of binding of HIV-1 anti-p24 antibodies to CD4+ lymphocytes from HIV-infected subjects
    • Cameron PU, Hunter SD, Jolley D, et al. Specificity of binding of HIV-1 anti-p24 antibodies to CD4+ lymphocytes from HIV-infected subjects. Cytometry. 1998;33:83-88.
    • (1998) Cytometry , vol.33 , pp. 83-88
    • Cameron, P.U.1    Hunter, S.D.2    Jolley, D.3
  • 45
    • 0030762506 scopus 로고    scopus 로고
    • CC chemokine receptor 5-mediated signaling and HIV-1 co-receptor activity share common structural determinants. Critical residues in the third extracellular loop support HIV-1 fusion
    • Alkhatib G, Ahuja SS, Light D, et al. CC chemokine receptor 5-mediated signaling and HIV-1 co-receptor activity share common structural determinants. Critical residues in the third extracellular loop support HIV-1 fusion. J Biol Chem. 1997;272:19771-19776.
    • (1997) J Biol Chem , vol.272 , pp. 19771-19776
    • Alkhatib, G.1    Ahuja, S.S.2    Light, D.3
  • 46
    • 0037799237 scopus 로고    scopus 로고
    • The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle
    • Blanpain C, Doranz BJ, Bondue A, et al. The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle. J Biol Chem. 2003;278:5179-5187.
    • (2003) J Biol Chem , vol.278 , pp. 5179-5187
    • Blanpain, C.1    Doranz, B.J.2    Bondue, A.3
  • 47
    • 0035450601 scopus 로고    scopus 로고
    • Adaptation to blockade of human immunodeficiency virus type 1 entry imposed by the anti-CCR5 monoclonal antibody 2D7
    • Aarons EJ, Beddows S, Willingham T, et al. Adaptation to blockade of human immunodeficiency virus type 1 entry imposed by the anti-CCR5 monoclonal antibody 2D7. Virology. 2001;287:382-390.
    • (2001) Virology , vol.287 , pp. 382-390
    • Aarons, E.J.1    Beddows, S.2    Willingham, T.3
  • 48
    • 0033214480 scopus 로고    scopus 로고
    • Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor
    • Mirzabekov T, Bannert N, Farzan M, et al. Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor. J Biol Chem. 1999;274:28745-28750.
    • (1999) J Biol Chem , vol.274 , pp. 28745-28750
    • Mirzabekov, T.1    Bannert, N.2    Farzan, M.3
  • 49
    • 0030779808 scopus 로고    scopus 로고
    • Interaction of chemokine receptor CCR5 with its ligands: Multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding
    • Wu L, LaRosa G, Kassam N, et al. Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding. J Exp Med. 1997;186:1373-1381.
    • (1997) J Exp Med , vol.186 , pp. 1373-1381
    • Wu, L.1    LaRosa, G.2    Kassam, N.3
  • 50
    • 0032211145 scopus 로고    scopus 로고
    • Virological and immunological features of long-term human immunodeficiency virus-infected individuals who have remained asymptomatic compared with those who have progressed to acquired immunodeficiency syndrome
    • Barker E, Mackewicz CE, Reyes-Teran G, et al. Virological and immunological features of long-term human immunodeficiency virus-infected individuals who have remained asymptomatic compared with those who have progressed to acquired immunodeficiency syndrome. Blood. 1998;92:3105-3114.
    • (1998) Blood , vol.92 , pp. 3105-3114
    • Barker, E.1    Mackewicz, C.E.2    Reyes-Teran, G.3
  • 51
    • 0030593031 scopus 로고    scopus 로고
    • Toward an understanding of the correlates of protective immunity to HIV infection
    • Haynes BF, Pantaleo G, Fauci AS. Toward an understanding of the correlates of protective immunity to HIV infection. Science. 1996; 271:324-328.
    • (1996) Science , vol.271 , pp. 324-328
    • Haynes, B.F.1    Pantaleo, G.2    Fauci, A.S.3
  • 52
    • 0141453850 scopus 로고    scopus 로고
    • Protection from HIV/AIDS: The importance of innate immunity
    • Levy JA, Scott I, Mackewicz C. Protection from HIV/AIDS: the importance of innate immunity. Clin Immunol. 2003;108:167-174.
    • (2003) Clin Immunol , vol.108 , pp. 167-174
    • Levy, J.A.1    Scott, I.2    Mackewicz, C.3
  • 53
    • 0348012902 scopus 로고    scopus 로고
    • CD4 responses to conserved HIV-1 T helper epitopes show both negative and positive associations with virus load in chronically infected subjects
    • Boaz MJ, Waters A, Murad S, et al. CD4 responses to conserved HIV-1 T helper epitopes show both negative and positive associations with virus load in chronically infected subjects. Clin Exp Immunol. 2003;134: 454-463.
    • (2003) Clin Exp Immunol , vol.134 , pp. 454-463
    • Boaz, M.J.1    Waters, A.2    Murad, S.3
  • 54
    • 3042720288 scopus 로고    scopus 로고
    • Humoral immunity in HIV-1 exposure: Cause or effect of HIV resistance?
    • Lopalco L. Humoral immunity in HIV-1 exposure: cause or effect of HIV resistance? Curr HIV Res. 2004;2:127-139.
    • (2004) Curr HIV Res , vol.2 , pp. 127-139
    • Lopalco, L.1
  • 55
    • 0033650130 scopus 로고    scopus 로고
    • Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection
    • Romiti ML, Colognesi C, Cancrini C, et al. Prognostic value of a CCR5 defective allele in pediatric HIV-1 infection. Mol Med. 2000;6: 28-36.
    • (2000) Mol Med , vol.6 , pp. 28-36
    • Romiti, M.L.1    Colognesi, C.2    Cancrini, C.3
  • 56
    • 0035108034 scopus 로고    scopus 로고
    • Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5
    • Shioda T, Nakayama EE, Tanaka Y, et al. Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5. J Virol. 2001;75:3462-3468.
    • (2001) J Virol , vol.75 , pp. 3462-3468
    • Shioda, T.1    Nakayama, E.E.2    Tanaka, Y.3
  • 57
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature. 1996;382:722-725.
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3
  • 58
    • 0013498832 scopus 로고    scopus 로고
    • Increased frequency of CCR-5 delta 32 heterozygotes among long-term non-progressors with HIV-1 infection
    • The Australian Long-Term Non-Progressor Study Group
    • Stewart GJ, Ashton LJ, Biti RA, et al. Increased frequency of CCR-5 delta 32 heterozygotes among long-term non-progressors with HIV-1 infection. The Australian Long-Term Non-Progressor Study Group. AIDS. 1997; 11:1833-1838.
    • (1997) AIDS , vol.11 , pp. 1833-1838
    • Stewart, G.J.1    Ashton, L.J.2    Biti, R.A.3
  • 59
    • 0035964091 scopus 로고    scopus 로고
    • The coreceptor mutation CCR5Delta32 influences the dynamics of HIV epidemics and is selected for by HIV
    • Sullivan AD, Wigginton J, Kirschner D. The coreceptor mutation CCR5Delta32 influences the dynamics of HIV epidemics and is selected for by HIV Proc Natl Acad Sci USA. 2001;98:10214-10219.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10214-10219
    • Sullivan, A.D.1    Wigginton, J.2    Kirschner, D.3
  • 60
    • 0035918313 scopus 로고    scopus 로고
    • The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation
    • Govaerts C, Blanpain C, Deupi X, et al. The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation. J Biol Chem. 2001;276:13217-13225.
    • (2001) J Biol Chem , vol.276 , pp. 13217-13225
    • Govaerts, C.1    Blanpain, C.2    Deupi, X.3
  • 61
    • 0031883554 scopus 로고    scopus 로고
    • A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5
    • Farzan M, Choe H, Vaca L, et al. A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5. J Virol. 1998; 72:1160-1164.
    • (1998) J Virol , vol.72 , pp. 1160-1164
    • Farzan, M.1    Choe, H.2    Vaca, L.3
  • 62
    • 0033515588 scopus 로고    scopus 로고
    • Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function
    • Lee B, Sharron M, Blanpain C, et al. Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J Biol Chem. 1999;274:9617-9626.
    • (1999) J Biol Chem , vol.274 , pp. 9617-9626
    • Lee, B.1    Sharron, M.2    Blanpain, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.