Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice

Circulation

Volumn 103, Issue 4, 2001, Pages 576-583

  Konstantinides, Stavros ^a   Schäfer, Katrin ^a   Thinnes, Therese ^a   Loskutoff, David J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Carotid arteries; Embolism; Fibrinolysis; Genes

Indexed keywords

FERRIC CHLORIDE; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR; VITRONECTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOT LYSIS; CAROTID ARTERY INJURY; CAROTID ARTERY THROMBOSIS; CONTROLLED STUDY; EMBOLISM; HISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0035970097     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.4.576     Document Type: Article

References (32)

1. The adipocyte and hemostatic balance in obesity studies of PAI-1
2. Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms
3. Structure of plasminogen activator inhibitor 1 (PAI-1) and its function in fibrinolysis: An update
4. Plasminogen activator inhibitor in plasma: Risk factor for recurrent myocardial infarction
5. Plasminogen activator inhibitor-1 gene-deficient mice, II: Effects on hemostasis, thrombosis, and thrombolysis
6. Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in mice
7. Differential role of components of the fibrinolytic system in the formation and removal of thrombus induced by endothelial injury
8. Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice
9. Regulation of cell adhesion by PAI-1
10. Role of vitronectin and its receptor in haemostasis and vascular remodeling
11. Vitronectin binds to activated human platelets and plays a role in platelet aggregation
12. Vitronectin inhibits the thrombotic response to arterial injury in mice
13. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
14. Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: A gene targeting and gene transfer study in mice
15. Rat model of arterial thrombosis induced by ferric chloride
16. Vitronectin is not essential for normal mammalian development and fertility
17. Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator
18. Vascular wound healing and neointima formation induced by perivascular electric injury in mice
19. Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening
20. Localization of vitronectin in the normal and atherosclerotic human vessel wall
21. Detection of vitronectin mRNA in tissues and cells of the mouse
22. Thrombolysis and reocclusion in experimental jugular vein and coronary artery thrombosis: Effects of a plasminogen activator inhibitor type 1-neutralizing monoclonal antibody
23. The PAI-1/vitronectin interaction: Two cats in a bag?
24. Iron loading of endothelial cells augments oxidant damage
25. Iron-dependent human platelet activation and hydroxyl radical formation: Involvement of protein kinase C
26. Photochemically induced endothelial injury in the mouse as a screening model for inhibitors of vascular intimal thickening
27. Mouse model of arterial injury
28. Plasminogen activator inhibitor type 1 and tissue inhibitor of metalloproteinases-2 increase after arterial injury in rats
29. Increased intramural expression of plasminogen activator inhibitor type I after balloon injury: A potential progenitor of restenosis
30. PAI-1 inhibits neointimal formation after arterial injury in mice: A new target for controlling restenosis?
31. Inhibitors of fibrinolysis are elevated in atherosclerotic plaque
32. Vitronectin expression and interaction with receptors in smooth muscle cells from human atheromatous plaque