Human β-defensin-1 mRNA is transcribed in tympanic membrane and adjacent auditory canal epithelium

Infection and Immunity

Volumn 67, Issue 9, 1999, Pages 4843-4846

  Bøe, Roald ^a   Silvola, Juha ^a   Yang, Jinghui ^a   Moens, Ugo ^a   Mccray Jr , Paul B ^b   Stenfors, Lars Eric ^a   Seljfelid, Rolf ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN; MESSENGER RNA;

ARTICLE; AUDITORY CANAL; EARDRUM; HOST RESISTANCE; HUMAN; HUMAN TISSUE; INFECTION RESISTANCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

EID: 0032794167     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.9.4843-4846.1999     Document Type: Article

References (30)

1. Bensch, K. W., M. Raida, H. J. Magert, P. Schulz Knappe, and W. G. Forssmann. 1995. hBD-1: a novel beta-defensin from human plasma. FEBS Lett. 368:331-335.
2. Boman, H. G. 1998. Gene-encoded peptide antibiotics and the concept of innate immunity: an updated review. Scand. J. Immunol. 48:15-25.
3. Boman, H. G., I. Nilsson, and B. Rasmuson. 1972. Inducible antibacterial defence system in Drosophila. Nature 237:232-235.
4. Brook, I. 1981. Microbial studies of the bacterial flora of the external auditory canal in children. Acta Otolaryngol. 91:285-287.
5. Brooks, G. F., J. S. Butel, L. N. Ornson, E. Jawetz, J. L. Melnick, and E. A. Adelberg. 1991. Jawetz, Melnick, and Adelberg's medical microbiology, 19th ed. Prentice-Hall Inc., London, United Kingdom.
6. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
7. Fulton, C., G. M. Anderson, M. Zaslof, R. Bull, and A. G. Quinn. 1997. Expression of natural peptide antibiotics in human skin. Lancet 350:1750-1751.
8. Ganz, T., M. E. Selsted, and R. I. Lehrer. 1990. Defensins. Eur. J. Haematol. 44:1-8.
9. Ganz, T., and J. Weiss. 1997. Antimicrobial peptides of phagocytes and epithelia. Semin. Hematol. 34:343-354.
10. Harder, J., J. Bartels, E. Christophers, and J.-M. Scröder. 1997. A peptide antibiotic from human skin. Nature 387:861.
11. Kamme, C., K. Lundgren, and P.-A. Mårdh. 1971. The aetiology of acute otitis media in children. Scand. J. Infect. Dis. 3:217-223.
12. Krisanaprakornkit, S., A. Weinberg, C. N. Perez, and B. A. Dale. 1998. Expression of the peptide antibiotic human β-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect. Immun. 66:4222-4228.
13. Lehrer, R. I., A. K. Lichtenstein, and T. Ganz. 1993. Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu. Rev. Immunol. 11:105-128.
14. Lim, D. J. 1968. Tympanic membrane. I. Pars tensa. Acta Otolaryngol. 66:181-198.
15. Lim, D. J. 1968. Tympanic membrane. II. Pars flaccida. Acta Otolaryngol. 66:47-56.
16. Liu, L., C. Zhao, H. H. Q. Heng, and T. Ganz. 1997. The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics 43:316-320.
17. Loennechen, T., U. Moens, H. Kildalsen, A. Andersen, O. P. Rekvig, and A. Aarbakke. 1997. Effects of 3-deazaadenosine on apoptosis-related gene transcripts in HL-60 cells. Pharmacol. Toxicol. 81:199-204.
18. McCray, P. B., Jr., and L. Bentley. 1997. Human airway epithelia express a beta-defensin. Am. J. Respir. Cell Mol. Biol. 16:343-349.
19. McGinley, K. J., J. J. Leyden, R. R. Marples, M. R. C. Path, and A. M. Kligman. 1975. Quantitative microbiology of the scalp in non-dandruff, dandruff, and seborrhoeic dermatitis. J. Invest. Dermatol. 64:401-405.
20. Nissen-Meyer, J., and I. F. Nes. 1997. Ribosomally synthesized antimicrobial peptides: their function, structure, biogenesis, and mechanism of action. Arch. Microbiol. 167:67-77.
21. Ostfeld, E., E. Rubinstein, and E. Gazit. 1977. Effect of systemic antibiotics on the microbial flora of the external ear canal in hospitalized children. Pediatrics 60:364-368.
22. Potter, B. S., C. F. Burgoon, and J. E. Johnson. 1973. Pityrosporum folliculitis. Arch. Dermatol. 107:388-391.
23. Schnapp, D., C. J. Reid, and A. Harris. 1998. Localization of expression of human beta defensin-1 in the pancreas and kidney. J. Pathol. 186:99-103.
24. Singh, P. K., H. P. Jia, K. Wiles, J. Hesselberth, L. D. Liu, B. A. D. Conway, E. P. Greenberg, E. V. Valore, M. J. Welsh, T. Ganz, B. F. Tack, and P. B. McCray, Jr. 1998. Production of β-defensins by human airway epithelia. Proc. Natl. Acad. Sci. USA 95:14961-14966.
25. Sipilä, P., A. M. M. Jokipii, L. Jokipii, and P. Karma. 1981. Bacteria in the middle ear and ear canal of patients with secretory otitis media and noninflamed ears. Acta Otolaryngol. 92:123-130.
26. Stenfors, L.-E., G. D. Blom, and S. Hellström. 1984. The tympanic membrane. Acta Otolaryngol. 414(Suppl.):28-30.
27. Stenfors, L.-E., and S. Räisänen. 1991. Is Pityrosporum ovale a pathogen of the external auditory meatus? Acta Otolaryngol. 111:943-945.
28. Stone, M., and R. S. Fulghum. 1984. Bactericidal activity of wet cerumen. Ann. Otol. Rhinol. Laryngol. 93:183-186.
29. Valore, E. V., C. H. Park, A. J. Quale, K. R. Wiles, P. B. McCray, Jr., and T. Ganz. 1998. Human β-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest. 101:1633-1642.
30. Zhao, C., I. Wang, and R. I. Lehrer. 1996. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett. 396:319-322.