A steady-state competition model describes the modulating effects of thrombomodulin on thrombin inhibition by plasminogen activator inhibitor-1 in the absence and presence of vitronectin

European Journal of Biochemistry

Volumn 270, Issue 9, 2003, Pages 1942-1951

  Dekker, Rob J ^a   Pannekoek, Hans ^a   Horrevoets, Anton J G ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Competitive inhibitor; Kinetic modeling; Serine protease; Serpin; Suicide substrate mechanism

Indexed keywords

PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBIN; THROMBOMODULIN; VITRONECTIN;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; MITOGENESIS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STEADY STATE; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE;

ANIMALS; BINDING SITES; COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN BINDING; SURFACE PLASMON RESONANCE; THROMBIN; THROMBOMODULIN; VITRONECTIN;

EID: 0038706557     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03552.x     Document Type: Article

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