Influence of the -675 4G/5G dimorphism of the plasminogen activator inhibitor 1 promoter on thrombotic risk in patients with factor V Leiden

British Journal of Haematology

Volumn 110, Issue 1, 2000, Pages 135-138

  Visanji, J M ^a   Seargent, J ^a   Tahri, D ^a   Croft, S A ^a   Makris, M ^a   Preston, F E ^a   Peake, I R ^a   Daly, M E ^a,b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

Dimorphism; PAI 1, 4G 5G; Thromboembolism; Venous

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; PLASMINOGEN ACTIVATOR INHIBITOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; RISK; VEIN THROMBOSIS;

ADULT; AGE OF ONSET; AGED; ALLELES; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CONFIDENCE INTERVALS; FACTOR V; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, GENETIC; RISK; THROMBOPHILIA;

EID: 0033871724     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02152.x     Document Type: Article

References (12)

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2. The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells
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4. Inherited thrombophilia. Part 1
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6. 506 in 41 patients with isolated pulmonary embolism
7. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
8. Arterial and venous thrombosis is not associated with the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor 1 gene in a large cohort of US men
9. 4G/5G polymorphism of PAI-1 gene promoter and fibrinolytic capacity in patients with deep vein thrombosis
10. The 4G/5G sequence polymorphism in the promoter of plasminogen activator inhibitor 1 (PAI-1) gene: Relationship to plasma PAI-1 level in venous thromboembolism
11. On estimating the relation between blood groups and disease
12. A common 4G allele in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene as a risk factor for pulmonary embolism and arterial thrombosis in hereditary protein S deficiency