Variants of tissue-type plasminogen activator that display extraordinary resistance to inhibition by the serpin plasminogen activator inhibitor type 1

Journal of Biological Chemistry

Volumn 272, Issue 23, 1997, Pages 14580-14585

  Tachias, Kathy ^a   Madison, Edwin L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLUTAMIC ACID; PLASMINOGEN ACTIVATOR INHIBITOR 1; SERINE PROTEINASE INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; ENZYME SUBSTRATE; FIBRINOLYSIS; GENE MUTATION; MONKEY; NONHUMAN; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

ARGININE; BASE SEQUENCE; CHROMOGENIC COMPOUNDS; DNA PRIMERS; KINETICS; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGOPEPTIDES; PLASMINOGEN ACTIVATOR INHIBITOR 1; POINT MUTATION; RECOMBINANT PROTEINS; TISSUE PLASMINOGEN ACTIVATOR; VARIATION (GENETICS);

ANIMALIA;

EID: 0030915443     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.23.14580     Document Type: Article

References (51)

1. Mann, K. G., and Lorand, L. (1993) Proteolytic Enzymes in Coagulation, Fibrinolysis, and Complement Activation, Vol. 223, Academic Press, San Diego, CA
2. High, K. A., and Roberts, H. R. (1995) Molecular Basis of Thrombosis and Hemostasis, Marcel Dekker, New York
3. Collen, D., and Lijnen, H. R. (1991) Blood 78, 3114-3124
4. Bergmann, S. R., Fox, K. A. A., Ter-Pogossian, M. M., and Sobel, B. E. (1983) Science 220, 1181-1183
5. Weimar, W., Stibbe, J., and van Seyen, A. J. (1981) Lancet 2, 1018-1020
6. Collen, D., and Verstraete, M. (1983) Circulation 68, 462-465
7. Van de Werf, F., Ludbrook, P. A., Bergmann, S. R., Tiefenbrunn, A. J., Fox, K. A. A., de Geest, H., Verstraete, M., Collen, D., and Sobel, B. E. (1984) N. Engl. J. Med. 310, 609-613
8. Collen, D., Lijnen, H. R., Todd, P. A., and Goa, K. L. (1989) Drugs 38, 346-388
9. Topol, E., and The GUSTO Investigators (1993) N. Engl. J. Med. 329, 673-682
10. Ross, A. M., Simoons, M. L., and The GUSTO Angiographic Investigators (1993) N. Engl. J. Med. 329, 1615-1622
11. Collen, D. (1992) Am. J. Cardiol. 69, 71A-81A
12. Lijnen, H. R., and Collen, D. (1991) Thromb. Haemostasis 66, 88-110
13. Madison, E. L. (1994) Fibrinolysis 8, Suppl. 1, 221-236
14. Keyt, B. A., Paoni, N. F., and Bennett, W. F. (1996) in Protein Engineering: Principles and Practice (Cleland, J. L., Craik, C. S., eds) pp. 435-466, Wiley-Liss, New York
15. Keyt, B. A., Paoni, N. F., Refino, C. J., Etcheverry, T., Ogez, J., Botstein, D., and Bennett, W. F. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 3670-3674
16. Paoni, N. F., Keyt, B. A., Refino, C. J., Chow, A. M., Nguyen, H. V., Berleau, L. T., Badillo, J. M., Pena, L. C., Brady, K., Wurm, F. M., Ogez, J., and Bennett, W. F. (1993) Thromb. Haemostasis 70, 307-312
17. Refino, C. J., Paoni, N. F., Keyt, B. A., Pater, C. S., Badillo, J. M., Wurm, F. M., Ogez, J., and Bennett, W. F. (1993) Thromb. Haemostasis 70, 313-319
18. Benedict, C. R., Refino, C. J., Keyt, B. A., Pakala, R., Paoni, N. F., Thomas, G. R., and Bennett, W. F. (1995) Circulation 92, 3032-3040
19. Collen, D., Stassen, J.-M., Yasuda, T., Refino, C., Paoni, N., Keyt, B., Roskams, T., Guerrero, J. L., Lijnen, H. R., Gold, H. K., and Bennett, W. F. (1994) Thromb. Haemostasis 72, 98-104
20. Gibson, M., McLean, C., Rizzo, M. J., Martin, N. E., Marble, S. J., Ootani, I., McCube, C. H., Cannon, C. P., and Braunwald, E. (1996) Circulation 94, Suppl. I, 89 (Abstr. 513)
21. Madison, E. L., Goldsmith, E. J., Gerard, R. D., Gething, M.-J., and Sambrook, J. F. (1989) Nature 339, 721-724
22. Madison, E. L., Goldsmith, E. J., Gerard, R. D., Gething, M. J., Sambrook, J. F., and Bassel-Duby, R. S. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 3530-3533
23. Zoller, M. J., and Smith, M. (1984) DNA (N. Y.) 3, 479-488
24. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 488-492
25. Madison, E. L., and Sambrook, J. F. (1993) Methods Enzymol. 223, 249-271
26. Madison, E. L., Kobe, A., Gething, M. J., Sambrook, J. F., and Goldsmith, E. J. (1993) Science 262, 419-421
27. Strandberg, L., and Madison, E. L. (1995) J. Biol. Chem. 270, 23444-23449
28. Tachias, K., and Madison, E. L. (1997) J. Biol. Chem. 272, 28-31
29. Tachias, K., and Madison, E. L. (1995) J. Biol. Chem. 270, 18319-18322
30. Beatty, K., Bieth, J., and Travis, J. (1980) J. Biol. Chem. 255, 3931-3934
31. Holmes, W. E., Lijnen, H. R., and Collen, D. (1987) Biochemistry 26, 5133-5140
32. Madison, E. L., Goldsmith, E. J., Gething, M. J., Sambrook, J. F., and Gerard, R. D. (1990) J. Biol. Chem. 265, 21423-21426
33. Horrevoets, A. J. G., Tans, G., Smilde, A. E., van Zonneveld, A.-J., and Pannekoek, H. (1993) J. Biol. Chem. 268, 779-782
34. van Meijer, M., Roelofs, Y., Neels, J., Horrevoets, A. J. G., van Zonneveld, A.-J., and Pannekoek, H. (1996) J. Biol. Chem. 271, 7423-7428
35. Tate, K. M., Higgins, D. L., Holmes, W. E., Winkler, M. E., Heyneker, H. L., and Vehar, G. A. (1987) Biochemistry 26, 338-343
36. Eastman, D., Wurm, F. M., van Reis, R., and Higgins, D. L. (1992) Biochemistry 31, 419-422
37. Paoni, N. F., Refino, C. J., Brady, K., Pena, L. D., Nguyen, H. V., Kerr, E. M., Johnson, A. C., Wurm, F. M., van Reis, R., Botstein, D., and Bennett, W. F. (1992) Protein Eng. 5, 259-266
38. Fay, W. P., Eitzman, D. T., Shapiro, A. D., Madison, E. L., and Ginsberg, D. (1994) Blood 83, 351-356
39. Shohet, R. V., Madison, E., Bassel-Duby, R., Spitzer, S., Getting, M. J., and Sambrook, J. (1994) Thromb. Haemastasis 71, 124-128
40. Ke, S.-H., Tachias, K., Lamba, D., Bode, W., and Madison. E. L. (1997) J. Biol. Chem. 272, 1811-1816
41. Bennett, W. F., Paoni, N. F., Keyt, B. A., Botstein, D., Jones, A. J. S., Presta, L., Wurm, F. M., and Zoller, M. J. (1991) J. Biol. Chem. 266, 5191-5201
42. Weening-Verhoeff, E. J. D., Quax, P. H. A., van Leeuwen, R. T. J., Rehberg, E. F., Marotti, K. R., and Verheijen, J. H. (1990) Protein Eng. 4, 191-198
43. Lucas, M. A., Fretto, L. J., and McKee, P. A. (1983) J. Biol. Chem. 258, 4249-4256
44. Suenson, E., and Thorsen, S. (1981) Biochem. J. 197, 619-628
45. Thorsen, S., Clemmensen, I., Sottrup-Jensen, L., and Magnusson, S. (1981) Biochim. Biophys. Acta 668, 377-387
46. Castellino, F. J. (1995) in Molecular Basis of Thrombosis and Hemostasis (High, K. A., Roberts, H. R., eds) pp. 495-515, Marcel Dekker, New York
47. Hoylaerts, M., Rijken, D. C., Lijnen, H. R., and Collen, D. (1982) J. Biol. Chem. 257, 2912-2919
48. Madison, E. L., Coombs, G. S., and Corey, D. R. (1995) J. Biol. Chem. 270, 7558-7562
49. Ding, L., Coombs, G. S., Strandberg, L., Navre, M., Corey, O. R., and Madison, E. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7627-7631
50. Lijnen, H. R., and Collen, D. (1993) Methods Enzymol. 223, 197-206
51. Lamba, B., Bauer, M., Huber, R., Fischer, S., Rudolph, R., Kohnert, U., and Bode, W. (1996) J. Mol. Biol. 258, 117-135