Personalized medicine: Revolutionizing drug discovery and patient care

Trends in Biotechnology

Volumn 19, Issue 12, 2001, Pages 491-496

  Ginsburg, Geoffrey S ^a   McCarthy, Jeanette J ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSIS; GENES; HEALTH; HEURISTIC METHODS;

DRUG DISCOVERIES;

MEDICINE;

BIOLOGICAL MARKER; BRCA1 PROTEIN; CELL SURFACE PROTEIN; CYTOCHROME P450; DOXORUBICIN; LEPTIN; POTASSIUM CHANNEL; SELECTIVE ESTROGEN RECEPTOR MODULATOR; STATIN; TRASTUZUMAB;

BIOTECHNOLOGY; HEALTH CARE;

CANCER; CANCER DIAGNOSIS; CLINICAL STUDY; DISEASE COURSE; DISEASE MARKER; DRUG EFFICACY; DRUG INDUSTRY; DRUG TARGETING; FOOD AND DRUG ADMINISTRATION; GENE EXPRESSION; GENETIC SCREENING; HEALTH CARE; HUMAN; MEDICAL PRACTICE; PATIENT CARE; PATIENT SELECTION; PHARMACOGENOMICS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DETERMINATION; REVIEW; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; VALIDATION PROCESS;

DRUG DESIGN; GENETICS, MEDICAL; GENOME, HUMAN; HUMANS; PATIENT CARE; PHARMACOGENETICS; PROGNOSIS;

EID: 0035575568     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-7799(01)01814-5     Document Type: Review

References (27)

1. Genomania meets the bottom line
2. Positional cloning of the mouse obese gene and its human homologue
3. Elevated levels of insulin, leptin and blood lipids in olanzapine-treated patients with schizophrenia or related psychoses
4. Monitoring serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), IGF-1/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth
5. A structural basis for drug-induced long QT syndrome
6. Genetic variability in susceptibility and response to toxicants
7. Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity
8. Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
9. Gene-expression profiles in hereditary breast cancer
10. Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management. Part III
11. Influence of genotype on clinical course of the long-QT syndrome
12. Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 as well as LQT3 models of the long-QT syndrome
13. + channel blockade and to increases in heart rate: Implications for gene-specific therapy
14. Advances in molecular genetics and management of hypertrophic cardiomyopathy
15. Progress in the prevention of breast cancer: Concept to reality
16. Prevention of postmenopausal osteoporosis with oestrogen replacement therapy and associated compounds: Update on clinical trials since 1995
17. Effective use of statins to prevent coronary heart disease
18. Characterization of single-nucleotide polymorphisms in coding regions of human genes
19. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
20. Prospects for whole-genome linkage disequilibrium mapping of common disease genes
21. Genomic analysis of metastasis reveals an essential role for RhoC
22. Molecular classification of cutaneous malignant melanoma by gene expression profiling
23. Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties
24. Drug-resistance genotyping in HIV-1 therapy: The VIRADAPT randomised controlled trial
25. Gene amplification as means for determining therapeutic strategies in human cancers
26. Political issues in the genome era
27. Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies