Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound

Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2002, Pages 563-566

  Mirzoeva, Salida ^a   Sawkar, Anu ^a   Zasadzki, Magdalena ^a   Guo, Ling ^a   Velentza, Anastasia V ^a   Dunlap, Vincent ^a   Bourguignonl, Jean Jacques ^b   Ramstrom, Helena ^b   Haiech, Jacques ^b   Van Eldik, Linda J ^a   Watterson, D M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 6 PHENYLPYRIDAZINE DERIVATIVE; ANTIINFLAMMATORY AGENT; APOLIPOPROTEIN E; BACTERIUM LIPOPOLYSACCHARIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 2; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG MECHANISM; DRUG SYNTHESIS; GLIA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTROCYTES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM AGENTS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; INTERLEUKIN-1; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PYRIDAZINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037204008     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm015573g     Document Type: Article

References (19)

1. Inflammation and Alzheimer's disease
2. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
3. Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques
4. Widespread peroxynitrite-mediated damage in Alzheimer's disease
5. The pervasiveness of interleukin-1 in Alzheimer pathogenesis: A role for specific polymorphisms in disease risk
6. Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets
7. Ligand modulation of glial activation: Cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1β and nitric oxide synthase II
8. Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of γ-aminobutyric acid acting as selective GABAA antagonists
9. 3-Aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities
10. Design, synthesis, and structure -activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylaminolpyridazine derivatives as acetylcholinesterase inhibitors
11. Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge
12. Gene-regulating protein kinases as important antiinflammatory targets
13. Notes on Buspirone's mechanisms of action
14. Buspirone: Future directions
15. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin- 1
16. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
17. A synthetic inhibitor of the mitogen-activated protein kinase cascade
18. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells
19. 2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells