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Volumn 73, Issue 4, 1999, Pages 1674-1682

The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes

Author keywords

AMP activated protein kinase; Astrocyte; Carnitine palmitoyltransferase I; Hypoxia; Ketone bodies; Neuroglial interactions

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; AZIDE; CARNITINE PALMITOYLTRANSFERASE; MALONYL COENZYME A; PALMITIC ACID; PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 0344994496     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.731674.x     Document Type: Article
Times cited : (110)

References (53)
  • 1
    • 0031934470 scopus 로고    scopus 로고
    • Astrocytic functions and physiological reactions to injury: The potential to induce and/or exacerbate neuronal disfunction - A forum position paper
    • Aschner M. (1998) Astrocytic functions and physiological reactions to injury: the potential to induce and/or exacerbate neuronal disfunction - a forum position paper. Neurotoxicology 19, 7-18.
    • (1998) Neurotoxicology , vol.19 , pp. 7-18
    • Aschner, M.1
  • 2
    • 0026020414 scopus 로고
    • Fatty acid oxidation and ketogenesis by astrocytes in primary culture
    • Auestad N., Korsak R. A., Morrow J. W., and Edmond J. (1991) Fatty acid oxidation and ketogenesis by astrocytes in primary culture. J. Neurochem. 56, 1376-1386.
    • (1991) J. Neurochem. , vol.56 , pp. 1376-1386
    • Auestad, N.1    Korsak, R.A.2    Morrow, J.W.3    Edmond, J.4
  • 4
    • 0023259178 scopus 로고
    • Measurement of acetyl-CoA carboxylase activity in isolated hepatocytes
    • Bijleveld C. and Geelen M. J. H. (1987) Measurement of acetyl-CoA carboxylase activity in isolated hepatocytes. Biochim. Biophys. Acta 918, 274-283.
    • (1987) Biochim. Biophys. Acta , vol.918 , pp. 274-283
    • Bijleveld, C.1    Geelen, M.J.H.2
  • 5
    • 0028892038 scopus 로고
    • Generation of ketone bodies from leucine by cultured astroglial cells
    • Bixel M. G. and Hamprecht B. (1995) Generation of ketone bodies from leucine by cultured astroglial cells. J. Neurochem. 65, 2450-2461.
    • (1995) J. Neurochem. , vol.65 , pp. 2450-2461
    • Bixel, M.G.1    Hamprecht, B.2
  • 6
    • 0031714313 scopus 로고    scopus 로고
    • Role of carnitine palmitoyltransferase I in the control of ketogenesis in primary cultures of rat astrocytes
    • Blázquez C., Sánchez C., Velasco G., and Guzmán M. (1998) Role of carnitine palmitoyltransferase I in the control of ketogenesis in primary cultures of rat astrocytes. J. Neurochem. 71, 1597-1606.
    • (1998) J. Neurochem. , vol.71 , pp. 1597-1606
    • Blázquez, C.1    Sánchez, C.2    Velasco, G.3    Guzmán, M.4
  • 7
    • 0345561550 scopus 로고    scopus 로고
    • The stimulation of ketogenesis by cannabinoids in astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme
    • Blázquez C., Sánchez C., Daza A., Galve-Roperh I., and Guzmán M. (1999) The stimulation of ketogenesis by cannabinoids in astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme. J. Neurochem. 72, 1759-1768.
    • (1999) J. Neurochem. , vol.72 , pp. 1759-1768
    • Blázquez, C.1    Sánchez, C.2    Daza, A.3    Galve-Roperh, I.4    Guzmán, M.5
  • 9
    • 0031722748 scopus 로고    scopus 로고
    • Hormonal regulation of the mRNA encoding the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in neonatal primary cultures of cortical astrocytes and meningeal fibroblasts
    • Cullingford T. E., Bhakoo K. K., and Clark J. B. (1998a) Hormonal regulation of the mRNA encoding the ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in neonatal primary cultures of cortical astrocytes and meningeal fibroblasts. J. Neurochem. 71, 1804-1812.
    • (1998) J. Neurochem. , vol.71 , pp. 1804-1812
    • Cullingford, T.E.1    Bhakoo, K.K.2    Clark, J.B.3
  • 10
    • 0032518858 scopus 로고    scopus 로고
    • Molecular cloning of rat mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase and detection of the corresponding mRNA and of those encoding the remaining enzymes comprising the ketogenic 3-hydroxy-3-methylglutaryl-CoA cycle in central nervous system of suckling rats
    • Cullingford T. E., Dolphin C. T., Bhakoo K. K., Peuchen S., Canevari L., and Clark J. B. (1998b) Molecular cloning of rat mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase and detection of the corresponding mRNA and of those encoding the remaining enzymes comprising the ketogenic 3-hydroxy-3-methylglutaryl-CoA cycle in central nervous system of suckling rats. Biochem. J. 329, 373-381.
    • (1998) Biochem. J. , vol.329 , pp. 373-381
    • Cullingford, T.E.1    Dolphin, C.T.2    Bhakoo, K.K.3    Peuchen, S.4    Canevari, L.5    Clark, J.B.6
  • 11
    • 0029793298 scopus 로고    scopus 로고
    • Flux control exerted by mitochondrial outer membrane carnitine palmitoyltransferase over β-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic states
    • Drynan L., Quant P. A., and Zammit V. A. (1996) Flux control exerted by mitochondrial outer membrane carnitine palmitoyltransferase over β-oxidation, ketogenesis and tricarboxylic acid cycle activity in hepatocytes isolated from rats in different metabolic states. Biochem. J. 317, 791-795.
    • (1996) Biochem. J. , vol.317 , pp. 791-795
    • Drynan, L.1    Quant, P.A.2    Zammit, V.A.3
  • 12
    • 0029902428 scopus 로고    scopus 로고
    • Mammalian mitochondrial β-oxidation
    • Eaton S., Bartlett K., and Pourfarzam M. (1996) Mammalian mitochondrial β-oxidation. Biochem. J. 320, 345-357.
    • (1996) Biochem. J. , vol.320 , pp. 345-357
    • Eaton, S.1    Bartlett, K.2    Pourfarzam, M.3
  • 13
    • 0027083503 scopus 로고
    • Energy metabolism in developing brain cells
    • Edmond J. (1992) Energy metabolism in developing brain cells. Can. J. Physiol. Pharmacol. 70, S118-S129.
    • (1992) Can. J. Physiol. Pharmacol. , vol.70
    • Edmond, J.1
  • 14
    • 0023470792 scopus 로고
    • Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture
    • Edmond J., Robbins R. A., Bergstrom J. D., Cole R. A., and de Vellis J. (1987) Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture. J. Neurosci. Res. 18, 551-561.
    • (1987) J. Neurosci. Res. , vol.18 , pp. 551-561
    • Edmond, J.1    Robbins, R.A.2    Bergstrom, J.D.3    Cole, R.A.4    De Vellis, J.5
  • 15
    • 0030856138 scopus 로고    scopus 로고
    • Induction of nerve growth factor synthesis by sphingomyelinase and ceramide in primary astrocyte cultures
    • Galve-Roperh I., Haro A., and Díaz-Laviada I. (1997) Induction of nerve growth factor synthesis by sphingomyelinase and ceramide in primary astrocyte cultures. Brain Res. Mol. Brain Res. 52, 90-97.
    • (1997) Brain Res. Mol. Brain Res. , vol.52 , pp. 90-97
    • Galve-Roperh, I.1    Haro, A.2    Díaz-Laviada, I.3
  • 17
    • 0025872114 scopus 로고
    • In situ measurement of HMG-CoA reductase activity in digitonin-permeabilized hepatocytes
    • Geelen M. J. H., Papiez J. S., Girgis K., and Gibson D. M. (1991) In situ measurement of HMG-CoA reductase activity in digitonin-permeabilized hepatocytes. Biochem. Biophys. Res. Commun. 180, 525-530.
    • (1991) Biochem. Biophys. Res. Commun. , vol.180 , pp. 525-530
    • Geelen, M.J.H.1    Papiez, J.S.2    Girgis, K.3    Gibson, D.M.4
  • 18
    • 0026707744 scopus 로고
    • Activity of carnitine palmitoyltransferase in mitochondrial outer membranes and peroxisomes in digitonin-permeabilized hepatocytes. Selective modulation of mitochondrial enzyme activity by okadaic acid
    • Guzmán M. and Geelen M. J. H. (1992) Activity of carnitine palmitoyltransferase in mitochondrial outer membranes and peroxisomes in digitonin-permeabilized hepatocytes. Selective modulation of mitochondrial enzyme activity by okadaic acid. Biochem. J. 287, 487-492.
    • (1992) Biochem. J. , vol.287 , pp. 487-492
    • Guzmán, M.1    Geelen, M.J.H.2
  • 19
    • 0027252589 scopus 로고
    • Regulation of fatty acid oxidation in mammalian liver
    • Guzmán M. and Geelen M. J. H. (1993) Regulation of fatty acid oxidation in mammalian liver. Biochim. Biophys. Acta 1167, 227-241.
    • (1993) Biochim. Biophys. Acta , vol.1167 , pp. 227-241
    • Guzmán, M.1    Geelen, M.J.H.2
  • 20
    • 0028818499 scopus 로고
    • Flexibility of zonation of fatty acid oxidation in rat liver
    • Guzmán M., Bijleveld C., and Geelen M. J. H. (1995) Flexibility of zonation of fatty acid oxidation in rat liver. Biochem. J. 311, 853-860.
    • (1995) Biochem. J. , vol.311 , pp. 853-860
    • Guzmán, M.1    Bijleveld, C.2    Geelen, M.J.H.3
  • 21
    • 0031007065 scopus 로고    scopus 로고
    • The AMP-activated protein kinase. Fuel gauge of the mammalian cell?
    • Hardie D. G. and Carling D. (1997) The AMP-activated protein kinase. Fuel gauge of the mammalian cell? Eur. J. Biochem. 246, 259-273.
    • (1997) Eur. J. Biochem. , vol.246 , pp. 259-273
    • Hardie, D.G.1    Carling, D.2
  • 22
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/ SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • Hardie D. G., Carling D., and Carlson M. (1998) The AMP-activated/ SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67, 821-855.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 24
    • 0031440995 scopus 로고    scopus 로고
    • Endogenous monocarboxylates sustain hippocampal synaptic function and morphological integrity during energy deprivation
    • Izumi Y., Benz A. M., Katsuki H., and Zorumski C. F. (1997) Endogenous monocarboxylates sustain hippocampal synaptic function and morphological integrity during energy deprivation. J. Neurosci. 17, 9448-9457.
    • (1997) J. Neurosci. , vol.17 , pp. 9448-9457
    • Izumi, Y.1    Benz, A.M.2    Katsuki, H.3    Zorumski, C.F.4
  • 25
    • 33846271011 scopus 로고    scopus 로고
    • Cellular bases of brain energy metabolism and their relevance to functional brain imaging
    • Magistretti P. J. and Pellerin L. (1996) Cellular bases of brain energy metabolism and their relevance to functional brain imaging. Cereb. Cortex 6, 50-61.
    • (1996) Cereb. Cortex , vol.6 , pp. 50-61
    • Magistretti, P.J.1    Pellerin, L.2
  • 26
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
    • McGarry J. D. and Brown N. F. (1997) The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244, 1-14.
    • (1997) Eur. J. Biochem. , vol.244 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 28
    • 0031238833 scopus 로고    scopus 로고
    • Regulation of energy metabolism by neurotransmitters in astrocytes in primary culture and in an immortalized cell line
    • Pellerin L., Stolz M., Sorg O., Martin J. C., Deschepper C. F., and Magistretti P. J. (1997) Regulation of energy metabolism by neurotransmitters in astrocytes in primary culture and in an immortalized cell line. Glia 21, 74-83.
    • (1997) Glia , vol.21 , pp. 74-83
    • Pellerin, L.1    Stolz, M.2    Sorg, O.3    Martin, J.C.4    Deschepper, C.F.5    Magistretti, P.J.6
  • 30
    • 0032536774 scopus 로고    scopus 로고
    • Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle
    • Ponticos M., Lu Q. L., Morgan J. E., Hardie D. G., Partridge T. A., and Carling D. (1998) Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. EMBO J. 17, 1688-1699.
    • (1998) EMBO J. , vol.17 , pp. 1688-1699
    • Ponticos, M.1    Lu, Q.L.2    Morgan, J.E.3    Hardie, D.G.4    Partridge, T.A.5    Carling, D.6
  • 31
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: Cellular and molecular cues to biological function
    • Ridet J. L., Malhotra S. K., Privat A., and Gage F. H. (1997) Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 20, 570-577.
    • (1997) Trends Neurosci. , vol.20 , pp. 570-577
    • Ridet, J.L.1    Malhotra, S.K.2    Privat, A.3    Gage, F.H.4
  • 34
    • 0031731914 scopus 로고    scopus 로고
    • Brain anaerobic lactate production: A suicide note or a survival kit?
    • Schurr A. and Rigor B. M. (1998) Brain anaerobic lactate production: a suicide note or a survival kit? Dev. Neurosci. 20, 348-357.
    • (1998) Dev. Neurosci. , vol.20 , pp. 348-357
    • Schurr, A.1    Rigor, B.M.2
  • 35
    • 0031239422 scopus 로고    scopus 로고
    • Glutamate transport and metabolism in astrocytes
    • Sonnewald U., Westergaard N., and Schousboe A. (1997) Glutamate transport and metabolism in astrocytes. Glia 21, 56-63.
    • (1997) Glia , vol.21 , pp. 56-63
    • Sonnewald, U.1    Westergaard, N.2    Schousboe, A.3
  • 36
    • 0030961969 scopus 로고    scopus 로고
    • The flux control coefficient of carnitine palmitoyltransferase I on palmitate β-oxidation in rat hepatocyte cultures
    • Spurway T. D., Sherratt H. A., Pogson C. I., and Agius L. (1997) The flux control coefficient of carnitine palmitoyltransferase I on palmitate β-oxidation in rat hepatocyte cultures. Biochem. J. 323, 119-122.
    • (1997) Biochem. J. , vol.323 , pp. 119-122
    • Spurway, T.D.1    Sherratt, H.A.2    Pogson, C.I.3    Agius, L.4
  • 38
    • 0024423544 scopus 로고
    • Fuel selection and carbon flux during the starved-to-fed transition
    • Sugden M. C., Holness M. J., and Palmer T. N. (1989) Fuel selection and carbon flux during the starved-to-fed transition. Biochem. J. 263, 313-323.
    • (1989) Biochem. J. , vol.263 , pp. 313-323
    • Sugden, M.C.1    Holness, M.J.2    Palmer, T.N.3
  • 39
    • 0029829149 scopus 로고    scopus 로고
    • Astrocyte glucose metabolism under normal and pathological conditions in vitro
    • Swanson R. A. and Benington J. H. (1996) Astrocyte glucose metabolism under normal and pathological conditions in vitro. Dev. Neurosci. 18, 515-521.
    • (1996) Dev. Neurosci. , vol.18 , pp. 515-521
    • Swanson, R.A.1    Benington, J.H.2
  • 40
    • 0031239618 scopus 로고    scopus 로고
    • Astrocyte energetics, function, and death under conditions of incomplete ischemia: A mechanism of glial death in the penumbra
    • Swanson R. A., Farrell K., and Stein B. A. (1997) Astrocyte energetics, function, and death under conditions of incomplete ischemia: a mechanism of glial death in the penumbra. Glia 21, 142-153.
    • (1997) Glia , vol.21 , pp. 142-153
    • Swanson, R.A.1    Farrell, K.2    Stein, B.A.3
  • 41
    • 0029927343 scopus 로고    scopus 로고
    • Metabolic coupling between glia and neurons
    • Tsacopoulos M. and Magistretti P. J. (1996) Metabolic coupling between glia and neurons. J. Neurosci. 16, 877-885.
    • (1996) J. Neurosci. , vol.16 , pp. 877-885
    • Tsacopoulos, M.1    Magistretti, P.J.2
  • 42
    • 0031238677 scopus 로고    scopus 로고
    • The nutritive function of glia is regulated by signals released by neurons
    • Tsacopoulos M., Poitry-Yamate C. L., Poitry S., Perrottet P., and Veuthey A. L. (1997) The nutritive function of glia is regulated by signals released by neurons. Glia 21, 84-91.
    • (1997) Glia , vol.21 , pp. 84-91
    • Tsacopoulos, M.1    Poitry-Yamate, C.L.2    Poitry, S.3    Perrottet, P.4    Veuthey, A.L.5
  • 43
    • 0033054706 scopus 로고    scopus 로고
    • Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system
    • Turnley A. M., Stapleton D., Mann R. J., Witters L. A., Kemp B. E., and Bartlett P. F. (1999) Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J. Neurochem. 72, 1707-1716.
    • (1999) J. Neurochem. , vol.72 , pp. 1707-1716
    • Turnley, A.M.1    Stapleton, D.2    Mann, R.J.3    Witters, L.A.4    Kemp, B.E.5    Bartlett, P.F.6
  • 44
    • 0031568242 scopus 로고    scopus 로고
    • Control of hepatic fatty acid oxidation by 5′-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism
    • Velasco G., Geelen M. J. H., and Guzmán M. (1997a) Control of hepatic fatty acid oxidation by 5′-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism. Arch. Biochem. Biophys. 337, 169-175.
    • (1997) Arch. Biochem. Biophys. , vol.337 , pp. 169-175
    • Velasco, G.1    Geelen, M.J.H.2    Guzmán, M.3
  • 45
    • 0031033160 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes
    • 2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes. Biochem. J. 321, 211-216.
    • (1997) Biochem. J. , vol.321 , pp. 211-216
    • Velasco, G.1    Guzmán, M.2    Zammit, V.A.3    Geelen, M.J.H.4
  • 47
    • 0345131692 scopus 로고    scopus 로고
    • Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components
    • Velasco G., Gómez del Pulgar T., Carling D., and Guzmán M. (1998b) Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components. FEBS Lett. 439, 317-320.
    • (1998) FEBS Lett. , vol.439 , pp. 317-320
    • Velasco, G.1    Gómez Del Pulgar, T.2    Carling, D.3    Guzmán, M.4
  • 48
    • 0031238567 scopus 로고    scopus 로고
    • Metabolic pathways for glucose in astrocytes
    • Wiesinger H., Hamprecht B., and Dringen R. (1997) Metabolic pathways for glucose in astrocytes. Glia 21, 22-34.
    • (1997) Glia , vol.21 , pp. 22-34
    • Wiesinger, H.1    Hamprecht, B.2    Dringen, R.3
  • 49
    • 0029925785 scopus 로고    scopus 로고
    • Characterization of AMP-activated protein kinase β and γ subunits. Assembly of the heterotrimer complex in vitro
    • Woods A., Cheung P. C. F., Smith F. C., Davison M. D., Scott J., Ben R. K., and Carling D. (1996) Characterization of AMP-activated protein kinase β and γ subunits. Assembly of the heterotrimer complex in vitro. J. Biol. Chem. 271, 10282-10290.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10282-10290
    • Woods, A.1    Cheung, P.C.F.2    Smith, F.C.3    Davison, M.D.4    Scott, J.5    Ben, R.K.6    Carling, D.7
  • 50
    • 0032520893 scopus 로고    scopus 로고
    • Cell culture models for reactive gliosis: New perspectives
    • Wu V. W. and Schwartz J. P. (1998) Cell culture models for reactive gliosis: new perspectives. J. Neurosci. Res. 51, 675-681.
    • (1998) J. Neurosci. Res. , vol.51 , pp. 675-681
    • Wu, V.W.1    Schwartz, J.P.2
  • 52
    • 2642692695 scopus 로고    scopus 로고
    • The pyruvate dehydrogenase complex is partially inactivated during early recirculation following short-term forebrain ischemia in rats
    • Zaidan E., Sheu K. F., and Sims N. R. (1998) The pyruvate dehydrogenase complex is partially inactivated during early recirculation following short-term forebrain ischemia in rats. J. Neurochem. 70, 233-241.
    • (1998) J. Neurochem. , vol.70 , pp. 233-241
    • Zaidan, E.1    Sheu, K.F.2    Sims, N.R.3
  • 53
    • 0028356482 scopus 로고
    • Regulation of ketone body metabolism. A cellular perspective
    • Zammit V. A. (1994) Regulation of ketone body metabolism. A cellular perspective. Diabetes Rev. 2, 132-155.
    • (1994) Diabetes Rev. , vol.2 , pp. 132-155
    • Zammit, V.A.1


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