Protein kinase C and its substrates

Molecular and Cellular Endocrinology

Volumn 116, Issue 1, 1996, Pages 1-29

  Liu, Jun Ping ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Domain structure; Eukaryotic cell; Intermolecular regulation; Intramolecular regulation; Molecular activation; Protein kinase C; Protein substrate

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; ENZYME INHIBITOR; ISOENZYME; PHORBOL ESTER; PROTEIN; PROTEIN 14 3 3; PROTEIN KINASE C; SPHINGOLIPID; TYROSINE 3 MONOOXYGENASE; DYNAMIN; MARCKS PROTEIN; NEUROMODULIN; PROTEIN KINASE C INHIBITOR;

ACTIVE TRANSPORT; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; REVIEW; AUTOPHOSPHORYLATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; FEEDBACK SYSTEM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TRANSPORT; PROTO ONCOGENE;

14-3-3 PROTEINS; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; CERAMIDES; DIGLYCERIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PHORBOL ESTERS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEINS; SPHINGOLIPIDS; SUBSTRATE SPECIFICITY; TYROSINE 3-MONOOXYGENASE;

EID: 0030584097     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/0303-7207(95)03706-3     Document Type: Review

References (505)

1. Abate, C., Marchak, D.R. and Curran, T. (1991) Oncogene 6, 2179-2185.
2. Abdel-Ghany, M., el-Gendy, K., Zhang, S., Raden, D. and Racker, E. (1989) Proc. Natl. Acad. Sci. USA 86, 1761-1765.
3. Aderem, A.A., Albert, K.A., Keum, M.M., Wang, J.K., Greengard, P. and Cohn, Z.A. (1988) Nature 332, 362-364.
4. Adrian, T.E., Allen, J.M., Bloom, S.R., Ghatei, M.A., Rossor, M.N., Roberts, G.W., Crow, T.J., Tatemoto, K. and Polak, J.M. (1983) Nature 306, 584-586.
5. Agwu, D.E., McPhail, L.C., Chabot, M.C., Daniel, L.W., Wykle, R.L. and McCall, C.E. (1989) J. Biol. Chem. 264, 1405-1413.
6. Ahmed, S., Lee, J., Kozma, R., Best, A., Monfries, C. and Lim, L. (1993) J. Biol. Chem. 268, 10709-10712.
7. Aigner, L. and Caroni, P. (1995) J. Cell Biol. 128, 647-660.
8. Aitken, A., Ellis, C.A., Harris, A., Sellers, L.A. and Toker, A. (1990) Nature 344, 594.
9. Aitken, A., Howell, S., Jones, D., Madrazo, J. and Patel, Y. (1995) J. Biol. Chem. 270, 5706-5709.
10. Akers, R.F. and Routtenberg, A. (1987) J. Neurosci. 7, 3976-3983.
11. Akimoto, K., Mizuno, K., Osada, S., Hirai, S., Tanuma, S., Suzuki, K. and Ohno, S. (1994) J. Biol. Chem. 269, 12677-12683.
12. Akita, Y., Ohno, S., Konno, Y., Yano, A. and Suzuki, K. (1990a) J. Biol. Chem. 265, 354-362.
13. Akita, Y., Ohno, S., Yajima, Y. and Suzuki, K. (1990b) Biochem. Biophys. Res. Commun. 172, 184-189.
14. Albert, K.A., Walaas, S.I., Wang, J.K. and Greengard, P. (1986) Proc. Natl. Acad. Sci. USA 83, 2822-2826.
15. Albert, K.A., Nairn, A.C. and Greengard, P. (1987) Proc. Natl. Acad. Sci. USA 84, 7046-7050.
16. Alexander, K.A., Wakim, B.T., Doyle, G.S., Walsh, K.A. and Storm, D.R. (1988) J. Biol. Chem. 263, 7544-7549.
17. Andreasen, T.J., Luetje, C.W., Heideman, W. and Storm, D.R. (1983) Biochemistry 22, 4615-4618.
18. Angel, P., Imagawa, M., Chiu, R., Stein, B., Imbra, R.J., Rahmsdorf, H.J., Jonat, C., Herrlich, P. and Karin, M. (1991) Cell 49, 729-739.
19. Apel, E.D., Byford, M.F., Au, D., Walsh, K.A. and Storm, D.R. (1990) Biochemistry 29, 2330-2335.
20. Areces, L.B., Kazanietz, M.G. and Blumberg, P.M. (1994) J Biol. Chem. 269, 19553-19558.
21. Arnold, T.P., Standaert, M.L., Hernandez, H., Watson, J., Mischak, H., Kazanietz, M.G., Zhao, L., Cooper, D.R. and Farese, R.V. (1993) Biochem. J. 295, 155-164.
22. Ashendel, C.L., Staller, J.M. and Boutwell, R.K. (1983) Cancer Res. 43, 4333-4337.
23. Azzi, A., Boscoboinik, D. and Hensey, C. (1992) Eur. J. Biochem. 208, 547-557.
24. Baccarini, M., Sabatini, D.M., App, H., Rapp, U.R. and Stanley, E.R. (1990) EMBO J. 9, 3649-3657.
25. Baetge, E.E. and Hammang, J.P. (1991) Neuron 6, 21-30.
26. Baker, S.J., Kerppola, T.K., Luk, D., Vandenberg, M.T., Marshak, D.R., Curran, T. and Abate, C. (1992) Mol. Cell Biol. 12, 4694-4705.
27. Ballester, R. and Rosen, O.M. (1985) J. Biol. Chem. 260, 15194-15199.
28. Ballester, R., Furth, M.E. and Rosen, O.M. (1987) J. Biol. Chem. 262, 2688-2695.
29. Banschbach, M.W., Geison, R.L. and Hokin-Neaverson, M. (1981) Biochim. Biophys. Acta 663, 34-45.
30. Barnes, C.A., Mizumori, S.J., Lovinger, D.M., Sheu, F.S., Murakami, K., Chan, S.Y., Linden, D.J., Nelson, R.B. and Routtenberg, A. (1988) Neurobiol. Aging 9, 393-398.
31. Barnett, R.L., Ruffini, L., Ramsammy, L., PasMantier, R., Friedlaender, M.M. and Nord, E.P. (1995) Am. J. Physiol. 268, C376-C381.
32. Baudier, J., Bronner, C., Kligman, D. and Cole, R.D. (1989) J. Biol. Chem. 264, 1824-1828.
33. Baudier, J., Deloulme, J.C., Van-Dorsselaer, A., Black, D. and Matthes, H.W. (1991) J. Biol. Chem. 266, 229-237.
34. Bazzi, M.D. and Nelsestuen, G.L. (1987) Biochem. Biophys. Res. Commun. 146, 203-207.
35. Bazzi, M.D. and Nelsestuen, G.L. (1990) Biochemistry 29, 7624-7630.
36. Bazzi, M.D. and Nelsestuen, G.L. (1991) Biochemistry 30, 7970-7977.
37. Bazzi, M.D. and Nelsestuen, G.L. (1992) J. Biol. Chem. 267, 22891-22896.
38. Begum, N. (1995) J. Biol. Chem. 270, 709-714.
39. Bell, R., Burns, D., Okazaki, T. and Hannun, V. (1992) Adv. Exp. Med. Biol. 318, 275-284.
40. Bell, R.M. and Burns, D.J. (1991) J. Biol. Chem. 266, 4661-4664.
41. Bennett, C.F. and Crooke, S.T. (1987) J. Biol. Chem. 262, 13789-13797.
42. Bennett, V., Gardner, K. and Steiner, J.P (1988) J. Biol. Chem. 263, 5860-5869.
43. Berridge, M.J. and Irvine, R.F. (1989) Nature 341, 197-205.
44. Besterman, J.M., Duronio, V. and Cuatrecasas, P. (1986) Proc. Natl. Acad. Sci. USA 83, 6785-6789,
45. Billah, M.M., Eckel, S., Mullmann, T.J., Egan, R.W. and Siegel, M.I. (1989) J. Biol. Chem. 264, 17069-17077.
46. Bird, G.St.J., Rossier, M.F., Obie, J.F. and Putney, J.W. Jr. (1993) J. Biol. Chem. 268, 8425-8428.
47. Bishop, W.R., Pachter, J.A. and Pai, J.K. (1992) Adv. Enzyme Regul. 32, 177-192.
48. Blackshear, P.J. (1993) J. Biol. Chem. 268, 1501-1504.
49. Blackshear, P.J., Wen, L., Glynn, B.P. and Witters, L.A. (1986) J. Biol. Chem. 261, 1459-1469.
50. Bocckino, S.B., Blackmore, P.F. and Exton, J.H. (1985) J. Biol. Chem. 260, 14201-14207.
51. Bocckino, S.B., Blackmore, P.F., Wilson, P.B. and Exton, J.H. (1987) J. Biol. Chem. 262, 15309-15315.
52. Bours, V., Villalobos, J., Burd, P.R., Kelly, K. and Siebenlist, U. (1990) Nature 348, 76-80.
53. Bredt, D.S., Ferris, C.D. and Snyder, S.H. (1992) J. Biol. Chem. 267, 10976-10981.
54. Brockerhoff, H. (1986) FEBS Lett. 201, 1-4.
55. Bronfman, M., Morales, M.N. and Orellana, A. (1988) Biochem. Biophys. Res. Commun. 152, 987-992.
56. Buchner, K., Otto, H., Hilbert, R., Lindschau, C., Haller, H. and Hucho, F. (1992) Biochem. J. 286, 369-375.
57. Buelt, M.K., Glidden, B.J. and Storm, D.R. (1994) J. Biol. Chem. 269, 29367-29370.
58. Burns, D.J. and Bell, R.M. (1991) J. Biol. Chem. 266, 18300-18338.
59. Buscher, M., Rahmsdorf, H.J., Litfin, M., Karin, M. and Herrlich, P. (1988) Oncogene. 3, 301-311.
60. Byers, D.M., St.C. Palmer, F.B., Spence, M.W. and Cook, H.W. (1993) J. Neurochem. 60, 1414-1421.
61. Cambier, J.C., Newell, M.K., Justement, L.B., McGuire, J.C., Leach, K.L. and Chen, Z.Z. (1987) Nature 327, 629-632.
62. Cantley, L.C., Auger, K.R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R. and Soltoff, S. (1991) Cell 64, 281-302.
63. Carraway, K.L. and Carraway, C.A. (1989) Biochim. Biophys. Acta 988, 147-171.
64. Carroll, M.P. and May, W.S. (1994) J. Biol. Chem. 269, 1249-1256.
65. Carroll, M.P., Clark-Lewis, I., Rapp, U.R. and May, W.S. (1990) J. Biol. Chem. 265, 19812-19817.
66. Carson-Jurica, M.A., Schrader, W.T. and O'Malley, B.W. (1990) Endocr. Rev. 11, 201-220.
67. Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U. and Nishizuka, Y. (1982) J. Biol. Chem. 257, 7847-7851.
68. Cazaubon, S., Bornancin, F. and Parker, P.J. (1994) Biochem. J. 301, 443-448.
69. Cazaubon, S.M. and Parker, P.J. (1993) J. Biol. Chem. 268, 17559-17563.
70. Chakravarthy, B.R., Whitfield, J.F. and Durkin, J.P. (1994) Biochem. J. 304, 809-816.
71. Chakravarthy, B.R., Isaacs, R.J., Morley, P., Durkin, J.P. and Whitfield, J.F. (1995) J. Biol. Chem. 270, 1362-1368.
72. Chakravarty, R., Rong, X.H. and Rice, R.H. (1990) Biochem. J. 271, 25-30.
73. Chan, B.L., Chao, M.V. and Saltiel, A.R. (1989) Proc. Natl. Acad. Sci. USA 86, 1756-1760.
74. Chapman, E.R., Estep, R.P. and Storm, D.R. (1992) J. Biol. Chem. 267, 25233-25238.
75. Chen, L.L. and Tai, P.C. (1987) Nature 328, 164-166.
76. Chen, M.S., Obar, R.A., Schroeder, C.C., Austin, T.W., Poodry, C.A., Wadsworth, S.C. and Vallee, R.B. (1991) Nature 351, 583-586.
77. Chen, S.G. and Murakami, K. (1992) Biochem. J. 282, 33-39.
78. Chida, K., Kato, N. and Kuroki, T. (1986) J. Biol. Chem. 261, 13013-13018.
79. Chida, K., Kasahara, K., Tsunenaga, M., Kohno, Y., Yamada, S., Ohmi, S. and Kuroki, T. (1990) Biochem. Biophys. Res. Commun. 173, 351-357.
80. Chiu, R., Imagawa, M., Imbra, R.J., Bockoven, J.R. and Karin, M. (1987) Nature 329, 648-651.
81. Chuang, L.F., Cooper, R.H., Yau, P., Bradbury, E.M. and Chuang, R.Y. (1987) Biochem. Biophys. Res. Commun. 145, 1376-1383.
82. Cimler, B.M., Andreasen, T.J., Andreasen, K.I. and Storm, D.R. (1985) J. Biol. Chem. 260, 10784-10788.
83. Cimler, B.M., Giebelhaus, D.H., Wakim, B.T., Storm, D.R. and Moon, R.T. (1987) J. Biol. Chem. 262, 12158-12163.
84. Clark, J.D., Lin, L.-L., Kriz, R.W., Ramesha, C.S., Sultzman, L.A., Lin, A.Y., Milona, N. and Knopf, J.L. (1991) Cell 65, 1043-1051.
85. Coggins, P.J. and Zwiers, H. (1989) J. Neurochem. 53, 1895-1901.
86. Cole, G., Dobkins, K.R., Hansen, L.A., Terry, R.D. and Saitoh, T. (1988) Brain Res. 452, 165-174.
87. Collins, M.K. and Rozengurt, E. (1984) J. Cell Physiol. 118, 133-142.
88. Conrad, R., Keranen, L.M. Ellington, A.D. and Newton, A.C. (1994) J. Biol. Chem. 269, 32051-32054.
89. Conricode, K.M., Brewer, K.A. and Exton, J.H. (1992) J. Biol. Chem. 267, 7199-7202.
90. Cook, S.J. and Wakelam, M.J. (1989) Biochem. J. 263, 581-587.
91. Costa-Casnellie, M.R., Segel, G.B. and Liehtman, M.A. (1985) Biochem. Biophys. Res. Commun. 133, 1139-1144.
92. Coussens, L., Parker, P.J., Rhee, L., Yang-Feng, T.L., Chen, E., Waterfield, M.D., Francke, U. and Ullrich, A. (1986) Science 233, 859-866.
93. Covarrubias, M., Wei, A., Salkoff, L. and Vyas, T.B. (1994) Neuron 13, 1403-1412.
94. Danziger, N., Yokoyama, M., Jay, T., Cordier, T. Glowinski, J. and Chneiweiss, H. (1995) J. Neurochem. 64, 1016-1025.
95. Davis, T.N., Urdea, M.S., Masiarz, F.R. and Thorner, J. (1986) Cell 47, 423-431.
96. De Bondt, H.L., Rosenblatt, J., Jancarik, J., Jones, H.D., Morgan, D.O. and Kim, S.-H. (1993) Nature 163, 595-602.
97. Dekker, L.V., De Graan, PN Spierenburg, H., De Wit, M., Versteeg, D.H. and Gispen, W.H. (1990) Eur. J. Pharmacol. 188, 113-122.
98. Deloulme, J.C., Janet, T., Au, D., Storm, D.R., Sensenbrenner, M. and Baudier, J. (1990) J. Cell Biol. 111, 1559-1569.
99. DeVore, R.F., Corbett, A.H. and Osheroff, N. (1992) Cancer Res. 52, 2156-2161.
100. Diaz-Meco, M.T., Larrodera, P., Lopez-Barahona, M., Cornet, M.F., Barreno, P.G. and Moscal, J. (1989) Biochem. J. 263, 115-120.
101. Diaz-Meco, M.T., Dominguez, I., Sanz, L., Dent, P., Lozano, J., Municio, M.M., Berra, E., Hay, R.T., Sturgill, T.W. and Moscat, J. (1994a) EMBO J. 13, 2842-2848.
102. Diaz-Meco, M.T., Lozano, J., Municio, M.M., Berra, L., Frutos, S., Sanz, L. and Moscat, J. (1994b) J. Biol. Chem. 269, 31706-31710.
103. Doglio, A., Dani, C., Grimaldi, P. and Ailhaud, G. (1989) Proc. Natl. Acad. Sci. USA 86, 1148-1152.
104. Downes, C.P. and Carter, A.N. (1991) Cell Signal. 3, 501-513.
105. Downward, J., Graves, J.D., Warne, P.H., Rayter, S. and Cantrell, D.A. (1990) Nature 346, 719-723.
106. Drummond, A.H. (1985) Nature 315, 752-755.
107. Drust, D.S. and Martin, T.F.J. (1985) Biochem. Biophys. Res. Commun. 128, 531-538.
108. Dutil, E.M., Keranen, L.M., DePaoli-Roach, A.A. and Newton, A.C. (1994) J. Biol. Chem. 269, 29359-29362.
109. Edelman, A.M., Blumenthal, D.K. and Krebs, E.G. (1987) Annu. Rev. Biochem. 56, 567-613.
110. Eldar, H., Ben-Chaim, J. and Livneh, E. (1992) Exp. Cell Res. 202, 259-266.
111. Eldar, H., Ben-Av, P., Schmidt, U.-S., Livneh, E. and Liscovitch, M. (1993) J. Biol. Chem. 268, 12560-12564.
112. Epstein, P.M., Curti, M., Jansson, L. Huang, C.K. and Schenkman, J.B. (1989) Arch. Biochem. Biophys. 271, 424-432.
113. Erusalimsky, J.D., Friedberg, I. and Rozengurl, E. (1988) J. Biol. Chem. 263, 19188-19194.
114. Eto, A., Akita, Y., Saido, T.C., Suzuki, K. and Kawashima, S. (1995) J. Biol. Chem. (in press).
115. Fantl, W.J., Escobedo, J.A., Martin, G.A., Turck, C.W., del-Rosario, M., McCormick, F. and Williams, L.T. (1992) Cell 69, 413-423.
116. Farrar, W.L. and Anderson, W.B. (1985) Nature 315, 233-235.
117. Fearon, C.W. and Tashjian, A.H. Jr. (1985) J. Biol. Chem. 260, 8366-8371.
118. Ferris, C.D., Huganir, R.L., Supattapone, S. and Snyder, S.H. (1989) Nature 342, 87-89.
119. Field, J., Broek, D., Kataoka, T. and Wigler, M. (1987) Mol. Cell Biol. 7, 2128-2133.
120. Fields, A.P., Tyler, G., Kraft, A.S. and May, W.S. (1990) J. Cell Sci. 96, 107-114.
121. Flint, A.J., Paladini, R.D. and Koshland, D.E. Jr. (1990) Science 249, 408-411.
122. Fraser, E.D. nd Walsh, M.P. (1991) FEBS Lett. 294, 285-289.
123. Freed, E., Gailit, J., van der Geer, P., Ruoslahti, E. and Hunter, T. (1989) EMBO J. 8, 2955-2965.
124. Fujise, A., Mizuno, K., Ueda, Y., Osada, S., Hirai, S., Takayanagi, A., Shimizu, N., Owada, M.K., Nakajima, H. and Ohno, S. (1994) J. Biol. Chem. 269, 31642-31648.
125. Funder, J.W. and Sheppard, K. (1987) Annu. Rev. Physiol. 49, 397-411.
126. Gandino, L., Di Renzo, M.F., Giordano, S., Bussolino, F. and Comoglio, P.M. (1990) Oncogene 5, 721-725.
127. Gandino, E., Longati, P., Medico, E., Prat, M. and Comoglio, P.M. (1994) J. Biol. Chem. 269, 1815-1820.
128. Gandy, S., Czernik, A.J. and Greengard, P. (1988) Proc. Natl. Acad. Sci. USA 85, 6218-6221.
129. Ganong, B.R., Loomis, C.R., Hannun, Y.A. and Bell, R.M. (1986) Proc. Natl. Acad. Sci. USA 83, 1184-1188.
130. Gates, L.K., Ulrich, C.D. and Miller, E. J. (1993) Am. J. Physiol. 264, G840-G847.
131. Gauthier-Rouviere, C., Fernandez, A. and Lamb, N.J. (1990) EMBO J. 9, 171-180.
132. George, D.J. and Blackshear, P.J. (1992) J. Biol. Chem. 267, 24879-24885.
133. Gerendasy, D.D., Herron, S.R., Jennings, P.A. and Sutcliffe, J.G. (1995) J. Biol. Chem. 270, 6741-6750.
134. Ghosh, S. and Baltimore, D. (1990) Nature 344, 678-682.
135. Goldberg, Y., Glineur, C., Gesquiere, J.C., Ricouart, A., Sap, J., Vennstrom, B. and Ghysdael, J. (1988) EMBO J. 7, 2425-2433.
136. Goode, N.T. and Parker, P.J. (1994) FEBS Lett. 340, 145-150.
137. Goode, N.T., Hughes, K., Woodgett, J.R. and Parker, P.J. (1992) J. Biol. Chem. 267, 16878-16882.
138. Goode, N.T., Hajibagheri, M.A. and Parker, P.J. (1995) J. Biol. Chem, 270, 2669-2673.
139. Gopalakrishna, R. and Anderson, W.B. (1987) FEBS Lett. 225, 233-237.
140. Goss, V.L., Hocevar, B.A., Thompson, L.J., Stratton, C.A., Burns, D.J. and Fields, A.P. (1994) J. Biol. Chem. 269, 19074-19080.
141. Gout, I., Dhand, R., Hues, I.D., Fry, M.J., Panayotou, G., Das, P., Truong, O., Totty, N.F., Hsuan, J., Booker, G.W., Campbell, I.D. and Waterfield, M.D. (1993) Cell 75, 25-36.
142. Graff, J.M., Gordon, J.I. and Blackshear, P.J. (1989a) Science 246, 503-506.
143. Graff, J.M., Young, T.N., Johnson, J.D. and Blackshear, P.J. (1989b) J. Biol. Chem. 264, 21818-21823.
144. Grillone, L.R., Clark, M.A., Godfrey, R.W., Slassen, F. and Crooke, S.T. (1988) J. Biol. Chem. 263, 2658-2663.
145. Gschwendt, M., Kittstein, W. and Marks, F. (1993) Biochem. Biophvs. Res. Commun. 194, 571-576.
146. Gulbins, E., Coggeshall, K.M., Baier, G., Telford, D., Langlet, C., Baier-Bitterlich, G., Bonnefoy-Berard, N., Burn, P., Wittinghofer, A. and Altman, A. (1994) Mol. Cell Biol. 14, 4749-4758.
147. Ha, K.-S. and Exton, J.H. (1993) J. Biol. Chem. 268, 10534-10539.
148. Hall, C., Monfries, C., Smith, P., Lim, H.H., Kozma, R., Ahmed, S., Vanniasingham, V., Leung, T. and Lim, L. (1990) J. Mol. Biol. 211, 11-16.
149. Hall, C., Sin, W.C., Teo, M., Michael, G.J., Smith, P., Dong, J.M., Lim, H.H., Mauser, E., Spurr, N.K., Jones, T.A, et al.(1993) Mol. Cell Biol. 13, 4986-4998.
150. Hall, D.J. and Stiles, C.D. (1987) J. Biol. Chem. 262, 15302-15308.
151. Han, Y., Wang, W., Schleuder, K.K., Ganjeizadeh, M. and Dokas, L.A. (1992) J. Neurochem. 59, 364-374.
152. Hanks, S.K., Quinn, A.M. and Hunter, T. (1988) Science 241, 42-52.
153. Hannun, Y.A. (1994) J. Biol. Chem. 269, 3125-3128.
154. Hannun, Y.A. and Bell, R.M. (1986) J. Biol. Chem. 261, 9341-9347.
155. Hannun, Y.A. and Bell, R.M. (1989) Science 243, 500-507.
156. Hannun, Y.A. and Bell, R.M. (1990) J. Biol. Chem. 265, 2962-2972.
157. Hannun, Y.A., Loomis, C.R. and Bell, R.M. (1985) J. Biol. Chem. 260, 10039-10043.
158. Hannun, Y.A., Loomis, C.R. and Bell, R.M. (1986) J. Biol. Chem. 261, 7184-7190.
159. Hardie, G. (1988) Nature 335, 592-593.
160. Hardy, S., Kong, Y. and Konieczny, S.F. (1993) Mol. Cell Biol. 13, 5943-5956.
161. Hartwig, J.H., Thelen, M., Rosen, A., Janmey, P.A., Nairn, A.C. and Aderem, A. (1992) Nature 356, 618-622.
162. Hashimoto, Y. and Soderling, T.R. (1989) J. Biol. Chem. 264, 16524-16529.
163. Haystead, T.A. and Hardie, D.G. (1988) Eur. J. Biochem. 175, 339-345.
164. Hell, J.W., Appleyard, S.M., Yokoyama, C.T., Warner, C. and Catterall, W.A. (1994) J. Biol. Chem. 269, 7390-7396.
165. Hens, J.J.H., Ghijsen, W.F.J.M., Dimjati, W., Wiegant, V.M., Oestreicher, A.B., Gispen, W.H. and De Graan, P.N.E, (1993) J. Neurochem. 61, 602-609.
166. Hepler, J.R., Earp, H.S. and Harden, T.K. (1988) J. Biol. Chem. 263, 7610-7619.
167. Hepler, J.R., Jeffs, R.A., Huckle, W.R., Outlaw, H.E., Rhee, S.G., Earp, H.S. and Harden, T.K. (1990) Biochem. J. 270, 337-344.
168. Herskovits, J.S., Burgess, C.C., Obar, R.A. and Vallee, R.B. (1993a) J. Cell Biol. 122, 565-578.
169. Herskovits, J.S., Shpetner, U.S., Burgess, C.C. and Vallee, R.B. (1993b) Proc. Natl. Acad. Sci. USA 90, 11468-11472.
170. Hirai, M. and Shimizu, N. (1990) Biochem. J 270, 583-589.
171. Hirota, K., Hirota, T., Aguilera, G. and Catt, K.J. (1985) J. Biol. Chem. 260, 3243-3246.
172. Hocevar, B.A., Burns, D.J. and Fields, A.P. (1993) J. Biol. Chem. 268, 7545-7552.
173. Hornbeek, P., Huang, K.P. and Paul, W.E. (1988) Proc. Natl. Acad Sci. USA 85, 2279-2283.
174. Hoshi, M., Akiyama, T., Shinohara, Y., Miyata, Y., Ogawara, H., Nishida, E. and Sakai, H. (1988) Eur. J. Biochem. 174, 225-230.
175. Houbre, D., Duportail, G., Deloulme, J.-C. and Baudier, J. (1991) J. Biol. Chem. 266, 7121-7131.
176. House, C. and Kemp, B.E. (1987) Science 238, 1726-1728.
177. House, C. and Kemp, B.F. (1990) Cell Signal, 2, 187-190.
178. Howard, P.W. and Maurer, R.A. (1994) J. Biol. Chem. 269, 28662-28669.
179. Hsieh, J.C., Junitka, P.W., Nakajima, S., Galligan, M.A., Haussler, C.A., Shimizu, Y., Shimizu, N., Whittield, G.K. and Haussler, M.R. (1993) J. Biol. Chem. 268, 15118-15126.
180. Huang, C.F. and Cabot, M.C. (1990) J. Biol. Chem. 265, 17468-17473.
181. Huang, F.L., Yoshida, Y., Cunha-Melo, J.R., Beaven, M.A. and Huang, K.P. (1989) J. Biol. Chem. 264, 4238-4243.
182. Huang, F.L. and Huang, K.P. (1991) J. Biol. Chem. 266, 8727-8733.
183. Huang, K.P. and Huang, F.L. (1993) Neurochem. Int. 22, 417-433.
184. Huang, K.P., Chan, K.F., Singh, T.J., Nakabayashi, H. and Huang, F.L. (1986) J. Biol. Chem. 261, 12134-12140.
185. Hubbard, S.R., Bishop, W.R., Kirschmeier, P., George, S.J., Cramer, S.P. and Hendrickson, W.A. (1991) Science 254, 1776-1779.
186. Hug, H. and Sarre, T.F. (1993) Biochem. J. 291, 329-343.
187. Hunter, T. (1991) Cell 64, 249-270.
188. Inoue, M., Kishimoto, Y., Takai, Y. and Nishizuka, Y. (1977) J. Biol. Chem. 252, 7610-7616.
189. Irving, H.R. and Exton, J.H. (1987) J. Biol. Chem. 262, 3440-3441.
190. Isakov, N., McMahon, P. and Altman, A. (1990) J. Biol. Chem. 265. 2091-2097.
191. Ishikawa, F., Takaku, F., Nagao, M. and Sugimura, T. (1986) Jpn. J. Cancer. Res. 77, 1183-1187.
192. Issandou, M. and Rozengurt, E. (1990) J. Biol. Chem. 265, 11890-11896.
193. Ito, M., Takami, Y., Tanabe, F., Shigeta, S., Tsukui, K. and Kawade, Y. (1988a) Biochem. Biophys. Res. Commun. 150, 126-132.
194. Ito, M., Tanabe, F., Takami, Y., Sato, A. and Shigeta, S. (1988b) Biochem. Biophys. Res. Commun. 153, 648-656.
195. Ivins, K.J., Neve, K.A., Feller, D.J., Fidel, S.A. and Neve, R.L. (1993) J. Neurochem. 60, 626-633.
196. Jackson, T.R., Stephens, L.R. and Hawkins, P.T. (1992) J. Biol. Chem. 267, 16627-16636.
197. James, G. and Olson, E.N. (1989a) J. Biol. Chem. 264, 20928-20933.
198. James, G. and Olson, E.N. (1989b) J. Biol. Chem. 264, 20928-20933.
199. James, G. and Olson, E. (1992) J. Cell Biol. 116, 863-874.
200. Jarvis, W.D., Fornari, F.A.J., Browning, J.L., Gewirtz, D.A., Kolesnick, R.N. and Grant, S. (1994) J. Biol. Chem. 269, 31685-31692.
201. Jayadev, S., Liu, B., Bielawska, A.E., Lee, J.Y., Nazaire, F., Pushkareva, M.Y., Obeid, L.M. and Hannun, Y.A. (1995) J. Biol. Chem. 270, 2047-2052.
202. Jeng, A.Y., Srivastava, S.K., Lacal, J.C. and Blumberg, P.M. (1987) Biochem. Biophys. Res. Commun. 145, 782-788.
203. Johannes, F.J., Prestle, J., Eis, S., Oberhagemann, P. and Pfizen-maier, K. (1994) J. Biol. Chem. 269, 6140-6148.
204. Jones, D.H.A., Martin, H., Madrazo, J., Robinson, K.A., Nielsen, P., Roseboom, P.H., Patel, Y., Howell, S.A. and Aitken, A. (1995) J. Mol. Biol. 245, 375-384.
205. Jones, M.J. and Murray, A.W. (1995) J. Biol. Chem. 270, 5007-5013.
206. Kaibuchi, K., Fukumoto, Y., Oku, N., Takai, Y., Arai, K. and Muramatsu, M. (1989) J. Biol. Chem. 264, 13489-13496.
207. Kaisr, H.W., O'Keefe, E. and Bennett, V. (1989) J. Cell Biol. 109, 557-569.
208. Kanakura, Y., Druker, B., Wood, K.W., Mamon, H.J., Okuda, K., Roberts, T.M. and Griffin, J.D. (1991) Blood 77, 243-248.
209. Kapiloff, M.S., Farkash, Y., Wegner, M. and Rosenfeld, M.G. (1991) Science 253, 786-789.
210. Karns, L.R., Ng, S.C., Freeman, J.A. and Fishman, M.C. (1987) Science 236, 597-600.
211. Kashishian, A., Kazlauskas, A. and Cooper, J.A. (1992) EMBO J. 11, 1373-1382.
212. Katoh, S., Sueoka, T., Yamamoto, Y. and Takahashi, S.Y. (1994) FEBS Lett, 341, 227-232.
213. Kazanietz, M.G., Krausz, K.W. and Blumberg, P.M. (1992) J. Biol. Chem. 267, 20878-20886.
214. Kazanietz, M.G., Bustelo, X.R., Barbacid, M., Kolch, W., Mischak, H., Wong, G., Pettit, G.R., Bruns, J.D. and Blumberg, P.M. (1994) J. Biol. Chem. 269, 11590-11594.
215. Kellenberger, S., Malherbe, P. and Sigel, E. (1992) J. Biol. Chem. 267, 25660-25663.
216. Kemp, B.E., Pearson, R.B., House, C., Robinson, P.J. and Means, A.R. (1989) Cell Signal. 1, 303-311.
217. Kessell, I , Hoist, B.D. and Roth, T.F. (1989) Proc. Natl. Acad. Sci. USA 86, 4968-4972.
218. Khan, W.A., Blobe, G.C. and Hannun, Y.A. (1992) J. Biol. Chem. 267, 3605-3612.
219. Kielbassa, K., Muller, H.J., Meyer, H.E., Marks, F. and Gschwendt, M. (1995) J. Biol. Chem. 270, 6156-6162.
220. Kieran, M., Blank, V., Logeat, F., Vandekerckhove, J., Lottspeich, F., Le Bail, O., Urban, M.B., Kourilsky, P., Baeuerle, P.A. and Israel, A. (1990) Cell 62, 1007-1018.
221. Kikkawa, U. and Nishizuka, Y. (1986) Annu. Rev. Cell Biol. 2, 149-178.
222. Kikkawa, U., Takai, Y., Minakuchi, K., Inohara, S. and Nishizuka. Y. (1982) J. Biol. Chem. 257, 13341-13348.
223. Kikkawa, U., Takai, Y., Tanaka, Y., Miyake, R. and Nishizuka, Y. (1983) J. Biol. Chem. 258, 11442-11445.
224. Kiley, S.C., Parker, P.J., Fabbro, D. and Jaken, S. (1991) J. Biol. Chem. 266, 23761-23768.
225. Kim, J., Shishido, T., Jiang, X., Aderem, A. and McLaughlin, S. (1994) J. Biol. Chem. 269, 28214-28219.
226. Kinsella, B.T., O'Mahony, D.J. and FitzGerald, G.A. (1994) J. Biol. Chem. 269, 29914-29919.
227. Kishimoto, A., Takai, Y., Mori, T., Kikkawa, U. and Nishizuka, Y. (1980) J. Biol. Chem. 255, 2273-2276.
228. Kishimoto, A., Kajikawa, N., Shiota, M. and Nishizuka, Y. (1983) J. Biol. Chem. 258, 1156-1164.
229. Kishimoto, A., Mikawa, K., Hashimoto, K., Yasuda, I., Tanaka, S., Tominaga, M., Kuroda, T. and Nishizuka, Y. (1989) J. Biol. Chem. 264, 4088-4092.
230. Kitamura, S., Ando, S., Shibata, M., Tanabe, K., Sato, C. and Inagaki, M. (1989) J. Biol. Chem. 264, 5674-5678.
231. Klee, C.B. (1988) Biochemistry 27, 6645-6653.
232. Knopf, J.L., Lee, M.H., Sultzman, L.A., Kriz, R.W., Loomis, C.R., Hewick, R.M. and Bell, R.M. (1986) Cell 46, 491-502.
233. Kochs, G., Hummel, R., Fiebich, B., Sarre, T.F., Marine, D. and Hug, H. (1993) Biochem. J. 291, 627-633.
234. Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Manne, D. and Rapp, U.R. (1993) Nature 364, 249-252.
235. Kolesnick, R. and Golde, D.W. (1994) Cell 77, 325-328.
236. Kolesnick, R.N. (1989) J. Biol. Chem. 264, 7617-7623.
237. Kosaka, T. and Ikeda, K. (1983a) J. Cell Biol. 97, 499 507.
238. Kosaka, T. and Ikeda, K. (1983b) J. Neurobiol. 14, 207-225.
239. Kraft, A.S. and Anderson, W.B. (1983) Nature 301, 621-623.
240. Kribben, A., Wieder, E.D., Li, X., Van Putten, V., Granot, Y., Schrier, R.W. and Nemenoff, R.A. (1993) Am. J. Physiol. Cell Physiol. 265, C939-C945.
241. Krueger, B.K., Forn, J. and Greengard, P. (1977) J. Biol. Chem. 252, 2764-2773.
242. Kucera, G.L. and Rittenhouse, S.E. (1990) J. Biol. Chem. 265, 5345-5348.
243. Kuo, J.F., Schatzman, R.C., Turner, R.S. and Mazzei, G.J. (1984) Mol. Cell. Endocrinol. 35, 65-73.
244. Larrodera, P., Cornet, M.E., Diaz-Meco, M.T., Lopez-Barahona, M., Diaz-Laviada, I., Guddal, P.H., Johansen, T. and Moscat, J. (1990) Cell 61, 1113-1120.
245. Lawen, A., Burger, M. and Martini, O.H. (1989) Eur. J. Biochem. 183, 245-253.
246. Leach, K.L. and Blumberg, P.M. (1985) Cancer Res. 45, 1958-1963.
247. Leach, K.L., Powers, E.A., Ruff, V.A., Jaken, S. and Kaufmann, S. (1989) J. Cell Biol. 109, 685-695.
248. Lee, M.H. and Bell, R.M. (1991) Biochemistry 30, 1041-1049.
249. Lee, W., Mitchell, P. and Tjian, R. (1991) Cell 49, 741-752.
250. Lehel, C., Olah, Z., Jakab, G. and Anderson, W.B. (1995) Proc. Natl. Acad. Sci. USA 92, 1406-1410.
251. Lehrich, R.W. and Forrest, J.N.J. (1994) J. Biol. Chem. 269, 32446-32450.
252. Lenardo, M.J. and Baltimore, D. (1989) Cell 58, 227-229.
253. Lewis, R.E., Cao, L., Perregaux, D. and Czech, M.P. (1990) Biochemistry 29, 1807-1813.
254. Li, L., Zhou, J., James, G., Heller-Harnson, R., Czech, M.P. and Olson, E.N. (1992) Cell 71, 1181-1194.
255. Li, P., Wood, K., Mamon, H., Haser, W. and Roberts, T. (1991) Cell 64, 479-482.
256. Linden, D.J., Sheu, F.S., Murakami, K. and Routtenberg, A. (1987) J. Neurosci. 7, 3783-3792.
257. Liscovitch, M. and Amsterdam, A. (1989) J. Biol. Chem. 264, 11762-11767.
258. Litchfield, D.W. and Ball, E.H. (1986) Biochem. Biophys. Res. Commun. 134, 1276-1283.
259. Litchfield, D.W. and Ball, E.H. (1987) J. Biol. Chem. 262, 8056-8060.
260. Liu, F. and Roth, R.A. (1994) FEBS Lett. 352, 389-392.
261. Liu, J.-P. and Robinson, P.J. (1995) Endocr. Rev. 16 (in press).
262. LIU, J.-P., Robinson, P.J., Funder, J.W. and Engler, D. (1990) J. Biol. Chem. 265, 14136-14142.
263. Liu, J.-P., Engler, D., Funder, J.W. and Robinson, P.J. (1992) Mol. Cell. Endocrinol. 87, 35-47.
264. Liu, J.-P., Engler, D., Funder, J.W. and Robinson, P.J. (1994a) Mol. Cell. Endocrinol. 101, 247-256.
265. Liu, J.-P., Powell, K.A., Südhof, T.C. and Robinson, PJ. (1994b) J. Biol. Chem. 269, 21043-21050.
266. Liu, J.-P., Sim, A.T.R. and Robinson, P.J. (1994c) Science 265, 970-973.
267. Liu, Y. and Storm, D.R. (1989) J. Biol. Chem. 264, 12800-12804.
268. Liu, Y. and Storm, D.R. (1990) Trends Pharmacol. Sci. 11, 107-111.
269. Liyanage, M., Frith, D., Livneh, E. and Stabel, S. (1992) Biochem. J. 283, 781-787.
270. Lopez-Briones, L.G., Wax, M.B. and Coca-Prados, M. (1990) Exp. Eye Res. 51, 277-286.
271. Louis, J.C., Revel, M.O. and Zwiller, J. (1993) Biochim. Biophys. Acta 1177, 299-306.
272. Lounsbury, K.M., Schlegel, B., Poncz, M., Brass, L.F. and Manning, D.R. (1993) J. Biol. Chem. 268, 3494-3498.
273. Lovinger, D.M., Colley, P.A., Akers, R.F., Nelson, R.B. and Routtenberg, A. (1986) Brain Res. 399, 205-211.
274. Lowndes, J.M., Hokin-Neaverson, M. and Bertics, P.J. (1990) Biochim. Biophys. Acta 1052, 143-151.
275. Lozano, J., Berra, E., Municio, M.M., Diaz-Meco, M.T., Dominguez, I., Sanz, L. and Moscat, J. (1994) J. Biol. Chem. 269, 19200-19202.
276. Luo, J.-H. and Weinstein, I.B. (1993) J. Biol. Chem. 268, 23580-23584.
277. Luo, J.-H., Kahn, S., O'Driscoll, K. and Weinstein, I.B. (1993) J. Biol. Chem. 268, 3715-3719.
278. Luttrell, L.M., Luttrell, D.K., Parsons, S.J. and Rogol, A.D. (1989) Oncogene 4, 317-324.
279. Mackanos, E.A., Pettit, G.R. and Ramsdell, J.S. (1991) J. Biol. Chem. 266, 11205-11212.
280. Macphee, C.H. and Drummond, A.H. (1984) Mol. Pharmacol. 25, 193-200.
281. Maeda, K., Nakata, T., Noda, Y., Sato-Yoshitake, R. and Hirokawa, N. (1992) Mol. Biol. Cell 3, 1181-1194.
282. Maekawa, S., Murofushi, H. and Nakamura, S. (1994) J. Biol. Chem. 269, 19462-19465.
283. Mahoney, C.W., Shuman, J., McKnight, S.L., Chen, H.-C. and Huang, K.-P. (1992) J. Biol. Chem. 267, 19396-19403.
284. Makowske, M. and Rosen, O.M. (1989) J. Biol. Chem. 264, 16155-16159.
285. Manenti, S., Sorokine, O., Van Dorsselaer, A. and Taniguchi, H. (1992) J. Biol. Chem. 267, 22310-22315.
286. Manenti, S., Sorokine, O., Van-Dorsselaer, A. and Taniguchi, H. (1994) J. Biol. Chem. 269, 8309-8313.
287. Martin, T.F.J., Hsieh, K.P. and Porter, B.W. (1990) J. Biol. Chem. 265, 7623-7631.
288. Martin, T.W. and Michaelis, K. (1989) J. Biol. Chem. 264, 8847-8856.
289. Maruyama, I.N. and Brenner, S. (1991) Proc. Natl. Acad. Sci. USA 88, 5729-5733.
290. Matter, N., Ritz, M.-F., Freyermuth, S., Rogue, P. and Malviya, A.N. (1993) J. Biol. Chem. 268, 732-736.
291. May, W.S, Jr., Sahyoun, N., Wolf, M. and Cuatrecasas, P. (1985) Nature 317, 549-551.
292. McArdle, C.A. and Conn, P.M. (1986) Mol. Pharmacol. 29, 570-576.
293. McFadden, P.N., Mandpe, A. and Koshland, D.E, Jr. (1989) J. Biol. Chem. 264, 12765-12771.
294. McIlhinney, R.A. and McGlone, K. (1990) Biochem. J. 271, 681-685.
295. McIlroy, B.K., Walters, J.D., Blackshear, P.J. and Johnson, J.D. (1991) J. Biol. Chem. 266, 4959-4964.
296. Meier, K.E., Weiel, J.E., Bloom, T.J. and Krebs, H.G. (1990) J. Biol. Chem. 265, 4635-4645.
297. Melloni, E., Pontremoli, S., Michetti, M., Sacco, O., Sparatore, B. and Horecker, B.L. (1986) J. Biol. Chem. 261, 4101-4105.
298. Merrill, A.H, Jr. and Stevens, V.L. (1989) Biochim. Biophys. Acta 1010, 131-139.
299. Mino, T., Yuasa, U., Naka, M. and Tanaka, T. (1995) Biochem. Biophys. Res Commun. 208, 397-404.
300. Mitchell, F.E., Marais, R.M. and Parker, P.J. (1989) Biochem. J. 261, 131-136.
301. Mitchell, P.J., Wang, C. and Tjian, R. (1987) Cell 50, 847-861.
302. Mochly-Rosen, D., Khaner, H., Lopez, J. and Smith, B.L. (1991) J. Biol. Chem. 266, 14866-14868.
303. Mochly-Rosen, D. and Koshland, D.E. Jr. (1987) J. Biol. Chem. 262. 2291-2297.
304. Montaner, S., Ramos, A., Perona, R., Esteve, P., Carnero, A. and Lacal, J.C. (1995) Oncogene 10, 2213-2220.
305. Morley, S.J., Dever, T.E., Etchison, D. and Trauen, J.A. (1991) J. Biol. Chem. 266, 4669-4672.
306. Morris, C. and Rozengurt, E. (1988) FEBS Lett. 231, 311-316.
307. Mosior, M. and Epand, R.M. (1993) Biochemistry 32, 66-75.
308. Mulcahy, L.S., Smith, M.R. and Stacey, D.W. (1985) Nature 313, 241-243.
309. Murakami, K., Whiteley, M.K. and Routtenherg, A. (1987) J. Biol. Chem. 262, 13902-13906.
310. Murakami, N., Elzinga, M., Singh, S.S. and Chauhan, V.P. (1994) J. Biol. Chem. 269, 16082-16090.
311. Nairn, A.C., Hemmings, H.C. Jr. and Greengard, P. (1985) Annu. Rev. Biochem. 54, 931-976.
312. Nakadate, T., Jeng, A.Y. and Blumberg, P.M. (1988) Biochem. Pharmacol. 37, 1541-1545.
313. Nakanishi, H., Brewer, K.A. and Exton, J.H. (1993) J. Biol. Chem. 268, 13-16.
314. Nambi, P., Watt, R., Whitman, M. Aijar, N., Moore, J.P., Evan, G.I. and Crooke, S. (1989) FEBS Lett. 245, 61-64.
315. Narindrasorasak, S., Brickenden, A., Ball, E. and Sanwal, B.D. (1987) J. Biol. Chem. 262, 10497-10501.
316. Nelson, D.H. and Murray, D.K. (1982) Proc. Natl. Acad. Sci. USA 79, 6690-6692.
317. Nelson, R.B., Linden, D.J., Hyman, C., Pfenninger, K.H. and Routtenberg, A. (1989) J. Neurosci. 9, 381-389.
318. Nemenoff, R.A., Winitz, S., Qian, N.X., Van-Putten, V., Johnson, G.L. and Heasley, L.E. (1993) J. Biol. Chem. 268, 1960-1964.
319. Newton, A.C. and Koshland, D.E. Jr. (1989) J. Biol. Chem. 264. 14909-14915.
320. Newton, A.C. and Taylor, S.S. (1995) FEBS 1, 2-3.
321. Newton, A.C. and Williams, D.S. (1993) J. Biol. Chem. 268, 18181-18186.
322. Ng, S.C., de la Monte, S.M., Conboy, G.L., Karns, L.R. and Fishman, M.C. (1988) Neuron I, 133-139.
323. Niedel, J.E. and Blackshear, P.J. Protein kinase C. (1986) In: Phosphoinositides and Receptor Mechanisms. (Putney, J.W. Jr., ed.). pp, 47-88, New York: Alan R. Liss, Inc.
324. Nielander, H.B., Schrama, L.H., van Rozen, A.J., Kaspcraitis, M., Oestreicher, A.B., Gispen, W.H. and Schotman, P. (1990) J. Neurochem. 55, 1442-1445.
325. Nishizuka, Y. (1980) Mol. Biol. Biochem. Biophys. 32, 113-135.
326. Nishizuka, Y. (1984) Science 225, 1365-1370.
327. Nishizuka, Y. (1986) Science 233, 305-312.
328. Nishizuka, Y. (1988) Nature 334, 661-665.
329. Nishizuka, Y. (1992) Science 258, 607-614.
330. Nishizuka, Y., Takai, Y., Kishimoto, A., Kikkawa, U. and Kaibuchi, K. (1984) Recent. Prog. Horm. Res. 40, 301-345.
331. Noland, T.A. Jr., Raynor, R.L. and Kuo, J.F. (1989) J. Biol. Chem. 264, 20778-20785.
332. O'Flaherty, J.T., Jacobson, D.P., Redman, J.F. and Rossi, A.G. (1990) J. Biol. Chem. 265, 9146-9152.
333. Obar, K.A., Collins, C.A., Hammarback, J.A., Shpetner, H.S. and Vallee, R.B. (1990) Nature 347, 256-261.
334. Oh-uchida, M., Yano, K., Kawamoto, S. and Shimizu, K. (1990) Jpn. J. Cancer. Res. 81, 799-806.
335. Ohno, S., Kawasaki, H., Imajoh, S., Suzuki, K., Inagaki, M., Yokokura, H., Sakoh, T. and Hidaka, H. (1987) Nature 325, 161-166.
336. Ohno, S., Akita, Y., Konno, Y., Imajoh, S. and Suzuki, K. (1988) Cell 53, 731-741.
337. Ohno, S., Konno, Y., Akita, Y., Yano, A. and Suzuki, K. (1990) J. Biol. Chem. 265, 6296-6300.
338. Okazaki, T., Bell, R.M. and Hannun, Y.A. (1989) J. Biol. Chem. 264, 19076-19080.
339. Olivier, A.R and Parker, P.J. (1992) J. Cell. Physiol. 152, 240-244.
340. Olivier, A.R. and Parker, P.J. (1994) J. Biol. Chem. 269, 2758-2763.
341. Ono, Y., Fujii, T., Igarashi, K., Kuno, T., Tanaka, C., Kikkawa, U. and Nishizuka, Y. (1989a) Proc. Natl. Acad. Sci. USA 86, 4868-4871.
342. Ono, Y., Fujii, T., Ogita, K., Kikkawa, U., Igarashi, K. and Nishizuka, Y. (1989b) Proc. Natl. Acad. Sci. USA 86, 3099-3103.
343. Orellana, S., Solski, P.A. and Brown, J.H. (1987) J. Biol. Chem. 262, 1638-1643.
344. Orr, J.W. and Newton, A.C. (1994) J. Biol. Chem. 269, 8383-8387.
345. Orr, J.W., Keranen, L.M. and Newton, A.C. (1992) J. Biol. Chem. 267, 15263-15266.
346. Ouimet, C.C., Wang, J.KT., Walaas, S.I., Albert, K.A. and Greengard, P. (1990) J. Neurosci. 10, 1683-1698.
347. Ozawa, K., Yamada, K., Kazanietz, M.G., Blumberg, P.M. and Beaven, M.A. (1993) J. Biol. Chem. 268, 2280-2283.
348. Pachter, J.A., Pai, J.-K., Mayer-Ezell, R., Petrin, J.M., Dobek, E. and Bishop, W.R. (1992) J. Biol. Chem. 267, 9826-9830.
349. Pai, J.K., Siegel, M.I., Egan, R.W. and Billah, M.M. (1988) J. Biol. Chem. 263, 12472-12477.
350. Pai, J.K., Pachter, J.A., Weinstein, I.B. and Bishop, W.R. (1991) Proc. Natl. Acad. Sci. USA 88, 598-602.
351. Pajares, M.A., Duran, C., Corrales, F. and Mato, J.M. (1994) Biochem. J. 303, 949-955.
352. Pandey, K.N. (1994a) J. Androl. 15, 100-109.
353. Pandey, K.N. (1994b) Mol. Cell. Biochem. 141, 103-111.
354. Pandol, S.J. and Schoeffield, M.S. (1986) J. Biol. Chem. 261, 4438-4444.
355. Park, D.J., Min, H.K. and Rhee, S.G. (1992) J. Biol. Chem. 267. 1496-1501.
356. Parker, P.J., Coussens, L., Totty, N., Rhee, L., Young, S., Chen, E., Stabel, S., Waterfield, M.D. and Ullrich, A. (1986) Science 233, 853-859.
357. Parker, P.J., Kour, G., Marais, R.M., Mitchell, F., Pears, C., Schaap, D., Stabel, S. and Webster, C. (1989) Mol. Cell. Endocrinol, 65, 111.
358. Patel, J. and Kligman, D. (1987) J. Biol. Chem. 262, 16686-16691.
359. Pears, C.J., Kour, G., House, C., Kemp, B.E. and Parker, P.J. (1990) Eur. J. Biochem. 194, 89-94.
360. Pearson, J.D., DeWald, D.B., Mathews, W.R., Mozier, N.M., Zurcher-Neely, H.A., Heinrikson, R.L., Morris, M.A., McCubbin, W.D., McDonald, J.R., Fraser, E.D, et al. (1990) J. Biol. Chem. 265, 4583-4591.
361. Pearson, R.B. and Kemp, B.E. (1991) Methods Enzymol. 200, 62-81.
362. Pendergast, A.M., Traugh, J.A. and Witte, O.N. (1987) Mol. Cell Biol. 7, 4280-4289.
363. Perin, M.S., Fried, V.A., Mignery, G.A., Jahn, R. and Südhof, T.C. (1990) Nature 345, 260-263.
364. Pfeilschifier, J. and Huwiler, A. (1993) FEBS Lett. 331, 267-271.
365. Pitcher, J., Lohse, M.J., Codina, J., Caron, M.G. and Lefkowitz, R.J. (1992) Biochemistry 31, 3193-3197.
366. Poodry, C.A. and Edgar, L. (1979) J. Cell Biol. 81, 520-527.
367. Preiss, J., Loomis, C.R., Bishop, W.R., Stein, R., Niedel, J.E. and Bell, R.M. (1986) J. Biol. Chem. 261, 8597-8600.
368. Price, B.D., Morris, J.D., Marshall, C.J. and Hall, A. (1989) J. Biol. Chem. 264, 16638-16643.
369. Pyne, N.J., Freissmuth, M. and Palmer, S. (1992) Biochem. J. 285. 333-338.
370. Qi, D.F., Schatzman, R.C., Mazzei, G.J., Turner, R.S., Raynor, R.L., Liao, S. and Kuo, J.F. (1983) Biochem. J. 213, 281-288.
371. Qian, Z. and Drewes, L.R. (1990) J. Biol. Chem. 265, 3607-3610.
372. Quest, A.F. and Bell, R.M. (1994) J. Biol. Chem. 269, 20000-20012.
373. Quest, A.F.G., Bardes, E.S.G. and Bell, R.M. (1994) J. Biol. Chem. 269, 2953-2960.
374. Rana, R.S. and Hokin, L.E. (1990) Physiol. Rev. 70, 115-164.
375. Rando, R.R. (1988) FASEB. J. 2, 2348-2355.
376. Rasmussen, C.D. and Means, A.R. (1989) EMBO J. 8, 73-82.
377. Raymond, J.R. (1991) J. Biol. Chem. 266, 14747-14753.
378. Reedijk, M., Liu, X., van-der-Geer, P., Letwin, K., Waterfield, M.D., Hunter, T. and Pawson, T. (1992) EMBO J. 11, 1365-1372.
379. Resh, M.D. and Ling, H.P. (1990) Nature 346, 84-86.
380. Rhee, S.G. and Choi, K.D. (1992) J. Biol. Chem. 267, 12393-12396.
381. Rittenhouse-Simmons, S. (1979) J. Clin. Invest. 63, 580-587.
382. Robinson, K., Jones, D., Patel, Y., Martin, H., Madrazo, J., Martin. S., Howell, S., Elmore, M., Finnen, M.J. and Aitken, A. (1994) Biochem. J. 299, 853-861.
383. Robinson, P.J. (1992) J. Biol. Chem. 267, 21637-21644.
384. Robinson, P.J. and Dunkley, P.R. (1983) J. Neurochem. 41, 909-918.
385. Robinson, P.J., Sontag, J.-M., Liu, J.-P., Fykse, E.M., Slaughter, C., McMahon, H. and Südhof, T.C. (1993) Nature 365, 163-166.
386. Rodriguez-Viciana, P., Warne, P.H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M.J., Watertield, M.D. and Downward, J. (1994) Nature 370, 527-532.
387. Ron, D., Chen, C.-H., Caldwell, J., Jamieson, L., Orr, E. and Mochly-Rosen, D. (1994) Proc. Natl. Acad. Sci. USA 91, 839-843.
388. Rosen, A., Keenan, K.F., Thelen, M., Nairn, A.C. and Aderem, A. (1990) J. Exp. Med. 172, 1211-1215.
389. Rosenthal, A., Chan, S.Y., Henzel, W., Haskell, C., Kuang, W.J., Chen, E., Wilcox, J.N., Ullrich, A., Goeddel, D.V. and Routtenberg, A. (1987) EMBO J. 6, 3641-3646.
390. Rosier, M. and Schoner, W. (1990) Arch. Biochem. Biophys, 281, 185-190.
391. Rosoff, P.M., Savage, N. and Dinardlo, C.A. (1988) Cell 54, 73-81.
392. Ross, C.A., Meldolesi, J., Milner, T.A., Satoh, T., Supattapone, S. and Snyder, S.H. (1989) Nature 339, 468-470.
393. Routtenberg, A., Colley, P., Linden, D., Lovinger, D., Murakami, K. and Sheu, F.S. (1986) Brain Res. 378, 174-378.
394. Rozengurt, E. (1990) Am. Rev. Respir. Dis. 142, S11-S15.
395. Saez, J.C., Nairn, A.C., Czernik, A.J., Spray, D.C., Hertzberg, E.L., Greengard, P. and Bennett, M.V. (1990) Eur. J. Biochem. 192, 263-273.
396. Safran, A., Provenzano, C., Sagi-Eisenberg, R. and Fuchs, S. (1990) Biochemistry 29, 6730-6734.
397. Sagi-Eisenberg, R., Traub, L.M., Spiegel, A.M. and Zick, Y. (1989) Cell Signal. 1, 519-531.
398. Sahyoun, N., Wolf, M., Besterman, J., Hsieh, T., Sander, M., LeVine, H., Chang, K.J. and Cuatrecasas, P. (1986) Proc. Natl. Acad. Sci. USA 83, 1603-1607.
399. Saitoh, T. and Dobkins, K.R. (1986) Brain Res. 379, 196-199.
400. Sakai, K., Hirai, M., Minoshima, S., Kudoh, J., Fukuyama, R. and Shimizu, N. (1989) Genomics 5, 309-315.
401. Sakane, F., Yamada, K., Kanoh, H., Yokohama, C. and Tanabe, T. (1990) Nature 344, 345-348.
402. Saksela, K., Makela, T.P., Evan, G. and Alitalo, K. (1989) EMBO J. 8, 149-157.
403. Samuels, D.S., Shimizu, Y. and Shimizu, N. (1989) FEBS Lett. 259, 57-60.
404. Sanchez-Bueno, A., Dixon, C.J., Woods, N.M., Cuthbertson, K.S.R and Cobbold, P.H. (1990) Biochem. J. 268, 627-632.
405. Sando, J.J. and Young, M.C. (1983) Proc. Natl. Acad. Sci. USA 80, 2642-2646.
406. Sano, K., Takai, Y., Yamanishi, J. and Nishizuka, Y. (1983) J. Biol. Chem. 258, 2010-2013.
407. Satoh, T., Endo, M., Nakamura, S. and Kaziro, Y. (1988) FEBS Lett. 236, 185-189.
408. Savart, M., Verret, C., Dutaud, D., Touyarot, K., Elamrani, N. and Ducastaing, A. (1995) FEBS Lett. 359, 60-64.
409. Schaap, D., Parker, P.J., Bristol, A., Kriz, R. and Knopf, J.L. (1989) FEBS Lett. 243, 351-357.
410. Schatzman, R.C., Raynor, R.L., Fritz, R.B. and Kuo, J.F. (1983) Biochem. J. 209, 435-443.
411. Schlaepfer, D.D., Jones, J. and Haigier, H.T. (1992) Biochemistry 31, 1886-1891.
412. Scott, J.D. and Soderling, T.R. (1992) Curr. Opin. Neurobiol. 2, 289-295.
413. Seifert, R., Schachtele, C., Rosenthal, W. and Schultz, G. (1988) Biochem. Biophys. Res. Commun. 154, 20-26.
414. Seki, K., Chen, H.C. and Huang, K.P. (1995) Arch. Biochem. Biophys. 316, 673-679.
415. Selbie, L.A., Schmits-Peiffer, C., Sheng, Y. and Eiden, T.J. (1993) J. Biol. Chem. 268, 24296-24302.
416. Sen, R. and Baltimore, D. (1986) Cell 47, 921-928.
417. Senter, L., Ceoldo, S., Petrusa, M.M. and Salviati, G. (1995) Biochem. Biophys. Res. Commun. 206, 57-63.
418. Sharma, R.K., Marala, R.B. and Duda, T.M. (1989) Steroids 53, 437-460.
419. Sharp, J.D., White, D.L., Chiou, X.G., Goodson, T., Gamboa, G.C., McClure, D., Burgett, S., Hoskins, J., Skatrud, P.L., Sportsman. J.R, et al. (1991) J. Biol. Chem. 266, 14850-14853.
420. Shea, T.B., Perrone-Bizzozero, N.I., Beermann, M.L. and Benowitz, L.I. (1991) J. Neurosci. 11, 1685-1690.
421. Sheu, F.S., Kasamatsu, T. and Routtenberg, A. (1990a) Brain Res. 524, 144-148.
422. Sheu, F.S., Marais, R.M., Parker, P.J., Bazan, N.G. and Routtenberg, A. (1990b) Biochem. Biophys. Res. Commun. 171, 1236-1243.
423. Sheu, F.S., Huang, F.L. and Huang, K.P. (1995) Arch. Biochem. Biophys. 316, 335-342.
424. Shinomuru, T., Asaoka, Y., Oka, M., Yoshida, K. and Nishizuka, Y. (1991) Proc. Natl. Acad. Sci. USA 88, 5149-5153.
425. Shirataki, H., Kaibuchi, K., Sakoda, T., Kishida, S., Yamaguchi, T., Wada, K., Miyazaki, M. and Takai, Y. (1993) Mol. Cell Biol. 13, 2061-2068.
426. Shpetner, H.S. and Vallee, R.B. (1992) Nature 355, 733-735.
427. Siddiqui, R.A. and Exton, J.H. (1992). J. Biol. Chem. 267, 5755-5761.
428. Siegel, J.N., Klausner, R.D., Rapp, U.R. and Samelson, L.E. (1990) J. Biol. Chem. 265, 18472-18480.
429. Sihag, R.K., Jeng, A.Y. and Nixon, R.A. (1988) FEBS Lett. 233. 181-185.
430. Simek, S.L., Kligman, D., Patel, J. and Colburn, N.H. (1989) Proc. Natl. Acad. Sci. USA 86, 7410-7414.
431. Singh, S.S., Chauhan, A., Brockerhoff, H. and Chauhan, V.P.S. (1993) Biochem. Biophys. Res. Commun. 195, 104-112.
432. Skene, J.H. and Virag, I. (1989) J. Cell Biol. 108, 613-624.
433. Skene, J.H., Jacobson, R.D., Snipes, G.L., McGuire, C.B., Norden, JJ. and Freeman, J.A. (1986) Science 233, 783-786.
434. Slater, S.J., Kelly, M.B., Taddeo, F.J., Larkin, J.D., Yeager, M.D., McLane, J.A., Ho, C. and Stubbs, C.D. (1995) J. Biol. Chem. 270, 6639-6643.
435. Slemmon, J.R. and Martzen, M.R. (1994) Biochemistry 33, 5653-5660.
436. Slivka, S.R., Meier, K.E. and Insel, P.A. (1988) J. Biol. Chem. 263. 12242-12246.
437. Solanki, V. and Slaga, T.J. (1982) Carcinogenesis 3, 993-998.
438. Souvignet, C. and Chambaz, E.M. (1990) Cell Signal, 2, 171-176.
439. Stassen, F.L., Schmidt, D.B., Papadopoulos, M. and Sarau, H.M. (1989) J. Biol. Chem. 264, 4916-4923.
440. Staudinger, J., Zhou, J., Burgess R., Elledge, S.J. and Olson, E.N. (1995) J. Cell Biol. 128, 263-271.
441. Steiner, J.P., Walke, H.T. Jr. and Bennett, V. (1989) J. Biol. Chem. 264, 2783-2791.
442. Steinschneider, A., McLean, M.P., Billhemier, J.T., Azhar, S. and Gibori, G. (1989) Endocrinology 125, 569-571.
443. Stephens, F.R, Hughes, K.T. and Irvine, R.F. (1991) Nature 351, 33-39.
444. Stoehr, S.J., Smolen, J.F. and Suchard, S.J. (1990) J. Immunol. 144, 3936-3945.
445. Strittmatter, S.M., Valenzuela, D., Kennedy, T.E., Neer, E.J. and Fishman, M.C. (1990) Nature 344, 836-841.
446. Strittmatter, S.M., Valenzuela, D., Sudo, N., Linder, M.E. and Fishman, M.C. (1991) J. Biol. Chem. 266, 22465-22471.
447. Stromqvist, M., Berglund, A., Shanbhag, V.P. and Backman, L. (1988) Biochemistry 27, 1104-1010.
448. Stumpo, D.J., Graff, J.M., Albert, K.A., Greengard, P. and Blackshear, P.J. (1989) Nucleic Acids Res. 17, 3987-3988.
449. Stumpo, D.J., Bock, C.B., Tuttle, J.S. and Blackshear, P.J. (1945) Proc. Natl. Acad. Sci. USA 92, 944-948.
450. Sturgill, T.W., Ray, L.B., Erikson, E. and Maller, J.L. (1988) Nature 334, 715-718.
451. Sudo, Y., Valenzuela, D., Beck-Sickinger, A.G., Fishman, M.C. and Strittmauer, S.M. (1992) EMBO J. 11, 2095-2102.
452. Takai, Y., Kishimoto, A., Inoue, M. and Nishizuka, Y. (1977) J. Biol. Chem. 252, 7603-7609.
453. Takel, K., McPherson, P.S., Schmid, S.U. and De-Camilli, P. (1995) Nature 374, 186-190.
454. Takenaka, I., Morin, F., Scizinger, B.R. and Kley, N. (1995) J. Biol. Chem. 270, 5405-5411.
455. Tan, S.F., Wenthold, R.J. and Soderling, T.R. (1994) J. Neurosci. 14, 1123-1129.
456. Tanaka, Y., Koide, S.S., Yoshihara, K. and Kamiya, T. (1987) Biochem. Biophys. Res. Commun. 148, 709-717.
457. Taniguchi, H. and Manenti, S (1993) J. Biol Chem. 268, 9960-9963.
458. Taniguchi, H., Manenti, S., Suzuki, M. and Titam, K. (1994) J. Biol. Chem. 269, 18299-18302.
459. Taubman, M.B., Berk, B.C., Izumo, S., Tsuda, T., Alexander, R.W. and Nadal-Ginard, B. (1989) J. Biol. Chem. 264, 526-530.
460. Taylor, S.S. and Radzio-Andzelm, E. (1994) Structure 2, 345-355.
461. Thakkar, J.K., Janero, D.R., Yarwood, C. and Sharif, H.M. (1993) Biochem. J. 291, 523-527.
462. Thelen, M., Rosen, A., Nairn, A.C. and Aderem, A. (1991) Nature 351, 320-322.
463. Toker, A., Ellis, C.A., Sellers, L.A. and Aitken, A. (1990) Eur. J. Biochem. 191, 421-429.
464. Toker, A., Sellers, L.A., Amess, B., Yasinma, P., Harris, A. and Aitken, A. (1992) Eur. J. Biochem. 206, 453-461.
465. Toker, A., Meyer, M., Reddy, K.K., Falek, J.R., Aneja, R., Aneja, S., Parra, A., Burns, D.J., Ballus, L.M. and Cantley, L.C. (1994) J. Biol. Chem. 269, 32358-32367.
466. Tokumitsu, H., Mizutani, A., Nomura, S., Watanabe, M. and Hidaka, H. (1989) Biochem. Biophys. Res. Commun. 163, 581-588.
467. Torchia, J., Yi, Q. and Sen, A.K. (1994) J. Biol. Chem. 269, 29778-29784.
468. Trilivas, I., McDonough, P.M. and Brown, J.H. (1991). J. Biol. Chem. 266, 8431-8438.
469. Tuma, P.F., Stachniak, M.C. and Collins, C.A. (1993) J. Biol. Chem. 268, 17240-17246.
470. Turgeon, J.F., Ashcroft, S.J., Waring, D.W., Milewski, M.A. and Walsh, D.A. (1984) Mol. Cell. Endocrinol. 34, 107-112.
471. Tyers, M., Rachubinski, R.A., Stewart, M.F, Varriehio, A.M., Shorr, R.G., Haslam, R.J. and Harley, C.B. (1988) Nature 333, 470-473.
472. Uchida, T. and Filburn, C.R. (1984) J. Biol. Chem. 259, 12311-12314.
473. Udovichenko, I.P., Cunnick, J., Gonzalez, K. and Takemoto, D.J. (1994) J. Biol. Chem. 269, 9850-9856.
474. Valverde, A.M., Sinnett-Smith, J., Van-Lint, J. and Rozengurt, E. (1994) Proc. Natl. Acad. Sci. USA 91, 8572-8576.
475. Van der Blick, A.M. and Meyerowitz, E.M. (1991) Nature 351, 411-414.
476. Van der Bliek, A.M., Redelmeier, T.E., Damke, H., Tisdale, E.J., Meyerowitz, E.M. and Schmid, S.L. (1993) J. Cell Biol. 122, 553-563.
477. Van Lint, J., Sinnett-Smith, J. and Rozengurt, E. (1995) J. Biol. Chem. 270, 1455-1461.
478. Vartiunski, L., Daley, G.Q., Jackson, P., Baltimore, D. and Cantley, L.C. (1991) Mol. Cell Biol. 11, 1107-1113.
479. Verkest, V., McArthur, M. and Hamilton, S. (1988) Biochem. Biophys. Res. Commun. 152, 825-829.
480. Vilgrain, I., Cochet, C. and Chambaz, E.M. (1984) J. Biol. Chem. 259, 3403-3406.
481. Wakim, B.T., Alexander, K.A., Masure, H.R., Cimier, B.M., Storm, D.R. and Walsh, K.A. (1987) Biochemistry 26, 7466-7470.
482. Walaas, S.I., Czernik, A.J., Olstad, O.K., Sletten, K. and Walaas, O. (1994) Biochem. J. 304, 635-640.
483. Wang, J.K.T., Walaas, S.I., Sihra, T.S., Aderem, A. and Greengard, P. (1989) Proc. Natl. Acad. Sci. USA 86, 2253-2256.
484. Wang, L.M. and Kucera, G.L. (1994) Biochim. Biophys. Acta 1224, 161-167.
485. Waxham, M.N. and Aronowski, J. (1993) Biochemistry 32, 2923-2930.
486. Ways, D.K., Cook, P.P., Webster, C. and Parker, P.J. (1992) J. Biol. Chem. 267, 4799-4805.
487. Werth, D.K. and Pastan, I. (1984) J. Biol. Chem. 259, 5264-5270.
488. Winkel, G.K., Sardet, C., Pouyssegur, J. and Ives, H.E. (1993) J. Biol. Chem. 268, 3396-3400.
489. Wise, B.C., Raynor, R.L. and Kuo, J.F. (1982) J. Biol. Chem. 257, 13341-13348.
490. Witters, L.A. and Blackshear, P.J. (1987) Methods Enzymol. 141, 412-424.
491. Wolf, M., LeVine, H., May, W.S, Jr., Cuatrecasas, P. and Sahyoun, N. (1985) Nature 317, 546-549.
492. Woodgett, J.R. and Hunter, T. (1987) Mol. Cell Biol. 7, 85-96.
493. Woods, N.M., Cuthbertson, K.S. and Cobbold, P.H. (1986) Nature 319, 600-602.
494. Worley, P.E., Baraban, J.M., Supattapone, S., Wilson, V.S. and Snyder, S.H. (1987) J. Biol. Chem. 262, 12132-12136.
495. Wotton, D., Ways, D.K., Parker, P.J. and Owen, M.J. (1993) J. Biol. Chem. 268, 17975-17982.
496. Wright, T.C. Jr., Pukac, L.A., Castellot, J.J. Jr., Karnovsky, M.J., Levine, R.A., Kim-Park, H.Y. and Campisi, J. (1989) Proc. Natl. Acad. Sci. USA 86, 3199-3203.
497. Yamamoto, K.K., Gonzalez, G.A., Biggs, W.H. and Montminy, M.R. (1988) Nature 334, 494-498.
498. Yamanishi, J., Takai, Y., Kaibuchi, K., Sano, K., Castagna, M. and Nishizuka, Y. (1983) Biochem. Biophys. Res. Commun. 112, 778-786.
499. Yankner, B.A., Benowitz, L.I., Villa-Komaroff, L. and Neve, R.L. (1990) Brain Res. Mol. Brain Res. 7, 39-44.
500. Yatomi, Y., Arata, Y., Tada, S., Kume, S. and Ui, M. (1992) Eur. J. Biochem. 205, 1003-1009.
501. Yoshida, K., Asaoka, Y. and Nishizuka, Y. (1992) Proc. Natl. Acad. Sci. USA 89, 6443-6446.
502. Yoshimasa, T., Sibley, D.R., Bouvier, M., Lefkowitz, R.J. and Caron, M.G. (1987) Nature 327, 67-70.
503. Zhang, F., Strand, A., Robbins, D., Cobb, M.H. and Goldsmith, E.J. (1994) Nature 367, 704-711.
504. Zhang, J., Wang, L., Schwartz, J., Bond, R.W. and Bishop, W.R. (1994) J. Biol. Chem. 269, 19578-19584.
505. Zhao, Z., Larocque, R., Ho, W.T., Fischer, E.H. and Shen, S.H. (19941 J. Biol. Chem. 269, 8780-8785.