Cell surface tagging and a suicide mechanism in a single chimeric human protein

Human Gene Therapy

Volumn 10, Issue 16, 1999, Pages 2651-2655

  Amara, Jane F ^a   Courage, Nancy L ^a   Gilman, Michael ^a,b   Clackson, Tim ^c  

^a Ariad Pharmaceutical   (United States)

^b BIOGEN   (United States)

^c ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL AGENT; NERVE GROWTH FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; CELL SURFACE; CELL VIABILITY; CHIMERA; CONTROLLED STUDY; DNA CROSS LINKING; GENE CONSTRUCT; GENE SEQUENCE; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MYRISTYLATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; SUICIDE GENE;

ANTIGENS, CD95; APOPTOSIS; CELL LINE; CELL MEMBRANE; DIMERIZATION; HUMANS; IMMUNOPHILINS; RECEPTOR, NERVE GROWTH FACTOR; RECOMBINANT PROTEINS; RETROVIRIDAE; TACROLIMUS BINDING PROTEINS; TRANSDUCTION, GENETIC;

EID: 0033229953     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950016681     Document Type: Article

References (14)

1. AMARA, J.F., CLACKSON, T., RIVERA, V.M., GUO, T., KEENAN, T., NATESAN, S., POLLOCK, R., YANG, W., COURAGE, N.L., HOLT, D.A., and GILMAN, M. (1997). A versatile synthetic dimerizer for the regulation of protein-protein interactions. Proc. Natl. Acad. Sci. U.S.A. 94, 10618-10623.
2. ASHKENAZI, A., and DIXIT, V.M. (1998). Death receptors: Signaling and modulation. Science 281, 1305-1308.
3. BONINI, C., FERRARI, G., VERZELETTI, S., SERVIDA, P., ZAPPONE, E., RUGGIERI, L., PONZONI, M., ROSSINI, S., MAVILIO, F., TRAVERSARI, C., and BORDIGNON, C. (1997). HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia. Science 276, 1719-1724.
4. CLACKSON, T., YANG, W., ROZAMUS, L.W., HATADA, M., AMARA, J.F., ROLLINS, C.T., STEVENSON, L.F., MAGARI, S.R., WOOD, S.A., COURAGE, N.L., LU, X., CERASOLI, F., GILMAN, M., and HOLT, D.A. (1998). Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc. Natl. Acad. Sci. U.S.A. 95, 10437-10442.
5. ITOH, N., and NAGATA, S. (1993). A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J. Biol. Chem. 268, 10932-10937.
6. KOLB, H.J., SCHATTENBERG, A., GOLDMAN, J.M., HERTENSTEIN, B., JACOBSEN, N., ARCESE, W., LJUNGMAN, P., FERRANT, A., VERDONCK, L., NIEDERWIESER, D., VAN RHEE, F., MITTERMULLER, J., DE WITTE, T., HOLLER, E., and ANSARI, H. (1995). Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 86, 2041-2050.
7. MAVILIO, F., FERRARI, G., ROSSINI, S., NOBILI, N., BONINI, C., CASORATI, G.,. TRAVERSARI, C., and BORDIGNON, C. (1994). Peripheral blood lymphocytes as target cells of retroviral vector-mediated gene transfer. Blood 83, 1988-1997.
8. MULLER, A.J., YOUNG, J.C., PENDERGAST, A.-M., PONDEL, M., LANDAU, N.R., LITTMAN, D.R., and WITTE, O. (1991). BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias. Mol. Cell. Biol. 11, 1785-1792.
9. PHILLIPS, K., GENTRY, T., MCCOWAGE, G., GILBOA, E., and SMITH, C. (1996). Cell-surface markers for assessing gene transfer into human hematopoietic cells. Nature Med. 2, 1154-1156.
10. RIDDELL, S.R., ELLIOTT, M., LEWINSOHN, D.A., GILBERT, M.J., WILSON, L., MANLEY, S.A., LUPTON, S.D., OVERELL, R.W., REYNOLDS, T.C., COREY, L., and GREENBERG, P.D. (1996). T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nature Med. 2, 216-223.
11. ROSS, A.H., GROB, P., BOTHWELL, M., ELDER, D.E., ERNST, C.S., MARANO, N., CHRIST, B.F.D., SLEMP, C.C., HERLYN, M., ATKINSON, B., and KOPROWSKI, H. (1984). Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies. Proc. Natl. Acad. Sci. U.S.A. 81, 6681-6685.
12. SPENCER, D.M., BELSHAW, P.J., CHEN, L., HO, S.N., RANDAZZO, F., CRABTREE, G.R., and SCHREIBER, S.L. (1996). Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization. Curr. Biol. 6, 839-847.
13. TIBERGHIEN, P. (1998). "Suicide" gene for the control of graft-versus-host disease. Curr. Opin. Hematol. 5, 478-482.
14. VERZELETTI, S., BONINI, C., MARKTEL, S., NOBILI, N., CICERI, F., TRAVERSARI, C., and BORDIGNON, C. (1998). Herpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: Clinical follow-up and improved new vectors. Hum. Gene Ther. 9, 2243-2251.