Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: A gene targeting and gene transfer study in mice

Circulation

Volumn 96, Issue 9, 1997, Pages 3180-3191

  Carmeliet, Peter ^a   Moons, Lieve ^a   Lijnen, Roger ^e   Janssens, Stefaan ^b   Lupu, Florea ^c   Collen, Désiré ^a   Gerard, Robert D ^a,d  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e NONE

Author keywords

Angioplasty; Genetics; Plasminogen; Stenosis; Viruses

Indexed keywords

PLASMINOGEN ACTIVATOR INHIBITOR 1;

ANGIOPLASTY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ARTICLE; CONTROLLED STUDY; FEMALE; GENE REPRESSION; GENE TRANSFER; HEMOSTASIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WOUND HEALING;

EID: 0030685740     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.96.9.3180     Document Type: Article

References (39)

1. Clowes AW, Clowes MM, Au YP, Reidy MA, Belin D. Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ Res. 1990;67:61-67.
2. Reidy MA, Irvin C, Lindner V. Migration of arterial wall cells: expression of plasminogen activators and inhibitors in injured rat arteries. Circ Res. 1996;78:405-414.
3. Carmeliet P, Collen D. Role of the plasminogen/plasmin system in thrombosis, hemostasis, restenosis and atherosclerosis: evaluation in transgenic animals. Trends Cardiovasc Med. 1995;5:117-122.
4. Okada SS, Großmyer SR, Barnathan ES. Contrasting effects of plasminogen activators, urokinase receptor, and LDL-related protein on smooth muscle cell migration and invasion. Arterioscler Thromb Vasc Biol. 1996;16:1269-1276.
5. Fearns C., Samad F, Loskutoff DJ. Synthesis and localisation of PAI-1 in the vessel wall. In: Advances in Vascular Biology. Camberwell Victoria, Australia: Gordon and Breach Publishers; 1995.
6. Libby P, Schwartz D, Brogi E, Tanaka H, Clinton SK. A cascade model for restenosis: a special case of atherosclerotic progression. Circulation. 1992;86 (suppl. III):III-47-III-52.
7. Jackson CL, Reidy MA. The role of plasminogen activation in smooth muscle cell migration after injury. Ann NY Acad Sci. 1992; 667:141-150.
8. Villaverde CA, Miralles M, Salvat N, Juan O, Tibau N, Pena E, Vigo P. Regulation of plasmin-generating activity in human arteries. Fibrinolysis. 1996;10(suppl 3):148a. Abstract.
9. Schneiderman J, Sawdey MS, Keeton M, Bordin GM, Bernstein EF, Dilley RB, Loskutoff DJ. Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic arteries. Proc Natl Acad Sci USA. 1992;89:6998-7002.
10. Lupu F, Bergonzelli GE, Heim DA, Cousin E, Genton CY, Bachmann F, Kruithof EKO. Localization and production of plasminogen activator inhibitor-1 in human healthy and atherosclerotic arteries. Arterioscl Thromb. 1993;13:1090-1100.
11. Fuji S, Sawa H, Saffitz JE, Lucore CL, Sobel BE. Induction of endothelial cell expression of the plasminogen activator inhibitor type 1 gene by thrombosis in vivo. Circulation. 1992;86:2000-2010.
12. Lee E, Vaughan DE, Parikh SH, Grodzinsky AJ, Libby P. Lark MW, Lee RT. Regulation of matrix metalloproteinases and plasminogen activator inhibitor-1 synthesis by plasminogen in cultured human vascular smooth muscle cells. Circ Res. 1996;78: 44-49.
13. Collen D, Lijnen HR. Basic and clinical aspects of fibrinolysis and thrombolysis. Blood. 1991;78:3114-3124.
14. Carmeliet P, Collen D. Gene manipulation and transfer of the plasminogen system and coagulation system in mice. Semin Thromb Haemost. 1996;22:525-542.
15. Saksela O, Rifkin DB. Cell-associated plasminogen activation: regulation and physiological function. Annu Rev Cell Biol. 1988;4: 93-126.
16. Clowes AW, Reidy MA, Clowes MM. Mechanisms of stenosis after arterial injury. Lab Invest. 1983;49:208-215.
17. Carmeliet P, Moons L, Ploplis V, Plow EF, Collen D. Impaired arterial neointima formation in mice with disruption of the plasminogen gene. J Clin Invest. 1997;99:200-208;1997.
18. Carmeliet P, Moons L, Herbert JM, Crawley J, Lupu F, Lijnen R, Collen D. Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice. Circ Res. 1997;81:829-839.
19. Carmeliet P, Stassen J-M, Schoonjans L, Ream B, van den Oord JJ, De Mol M, Mulligan RC, Collen D. Plasminogen activator inhibitor-1 gene-deficient mice, II: effects on hemostasis, thrombosis and thrombolysis. J Clin Invest. 1993;92:2756-2760.
20. Carmeliet P, Moons L, Stassen JM, Van Vlaenderen I, Declercq C, Kockx M, Collen D. Vascular wound healing and neointima formation induced by perivascular injury in mice. Am J Pathol. 1997; 150:761-776.
21. Lindner V, Fingerle J, Reidy MA. Mouse model of arterial injury. Circ Res. 1993;73:792-796.
22. Preissner KT, Grulich-Henn J, Ehrlich HJ, Declerck P, Justus C, Collen D, Pannekoek H, Müller-Berghaus G. Structural requirements for the extracellular interaction of plasminogen activator inhibitor-1 with endothelial cell matrix-associated vitronectin. J Biol Chem. 1990;265:18490-18498.
23. Lupu F, Heim DA, Bachmann F, Hurni M, Kakkar VV, Kruithof EKO. Plasminogen activator expression in human atherosclerotic lesions. Arterioscl Thromb Vasc Biol. 1995;15:1444-1455.
24. Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, De Vos R, van den Oord JJ, Collen D, Mulligan RC. Physiological consequences of loss of plasminogen activator gene function in mice. Nature. 1994;368:419-423.
25. Reido FX, Munford RS, Campbell WB, Reisch JS, Chien KR, Gerard RD. Deacylated lipopolysaccharide inhibits plasminogen activator inhibitor-1, prostacyclin, and prostaglandin E2 induction by lipopolysaccharide but not by tumor necrosis factor-alpha. J Immunol. 1990;144:3506-3512.
26. Alcorn JL, Gao E, Chen Q, Smith ME, Gerard RD, Mendelson CR. Genomic elements involved in transcriptional regulation of the rabbit surfactant protein-A gene. Mol Endocrinol. 1993;7: 1072-1085.
27. Gerard RD, Meidell RS. Adenovirus vectors. In: Hames BD, Glover D, eds. DNA Cloning: A Practical Approach: Mammalian Systems. Oxford, UK: Oxford University Press; 1995.
28. Verheijen JH, Mullaart E, Chang TG, Kluft C, Wijngaards G. A simple, sensitive spectrophotometric assay for extrinsic (tissue-type) plasminogen activator applicable to measurements in plasma. Thromb Haemost. 1982;48:266-269.
29. Declerck P, Alessi MC, Verstreken M, Kruithof EKO, Juhan-Vague I, Collen D. Measurements of PAI-1 in biological fluids with a murine monoclonal antibody-based enzyme linked immunoassay. Blood. 1988; 71:220-225.
30. 3 binding to vitronectin. Nature. 1996;383: 441-443.
31. Deng G, Curriden SA, Wang S, Rosenberg S, Loskutoff DJ. Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release. J Cell Biol. 1996;134:1563-1571.
32. Loskutoff DJ, Sawdey M, Keeton M, Schneiderman J. Regulation of PAI-1 gene expression in vivo. Thromb Haemost. 1993;70:135-137.
33. Pepper MS, Sappino AP, Montesano R, Orci L, Vassalli JD. Plasminogen activator inhibitor-1 is induced in migrating endothelial cells. J Cell Physiol. 1992;153:129-139.
34. Herz J, Gerard RD. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci. USA. 1993;90:2812-2816.
35. Lijnen RH, Moons L, Beelen V, Carmeliet P, Collen D. Biological effects of combined inactivation of plasminogen activator and plasminogen activator inhibitor-1 gene function in mice. Thromb Haemost. 1995;74:1126-1131.
36. Bendeck MP, Zempo N, Clowes AW, Galardy RE, Reidy MA. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Clin Res. 1994;75:539-545.
37. Bacharach E, Itin A, Keshet E. In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis. Proc Natl Acad Sci USA. 1992; 89:10686-10690.
38. Sabapathy KT, Pepper MS, Kiefer F, Möhel-Steinlein U, Tacchini-Cottier F, Fetka I, Breier G, Risau W, Carmeliet P, Montesano R, Wagner EF. Polyoma middle-T induced vascular tumor formation: the role of the plasminogen activator/plasmin system. J Cell Biol. 1997;137:953-963.
39. Lucas A, Liu L, Macen J, Nash P, Dai E, Stewart M, Graham K, Etches W, Boshkov L, Nation PN, Humen D, Lundstrom-Hobman M, McFadden G. Virus-encoded serine proteinase inhibitor SERP-1 inhibits atherosclerotic plaque development after balloon angioplasty. Circulation. 1996;94:2890-2900.