Molecular mimicry in type 1 diabetes: Immune cross-reactivity between islet autoantigen and human cytomegalovirus but not Coxsackie virus

Annals of the New York Academy of Sciences

Volumn 958, Issue , 2002, Pages 163-165

  Roep, B O ^a   Hiemstra, H S ^a   Schloot, N C ^a   De Vries, R R P ^a   Chaudhuri, A ^b   Behan, P O ^b   Drijfhout, J W ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SOUTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

Autoreactive T cells; Insulindependent diabetes mellitus; Microarray; Molecular mimicry

Indexed keywords

GLUTAMATE DECARBOXYLASE ANTIBODY; PANCREAS ISLET CELL ANTIBODY;

ANTIGEN RECOGNITION; CELL DESTRUCTION; CONFERENCE PAPER; COXSACKIE VIRUS; CROSS REACTION; DNA MICROARRAY; HLA SYSTEM; HUMAN; HUMAN CYTOMEGALOVIRUS; INSULIN DEPENDENT DIABETES MELLITUS; MOLECULAR MIMICRY; PANCREAS ISLET BETA CELL; SEQUENCE HOMOLOGY; T LYMPHOCYTE;

COXSACKIEVIRUS; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 0036274774     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb02961.x     Document Type: Conference Paper

References (13)

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3. Cellular immunity to a determinant common to glutamate decarboxylase and Coxsackie virus in insulin-dependent diabetes
4. Molecular mimicry in type 1 diabetes revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie and proinsulin peptides do not crossreact with homologous counterpart
5. Acute onset of type I diabetes mellitus after severe echovirus 9 infection: Putative pathogenic pathways
6. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
7. Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries
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10. Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase
11. Association of cytomegalovirus infection with autoimmune type 1 diabetes
12. Characterization of T lymphocytes infiltrating human pancreas allograft affected by isletitis and recurrent diabetes
13. Human pancreatic islet cell specific 38 kilodalton autoantigen identified by cytomegalovirus-induced monoclonal islet cell autoantibody