Heterocyclic Bis-Cations as Starting Hits for Design of Inhibitors of the Bifunctional Enzyme Histidine-Containing Protein Kinase/Phosphatase from Bacillus subtilis

Journal of Medicinal Chemistry

Volumn 47, Issue 9, 2004, Pages 2264-2275

  Ramström, Helena ^a   Bourotte, Maryline ^a   Philippe, Claude ^a   Schmitt, Martine ^a   Haiech, Jacques ^a   Bourguignon, Jean Jacques ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOBENZIMIDAZOLE; ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CYTOSINE; GUANINE; HISTIDINE; HISTIDINE CONTAINING PHOSPHATASE; HISTIDINE CONTAINING PROTEIN; HISTIDINE CONTAINING PROTEIN KINASE; N,N' BIS(2 AMINO 1 BENZYLBENZIMIDAZOL 3 YL) 1,12 DODECANE OXALATE; PHOSPHATASE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; SERINE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; DRUG DESIGN; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; IN VITRO STUDY; LACTOBACILLUS CASEI; NONHUMAN; PROTEIN PHOSPHORYLATION; STAPHYLOCOCCUS XYLOSUS;

ADENOSINE TRIPHOSPHATE; BACILLUS SUBTILIS; BENZIMIDAZOLES; CATIONS; COMBINATORIAL CHEMISTRY TECHNIQUES; DATABASES, FACTUAL; DRUG DESIGN; DRUG INTERACTIONS; HETEROCYCLIC COMPOUNDS, 2-RING; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1842729458     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021043o     Document Type: Article

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