Plasminogen activator inhibitor 1 and vitronectin protect against stenosis in a murine carotid artery ligation model

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 12, 2002, Pages 1978-1983

  De Waard, Vivian ^a   Arkenbout, E Karin ^a   Carmeliet, Peter ^b   Lindner, Volkhard ^c   Pannekoek, Hans ^a,d  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Flander Interuniv Inst Biotechnol   (Belgium)

^c Maine Medical Center Research Institute   (United States)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Plasminogen activator inhibitor 1; Restenosis; Smooth muscle cells; Thrombin; Vitronectin

Indexed keywords

CYCLINE; HIRUDIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTHROMBIN; THROMBIN INHIBITOR; VITRONECTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY LIGATION; CELL COUNT; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE MODEL; IMMUNOHISTOCHEMISTRY; INTIMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RESTENOSIS; SMOOTH MUSCLE FIBER;

ANIMALS; CAROTID ARTERIES; CAROTID STENOSIS; CELL DIVISION; CONNECTIVE TISSUE; DISEASE MODELS, ANIMAL; HIRUDINS; IMMUNOHISTOCHEMISTRY; LIGATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTHROMBIN; TUNICA INTIMA; TUNICA MEDIA; VITRONECTIN;

EID: 0036928842     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000042231.04318.E6     Document Type: Article

References (36)

1. Van Meijer M. Pannekoek H. Structure of plasminogen activator inhibitor I (PAI-1) and its function in fibrinolysis: An update. Fibrinol Proteolysis. 1995;9:263-276.
2. vβ3 binding to vitronectin. Nature. 1996;383:441-443.
3. Carmeliet P, Moons L, Lijnen R, Janssens S, Lupu F, Collen D, Gerard RD. Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: A gene targeting and gene transfer study in mice. Circulation. 1997;96:3180-3191.
4. Hasenstab D, Lea H, Clowes AW. Local plasminogen activator inhibitor type I overexpression in rat carotid artery enhances thrombosis and endothelial regeneration while inhibiting intimal thickening. Arterioscler Thromb Vasc Biol. 2000;20:853-859.
5. Ploplis VA, Comehssen I, Sandoval-Cooper MJ, Weeks L, Noria FA., Castellino FJ. Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1. Am J Pathol. 2001:158:107-117.
6. Zhu Y, Farrehi PM, Fay WP. Plasminogen activator inhibitor type 1 enhances neointima formation after oxidative vascular injury in atherosclerosis-prone mice. Circulation. 2001;103:3105-3110.
7. Peng L, Bhatia N, Parker AC, Zhu Y, Fay WP. Endogenous vitronectin and plasminogen activator inhibitor-1 promote neointima fomation in murine carotid arteries. Arterioscl Thromb Vasc. 2002;22:934-939.
8. Eitzman DT. Westrick RJ, Xu Z, Tyson J, Ginsburg D. Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Blood. 2000;96:4212-4215.
9. Luttun A, Lupu F, Storkebaum E, Hoylaerts MF, Moons L, Crawley J, Bono F, Poole AR, Tipping P, Herbert J-M, Collen D, Carmeliet P., Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice. Arterioscl Thromb Vasc Biol. 2002;22:499-505.
10. Sjoland H, Eitzman DT, Gordon D,. Westrick R,. Nabel EG,. Ginsburg D. Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-l. Arterioscl Thromb Vasc Biol. 2000;20:846-852.
11. DeYoung MB, Tom C, Dichek DA. Plasminogen activator type 1 increases neointima formation in balloon-injured rat carotid arteries. Circulation. 2001;104:1972-1977.
12. Kawasaki T, Dewerchin M, Lijnen HR, Vreys I, Vermylen J, Hoylaerts MF. Mouse carotid artery ligation induces platelet-leukocyte-dependent luminal fibrin, required for neointima development. Circ Res. 2001;88:159-166.
13. Kumar A, Lindner V. Remodeling with neointima formation in the mouse carotid artery after cessation of blood flow. Arterioscler Thromb Vasc Biol. 1997;17:2238-2244.
14. Kumar A, Hoover JL, Simmons CA, Lindner V, Shebuski RJ. Remodeling and neointima formation in the carotid artery of normal and P-selectin-deficient mice. Circulation. 1997:96:4333-4342.
15. Ehrlich HJ, Gebbink RK, Keijer J, Linders M, Preissner KT, Pannekoek H. Alteration of serpin specificity by a protein cofactor: Vitronectin endows plasminogen activator inhibitor 1 with thrombin inhibitory properties. J Biol Chem. 1990;265:13029-13035.
16. Naski MC, Lawrence DA, Mosher DF, Podor TJ, Ginsburg D. Kinetics of inactivation of alpha-thrombin by plasminogen activator inhibitor-1: Comparison of the effects of native and urea-treated forms of vitronectin. J Biol Chem. 1993:268:12367-12372.
17. Van Meijer M, Smilde A, Tans G, Nesheim ME, Pannekoek H, Horrevoets AJ. The suicide substrate reaction between plasminogen activator inhibitor I and thrombin is regulated by the cofactors vitronectin and heparin. Blood. 1997;90:1874-1882.
18. McNamara CA, Sarembock IJ, Bachhuber BG, Stouffer GA, Ragosta M, Barry W, Gimple LW, Powers ER, Owens GK. Thrombin and vascular smooth muscle cell proliferation: Implications for atherosclerosis and restenosis. Semin Thromb Hemost. 1996;22:139-144.
19. Patterson C, Stouffer GA, Madamanchi N, Runge MS. New tricks for old dogs: Nonthrombotic effects of thrombin in vessel wall biology. Circ Res. 2001;88:987-997.
20. Sarembock IJ, Gertz SD, Gimple LW, Owen RM. Powers ER, Roberts WC. Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation. 1991;84:232-243.
21. Gerdes C, Faber-Steinfeld V, Yalkinoglu O, Wohlfeil S. Comparison of the effects of the thrombin inhibitor r-hirudin in four animal models of neointima formation after arterial injury. Arterioscler Thromb Vasc Biol. 1996:16:1306-1311.
22. Rade JJ, Schulick AH, Virmani R, Dichek DA. Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury. Nat Med. 1996;2:293-298.
23. Stoop AA, Lupu F, Pannekoek H. Colocalization of thrombin, PAI-I and vitronectin in the atherosclerotic vessel wall: A potential regulatory mechanism of thrombin activity by PAI-I/vitro nectin complexes. Arterioscler Thromb Vasc Biol., 2000;20:1143-1149
24. Westmuckett AD, Lupu C,. Goulding DA, Das S, Kakkar VV, Lupu F. In situ analysis of tissue factor dependent thrombin generation in human atherosclerotic vessels. Thromb Haemost. 2000:84:901-911.
25. Smith EB. Crosbie L, Carey S. Prothrombin-related antigens in human aortic intima. Semin Thromb Haemost. 1996;22:347-350.
26. Schneiderman J, Sawdey MS, Keeton MR, Bordin GM, Bernstein EF, Dilley RB, Loskutoff DJ. Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc Natl Acad USA. 1992;89:6998-7002.
27. Lupu F, Bergonzelli GE, Heim DA, Cousin E, Genton CY, Bachmann F, Kruithof EK. Localization and production of plasminogen activator inhibitor-I in human healthy and atherosclerotic arteries. Arterioscler Thromb. 1993;13:1090-10100.
28. van Aken BE, Seiffert D, Thinnes T, Loskutoff DJ. Localization of vitronectin in the normal and atherosclerotic human vessel wall. Histochem Celt Biol. 1997;107:313-320.
29. Carmeliet P, Kieckens L, Schoonjans L, Ream B, van Nuffelen A, Prendergast G, Cole M, Bronson R, Collen D, Mulligan RC. Plasminogen activator inhibitor-1 gene deficient mice, I: Generation by homologous recombination and characterization. J Clin Invest. 1993:92:2746-2755.
30. Zheng X, Saunders TL, Camper SA, Samuelson LC, Ginsburg D, Vitronectin is not essential for normal mammalian development and fertility. Proc Natl Acad Sci USA. 1995;92:12426-12430.
31. Ross R. Atherosclerosis: An inflammatory disease. N Engl J Med. 1999:340:115-126.
32. He C, Wilhelm SM, Pentland AP, Marmer BL, Grant GA, Eisen AZ, Goldberg GI. Tissue cooperation in a proteolytic cascade activating human interstitial collagenase. Proc Natl Acad Sci USA. 1989;86:2632-2636.
33. Carmeliet P, Moons L, Herbert JM, Crawley J, Lupu F, Lijnen R, Collen D. Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice. Circ Res., 1997;81:829-39.
34. Loskutoff DJ, Curriden SA, Hu G, Deng G. Regulation of cell adhesion by PAI-1. APMIS, 1999;107:54-61.
35. Weiler H, Lindner V, Kerlin B, Isermann BH, Hendrickson SB, Cooley BC, Meh DA, Mosesson MW, Shworak NW, Post MJ, Conway EM, Ulfman LH, von Andiian UH, Weitz JL, Characterization of a mouse model for thrombomodulin deficiency. Arterioscl Thromb Vasc Biol. 2001;21:1531-1537
36. Noda-Heiny H, Fujii S, Sobel BE. Induction of vascular smooth muscle cell expression of plasminogen activator inhibitor-1 by thrombin. Circ Res. 1993;72:36-43.