CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: A comparison with polyethylenimine/DNA complexes

Gene Therapy

Volumn 11, Issue 1, 2004, Pages 109-114

  Li, Y ^a,b   Wang, J ^c,d   Lee, C G L ^e   Wang, C Y ^a,b   Gao, S J ^a,b   Tang, G P ^a,b   Ma, Y X ^a,b   Yu, H ^e   Mao, H Q ^c   Leong, K W ^c,d   Wang, S ^a,b,f  

^a INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY   (Singapore)

^b INSTITUTE OF MATERIALS RESEARCH AND ENGINEERING   (Singapore)

^c Johns Hopkins Singapore   (Singapore)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Department of Biochemistry ^*  (Singapore)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Biocompatibility; Brain; Degradability; Gene transfer; Polycation; Polyphosphoester

Indexed keywords

NAKED DNA; PLASMID DNA; POLYAMINOETHYLPROPYLENE PHOSPHATE; POLYCATION; POLYETHYLENEIMINE; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; BASAL GANGLION; BIOCOMPATIBILITY; BIODEGRADABILITY; BRAIN; BRAIN CORTEX; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; COMPLEX FORMATION; CONTROLLED RELEASE FORMULATION; CYTOTOXICITY; DIENCEPHALON; FEASIBILITY STUDY; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; IMMUNOGENICITY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; SUBARACHNOID SPACE; SUSTAINED RELEASE PREPARATION;

ANIMALS; BRAIN; DNA; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; LUCIFERASES; MICE; ORGANOPHOSPHORUS COMPOUNDS; PARTICLE SIZE; POLYETHYLENEIMINE; POLYMERS; TRANSFECTION;

EID: 9144230031     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302135     Document Type: Article

References (18)

1. Boussif O et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297-7302.
2. Godbey WT, Wu KK, Mikos AG. Poly(ethylenimine) and its role in gene delivery. J Control Rel 1999; 60: 149-160.
3. Lemkine GF, Demeneix BA. Polyethylenimines for in vivo gene delivery. Curr Opin Mol Ther 2001; 3: 178-182.
4. Kircheis R et al. Tumor targeting with surface-shielded ligand-polycation DNA complexes. J Control Rel 2001; 72: 165-170.
5. Abdallah B et al. A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum Gene Ther 1996; 7: 1947-1954.
6. 2+ channel structure and function with antisense oligonucleotides. Mol Cell Neurosci 1996; 7: 239-246.
7. Goula D et al. Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Therapy 1998; 5: 712-717.
8. Wang S et al. Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes. Mol Ther 2001; 3: 658-664.
9. Shi L et al. Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord. Gene Therapy 2003; 10: 1179-1188.
10. Godbey WT, Wu KK, Mikos AG. Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc Natl Acad Sci USA 1999; 96: 5177-5181.
11. Godbey WT, Wu KK, Mikos AG. Poly(ethylenimine)-mediated gene delivery affects endothelial cell function and viability. Biomaterials 2001; 22: 471-480.
12. Wang J, Mao H-Q, Leong KW. A novel biodegradable gene carrier based on polyphosphoester. J Am Chem Soc 2001; 123: 9480-9481.
13. Wang J, P-C Zhang, Mao H-Q, Leong KW. Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier. Gene Therapy 2002; 9: 1254-1261.
14. Nguyen H-K et al. Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents. Gene Therapy 2000; 7: 126-138.
15. Ogris M et al. PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Therapy 1999; 6: 595-605.
16. Hecker JG, Hall LL, Irion VR. Nonviral gene delivery to the lateral ventricles in rat brain: initial evidence for widespread distribution and expression in the central nervous system. Mol Ther 2001; 3: 375-384.
17. Driesse MJ et al. Intra-CSF administered recombinant adenovirus causes an immune response-mediated toxicity. Gene Therapy 2000; 7: 1401-1409.
18. Reijneveld JC, Taphoorn MJB, Voest EE. A simple mouse model for leptomeningeal metastases and repeated intrathecal therapy. J Neuro-Oncol 1999; 42: 137-142.