Thrombomodulin: A linker of coagulation and fibrinolysis and predictor of risk of arterial thrombosis

Annals of Medicine

Volumn 32, Issue SUPPL. 1, 2000, Pages 73-77

  Wu, K K ^a   Matijevic Aleksic, N ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Arterial thrombosis; Coagulation; Coronary heart disease; Fibrinolysis; Soluble thrombomodulin; Thrombomodulin

Indexed keywords

PROTEIN C; THROMBIN; THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR; THROMBOMODULIN;

ANTICOAGULATION; ARTERY ENDOTHELIUM; ARTERY THROMBOSIS; BLOOD CLOTTING; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; FIBRINOLYSIS; GENETIC POLYMORPHISM; HUMAN; ISCHEMIC HEART DISEASE; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RISK FACTOR;

BLOOD COAGULATION; ENDOTHELIUM, VASCULAR; FIBRINOLYSIS; HUMANS; PLASMINOGEN ACTIVATORS; PROTEIN C; THROMBOMODULIN; THROMBOSIS;

EID: 0034508887     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (28)

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2. Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor
3. Human thrombomodulin gene is intron depleted: Nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control
4. Heterogeneous regulation of constitutive thrombomodulin or inducible tissue factor activities on the surface of human saphenous vein endothelial cells in culture
5. Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro
6. Thrombomodulin structure and function
7. Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface
8. Structure and function of thrombomodulin: A natural anticoagulant
9. The turnover of thrombin-thrombomodulin complex in cultured human umbilical vein endothelial cells and A549 lung cancer cells. Endocytosis and degradation of thrombin
10. TAFI, or plasma pro-carboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex
11. A study of the mechanism of inhibition of fibrinolysis by activated thrombin-activable fibrinolysis inhibitor
12. Thrombomodulin is present in human plasma and urine
13. Characterization of soluble thrombomodulin fragments in human urine
14. Soluble thrombomodulin purified from human urine exhibits a potent anticoagulant effect in vitro and in vivo
15. Both cellular and soluble forms of thrombomodulin inhibit fibrinolysis by potentiating the activation of thrombin-activable fibrinolysis inhibitor
16. Plasma thrombomodulin as a marker of vascular disorders in thrombotic thrombocytopenic purpura and disseminated intravascular coagulation
17. Increased soluble fibrin monomer and soluble thrombomodulin levels in non-insulin-dependent diabetes mellitus
18. Predictive value of plasma thrombomodulin in preeclampsia and gestational hypertension
19. Serum thrombomodulin-a reliable marker of disease activity in systemic lupus erythematosus (SLE): Advantage over established serological parameters to indicate disease activity
20. Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities (ARIC) Study: A case-cohort study
21. A common thrombomodulin amino acid dimorphism is associated with myocardial infarction
22. 127G to A coding for Ala25Thr and the risk of myocardial infarction in men
23. Thrombomodulin gene mutations associated with myocardial infarction
24. The first mutation identified in the thrombomodulin gene in a 45-year-old man presenting with thromboembolic disease
25. Identification and characterization of a thrombomodulin gene mutation coding for an elongated protein with reduced expression in a kindred with myocardial infarction
26. Thrombomodulin with the Asp468Tyr mutation is expressed on the cell surface with normal cofactor activity for protein C activation
27. Mutations in promoter region of thrombomodulin and venous thromboembolic disease
28. Thrombomodulin 455 A/V dimorphism is a risk factor for developing coronary heart disease in African Americans but not in Caucasians: The ARIC study