Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis

Journal of Clinical Investigation

Volumn 108, Issue 4, 2001, Pages 537-546

  Isermann, B ^a   Hendrickson, S B ^a   Zogg, M ^a   Wing, M ^a   Cummiskey, M ^a   Kisanuki, Y Y ^a   Yanagisawa, M ^a   Weiler, H ^a  

^a BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE C; THROMBOMODULIN; WARFARIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; FEMALE; HYPERCOAGULABILITY; MALE; MOUSE; NONHUMAN; ONSET AGE; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; THROMBOSIS; VASCULAR ENDOTHELIUM;

AGE FACTORS; ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; CARDIOMEGALY; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DISSEMINATED INTRAVASCULAR COAGULATION; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; GENES, LETHAL; GENES, SYNTHETIC; HUMANS; INTEGRASES; MALE; MICE; MICE, TRANSGENIC; MYOCARDIUM; ORGAN SPECIFICITY; PROTEIN C; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TIE-2; RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC; SEXUAL MATURATION; THROMBOMODULIN; THROMBOPHILIA; THROMBOSIS; VIRAL PROTEINS; WARFARIN;

EID: 0034892611     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200113077     Document Type: Article

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