-
1
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER 2 overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2 overexpressing metastatic breast cancer. J. Clin. Oncol. 20, 719-726 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
-
2
-
-
0034584880
-
STI571: An inhibitor of the BCR-ABL tyrosine kinase for the treatment of chronic myelogenous leukaemia
-
O'Dwyer ME, Druker BJ. STI571: An inhibitor of the BCR-ABL tyrosine kinase for the treatment of chronic myelogenous leukaemia. Lancet Oncol. 1, 207-211 (2000).
-
(2000)
Lancet Oncol.
, vol.1
, pp. 207-211
-
-
O'Dwyer, M.E.1
Druker, B.J.2
-
3
-
-
0035998276
-
Molecular diagnostics: Impact upon cancer detection
-
Keesee SK. Molecular diagnostics: Impact upon cancer detection. Expert Rev. Mol. Diagn. 2, 91-92 (2002).
-
(2002)
Expert Rev. Mol. Diagn.
, vol.2
, pp. 91-92
-
-
Keesee, S.K.1
-
4
-
-
0035557625
-
Molecular diagnostics: A powerful new component of the healthcare value chain
-
Poste G. Molecular diagnostics: A powerful new component of the healthcare value chain. Expert Rev. Mol. Diagn. 1, 1-5 (2001).
-
(2001)
Expert Rev. Mol. Diagn.
, vol.1
, pp. 1-5
-
-
Poste, G.1
-
5
-
-
0034939464
-
The present and future of molecular diagnostics
-
Leonard DG. The present and future of molecular diagnostics. Mol. Diagn. (1)6, 71-72 (2001).
-
(2001)
Mol. Diagn.
, vol.6
, Issue.1
, pp. 71-72
-
-
Leonard, D.G.1
-
6
-
-
0036198528
-
Commercial molecular diagnostics in the US: The Human Genome Project to the clinical laboratory
-
Amos J, Patnaik M. Commercial molecular diagnostics in the US: The Human Genome Project to the clinical laboratory. Hum Mutat. 19, 324-333 (2002).
-
(2002)
Hum Mutat.
, vol.19
, pp. 324-333
-
-
Amos, J.1
Patnaik, M.2
-
7
-
-
0035293209
-
A revolution in genetics: Changing medicine, changing lives
-
Bottles K. A revolution in genetics: Changing medicine, changing lives. Physician Exec. 27, 58-63 (2001).
-
(2001)
Physician Exec.
, vol.27
, pp. 58-63
-
-
Bottles, K.1
-
9
-
-
0034464820
-
Analysis of the direct cost of adverse drug reactions in hospitalised patients
-
Bordet P, Gautier S, Le Louet H, Dupuis B, Caron J. Analysis of the direct cost of adverse drug reactions in hospitalised patients. Eur. J. Clin. Pharmacol. 56, 935-941 (2001).
-
(2001)
Eur. J. Clin. Pharmacol.
, vol.56
, pp. 935-941
-
-
Bordet, P.1
Gautier, S.2
Le Louet, H.3
Dupuis, B.4
Caron, J.5
-
10
-
-
0033636535
-
Clinical and economic impact of adverse drug reactions in hospitalized patients
-
Suh DC, Woodall BS, Shin SK, Hermes-De Santis ER. Clinical and economic impact of adverse drug reactions in hospitalized patients. Ann Pharmacother. 34, 1373-1379 (2000).
-
(2000)
Ann Pharmacother.
, vol.34
, pp. 1373-1379
-
-
Suh, D.C.1
Woodall, B.S.2
Shin, S.K.3
Hermes-De Santis, E.R.4
-
11
-
-
0035166337
-
In human therapy, is the drug-drug interaction or the adverse drug reaction the issue?
-
du Souich P. In human therapy, is the drug-drug interaction or the adverse drug reaction the issue? J. Clin. Pharmacol. 8, 153-161 (2001).
-
(2001)
J. Clin. Pharmacol.
, vol.8
, pp. 153-161
-
-
Du Souich, P.1
-
12
-
-
0035575568
-
Personalized medicine: Revolutionizing drug discovery and patient care
-
Ginsburg GS, McCarthy JJ. Personalized medicine: Revolutionizing drug discovery and patient care. Trends Biotechnol. 19, 491-496 (2001).
-
(2001)
Trends Biotechnol.
, vol.19
, pp. 491-496
-
-
Ginsburg, G.S.1
McCarthy, J.J.2
-
13
-
-
0031684721
-
The HER-2/neu Oncogene in breast cancer: Prognostic factor, predictive factor and target for therapy
-
Ross JS, Fletcher JA. The HER-2/neu Oncogene in breast cancer: Prognostic factor, predictive factor and target for therapy. Oncologist 3, 237-252 (1998).
-
(1998)
Oncologist
, vol.3
, pp. 237-252
-
-
Ross, J.S.1
Fletcher, J.A.2
-
14
-
-
0031863748
-
Modern molecular diagnostics and the management of haematological malignancies
-
Morgan GJ, Pratt G. Modern molecular diagnostics and the management of haematological malignancies. Clin. Lab. Haematol. 20, 135-141 (1998).
-
(1998)
Clin. Lab. Haematol.
, vol.20
, pp. 135-141
-
-
Morgan, G.J.1
Pratt, G.2
-
15
-
-
0032189139
-
Influence of genotype on clinical course of the long-QT syndrome
-
Zareba. W, Moss AJ, Schwartz PJ et al. Influence of genotype on clinical course of the long-QT syndrome. N. Engl. J. Med. 339, 960-965 (1998).
-
(1998)
N. Engl. J. Med.
, vol.339
, pp. 960-965
-
-
Zareba, W.1
Moss, A.J.2
Schwartz, P.J.3
-
16
-
-
0030819433
-
Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 as well as LQT3 models of the long-QT syndrome
-
Shimizu W, Antzelevitch C. Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 as well as LQT3 models of the long-QT syndrome. Circulation 96, 2038-2047 (1997).
-
(1997)
Circulation
, vol.96
, pp. 2038-2047
-
-
Shimizu, W.1
Antzelevitch, C.2
-
17
-
-
0028874658
-
+ channel blockade and to increases in heart rate: Implications for gene-specific therapy
-
+ channel blockade and to increases in heart rate: Implications for gene-specific therapy. Circulation 92, 3381-3386 (1995).
-
(1995)
Circulation
, vol.92
, pp. 3381-3386
-
-
Schwartz, P.J.1
Priori, S.G.2
Locati, E.H.3
-
18
-
-
0034735869
-
Progress in the prevention of breast cancer: Concept to reality
-
Jordan VC. Progress in the prevention of breast cancer: Concept to reality. J. Steroid Biochem. Mol. Biol. 74, 269-277 (2000).
-
(2000)
J. Steroid Biochem. Mol. Biol.
, vol.74
, pp. 269-277
-
-
Jordan, V.C.1
-
19
-
-
0033809982
-
Prevention of postmenopausal osteoporosis with oestrogen replacement therapy and associated compounds: Update on clinical trials since 1995
-
Doren M, Samsioe G. Prevention of postmenopausal osteoporosis with oestrogen replacement therapy and associated compounds: Update on clinical trials since 1995. Hum Reprod. Update 6, 419-426 (2000).
-
(2000)
Hum Reprod. Update
, vol.6
, pp. 419-426
-
-
Doren, M.1
Samsioe, G.2
-
20
-
-
0035862755
-
Effective use of statins to prevent coronary heart disease
-
Crouch MA. Effective use of statins to prevent coronary heart disease. Am. Fam. Physician 63, 309-320 (2001).
-
(2001)
Am. Fam. Physician
, vol.63
, pp. 309-320
-
-
Crouch, M.A.1
-
21
-
-
0034762644
-
Using genetic variation to study human disease
-
Taylor JG, Choi EH, Foster CB, Chanock SJ. Using genetic variation to study human disease. Trends Mol. Med. 7, 507-512 (2001).
-
(2001)
Trends Mol. Med.
, vol.7
, pp. 507-512
-
-
Taylor, J.G.1
Choi, E.H.2
Foster, C.B.3
Chanock, S.J.4
-
23
-
-
0033967208
-
Single-nucleotide polymorphism analysis by MALDI TOF mass spectrometry
-
Griffin TJ, Smith LM. Single-nucleotide polymorphism analysis by MALDI TOF mass spectrometry. Trends Biotechnol. 18, 77-84 (2000).
-
(2000)
Trends Biotechnol.
, vol.18
, pp. 77-84
-
-
Griffin, T.J.1
Smith, L.M.2
-
24
-
-
0035052391
-
Biochip technologies in cancer research
-
Kallioniemi OP. Biochip technologies in cancer research. Ann. Med. 33, 142-147 (2001). Overview of high-throughput microarrays and their potential clinical applications.
-
(2001)
Ann. Med.
, vol.33
, pp. 142-147
-
-
Kallioniemi, O.P.1
-
25
-
-
0035524458
-
Pharmacogenetics and cancer therapy
-
Relling MV, Dervieux T. Pharmacogenetics and cancer therapy. Nature Rev. Cancer 1, 99-108 (2001). Reviews the use of SNP detection and cancer therapy selection.
-
(2001)
Nature Rev. Cancer
, vol.1
, pp. 99-108
-
-
Relling, M.V.1
Dervieux, T.2
-
26
-
-
0034751402
-
Molecular and pathological characterization of inherited breast cancer
-
Borg A. Molecular and pathological characterization of inherited breast cancer. Semin. Cancer Biol. 11, 375-385 (2001).
-
(2001)
Semin. Cancer Biol.
, vol.11
, pp. 375-385
-
-
Borg, A.1
-
28
-
-
0034585282
-
Familial colorectal cancer: Pathology and molecular characteristics
-
Jass JR. Familial colorectal cancer: Pathology and molecular characteristics. Lancet Oncol. 1, 220-226 (2000).
-
(2000)
Lancet Oncol.
, vol.1
, pp. 220-226
-
-
Jass, J.R.1
-
30
-
-
0036152382
-
Genetic testing for cancer predisposition
-
Calzone KA, Biesecker BB. Genetic testing for cancer predisposition. Cancer Nurs. 25, 15-25 (2002).
-
(2002)
Cancer Nurs.
, vol.25
, pp. 15-25
-
-
Calzone, K.A.1
Biesecker, B.B.2
-
31
-
-
0035479620
-
Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes
-
Ingelman-Sundberg M. Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes. Mutat. Res. 482, 11-19 (2001).
-
(2001)
Mutat. Res.
, vol.482
, pp. 11-19
-
-
Ingelman-Sundberg, M.1
-
32
-
-
0035721949
-
Pharmacogenetics: An opportunity for a safer and more efficient pharmacotherapy
-
Ingelman-Sundberg M. Pharmacogenetics: An opportunity for a safer and more efficient pharmacotherapy. J. Intern. Med. 250, 186-200 (2001).
-
(2001)
J. Intern. Med.
, vol.250
, pp. 186-200
-
-
Ingelman-Sundberg, M.1
-
33
-
-
0036133178
-
Pharmacogenetic screening and therapeutic drugs
-
Steimer W, Potter JM. Pharmacogenetic screening and therapeutic drugs. Clin. Chim. Acta. 315, 137-155 (2002).
-
(2002)
Clin. Chim. Acta
, vol.315
, pp. 137-155
-
-
Steimer, W.1
Potter, J.M.2
-
34
-
-
0035474758
-
Pharmacogenetics
-
Roses AD. Pharmacogenetics. Hum. Mol. Genet. 10, 2261-2267 (2001). Thorough review of SNP testing and predicting drug toxicity.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 2261-2267
-
-
Roses, A.D.1
-
35
-
-
0033832450
-
The role of pharmacogenetics and pharmacogenomics in cancer chemotherapy with 5-fiuorouracil
-
Diasio RB, Johnson MR. The role of pharmacogenetics and pharmacogenomics in cancer chemotherapy with 5-fiuorouracil. Pharmacology 61, 199-203 (2000).
-
(2000)
Pharmacology
, vol.61
, pp. 199-203
-
-
Diasio, R.B.1
Johnson, M.R.2
-
37
-
-
0034953523
-
Genetic mechanisms for variability in drug response and toxicity
-
Linder MW, Valdes R Jr. Genetic mechanisms for variability in drug response and toxicity. J. Anal. Toxicol. 25, 405-413 (2001).
-
(2001)
J. Anal. Toxicol.
, vol.25
, pp. 405-413
-
-
Linder, M.W.1
Valdes R., Jr.2
-
38
-
-
0035425225
-
Pharmacogenetic determinants of anticancer drug activity and toxicity
-
Danesi R, De Braud F, Fogli S, Di Paolo A, Del Tacca M. Pharmacogenetic determinants of anticancer drug activity and toxicity. Trends Pharmacol. Sci. 22, 420-426 (2001).
-
(2001)
Trends Pharmacol. Sci.
, vol.22
, pp. 420-426
-
-
Danesi, R.1
De Braud, F.2
Fogli, S.3
Di Paolo, A.4
Del Tacca, M.5
-
39
-
-
0035750549
-
Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
-
Pullarkat ST, Stoehlmacher J, Ghaderi V et al. Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J. 1, 65-70 (2001).
-
(2001)
Pharmacogenomics J.
, vol.1
, pp. 65-70
-
-
Pullarkat, S.T.1
Stoehlmacher, J.2
Ghaderi, V.3
-
40
-
-
0033606540
-
Drug resistance genotyping in HIV-1 therapy: The VIRADAPT randomised controlled trial
-
Durant J, Clevenbergh P, Halfon P et al. Drug resistance genotyping in HIV-1 therapy: The VIRADAPT randomised controlled trial. Lancet 353, 2195-2199 (1999).
-
(1999)
Lancet
, vol.353
, pp. 2195-2199
-
-
Durant, J.1
Clevenbergh, P.2
Halfon, P.3
-
41
-
-
0035092089
-
Pharmacogenomics: A clinician's primer on emerging technologies for improved patient care
-
Rusnak JM, Kisabeth RM, Herbert DP, McNeil DM. Pharmacogenomics: A clinician's primer on emerging technologies for improved patient care. Mayo Clin. Proc. 76, 299-309 (2001).
-
(2001)
Mayo Clin. Proc.
, vol.76
, pp. 299-309
-
-
Rusnak, J.M.1
Kisabeth, R.M.2
Herbert, D.P.3
McNeil, D.M.4
-
42
-
-
0033428029
-
Impact of pharmacogenomics on the clinical laboratory
-
Hess P, Cooper D. Impact of pharmacogenomics on the clinical laboratory. Mol. Diagn. 4, 289-298 (1999).
-
(1999)
Mol. Diagn.
, vol.4
, pp. 289-298
-
-
Hess, P.1
Cooper, D.2
-
43
-
-
0033668758
-
Uncovering functionally relevant signaling pathways using microarray based expression profiling
-
Harkin DP. Uncovering functionally relevant signaling pathways using microarray based expression profiling. Oncologist 5, 501-507 (2000).
-
(2000)
Oncologist
, vol.5
, pp. 501-507
-
-
Harkin, D.P.1
-
44
-
-
0033664021
-
Microarray techniques in pathology: Tool or toy?
-
Snijders AM, Meijer GA, Brakenhoff RH, van den Brule AJ, van Diest PJ. Microarray techniques in pathology: Tool or toy? Mol. Pathol. 53, 289-294 (2000).
-
(2000)
Mol. Pathol.
, vol.53
, pp. 289-294
-
-
Snijders, A.M.1
Meijer, G.A.2
Brakenhoff, R.H.3
Van den Brule, A.J.4
Van Diest, P.J.5
-
45
-
-
0035672381
-
Gene expression profiling. Methods and clinical applications in oncology
-
Raetz EA, Moos PJ, Szabo A, Carroll WL. Gene expression profiling. Methods and clinical applications in oncology. Hematol. Oncol. Clin. North Am. 15, 911-930 (2001).
-
(2001)
Hematol. Oncol. Clin. North Am.
, vol.15
, pp. 911-930
-
-
Raetz, E.A.1
Moos, P.J.2
Szabo, A.3
Carroll, W.L.4
-
46
-
-
0035367507
-
Gene discovery using the serial analysis of gene expression technique: Implications for cancer research
-
Polyak K, Riggins GJ. Gene discovery using the serial analysis of gene expression technique: Implications for cancer research. J. Clin. Oncol. 19, 2948-2958 (2001).
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 2948-2958
-
-
Polyak, K.1
Riggins, G.J.2
-
47
-
-
0034812285
-
Unlocking the archive gene expression in paraffin-embedded tissue
-
Lewis F, Maughan NJ, Smith V, Hillan K, Quirke P. Unlocking the archive gene expression in paraffin-embedded tissue. J. Pathol. 195, 66-71 (2001).
-
(2001)
J. Pathol.
, vol.195
, pp. 66-71
-
-
Lewis, F.1
Maughan, N.J.2
Smith, V.3
Hillan, K.4
Quirke, P.5
-
48
-
-
0034806364
-
An introduction to arrays
-
Maughan NJ, Lewis FA, Smith V. An introduction to arrays. J. Pathol. 195, 3-6 (2001). Reviews the different types of microarrays.
-
(2001)
J. Pathol.
, vol.195
, pp. 3-6
-
-
Maughan, N.J.1
Lewis, F.A.2
Smith, V.3
-
49
-
-
0034812859
-
Towards a novel classification of human malignancies based on gene expression patterns
-
Alizadeh AA, Ross DT, Perou CM, van de Rijn M. Towards a novel classification of human malignancies based on gene expression patterns. J. Pathol. 195, 41-52 (2001).
-
(2001)
J. Pathol.
, vol.195
, pp. 41-52
-
-
Alizadeh, A.A.1
Ross, D.T.2
Perou, C.M.3
Van de Rijn, M.4
-
50
-
-
0036534202
-
DNA microarrays in clinical oncology
-
Ramaswamy S, Golub TR. DNA microarrays in clinical oncology. J. Clin. Oncol. 20, 1932-1941 (2002). Considers the impact of tumor classification by gene expression profiling.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 1932-1941
-
-
Ramaswamy, S.1
Golub, T.R.2
-
51
-
-
0028806048
-
Quantitative monitoring of gene expression patterns with a complementary DNA microarray
-
Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270, 467-470 (1995).
-
(1995)
Science
, vol.270
, pp. 467-470
-
-
Schena, M.1
Shalon, D.2
Davis, R.W.3
Brown, P.O.4
-
52
-
-
0034330378
-
Gene expression analysis as an aid to the identification of drug targets
-
Zanders ED. Gene expression analysis as an aid to the identification of drug targets. Pharmacogenomics 1, 375-384 (2000). How companies are using transcriptional profiling to detect new drug targets.
-
(2000)
Pharmacogenomics
, vol.1
, pp. 375-384
-
-
Zanders, E.D.1
-
53
-
-
0034626986
-
Pharmacogenomics -teaching old drugs new tricks
-
Weinstein JN. Pharmacogenomics -teaching old drugs new tricks. N. Engl. J. Med. 343, 1408-1409 (2000). Basic primer on pharmacogenomics.
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1408-1409
-
-
Weinstein, J.N.1
-
54
-
-
0033832450
-
The role of pharmacogenetics and pharmacogenomics in cancer chemotherapy with 5-fluorouracil
-
Diasio RB, Johnson MR. The role of pharmacogenetics and pharmacogenomics in cancer chemotherapy with 5-fluorouracil. Pharmacology 61, 199-203 (2000).
-
(2000)
Pharmacology
, vol.61
, pp. 199-203
-
-
Diasio, R.B.1
Johnson, M.R.2
-
55
-
-
33748684161
-
Using mRNA expression profiling to determine anticancer drug efficacy
-
Los G, Yang F, Samimi G et al. Using mRNA expression profiling to determine anticancer drug efficacy. Cytometry 47, 66-71 (2002).
-
(2002)
Cytometry
, vol.47
, pp. 66-71
-
-
Los, G.1
Yang, F.2
Samimi, G.3
-
56
-
-
0035020425
-
Transcriptional profiling in cancer: The path to clinical pharmacogenomics
-
Slonim DK. Transcriptional profiling in cancer: The path to clinical pharmacogenomics. Pharmacogenomics 2, 123-136 (2001).
-
(2001)
Pharmacogenomics
, vol.2
, pp. 123-136
-
-
Slonim, D.K.1
-
57
-
-
0036207548
-
Inference from clustering with application to gene-expression microarrays
-
Dougherty ER, Barrera J, Brun M et al. Inference from clustering with application to gene-expression microarrays. J. Comput. Biol. 105-126 (2002).
-
(2002)
J. Comput. Biol.
, pp. 105-126
-
-
Dougherty, E.R.1
Barrera, J.2
Brun, M.3
-
58
-
-
0036213202
-
Global analysis of gene expression: Methods, interpretation and pitfalls
-
Fryer RM, Randall J, Yoshida T et al. Global analysis of gene expression: Methods, interpretation and pitfalls. Exp. Nephrol. 10, 64-74 (2002).
-
(2002)
Exp. Nephrol.
, vol.10
, pp. 64-74
-
-
Fryer, R.M.1
Randall, J.2
Yoshida, T.3
-
59
-
-
0034037622
-
Proteasome inhibition measurements: Clinical application
-
Lightcap ES, McCormack TA, Pien CS, Chau V, Adams J, Elliott PJ. Proteasome inhibition measurements: Clinical application. Clin. Chem. 46, 673-683 (2000).
-
(2000)
Clin. Chem.
, vol.46
, pp. 673-683
-
-
Lightcap, E.S.1
McCormack, T.A.2
Pien, C.S.3
Chau, V.4
Adams, J.5
Elliott, P.J.6
-
60
-
-
0036181371
-
Development of the proteasome inhibitor PS-341
-
Adams J. Development of the proteasome inhibitor PS-341. Oncologist 7, 9-16 (2002). The proteasome inhibitor PS-341 shows significant promise for the treatment of patients with multiple myeloma.
-
(2002)
Oncologist
, vol.7
, pp. 9-16
-
-
Adams, J.1
-
61
-
-
0035736099
-
The proteasome: A new target for novel drug therapies
-
Elliott PJ, Ross JS. The proteasome: A new target for novel drug therapies. Am. J. Clin. Pathol. 116, 637-646 (2001).
-
(2001)
Am. J. Clin. Pathol.
, vol.116
, pp. 637-646
-
-
Elliott, P.J.1
Ross, J.S.2
-
62
-
-
0036139727
-
Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition
-
Albanell J, Rojo F, Averbuch S et al. Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition. J. Clin. Oncol. 20, 110-124 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 110-124
-
-
Albanell, J.1
Rojo, F.2
Averbuch, S.3
-
63
-
-
0035190398
-
Discovery in toxicology: Mediation by gene expression array technology
-
Hamadeh HK, Bushel P, Paules R, Afshari CA. Discovery in toxicology: Mediation by gene expression array technology. J. Biochem. Mol. Toxicol. 15, 231-242 (2001).
-
(2001)
J. Biochem. Mol. Toxicol.
, vol.15
, pp. 231-242
-
-
Hamadeh, H.K.1
Bushel, P.2
Paules, R.3
Afshari, C.A.4
-
64
-
-
0035092715
-
Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology
-
Fielden MR, Zacharewski TR. Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicol. Sci. 60, 6-10 (2001).
-
(2001)
Toxicol. Sci.
, vol.60
, pp. 6-10
-
-
Fielden, M.R.1
Zacharewski, T.R.2
-
65
-
-
0035124707
-
Analysis of genetic and epigenetic mechanisms of toxicity: Potential roles of toxicogenomics and proteomics in toxicology
-
Burchiel SW, Knall CM, Davis JW 2nd, Paules RS, Boggs SE, Afshari CA. Analysis of genetic and epigenetic mechanisms of toxicity: Potential roles of toxicogenomics and proteomics in toxicology. Toxicol. Sci. 59, 193-195 (2001).
-
(2001)
Toxicol. Sci.
, vol.59
, pp. 193-195
-
-
Burchiel, S.W.1
Knall, C.M.2
Davis J.W. II3
Paules, R.S.4
Boggs, S.E.5
Afshari, C.A.6
-
66
-
-
0036207748
-
An overview of toxicogenomics
-
Hamadeh HK, Amin RP, Paules RS, Afshari CA. An overview of toxicogenomics. Curr. Issues Mol. Biol. 4, 45-56 (2002).
-
(2002)
Curr. Issues Mol. Biol.
, vol.4
, pp. 45-56
-
-
Hamadeh, H.K.1
Amin, R.P.2
Paules, R.S.3
Afshari, C.A.4
-
67
-
-
0034710933
-
A structural basis for drug-induced long QT syndrome
-
Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC. A structural basis for drug-induced long QT syndrome. Proc. Natl. Acad. Sci. USA 97, 12329-12333 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 12329-12333
-
-
Mitcheson, J.S.1
Chen, J.2
Lin, M.3
Culberson, C.4
Sanguinetti, M.C.5
-
68
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for Metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S et al. Use of chemotherapy plus a monoclonal antibody against HER2 for Metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783-792 (2001). Original Herceptin clinical trial story.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
69
-
-
0034889082
-
HER2/neu as a predictive factor in breast cancer
-
Lohrisch C, Piccart M. HER2/neu as a predictive factor in breast cancer. Clin. Breast Cancer 2, 129-135 (2001).
-
(2001)
Clin. Breast Cancer
, vol.2
, pp. 129-135
-
-
Lohrisch, C.1
Piccart, M.2
-
70
-
-
0036216405
-
STI571 (Gleevec) as a paradigm for cancer therapy
-
Druker BJ. STI571 (Gleevec) as a paradigm for cancer therapy. Trends Mol. Med. 8, S14-8 (2002). Most recently approved anticancer targeted therapy.
-
(2002)
Trends Mol. Med.
, vol.8
-
-
Druker, B.J.1
-
71
-
-
0037080402
-
Treatment of inoperable gastrointestinal stromal tumor (GIST) with Imatinib (Glivec, Gleevec)
-
Joensuu H. Treatment of inoperable gastrointestinal stromal tumor (GIST) with Imatinib (Glivec, Gleevec). Med Klin. 97(Suppl.) 1, 28-30 (2002).
-
(2002)
Med Klin.
, vol.97
, Issue.SUPPL.
, pp. 1
-
-
Joensuu, H.1
-
72
-
-
0036570107
-
Targeting the epidermal growth factor receptor with tyrosine kinase inhibitors: Small molecules, big hopes
-
Baselga J. Targeting the epidermal growth factor receptor with tyrosine kinase inhibitors: Small molecules, big hopes. J. Clin. Oncol. 20, 2217-2219 (2002).
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2217-2219
-
-
Baselga, J.1
-
73
-
-
0035352721
-
Angiogenesis: Pathological, prognostic and growth-factor pathways and their link to trial design and anticancer drugs
-
Fox SB, Gasparini G, Harris AL. Angiogenesis: Pathological, prognostic and growth-factor pathways and their link to trial design and anticancer drugs. Lancet Oncol. 2, 278-289 (2001).
-
(2001)
Lancet Oncol.
, vol.2
, pp. 278-289
-
-
Fox, S.B.1
Gasparini, G.2
Harris, A.L.3
-
74
-
-
0036124415
-
Epidermal growth factor receptors as a target for cancer treatment: The emerging role of IMC-C 225 in the treatment of lung and head and neck cancers
-
Herbst RS, Langer CJ. Epidermal growth factor receptors as a target for cancer treatment: The emerging role of IMC-C225 in the treatment of lung and head and neck cancers. Semin. Oncol. 29, 27-36 (2002).
-
(2002)
Semin. Oncol.
, vol.29
, pp. 27-36
-
-
Herbst, R.S.1
Langer, C.J.2
-
75
-
-
0034327512
-
An α-particle emitting antibody ([213BI ] J 591]J591) for radioimmunotherapy of prostate cancer
-
McDevitt MR, Barendswaard E, Ma D et al. An α-particle emitting antibody ([213BI ] J 591]J591) for radioimmunotherapy of prostate cancer. Cancer Res. 60, 6095-6100 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 6095-6100
-
-
McDevitt, M.R.1
Barendswaard, E.2
Ma, D.3
-
76
-
-
0034753903
-
Mylotarg: Antibody-targeted chemotherapy comes of age
-
Sievers EL, Linenberger M. Mylotarg: Antibody-targeted chemotherapy comes of age. Curr. Opin. Oncol. 13, 522-527 (2001).
-
(2001)
Curr. Opin. Oncol.
, vol.13
, pp. 522-527
-
-
Sievers, E.L.1
Linenberger, M.2
-
78
-
-
0035039582
-
Early rheumatoid arthritis: Can we predict its outcome?
-
Williamson AA, McColl GJ. Early rheumatoid arthritis: Can we predict its outcome? Intern. Med. J. 31, 168-180 (2001).
-
(2001)
Intern. Med. J.
, vol.31
, pp. 168-180
-
-
Williamson, A.A.1
McColl, G.J.2
-
79
-
-
0036105388
-
The genetic jigsaw of inflammatory bowel disease
-
Watts DA, Satsangi J. The genetic jigsaw of inflammatory bowel disease. Gut 50(Suppl.3), 31-36 (2002).
-
(2002)
Gut
, vol.50
, Issue.SUPPL. 3
, pp. 31-36
-
-
Watts, D.A.1
Satsangi, J.2
-
80
-
-
0035379127
-
Genetics of inflammatory bowel disease: From bench to bedside?
-
Satsangi J. Genetics of inflammatory bowel disease: From bench to bedside? Acta Odontol. Scand. 59, 187-192 (2001).
-
(2001)
Acta Odontol. Scand.
, vol.59
, pp. 187-192
-
-
Satsangi, J.1
-
81
-
-
0035003550
-
C-reactive protein: A 'golden marker' for inflammation and coronary artery disease
-
Parel VB, Robbins MA, Topol EJ. C-reactive protein: A 'golden marker' for inflammation and coronary artery disease. Cleveland Clin. J. Med. 68, 521-524 (2001).
-
(2001)
Cleveland Clin. J. Med.
, vol.68
, pp. 521-524
-
-
Parel, V.B.1
Robbins, M.A.2
Topol, E.J.3
-
82
-
-
0037034968
-
Noninvasive surrogate markers of atherosclerosis
-
Feinstein SB, Voci P, Pizzuto F. Noninvasive surrogate markers of atherosclerosis. Am J. Cardiol. 89(5A), 31C-43C (2002).
-
(2002)
Am J. Cardiol.
, vol.89
, Issue.5 A
-
-
Feinstein, S.B.1
Voci, P.2
Pizzuto, F.3
-
83
-
-
0035895631
-
Laboratory surrogates for anti-atherosclerotic drug development
-
Stein E. Laboratory surrogates for anti-atherosclerotic drug development. Am. J. CardioL 87(4A), 21A-26A (2001).
-
(2001)
Am. J. CardioL
, vol.87
, Issue.4 A
-
-
Stein, E.1
-
84
-
-
0035557623
-
Molecular diagnostics in monogenic and multifactorial forms of Type 2 diabetes
-
McCarthy MI, Hattersley AT. Molecular diagnostics in monogenic and multifactorial forms of Type 2 diabetes. Expert Rev. Mol. Diagn. 1, 403-412 (2001).
-
(2001)
Expert Rev. Mol. Diagn.
, vol.1
, pp. 403-412
-
-
McCarthy, M.I.1
Hattersley, A.T.2
-
85
-
-
0036000310
-
Viral genome quantification as a tool for improving patient management: The example of HIV, HBV, HCV and CMV
-
Berger A, Preiser W. Viral genome quantification as a tool for improving patient management: The example of HIV, HBV, HCV and CMV. J. Antimicrob. Chemother. 49, 713-721 (2002).
-
(2002)
J. Antimicrob. Chemother.
, vol.49
, pp. 713-721
-
-
Berger, A.1
Preiser, W.2
-
86
-
-
0008730523
-
Laboratory guidelines for the practical use of HIV drug resistance tests in patient follow-up
-
Vandamme AM, Houyez F, Banhegyi D et al. Laboratory guidelines for the practical use of HIV drug resistance tests in patient follow-up. Antivir. Ther. 6, 21-39 (2001).
-
(2001)
Antivir. Ther.
, vol.6
, pp. 21-39
-
-
Vandamme, A.M.1
Houyez, F.2
Banhegyi, D.3
-
87
-
-
0035294312
-
Measuring the effectiveness of antiretroviral agents
-
Buss N, Cammack N. Measuring the effectiveness of antiretroviral agents. Antivir. Ther. 6, 1-7 (2001). Retroviral therapy monitoring remains the most frequently utilized molecular diagnostic test yet discovered.
-
(2001)
Antivir. Ther.
, vol.6
, pp. 1-7
-
-
Buss, N.1
Cammack, N.2
-
88
-
-
0034495721
-
Hereditary common cancers: Molecular and clinical genetics
-
Russo A, Zanna I, Tubiolo C et al. Hereditary common cancers: Molecular and clinical genetics. Anticancer Res. 20, 4841-4851 (2001).
-
(2001)
Anticancer Res.
, vol.20
, pp. 4841-4851
-
-
Russo, A.1
Zanna, I.2
Tubiolo, C.3
-
89
-
-
0035663606
-
New molecular tools for efficient screening of cervical cancer
-
von Knebel Doeberitz M. New molecular tools for efficient screening of cervical cancer. Dis. Markers 17, 123-128 (2001).
-
(2001)
Dis. Markers
, vol.17
, pp. 123-128
-
-
Von Knebel Doeberitz, M.1
-
90
-
-
0033499854
-
Economic, regulatory and practice issues in molecular pathology and diagnostics
-
Ross JS. Economic, regulatory and practice issues in molecular pathology and diagnostics. Am. J. Clin. Pathol. 112(Suppl. 1), S7-10 (1999).
-
(1999)
Am. J. Clin. Pathol.
, vol.112
, Issue.SUPPL. 1
-
-
Ross, J.S.1
-
91
-
-
0034573969
-
Molecular diagnostics of infectious diseases: State of the technology
-
Sakallah SA. Molecular diagnostics of infectious diseases: State of the technology. Biotechnol. Ann. Rev. 6, 141-161 (2000).
-
(2000)
Biotechnol. Ann. Rev.
, vol.6
, pp. 141-161
-
-
Sakallah, S.A.1
-
92
-
-
0031719866
-
Molecular diagnostics for cardiovascular disease
-
Pang CP. Molecular diagnostics for cardiovascular disease. Clin. Chem. Lab. Med. 36, 605-614 (1998).
-
(1998)
Clin. Chem. Lab. Med.
, vol.36
, pp. 605-614
-
-
Pang, C.P.1
-
93
-
-
0034768115
-
Technical aspects of minimal residual disease detection in carcinoma patients
-
Lacroix J, Doeberitz MK. Technical aspects of minimal residual disease detection in carcinoma patients. Semin. Surg. Oncol. 20, 252-264 (2001).
-
(2001)
Semin. Surg. Oncol.
, vol.20
, pp. 252-264
-
-
Lacroix, J.1
Doeberitz, M.K.2
-
94
-
-
0031863748
-
Modern molecular diagnostics and the management of haematological malignancies
-
Morgan GJ, Pratt G. Modern molecular diagnostics and the management of haematological malignancies. Clin. Lab. Haematol. 20, 135-141 (1998).
-
(1998)
Clin. Lab. Haematol.
, vol.20
, pp. 135-141
-
-
Morgan, G.J.1
Pratt, G.2
-
95
-
-
0034331666
-
Applications of proteomics in oncology
-
Jain KK. Applications of proteomics in oncology. Pharmacogenomics 1, 385-393 (2000).
-
(2000)
Pharmacogenomics
, vol.1
, pp. 385-393
-
-
Jain, K.K.1
-
96
-
-
0035371837
-
Proteomics: A technology-driven and technology-limited discovery science
-
Lee KH. Proteomics: A technology-driven and technology-limited discovery science. Trends Biotechnol. 19, 217-222 (2001).
-
(2001)
Trends Biotechnol.
, vol.19
, pp. 217-222
-
-
Lee, K.H.1
-
98
-
-
0034828488
-
Proteomics in early detection of cancer
-
Srinivas PR, Srivastava S, Hanash S, Wright GL Jr. Proteomics in early detection of cancer. Clin. Chem. 47, 1901-1911 (2001).
-
(2001)
Clin. Chem.
, vol.47
, pp. 1901-1911
-
-
Srinivas, P.R.1
Srivastava, S.2
Hanash, S.3
Wright G.L., Jr.4
-
99
-
-
0037116832
-
Use of proteomic patterns in serum to identify ovarian cancer
-
Petricoin EF, Ardekani AM, Hitt BA et al. Use of proteomic patterns in serum to identify ovarian cancer. Lancet 359, 572-577 (2002). SELDI baroode proteomics detects 100% of Stage I ovarian cancer. If validated, this technique could 'revolutionize' molecular diagnostics.
-
(2002)
Lancet
, vol.359
, pp. 572-577
-
-
Petricoin, E.F.1
Ardekani, A.M.2
Hitt, B.A.3
-
100
-
-
0034126959
-
PET: The merging of biology and imaging into molecular imaging
-
Phelps ME. PET: The merging of biology and imaging into molecular imaging. J. Nucl. Med. 41, 661-681 (2000).
-
(2000)
J. Nucl. Med.
, vol.41
, pp. 661-681
-
-
Phelps, M.E.1
|