Ligands for L-selectin: Homing, inflammation, and beyond

Annual Review of Immunology

Volumn 22, Issue , 2004, Pages 129-156

  Rosen, Steven D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endothelium; Glycosylation; HEV; Leukocyte trafficking; Sulfation

Indexed keywords

CARBOHYDRATE; CD34 ANTIGEN; CHONDROITIN SULFATE; ENDOGLYCAN; ENDOMUCIN; ENZYME; GLYCOSYLTRANSFERASE; L SELECTIN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MECA 79; PODOCALYXIN; PROTEIN PSGL 1; PROTEOGLYCAN; PROTEOHEPARAN SULFATE; SIALOMUCIN; SULFATIDE; UNCLASSIFIED DRUG;

CARCINOMA CELL; CELL ADHESION; CHRONIC INFLAMMATION; DEMYELINATION; DISEASE SEVERITY; EXTRAVASCULAR SPACE; HUMAN; LEUKOCYTE; LIGAND BINDING; LYMPH NODE; LYMPHOCYTE HOMING; LYMPHOID ORGAN; METASTASIS; NERVE FIBER; NIDATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW; TONSIL; VASCULAR ENDOTHELIUM;

ANIMALS; CELL ADHESION; CELL MOVEMENT; ENDOTHELIUM, VASCULAR; HUMANS; INFLAMMATION; L-SELECTIN; LEUKOCYTES; LIGANDS;

EID: 1942542931     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.21.090501.080131     Document Type: Review

References (136)

1. Gowans JL, Knight EJ. 1964. The route of recirculation of lymphocytes in the rat. Proc. R. Soc. London Ser. B 159:257-82
2. Butcher EC, Picker LJ. 1996. Lymphocyte homing and homeostasis. Science 272:60-66
3. Salmi M, Jalkanen S. 1997. How do lymphocytes know where to go: current concepts and enigmas of lymphocyte homing. Adv. Immunol. 64:139-218
4. von Andrian UH, Mackay CR. 2000. T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 343:1020-34
5. Stamper H, Woodruff J. 1976. Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules. J. Exp. Med. 144:828-33
6. Gallatin W, Weissman I, Butcher E. 1983. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature 304:30-34
7. Lasky LA. 1995. Selectin-carbohydrate interactions and the initiation of the inflammatory response. Annu. Rev. Biochem. 64:113-39
8. Stoolman LM, Rosen SD. 1983. Possible role for cell surface carbohydrate-binding molecules in lymphocyte recirculation. J. Cell Biol. 96:722-29
9. Rosen SD, Singer MS, Yednock TA, Stoolman LM. 1985. Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation. Science 228:1005-7
10. Yednock TA, Butcher EC, Stoolman LM, Rosen SD. 1987. Receptors involved in lymphocyte homing: relationship between a carbohydrate-binding receptor and the MEL-14 antigen. J. Cell Biol. 104:725-31
11. Arbonés ML, Ord DC, Ley K, Ratech H, Maynard-Curry C, et al. 1994. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1:247-60
12. Drickamer K, Taylor ME. 1993. Biology of animal lectins. Annu. Rev. Cell Biol. 9:237-64
13. Kansas GS. 1996. Selectins and their ligands: current concepts and controversies. Blood 88:3259-87
14. Vestweber D, Blanks JE. 1999. Mechanisms that regulate the function of the selectins and their ligands. Physiol. Rev. 79:181-213
15. Springer TA. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301-14
16. Tedder TF, Steeber DA, Chen A, Engel P. 1995. The selectins: vascular adhesion molecules. FASEB J. 9:866-73
17. Winn R, Vedder N, Ramamoorthy C, Sharar S, Harlan J. 1998. Endothelial and leukocyte adhesion molecules in inflammation and disease. Blood Coagul. Fibrinolysis 9(Suppl. 2):S17-23
18. Gesner BM, Ginsburg V. 1964. Effect of glycosidases on the fate of transfused lymphocytes. Proc. Natl. Acad. Sci. USA 52:750-55
19. Andrews P, Ford W, Stoddart R. 1980. Metabolic studies of high-walled endothelium of postcapillary venules in rat lymph nodes. CIBA Symp. 71:211-30
20. Imai Y, Singer MS, Fennie C, Lasky LA, Rosen SD. 1991. Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor. J. Cell Biol. 113:1213-21
21. Puri KD, Finger EB, Gaudernack G, Springer TA. 1995. Sialomucin CD34 is the major L-selectin ligand in human tonsil high endothelial venules. J. Cell Biol. 131:261-70
22. Sassetti C, Tangemann K, Singer MS, Kershaw DB, Rosen SD. 1998. Identification of podocalyxin as an HEV ligand for L-selectin: parallels to CD34. J. Exp. Med. 187:1965-75
23. Rasmussen LK, Johnsen LB, Petersen TE, Sorensen ES. 2002. Human GlyCAM-1 mRNA is expressed in the mammary gland as splicing variants and encodes various aberrant truncated proteins. Immunol. Lett. 83:73-75
24. Renkonen J, Tynninen O, Hayry P, Paavonen T, Renkonen R. 2002. Glycosylation might provide endothelial zip codes for organ-specific leukocyte traffic into inflammatory sites. Am. J. Pathol. 161:543-50
25. McNagny KM, Pettersson I, Rossi F, Flamme I, Shevchenko A, et al. 1997. Thrombomucin, a novel cell surface protein that defines thrombocytes and multipotent hematopoietic progenitors. J. Cell Biol. 138:1395-407
26. Rosen SD. 1999. Endothelial ligands for L-selectin: from lymphocyte recirculation to allograft rejection. Am. J. Pathol. 155: 1013-20
27. Streeter PR, Rouse BTN, Butcher EC. 1988. Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes. J. Cell Biol. 107:1853-62
28. von Andrian UH. 1996. Intravital microscopy of the peripheral lymph node microcirculaton in mice. Microcirculation 3:287-300
29. Hemmerich S, Butcher EC, Rosen SD. 1994. Sulfation-dependent recognition of HEV-ligands by L-selectin and MECA 79, an adhesion-blocking mAb. J. Exp. Med. 180:2219-26
30. Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, et al. 2002. Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope. Am. J. Pathol. 160:1669-81
31. Berg EL, McEvoy LM, Berlin C, Bargatze RF, Butcher EC. 1993. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Nature 366:695-98
32. Clark RA, Fuhlbrigge RC, Springer TA. 1998. L-selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules. J. Cell Biol. 140:721-31
33. Suzuki A, Andrew DP, Gonzalo JA, Fukumoto M, Spellberg J, et al. 1996. CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein. Blood 87:3550-62
34. Sako D, Chang XJ, Barone KM, Vachino G, White HM, et al. 1993. Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 75:1179-86
35. McEver RP, Cummings RD. 1997. Role of PSGL-1 binding to selectins in leukocyte recruitment. J. Clin. Invest. 100:S97-103
36. Puri KD, Finger EB, Springer TA. 1997. The faster kinetics of L-selectin than of E-selectin and P-selectin rolling at comparable binding strength. J. Immunol. 158:405-13
37. Ley K, Tedder TF. 1995. Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. J. Immunol. 155:525-28
38. Finger EB, Puri KD, Alon R, Lawrence MB, Von Andrian UH, Springer TA. 1996. Adhesion through L-selectin requires a threshold hydrodynamic shear. Nature 379:266-69
39. Chen SQ, Springer TA. 1999. An automatic braking system that stabilizes leukocyte rolling by an increase in selectin bond number with shear. J. Cell Biol. 144:185-200
40. Varki A. 1997. Selectin ligands: Will the real ones please stand up? J. Clin. Invest. 99:158-62
41. Lowe JB. 2002. Glycosylation in the control of selectin counter-receptor structure and function. Immunol. Rev. 186:19-36
42. x tetrasaccharide, free in solution and bound to E-, P-, and L-selectin. J. Am. Chem. Soc. 119:1727-36
43. Girard J-P, Springer TA. 1995. High endothelial venules: specialized endothelium for lymphocyte migration. Immunol. Today 16:449-57
44. Satomaa T, Renkonen O, Helin J, Kirveskari J, Makitie A, Renkonen R. 2002. O-glycans on human high endothelial CD34 putatively participating in L-selectin recognition. Blood 99:2609-11
45. Van Zante A, Rosen SD. 2003. Sulphated endothelial ligands for L-selectin in lymphocyte homing and inflammation. Biochem. Soc. Trans. 31:313-17
46. Imai Y, Lasky LA, Rosen SD. 1993. Sulphation requirement for GlyCAM-1, an endothelial ligand for L-selectin. Nature 361:555-57
47. Hemmerich S, Leffler H, Rosen SD. 1995. Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for L-selectin. J. Biol. Chem. 270:12035-47
48. x which is an inhibitor of L-selectin binding to peripheral addressin. Glycobiology 4:929-33
49. Bistrup A, Bhakta S, Lee JK, Belov YC, Gunn MD, et al. 1999. Sulfotransferases of two specificities function in the reconstitution of high-endothelial-cell ligands for L-Selectin. J. Cell Biol. 145:899-910
50. Kimura N, Mitsuoka C, Kanamori A, Hiraiwa N, Uchimura K, et al. 1999. Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-3 fucosyltransferase VII and newly cloned GlcNAc beta: 6-sulfotransferase cDNA. Proc. Natl. Acad. Sci. USA 96:4530-35
51. Kanamori A, Kojima N, Uchimura K, Muramatsu T, Tamatani T, et al. 2002. Distinct sulfation requirements of selectins disclosed using cells that support rolling mediated by all three selectins under shear flow. L-selectin prefers carbohydrate 6-sulfation totyrosine sulfation, whereas P-selectin does not. J. Biol. Chem. 277:32578-86
52. Mitsuoka C, Sawada-Kasugai M, Ando-Furui K, Izawa M, Nakanishi H, et al. 1998. Identification of a major carbohydrate capping group of the L-selectin ligand on high endothelial venules in human lymph nodes as 6-sulfo sialyl Lewis X. J. Biol. Chem. 273:11225-33
53. Bruehl RE, Bertozzi CR, Rosen SD. 2000. Minimal sulfated carbohydrates for recognition by L-selectin and the MECA-79 antibody. J. Biol. Chem. 275:32642-48
54. Homeister JW, Thall AD, Petryniak B, Maly P, Rogers CE, et al. 2001. The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity 15:115-26
55. Galustian C, Childs RA, Stoll M, Ishida H, Kiso M, Feizi T. 2002. Synergistic interactions of the two classes of ligand, sialyl-Lewis(a/x) fuco-oligosaccharides and short sulpho-motifs, with the P- and L-selectins: implications for therapeutic inhibitor designs. Immunology 105:350-59
56. Yeh JC, Hiraoka N, Petryniak B, Nakayama J, Ellies LG, et al. 2001. Novel sulfated lymphocyte homing receptors and their control by a Corel extension beta 1, 3-N-acetylglucosaminyltransferase. Cell 105:957-69
57. Nicholson MW, Barclay AN, Singer MS, Rosen SD, van der Merwe PA. 1998. Affinity and kinetic analysis of L-selectin (CD62L) binding to GlyCAM-1. J. Biol. Chem. 273:763-70
58. Toppila S, Lauronen J, Mattila P, Turunen JP, Penttilä L, et al. 1997. L-selectin ligands in rat high endothelium: Multivalent sialyl Lewis x glycans are high-affinity inhibitors of lymphocyte adhesion. Eur. J. Immunol. 27:1360-65
59. Lowe JB, Marth JD. 2003. A genetic approach to mammalian glycan function. Annu. Rev. Biochem. 72:643-91
60. Ellies LG, Tsuboi S, Petryniak B, Lowe JB, Fukuda M, Marth JD. 1998. Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity 9:881-90
61. Mitoma J, Petryniak B, Hiraoka N, Yeh J-C, Lowe JB, Fukuda M. 2003. Extended core 1 and core 2 branched O-glycans differentially modulate sialyl Lewis x-type L-selectin ligand activity. J. Biol. Chem. 278:9953-61
62. Maly P, Thall AD, Petryniak B, Rogers CE, Mith PL, et al. 1996. The α(1,3)fucosyltransferase FuC-TVII controls leukocyte trafficking through an essential role in L-, E- and P-selectin ligand biosynthesis. Cell 86:643-53
63. Hemmerich S, Rosen SD. 2000. Carbohydrate sulfotransferases in lymphocyte homing. Glycobiology 10:849-56
64. Grunwell JR, Bertozzi CR. 2002. Carbohydrate sulfotransferases of the GalNAc/Gal/GlcNAc6ST family. Biochemistry 41:13117-26
65. Hiraoka N, Petryniak B, Nakayama J, Tsuboi S, Suzuki M, et al. 1999. A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl lewis x, an L-selectin ligand displayed by CD34. Immunity 11:79-89
66. Tangemann K, Bistrup A, Hemmerich S, Rosen SD. 1999. Sulfation of an HEV-expressed ligand for L-selectin: effects on tethering and rolling of lymphocytes. J. Exp. Med. 190:935-41
67. Hemmerich S, Bistrup A, Singer MS, van Zante A, Lee JK, et al. 2001. Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Immunity 15:237-47
68. Uchimura K, Muramatsu H, Kadomatsu K, Fan QW, Kurosawa N, et al. 1998. Molecular cloning and characterization of an N-acetylglucosamine-6-O- sulfotransferase. J. Biol. Chem. 273:22577-83
69. Fieger CB, Sassetti CM, Rosen SD. 2003. Endoglycan, a member of the CD34 family, functions as a L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x. J. Biol. Chem. 278:27390-98
70. Ellies LG, Sperandio M, Underhill GH, Yousif J, Smith M, et al. 2002. Sialyltransferase specificity in selectin ligand formation. Blood 100:3618-25
71. Seko A, Dohmae N, Takio K, Yamashita K. 2003. Beta 1,4- galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. J. Biol. Chem. 278:9150-58
72. Asano M, Nakae S, Kotani N, Shirafuji N, Nambu A, et al. 2003. Impaired selectin ligand biosynthesis and reduced inflammatory responses in {beta}-1,4-galactosyltransferase-I-deficient mice. Blood. 102:1678-85
73. Bargatze RF, Jutila MA, Butcher EC. 1995. Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: the multistep model confirmed and refined. Immunity 3:99-108
74. Sperandio M, Forlow SB, Thatte J, Ellies LG, Marth JD, Ley K. 2001. Differential requirements for core2 glucosaminyltransferase for endothelial L-selectin ligand function in vivo. J. Immunol. 167:2268-74
75. Mackay CR, Marston WL, Dudler L, Spertini O, Tedder TF, Hein WR. 1992. Tissue-specific migration pathways by phenotypically distinct subpopulations of memory T cells. Eur. J. Immunol. 22:887-95
76. Xu BH, Wagner N, Pham LN, Magno V, Shan ZY, et al. 2003. Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha(4)beta(1) integrin/VCAM-1, and LFA-1 adhesion pathways. J. Exp. Med. 197:1255-67
77. Csencsits KL, Jutila MA, Pascual DW. 1999. Nasal-associated lymphoid tissue: phenotypic and functional evidence for the primary role of peripheral node addressin in naive lymphocyte adhesion to high endothelial venules in a mucosal site. J. Immunol. 163:1382-89
78. Ruddle NH. 1999. Lymphoid neoorganogenesis: lymphotoxin's role in inflammation and development. Immunol. Res. 19:119-25
79. Hjelmstrom P. 2001. Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines. J. Leukoc. Biol. 69:331-39
80. Drayton DL, Ying XY, Lee J, Lesslauer W, Ruddle NH. 2003. Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase. J. Exp. Med. 197:1153-63
81. Weninger W, Carlsen HS, Goodarzi M, Moazed F, Crowley MA, et al. 2003. Naive T cell recruitment to nonlymphoid tissues: a role for endothelium- expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis. J. Immunol. 170:4638-48
82. Takemura S, Braun A, Crowson C, Kurtin PJ, Cofield RH, et al. 2001. Lymphoid neogenesis in rheumatoid synovitis. J. Immunol. 167:1072-80
83. Salmi M, Rajala P, Jalkanen S. 1997. Homing of mucosal leukocytes to joints. Distinct endothelial ligands in synovium mediate leukocyte-subtype specific adhesion. J. Clin. Invest. 99:2165-72
84. Michie SA, Streeter PR, Bolt PA, Butcher EC, Picker LJ. 1993. The human peripheral lymph node vascular addressin. Am. J. Pathol. 143:1688-98
85. Onrust SV, Hartl PM, Rosen SD, Hanahan D. 1996. Modulation of L-selectin ligand expression during an immune response accompanying tumorigenesis in transgenic mice. J. Clin. Invest. 97:54-64
86. Hänninen A, Taylor C, Streeter PR, Stark LS, Sarte JM, et al. 1993. Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid binding to islet endothelium. J. Clin. Invest. 92:2509-15
87. Michie SA, Streeter PR, Butcher EC, Rouse RV. 1995. L-selectin and alpha 4 beta 7 integrin homing receptor pathways mediate peripheral lymphocyte traffic to AKR mouse hyperplastic thymus. Am. J. Pathol. 147:412-21
88. Mikulowska-Mennis A, Xu B, Berberian JM, Michie SA. 2001. Lymphocyte migration to inflamed lacrimal glands is mediated by vascular cell adhesion molecule-1/alpha(4)beta(1) integrin, peripheral node addressin/L-selectin, and lymphocyte function-associated antigen-1 adhesion pathways. Am. J. Pathol. 159:671-81
89. Tedder TF, Steeber DA, Pizcueta P. 1995. L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites. J. Exp. Med. 181:2259-64
90. Ley K, Tedder TF, Kansas GS. 1993. L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin. Blood 82:1632-38
91. Bargatze RF, Kurk S, Butcher EC, Jutila MA. 1994. Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells. J. Exp. Med. 180:1785-92
92. Alon R, Fuhlbrigge RC, Finger EB, Springer TA. 1996. Interactions through L-selectin and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow. J. Cell Biol. 135:849-65
93. Eriksson EE, Xie X, Werr J, Thoren P, Lindbom L. 2001. Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo. J. Exp. Med. 194:205-18
94. Giuffrè L, Cordey AS, Monai N, Tardy Y, Schapira M, Spertini O. 1997. Monocyte adhesion to activated aortic endothelium: role of L-selectin and heparan sulfate proteoglycans. J. Cell Biol. 136:945-56
95. Zakrzewicz A, Grafe M, Terbeek D, Bongrazio M, Auch-Schwelk W, et al. 1997. L-selectin-dependent leukocyte adhesion to microvascular but not to macrovascular endothelial cells of the human coronary system. Blood 89:3228-35
96. Tu L, Delahunty MD, Ding H, Luscinskas FW, Tedder TF. 1999. The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. J. Exp. Med. 189:241-52
97. Sassetti C, Van Zante M, Rosen SD. 2000. Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins. J. Biol. Chem. 275:9001-10
98. Sperandio M, Smith ML, Forlow SB, Olson TS, Xia L, et al. 2003. P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules. J. Exp. Med. 197:1355-63
99. Moore KL, Patel KD, Bruehl RE, Fugang L, Johnson DA, et al. 1995. P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. J. Cell Biol. 128:661-71
100. Ramos CL, Smith MJ, Snapp KR, Kansas GS, Stickney GW, et al. 1998. Functional characterization of L-selectin ligands on human neutrophils and leukemia cell lines: evidence for mucinlike ligand activity distinct from P-selectin glycoprotein ligand-1. Blood 91:1067-75
101. Hirata T, Merrill-Skoloff G, Aab M, Yang J, Furie BC, Furie B. 2000. P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration. J. Exp. Med. 192:1669-76
102. Xia L, Sperandio M, Yago T, McDaniel JM, Cummings RD, et al. 2002. P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J. Clin. Invest. 109:939-50
103. Somers WS, Tang J, Shaw GD, Camphausen RT. 2000. Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound Slex(X) and PSGL-1. Cell 103:467-79
104. Bernimoulin MP, Zeng XL, Abbal C, Giraud S, Martinez M, et al. 2003. Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51. J. Biol. Chem. 278:37-17
105. Leppanen A, Yago T, Otto VI, McEver RP, Cummings RD. 2003. Model glycosulfopeptides from PSGL-1 require tyrosine sulfation and a core-2 branched O-glycan to bind to L-selectin. J. Biol. Chem. 278:26391-400
106. Moore KL. 2003. The biology and enzymology of protein tyrosine O-sulfation. J. Biol. Chem. 278:24243-46
107. Kanamori A, Kojima N, Uchimura K, Muramatsu T, Tamatani T, et al. 2002. Distinct sulfation requirements of selectins disclosed using cells which support rolling mediated by all three selectins under shear flow. J. Biol. Chem. 277:32578-86
108. Kannagi R. 2002. Regulatory roles of carbohydrate ligands for selectins in the homing of lymphocytes. Curr. Opin. Struct. Biol. 12:599-608
109. Andre P, Spertini O, Guia S, Rihet P, Dignat-George F, et al. 2000. Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin. Proc. Natl. Acad. Sci. USA 97:3400-5
110. Walcheck B, Moore KL, McEver RP, Kishimoto TK. 1996. Neutrophil- neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro. J. Clin. Invest. 98:1081-87
111. Kawashima H, Atarashi K, Hirose M, Hirose J, Yamada S, et al. 2002. Oversulfated chondroitin/dermatan sulfates containing GlcA beta 1/IdoA alpha 1-3GalNAc(4,6-O-disulfate) interact with L- and P-selectin and chemokines. J. Biol. Chem. 277:12921-30
112. Derry CJ, Faveeuw C, Mordsley KR, Ager A. 1998. Novel chondroitin sulfate modified ligands for L-selectin on lymph node high endothelial venules. Eur. J. Immunol. 29:419-30
113. Fukuda M. 1996. Possible roles of tumor-associated carbohydrate antigens. Cancer Res. 56:2237-44
114. Nakamori S, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, et al. 1993. Increased expression of sialyl Lewis x antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. Cancer Res. 53:3632-37
115. Mannori G, Crottet P, Cecconi O, Hanasaki K, Aruffo A, et al. 1995. Differential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucintype glycoproteins. Cancer Res. 55:4425-31
116. Borsig L, Wong R, Feramisco J, Nadeau DR, Varki NM, Varki A. 2001. Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis. Proc. Natl. Acad. Sci. USA 98:3352-57
117. Borsig L, Wong R, Hynes RO, Varki NM, Varki A. 2002. Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc. Natl. Acad. Sci. USA 99: 2193-98
118. Qian F, Hanahan D, Weissman IL. 2001. L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis. Proc. Natl. Acad. Sci. USA 98:3976-81
119. Coussens LM, Werb Z. 2002. Inflammation and cancer. Nature 420:860-67
120. Waddell TK, Fialkow L, Chan CK, Kishimoto TK, Downey GP. 1995. Signaling functions of L-selectin. Enhancement of tyrosine phosphorylation and activation of MAP kinase. J. Biol. Chem. 270:15403-11
121. Hwang ST, Singer MS, Giblin PA, Yednock TA, Bacon KB, et al. 1996. GlyCAM-1, a physiological ligand for L-selectin, activates β2 integrins on naive peripheral lymphocytes. J. Exp. Med. 184:1343-48
122. Giblin PA, Hwang ST, Katsumoto TR, Rosen SD. 1997. Ligation of L-selectin on T lymphocytes activates beta 1 integrins and promotes adhesion to fibronectin. J. Immunol. 159:3498-507
123. Tsang YT, Neelamegham S, Hu Y, Berg EL, Burns AR, et al. 1997. Synergy between L-selectin signaling and chemotactic activation during neutrophil adhesion and transmigration. J. Immunol. 159:4566-77
124. Irjala H, Johansson EL, Grenman R, Alanen K, Salmi M, Jalkanen S. 2001. Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium. J. Exp. Med. 194:1033-42
125. Hickey MJ, Forster M, Mitchell D, Kaur J, De Caigny C, Kubes P. 2000. L-selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses in vivo. J. Immunol. 165:7164-70
126. Kawashima H, Li YF, Watanabe N, Hirose J, Hirose M, Miyasaka M. 1999. Identification and characterization of ligands for L-selectin in the kidney. I. Versican, a large chondroitin sulfate proteoglycan, is a ligand for L-selectin. Int. Immunol. 11:393-405
127. Wang L, Brown JR, Varki A, Esko JD. 2002. Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J. Clin. Invest. 110:127-36
128. Kawashima H, Watanabe N, Hirose M, Sun X, Atarashi K, et al. 2003. Collagen XVIII, a basement membrane heparan sulfate proteoglycan, interacts with L-selectin and monocyte chemoattractant protein-1. J. Biol. Chem. 278:13069-76
129. Shikata K, Suzuki Y, Wada J, Hirata K, Matsuda M, et al. 1999. L-selectin and its ligands mediate infiltration of mononuclear cells into kidney interstitium after ureteric obstruction. J. Pathol. 188:93-99
130. Alon R, Feizi T, Yuen C-T, Fuhlbrigge RC, Springer TA. 1995. Glycolipid ligands for selectins support leukocyte tethering and rolling under physiologic flow conditions. J. Immunol. 154:5356-66
131. Kuttner B, Woodruff J. 1979. Selective adherence of lymphocytes to myelinated areas of rat brain. J. Immunol. 122:1666-68
132. Huang K, Geoffroy JS, Singer MS, Rosen SD. 1991. A lymphocyte homing receptor (L-selectin) mediates the in vitro attachment of lymphocytes to myelinated tracts of the central nervous system. J. Clin. Invest. 88:1778-83
133. Huang K, Kikuta A, Rosen SD. 1994. Myelin localization of a central nervous system ligand for L-selectin. J. Neuroimmunol. 53:133-41
134. Grewal IS, Foellmer HG, Grewal KD, Wang H, Lee WP, et al. 2001. CD62L is required on effector cells for local interactions in the CNS to cause myelin damage in experimental allergic encephalomyelitis. Immunity 14:291-302
135. Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, et al. 2003. Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface. Science 299:405-8
136. Kao LC, Germeyer A, Tulac S, Lobo S, Yang JP, et al. 2003. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology 144:2870-81