Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols

Chemical Research in Toxicology

Volumn 18, Issue 5, 2005, Pages 880-888

  Reddy, Vijay Bhasker G ^a   Karanam, Bindhu V ^a   Gruber, Wendy L ^a   Wallace, Michael A ^a   Vincent, Stella H ^a   Franklin, Ronald B ^a   Baillie, Thomas A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 [(2,4 DIOXOTHIAZOLIDIN 5 YL)METHYL] 2 METHOXY N [[(4 TRIFLUOROMETHOXY)PHENYL]METHYL]BENZAMIDE; CUMENE HYDROPEROXIDE; CYTOCHROME P450; CYTOCHROME P450 3A4; DIMER; DISULFIDE; DRUG METABOLITE; GLUTATHIONE; MRL A; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; S ADENOSYLMETHIONINE; SULFENIC ACID DERIVATIVE; THIOL DERIVATIVE; TROGLITAZONE; UNCLASSIFIED DRUG;

ARTICLE; AUTOOXIDATION; DIMERIZATION; GLUTATHIONE METABOLISM; LIVER MICROSOME; METABOLIC ACTIVATION; NONHUMAN; OXIDATION; REACTION ANALYSIS;

ANIMALS; BENZAMIDES; BENZENE DERIVATIVES; CYTOCHROME P-450 ENZYME SYSTEM; DIMERIZATION; DISULFIDES; GLUTATHIONE; HAPLORHINI; MICROSOMES, LIVER; MODELS, CHEMICAL; NADP; OXIDATION-REDUCTION; OXYGEN; S-ADENOSYLMETHIONINE; SULFHYDRYL COMPOUNDS; THIAZOLIDINEDIONES;

EID: 18944394811     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0500373     Document Type: Article

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