The genetic jigsaw of inflammatory bowel disease

Gut

Volumn 50, Issue SUPPL. 3, 2002, Pages

  Watts, D A ^a   Satsangi, J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONFERENCE PAPER; CROHN DISEASE; DISEASE PREDISPOSITION; ENTERITIS; GENE LOCUS; GENETIC LINKAGE; HUMAN; MOLECULAR GENETICS; PATHOGENESIS; PRIORITY JOURNAL; ULCERATIVE COLITIS;

EID: 0036105388     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.50.suppl_3.iii31     Document Type: Conference Paper

References (54)

1. Inflammatory bowel disease: Epidemiology and management in an English general practice population
2. Incidence of juvenile onset Crohn's disease in Scotland
3. Prospective survey of childhood inflammatory bowel disease in the British Isles
4. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin 10 deficient mice Infect
5. Association of NOD-2 leucine rich repeat variants with susceptibility to Crohn's disease
6. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
7. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking
8. Inflammatory bowel disease in a Danish twin register
9. Genetics versus environment in inflammatory bowel disease: Results of a British twin study
10. Review article: The genetics of inflammatory bowel disease
11. Leading article. The genetics of inflammatory bowel disease
12. Clinical patterns of familial inflammatory bowel disease
13. Crohn's disease: Concordance for site and clinical type in affected family members - Potential hereditary influences
14. Studies of family history among patients with inflammatory bowel disease
15. Familial empirical risks for inflammatory bowel disease: Differences between Jews and non-Jews
16. Aetiology and natural history of primary sclerosing cholangitis: A decade of progress?
17. Inflammatory bowel disease and the X chromosome
18. Investigation of inheritance of chronic inflammatory bowel diseases by complex segregation analysis
19. A second generation linkage map of the human genome
20. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11 q
21. Limits on fine mapping of complex traits
22. Searching for genetic determinants in the new millennium
23. Mapping of a susceptibility locus for Crohn's disease on chromosome 16
24. Two-stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12
25. The international IBD genetics consortium confirms linkage of Crohn's disease to a locus on chromosome 16 (IBD1)
26. Linkage and association between inflammatory bowel disease and a locus on chromosome 12
27. Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16
28. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1
29. Linkage heterogenetity between ulcerative colitis and Crohn's disease at the IBD2 locus
30. Identification of multiple candidate genes for IBD susceptibility using high density transcript mapping in the IBD2 locus on chromosome 12q
31. Novel polymorphisms in the beta 7 integrin gene family based association studies in IBD
32. Family based association studies of STAT6, a positional candidate gene for IBD
33. Contribution of genes of the major histocompatibility complex to susceptibilily and disease phenotype in inflammatory bowel disease
34. HLA-DR -DQ phenotypes in inflammatory bowel disease: A meta-analysis
35. A genome-wide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort
36. Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses
37. Complete sequence and gene map of a major histocompatibility complex
38. Genetic markers may predict disease behaviour in patients with ulcerative colitis
39. Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease
40. Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis
41. Crohn's disease is associated with novel polymorphisms in the 5′ flanking region of the tumour necrosis gene
42. Transmission dysequilibrium testing confirms the association of the TNFα 1031C allele with Crohn's disease
43. Response to anti TNFa treatment is associated with the TNFa-308* 1 allele
44. TNF microsatellite polymorphism does not predict response to infliximab in patients with Crohn's disease
45. A genome wide search identifies potential new susceptibility loci for Crohn's disease
46. High-density genome scan in Crohn's disease shows confirmed linkage to chromosome 14q 11-12
47. Replication of linkage on 14q11-12 in inflammatory bowel disease
48. Utilisation of erythrocyte-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease
49. Genotypic analysis of thiopurine 5-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
50. ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease
51. Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene, IKBL