Induction of COX-2 and PGE2 biosynthesis by IL-1β is mediated by PKC and mitogen-activated protein kinases in murine astrocytes

British Journal of Pharmacology

Volumn 131, Issue 1, 2000, Pages 152-159

  Molina Holgado, Eduardo ^a   Ortiz, Sergio ^a   Molina Holgado, Francisco ^b   Guaza, Carmen ^a  

^a INSTITUTO CAJAL   (Spain)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cyclo oxygenase 2; Interleukin 1 ; Mitogen activated protein kinases; Murine astrocytes; Protein kinase C

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BISINDOLYLMALEIMIDE; CALPHOSTIN C; CYCLOHEXIMIDE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN E2; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN SYNTHESIS INHIBITOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ENZYME INDUCTION; GENE EXPRESSION; IMMUNOBLOTTING; INTRACELLULAR TRANSPORT; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT;

EID: 0033821771     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703557     Document Type: Article

References (57)

1. PD 98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase, in vitro and in vivo
2. Regulation of leukemia inhibitory factor synthesis in culture human astrocytes
3. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/ p38kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
4. Interleukin-1β and tumor necrosis factor α mediated regulation of ICAM-I gene expression in astrocytes requires protein kinase C activity
5. Interleukin-1 binding sites on astrocytes
6. Inflammatory cytokines within the central nervous system: Sources, function and mechanism of action
7. Corticotropin-releasing-factor producing neurons in the rat activated by interleukin-1
8. Diversity in function and regulation of MAP kinase pathways
9. A longitudinal study of the prostaglandin content of central nervous system from guinea pigs with acute experimental allergic encephalomyelitis
10. Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolyssacharide
11. Parallel signal processing among mammalian MAPKs
12. Endothelial cells of the rat brain vasculature express cyclooxygenase-2 messenger RNA in response to systemic interleukin-1: A possible site of prostaglandin synthesis responsible for fever
13. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
14. 2 production through a protein kinase C independent mechanisms in chondrocytes
15. Cyclooxygenase 1 and 2 expression in rheumatoid synovial tissues: Effects of interleukin-1β, phorbol ester, and corticosteroids
16. Biologic basis for interleukin-1 disease
17. Experimental brain injury induces expression of interleukin-1β mRNA in the rat brain
18. Potential role of prostaglandins and leukotrienes in multiple sclerosis and experimental allergic encephalomyelitis
19. Selective inhibition of NS-398 on prostanoid production in inflammed tissue in rat carrageenanair-pouch inflammation
20. Pertussis and cholera toxins inhibit prostaglandin synthesis in rat astrocyte cultures at distinct metabolic steps
21. Interleukin-1 of the central nervous system is produced by ameboid microglia
22. Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia
23. 2 biosynthesis stimulated by interleukin- 1β
24. Induction of cyclooxygenase-2 by the activated MEKK 1, SEK1/MKK4 p38 mitogen activated protein kinase pathway
25. Activation of C-Jun N-terminal kinase in bacterial lipopolyssacharide-stimulated macrophages
26. Subdiaphragmatic vagotomy blocks the sleep- and fever-promoting effects of interleukin-1β
27. Recombinant interleukin-1β stimulates eicosanoid production in rat primary culture astrocytes
28. Prostaglandin synthase 2
29. The potential for isoenzyme-selective modulation of protein kinase C
30. Cytokines in the nervous system I. Expression and recognition
31. Protein kinase C isoenzymes: Divergence in signal transduction?
32. 2 in rat astrocyte cultures: Modulatory effects of neuropetides
33. Sounding the alarm: Protein kinases cascades activated by stress and inflammation
34. Effect of acute systemic inflammatory response and cytokines on the transcription of genes encoding cyclooxygenase enzymes COX-1 and COX-2 in the rat brain
35. Peripheral administration of lipopolyssacharide induces the expression of cytokine transcripts in the brain and pituitary of mice
36. cPLA2 is phosphorylated and activated by MAP kinase
37. Dexamethasone regulation of interleukin-1 receptors in the hippocampus of Theiler's virus infected mice: Effects on virus-mediated demyelination
38. Induction of immunoreactive interleukin-1β and tumor necrosis factor-α in the brains of rabiesvirus-infected rats
39. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue
40. Cytokines in inflammatory brain lesions
41. Evidence for cyclooxygenase activation by nitric oxide in astrocytes
42. Rapid induction of prostaglandin synthesis in piglet astroglial cells by interleukin-1-α
43. MAP kinase pathways as a route for regulatory mechanisms of IL-10 and IL-4 which inhibit COX-2 expression in human monocytes
44. Studies and perspectives of protein kinase C
45. Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C
46. Cyclooxygenase-2 gene expression in neurons contributes to ischemic brain damage
47. Signal transduction pathways mediating IL-6 induction by IL-1β and tumor necrosis factor α
48. Interleukin-1β induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary routine astrocyte cultures
49. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase
50. 2 in rat cultured astrocytes
51. Signal transduction pathways activated by the IL-1 receptor family: Ancient signalling machinary in mammals, insect and plants
52. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain
53. Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase
54. Functions and mechanisms of action of interleukin-1 in the brain
55. Activation of multiple proline-directed kinases by bacterial lipopolyssacharide in routine macrophages
56. Cyclooxygenases 1 and 2
57. Interleukin-1β induction of mitogen-activated protein kinases in human mesangial cells