The fate of a thiazolidinedione antidiabetic agent in rat and dog

Xenobiotica

Volumn 26, Issue 6, 1996, Pages 627-636

  Bolton, G C ^a   Keogh, J P ^a   East, P D ^a   Hollis, F J ^a   Shore, A D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ORAL ANTIDIABETIC AGENT; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DOG; DRUG CLEARANCE; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG SULFATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; RAT; SPECIES DIFFERENCE;

ANIMALIA; CANIS FAMILIARIS;

EID: 0029900481     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259609046738     Document Type: Article

References (8)

1. CAWTHORNE, M. A., LISTER, C. A., HOLDER, J. C., KIRKHAM, D. M., YOUNG, P. W., CANTELLO, B. C., HINDLEY, R. M., and SMITH, S. A., 1993, Anti-hyperglycaemic efficacy of a highly potent thiazolidinedione in animal models of non-insulin dependent diabetes. Diabetes, 42, (suppl. 1), 204A.
2. DOI, T., TSUKAMOTO, T., TORII, H., YOSHIDA, K., and TANAYAMA, S., 1984, Metabolism and disposition of 5-(3-ethoxy-4-pentyloxyphenyl)-2,4-thiazolidinedione (CT-112), a new aldose reductase inhibitor, in rats and dogs. Journal of the Takeda Research Laboratory, 43, 19-32.
3. FOUDA, H. G., LUKASZEWICZ, J., CLARKE, D. A., and HULIN, B., 1991, Metabolism of a new thiazolidinedione hypoglycemic agent CP-68,722 in rat: metabolite identification by gas chromatography mass spectrometry. Xenobiotica, 21, 925-934.
4. IBRAHIMI, A., TEBOUL, L., GAILLARD, D., AMRI, E., AILHAUD, G., YOUNG, P., CAWTHORNE, M. A., and GRIMALDI, P. A., 1994, Evidence for a common mechanism of action for fatty acids and thiazolidinediones antidiabetic agents on gene expression in preadipose cells. Molecular Pharmacology, 46, 1070-1076.
5. KRIETER, P. A., COLLETTI, A. E., DOSS, D. A., and MILLER, R. R., 1994, Disposition and metabolism of the hypoglycemic agent pioglitazone in rats. Drug Metabolism and Disposition, 22, 625-630.
6. TOMLINSON, P. W., JEFEERY, D. J., and FILER, C. W., 1981, A novel technique for assessment of biliary secretion and enterohepatic circulation in the unrestrained conscious rat. Xenobiotica, 11, 863-870.
7. TORII, H., YOSHIDA, K., TSUKAMOTO, T., and TANAYAMA, S., 1984, Disposition in rats and dogs of ciglitazone, a new antidiabetic agent. Xenobiotica, 14, 259-268.
8. YOSHIDA, K., TORII, H., SUGIYAMA, Y., FUJITA, T., and TANAYAMA, S., 1984, Rat plasma metabolites of ciglitazone, a new antidiabetic agent, Xenobiotica, 14, 249-257.