-
1
-
-
0242585716
-
Blood coagulation
-
Dahlbäck B. Blood coagulation. Lancet 2000; 355: 1627-32.
-
(2000)
Lancet
, vol.355
, pp. 1627-1632
-
-
Dahlbäck, B.1
-
2
-
-
0034925134
-
Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation
-
Esmon CT. Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation. Crit Care Med 2001; 29: S48-51.
-
(2001)
Crit Care Med
, vol.29
-
-
Esmon, C.T.1
-
3
-
-
0002866615
-
The protein C anticoagulant system. Stamatoyannopoulos
-
G, Majerus, PW, Perlmutter, RM, Varmus, H, eds. 3rd edn. Philadelphia: W.B. Saunders Co
-
Dahlbäck B, Stenflo J. The protein C anticoagulant system. In: Stamatoyannopoulos, G, Majerus, PW, Perlmutter, RM, Varmus, H, eds. The molecular Basis of Blood Diseases, 3rd edn. Philadelphia: W.B. Saunders Co, 2001: 614-56.
-
(2001)
The molecular Basis of Blood Diseases
, pp. 614-656
-
-
Dahlbäck, B.1
Stenflo, J.2
-
4
-
-
0036124011
-
Factor Vand thrombotic disease: description of a Janus-faced protein
-
Nicolaes GA, Dahlbäck B. Factor Vand thrombotic disease: description of a Janus-faced protein. Arterioscler Thromb Vasc Biol 2002; 22: 530-8.
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 530-538
-
-
Nicolaes, G.A.1
Dahlbäck, B.2
-
5
-
-
0035030340
-
Factor V: Dr. Jekyll and Mr Hyde
-
Mann KG, Kalafatis M. Factor V: Dr. Jekyll and Mr Hyde. Adv Exp Med Biol 2001; 489: 31-43.
-
(2001)
Adv Exp Med Biol
, vol.489
, pp. 31-43
-
-
Mann, K.G.1
Kalafatis, M.2
-
7
-
-
0028959158
-
Inherited thrombophilia. resistance to activated protein C as a pathogenic factor of venous thromboembolism
-
Dahlbäck B. Inherited thrombophilia. resistance to activated protein C as a pathogenic factor of venous thromboembolism. Blood 1995; 85: 607-14.
-
(1995)
Blood
, vol.85
, pp. 607-614
-
-
Dahlbäck, B.1
-
8
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
-
(2001)
N Engl J Med
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.L.2
Laterre, P.F.3
LaRosa, S.P.4
Dhainaut, J.F.5
Lopez-Rodriguez, A.6
Steingrub, J.S.7
Garber, G.E.8
Helterbrand, J.D.9
Ely, E.W.10
Fisher Jr., C.J.11
-
9
-
-
0034059213
-
The endothelial cell protein C receptor
-
Esmon CT. The endothelial cell protein C receptor. Thromb Haemost 2000; 83: 639-43.
-
(2000)
Thromb Haemost
, vol.83
, pp. 639-643
-
-
Esmon, C.T.1
-
10
-
-
0028832910
-
The protein C anticoagulant system: inherited defects as basis for venous thrombosis
-
Dahlbäck B. The protein C anticoagulant system: inherited defects as basis for venous thrombosis. Thromb Res 1995; 77: 1-43.
-
(1995)
Thromb Res
, vol.77
, pp. 1-43
-
-
Dahlbäck, B.1
-
11
-
-
0000306073
-
Vitamin K-dependent proteins in blood coagulation
-
Stamatoyannopoulos, G, Majerus, PW, Perlmutter, RM, Varmus, H, eds. 3rd edn. Philadelphia: W.B. Saunders Co
-
Stenflo J, Dahlbäck B. Vitamin K-dependent proteins in blood coagulation. In: Stamatoyannopoulos, G, Majerus, PW, Perlmutter, RM, Varmus, H, eds. The molecular Bais of Blood Diseases, 3rd edn. Philadelphia: W.B. Saunders Co., 2001: 579-613.
-
(2001)
The molecular Bais of Blood Diseases
, pp. 579-613
-
-
Stenflo, J.1
Dahlbäck, B.2
-
12
-
-
0034732094
-
Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex
-
Fuentes-Prior P, Iwanaga Y, Huber R, Pagila R, Rumennik G, Seto M, Morser J, Light DR, Bode W. Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex. Nature 2000; 404: 518-25.
-
(2000)
Nature
, vol.404
, pp. 518-525
-
-
Fuentes-Prior, P.1
Iwanaga, Y.2
Huber, R.3
Pagila, R.4
Rumennik, G.5
Seto, M.6
Morser, J.7
Light, D.R.8
Bode, W.9
-
13
-
-
0033135017
-
Probing the activation of protein C by the thrombin-thrombomodulin complex using structural analysis, site-directed mutagenesis, and computer modeling
-
Knobe KE, Berntsdotter A, Shen L, Morser J, Dahlbäck B, Villoutreix BO. Probing the activation of protein C by the thrombin-thrombomodulin complex using structural analysis, site-directed mutagenesis, and computer modeling. Proteins 1999; 35: 218-34.
-
(1999)
Proteins
, vol.35
, pp. 218-234
-
-
Knobe, K.E.1
Berntsdotter, A.2
Shen, L.3
Morser, J.4
Dahlbäck, B.5
Villoutreix, B.O.6
-
14
-
-
0029787653
-
Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin
-
Gerlitz B, Grinnell BW. Mutation of protease domain residues Lys37-39 in human protein C inhibits activation by the thrombomodulin-thrombin complex without affecting activation by free thrombin. J Biol Chem 1996; 271: 22285-8.
-
(1996)
J Biol Chem
, vol.271
, pp. 22285-22288
-
-
Gerlitz, B.1
Grinnell, B.W.2
-
15
-
-
0035968239
-
Structural and energetic characteristics of the heparin-binding site in antithrombotic protein C
-
Friedrich U, Blom AM, Dahlbäck B, Villoutreix BO. Structural and energetic characteristics of the heparin-binding site in antithrombotic protein C. J Biol Chem 2001; 276: 24122-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 24122-24128
-
-
Friedrich, U.1
Blom, A.M.2
Dahlbäck, B.3
Villoutreix, B.O.4
-
16
-
-
0029790055
-
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex
-
Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA 1996; 93: 10212-6.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10212-10216
-
-
Stearns-Kurosawa, D.J.1
Kurosawa, S.2
Mollica, J.S.3
Ferrell, G.L.4
Esmon, C.T.5
-
17
-
-
0035869411
-
Endothelial cell protein C receptor plays an important role in protein C activation in vivo
-
Taylor FB Jr, Peer GT, Lockhart MS, Ferrell G, Esmon CT. Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood 2001; 97: 1685-8.
-
(2001)
Blood
, vol.97
, pp. 1685-1688
-
-
Taylor Jr., F.B.1
Peer, G.T.2
Lockhart, M.S.3
Ferrell, G.4
Esmon, C.T.5
-
18
-
-
0037067752
-
The crystal structure of the endothelial protein C receptor and a bound phospholipid
-
Oganesyan V, Oganesyan N, Terzyan S, Qu D, Dauter Z, Esmon NL, Esmon CT. The crystal structure of the endothelial protein C receptor and a bound phospholipid. J Biol Chem 2002; 277: 24851-4.
-
(2002)
J Biol Chem
, vol.277
, pp. 24851-24854
-
-
Oganesyan, V.1
Oganesyan, N.2
Terzyan, S.3
Qu, D.4
Dauter, Z.5
Esmon, N.L.6
Esmon, C.T.7
-
19
-
-
2642679231
-
Structural investigation of the A domains of human blood coagulation factor V by molecular modeling
-
Villoutreix BO, Dahlbäck B. Structural investigation of the A domains of human blood coagulation factor V by molecular modeling. Protein Sci 1998; 7: 1317-25.
-
(1998)
Protein Sci
, vol.7
, pp. 1317-1325
-
-
Villoutreix, B.O.1
Dahlbäck, B.2
-
20
-
-
0001238260
-
Molecular models for the C1 and C2 domains of factor V: new structurefunction insights
-
Villoutreix B, Bucher P, Hofmann K, Baumgartner S, Dahlbäck B. Molecular models for the C1 and C2 domains of factor V: new structurefunction insights. J Mol Model 1998; 4: 268-75.
-
(1998)
J Mol Model
, vol.4
, pp. 268-275
-
-
Villoutreix, B.1
Bucher, P.2
Hofmann, K.3
Baumgartner, S.4
Dahlbäck, B.5
-
21
-
-
0030903424
-
A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin
-
Pemberton S, Lindley P, Zaitsev V, Card G, Tuddenham EG, Kemball-Cook G. A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin. Blood 1997 1998; 89: 2413-21.
-
(1997)
Blood
, vol.89
, pp. 2413-2421
-
-
Pemberton, S.1
Lindley, P.2
Zaitsev, V.3
Card, G.4
Tuddenham, E.G.5
Kemball-Cook, G.6
-
22
-
-
0031804517
-
The Factor VIII structure and mutation resource site: HAMSTeRS, version 4
-
Kemball-Cook G, Tuddenham EG, Wacey AI. The Factor VIII structure and mutation resource site: HAMSTeRS, version 4. Nucleic Acids Res 1998; 26: 216-9.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 216-219
-
-
Kemball-Cook, G.1
Tuddenham, E.G.2
Wacey, A.I.3
-
23
-
-
0032467348
-
Homology models of the C domains of blood coagulation factors V and VIII: a proposed membrane binding mode for FV and FVIII C2 domains
-
Pellequer JL, Gale AJ, Griffin JH, Getzoff ED. Homology models of the C domains of blood coagulation factors V and VIII: a proposed membrane binding mode for FV and FVIII C2 domains. Blood Cells Mol Dis 1998; 24: 448-61.
-
(1998)
Blood Cells Mol Dis
, vol.24
, pp. 448-461
-
-
Pellequer, J.L.1
Gale, A.J.2
Griffin, J.H.3
Getzoff, E.D.4
-
24
-
-
0033709870
-
Three-dimensional model of coagulation factor Va bound to activated protein C
-
Pellequer JL, Gale AJ, Getzoff ED, Griffin JH. Three-dimensional model of coagulation factor Va bound to activated protein C. Thromb Haemost 2000; 84: 849-57.
-
(2000)
Thromb Haemost
, vol.84
, pp. 849-857
-
-
Pellequer, J.L.1
Gale, A.J.2
Getzoff, E.D.3
Griffin, J.H.4
-
25
-
-
0037082464
-
3-Dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography
-
Stoilova-McPhie S, Villoutreix BO, Mertens K, Kemball-Cook G, Holzenburg A. 3-Dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography. Blood 2002; 99: 1215-23.
-
(2002)
Blood
, vol.99
, pp. 1215-1223
-
-
Stoilova-McPhie, S.1
Villoutreix, B.O.2
Mertens, K.3
Kemball-Cook, G.4
Holzenburg, A.5
-
26
-
-
0036707993
-
Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C
-
Gale AJ, Xu X, Pellequer JL, Getzoff ED, Griffin JH. Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C. Protein Sci 2002; 11: 2091-101.
-
(2002)
Protein Sci
, vol.11
, pp. 2091-2101
-
-
Gale, A.J.1
Xu, X.2
Pellequer, J.L.3
Getzoff, E.D.4
Griffin, J.H.5
-
27
-
-
0033604610
-
Crystal structures of the membrane-binding C2 domain of human coagulation factor V
-
Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH, Fuentes-Prior P. Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Nature 1999; 402: 434-9.
-
(1999)
Nature
, vol.402
, pp. 434-439
-
-
Macedo-Ribeiro, S.1
Bode, W.2
Huber, R.3
Quinn-Allen, M.A.4
Kim, S.W.5
Ortel, T.L.6
Bourenkov, G.P.7
Bartunik, H.D.8
Stubbs, M.T.9
Kane, W.H.10
Fuentes-Prior, P.11
-
28
-
-
0033604501
-
Structure of the C2 domain of human factor VIII at 1.5 A resolution
-
Pratt KP, ShenBW, Takeshima K, Davie EW, Fujikawa K, Stoddard BL. Structure of the C2 domain of human factor VIII at 1.5 A resolution Nature 1999; 402: 439-42.
-
(1999)
Nature
, vol.402
, pp. 439-442
-
-
Pratt, K.P.1
Shen, B.W.2
Takeshima, K.3
Davie, E.W.4
Fujikawa, K.5
Stoddard, B.L.6
-
29
-
-
0033953116
-
Mutations in a potential phospholipid binding loop in the C2 domain of factor V affecting the assembly of the prothrombinase complex
-
Nicolaes GA, Villoutreix BO, Dahlbäck B. Mutations in a potential phospholipid binding loop in the C2 domain of factor V affecting the assembly of the prothrombinase complex. Blood Coagul Fibrinolysis 2000; 11: 89-100.
-
(2000)
Blood Coagul Fibrinolysis
, vol.11
, pp. 89-100
-
-
Nicolaes, G.A.1
Villoutreix, B.O.2
Dahlbäck, B.3
-
30
-
-
0001252591
-
Identification of functionally important amino acid residues within the C2-domain of human factor V using alaninescanning mutagenesis
-
Kim SW, Quinn-Allen MA, Camp JT, Macedo-Ribeiro S, Fuentes-Prior P, Bode W, Kane WH. Identification of functionally important amino acid residues within the C2-domain of human factor V using alaninescanning mutagenesis. Biochemistry 2000; 39: 1951-8.
-
(2000)
Biochemistry
, vol.39
, pp. 1951-1958
-
-
Kim, S.W.1
Quinn-Allen, M.A.2
Camp, J.T.3
Macedo-Ribeiro, S.4
Fuentes-Prior, P.5
Bode, W.6
Kane, W.H.7
-
31
-
-
0037155149
-
Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs
-
Gilbert GE, Kaufman RJ, Arena AA, Miao H, Pipe SW. Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs. J Biol Chem 2002; 277: 6374-81.
-
(2002)
J Biol Chem
, vol.277
, pp. 6374-6381
-
-
Gilbert, G.E.1
Kaufman, R.J.2
Arena, A.A.3
Miao, H.4
Pipe, S.W.5
-
32
-
-
0035412387
-
Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII
-
Spiegel PC Jr, Jacquemin M, Saint-Remy JM, Stoddard BL, Pratt KP. Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII. Blood 2001; 98: 13-9.
-
(2001)
Blood
, vol.98
, pp. 13-19
-
-
Spiegel Jr., P.C.1
Jacquemin, M.2
Saint-Remy, J.M.3
Stoddard, B.L.4
Pratt, K.P.5
-
33
-
-
0033602920
-
A model describing the inactivation of factor Va by APC: bond cleavage, fragment dissociation, and product inhibition
-
Hockin MF, Cawthern KM, Kalafatis M, Mann KG. A model describing the inactivation of factor Va by APC: bond cleavage, fragment dissociation, and product inhibition. Biochemistry 1999; 38: 6918-34.
-
(1999)
Biochemistry
, vol.38
, pp. 6918-6934
-
-
Hockin, M.F.1
Cawthern, K.M.2
Kalafatis, M.3
Mann, K.G.4
-
34
-
-
0031417262
-
The regulation of clotting factors
-
Kalafatis M, Egan JO, van't Veer C, Cawthern KM, Mann KG. The regulation of clotting factors. Crit Rev Eukaryot Gene Expr 1997; 7: 241-80.
-
(1997)
Crit Rev Eukaryot Gene Expr
, vol.7
, pp. 241-280
-
-
Kalafatis, M.1
Egan, J.O.2
van't Veer, C.3
Cawthern, K.M.4
Mann, K.G.5
-
35
-
-
0025888388
-
Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity
-
Fay PJ, Smudzin TM, Walker FJ. Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity. J Biol Chem 1991; 266: 20139-45.
-
(1991)
J Biol Chem
, vol.266
, pp. 20139-20145
-
-
Fay, P.J.1
Smudzin, T.M.2
Walker, F.J.3
-
36
-
-
0032697629
-
Regulation of factor VIIIa in the intrinsic factor Xase
-
Fay PJ. Regulation of factor VIIIa in the intrinsic factor Xase. Thromb Haemost 1999; 82: 193-200.
-
(1999)
Thromb Haemost
, vol.82
, pp. 193-200
-
-
Fay, P.J.1
-
37
-
-
0029133654
-
Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C
-
Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, Schwarz HP, Rosing J. Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 1995; 270: 21158-66.
-
(1995)
J Biol Chem
, vol.270
, pp. 21158-21166
-
-
Nicolaes, G.A.1
Tans, G.2
Thomassen, M.C.3
Hemker, H.C.4
Pabinger, I.5
Varadi, K.6
Schwarz, H.P.7
Rosing, J.8
-
38
-
-
0028810678
-
Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C
-
Rosing J, Hoekema L, Nicolaes GA, Thomassen MC, Hemker HC, Varadi K, Schwarz HP, Tans G. Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C. J Biol Chem 1995; 270: 27852-8.
-
(1995)
J Biol Chem
, vol.270
, pp. 27852-27858
-
-
Rosing, J.1
Hoekema, L.2
Nicolaes, G.A.3
Thomassen, M.C.4
Hemker, H.C.5
Varadi, K.6
Schwarz, H.P.7
Tans, G.8
-
39
-
-
0034661942
-
The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites
-
Gale AJ, Heeb MJ, Griffin JH. The autolysis loop of activated protein C interacts with factor Va and differentiates between the Arg506 and Arg306 cleavage sites. Blood 2000; 96: 585-93.
-
(2000)
Blood
, vol.96
, pp. 585-593
-
-
Gale, A.J.1
Heeb, M.J.2
Griffin, J.H.3
-
40
-
-
0035933906
-
Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va
-
Friedrich U, Nicolaes GA, Villoutreix BO, Dahlbäck B. Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va. J Biol Chem 2001; 276: 23105-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 23105-23108
-
-
Friedrich, U.1
Nicolaes, G.A.2
Villoutreix, B.O.3
Dahlbäck, B.4
-
41
-
-
0035853784
-
Cleavage of factor VIII heavy chain is required for the functional interaction of a2 subunit with factor IXA
-
Fay PJ, Mastri M, Koszelak ME, Wakabayashi H. Cleavage of factor VIII heavy chain is required for the functional interaction of a2 subunit with factor IXA. J Biol Chem 2001; 276: 12434-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 12434-12439
-
-
Fay, P.J.1
Mastri, M.2
Koszelak, M.E.3
Wakabayashi, H.4
-
42
-
-
0028290275
-
Factor Vand protein S, as synergistic cofactors to activated protein C, in degradation of factor VIIIa
-
Shen L, Dahlbäck B. Factor Vand protein S, as synergistic cofactors to activated protein C, in degradation of factor VIIIa. J Biol Chem 1994; 269: 18735-8.
-
(1994)
J Biol Chem
, vol.269
, pp. 18735-18738
-
-
Shen, L.1
Dahlbäck, B.2
-
43
-
-
0030821008
-
Synergistic cofactor function of factor V and protein S to activated protein C in the inactivation of the factor VIIIa - factor IXa complex- species specific interactions of components of the protein C anticoagulant system
-
Shen L, He X, Dahlbäck B. Synergistic cofactor function of factor V and protein S to activated protein C in the inactivation of the factor VIIIa - factor IXa complex- species specific interactions of components of the protein C anticoagulant system. Thromb Haemost 1997; 78: 1030-6.
-
(1997)
Thromb Haemost
, vol.78
, pp. 1030-1036
-
-
Shen, L.1
He, X.2
Dahlbäck, B.3
-
44
-
-
0029792536
-
Factor V enhances the cofactor function of protein S in the APC-mediated inactivation of factor VIII: influence of the factor VR506Q mutation
-
Varadi K, Rosing J, Tans G, Pabinger I, Keil B, Schwarz HP. Factor V enhances the cofactor function of protein S in the APC-mediated inactivation of factor VIII: influence of the factor VR506Q mutation. Thromb Haemost 1996; 76: 208-14.
-
(1996)
Thromb Haemost
, vol.76
, pp. 208-214
-
-
Varadi, K.1
Rosing, J.2
Tans, G.3
Pabinger, I.4
Keil, B.5
Schwarz, H.P.6
-
45
-
-
0033561431
-
Cleavage of factorVat Arg 506 by activated protein C and the expression of anticoagulant activity of factor V
-
Thorelli E, Kaufman RJ, Dahlbäck B. Cleavage of factorVat Arg 506 by activated protein C and the expression of anticoagulant activity of factor V. Blood 1999; 93: 2552-8.
-
(1999)
Blood
, vol.93
, pp. 2552-2558
-
-
Thorelli, E.1
Kaufman, R.J.2
Dahlbäck, B.3
-
46
-
-
0032569021
-
The C-terminal region of the factor V B-domain is crucial for the anticoagulant activity of factor V
-
Thorelli E, Kaufman RJ, Dahlbäck B. The C-terminal region of the factor V B-domain is crucial for the anticoagulant activity of factor V. J Biol Chem 1998; 273: 16140-5.
-
(1998)
J Biol Chem
, vol.273
, pp. 16140-16145
-
-
Thorelli, E.1
Kaufman, R.J.2
Dahlbäck, B.3
-
47
-
-
0026631565
-
Protein S and thrombotic disease
-
Walker FJ. Protein S and thrombotic disease. Proc Soc Exp Biol Med 1992; 200: 285-95.
-
(1992)
Proc Soc Exp Biol Med
, vol.200
, pp. 285-295
-
-
Walker, F.J.1
-
48
-
-
0025303669
-
Characterization of functionally important domains in human vitamin K-dependent protein S using monoclonal antibodies
-
Dahlbäck B, Hildebrand B, Malm J. Characterization of functionally important domains in human vitamin K-dependent protein S using monoclonal antibodies. J Biol Chem 1990; 265: 8127-35.
-
(1990)
J Biol Chem
, vol.265
, pp. 8127-8135
-
-
Dahlbäck, B.1
Hildebrand, B.2
Malm, J.3
-
49
-
-
0028809322
-
Expression and functional characterization of chimeras between human and bovine vitamin-K-dependent protein-S-defining modules important for the species specificity of the activated protein C cofactor activity
-
He X, Shen L, Dahlbäck B. Expression and functional characterization of chimeras between human and bovine vitamin-K-dependent protein-S-defining modules important for the species specificity of the activated protein C cofactor activity. Eur J Biochem 1995; 227: 433-40.
-
(1995)
Eur J Biochem
, vol.227
, pp. 433-440
-
-
He, X.1
Shen, L.2
Dahlbäck, B.3
-
50
-
-
0032538548
-
Amino acid residues in thrombin-sensitive region and first epidermal growth factor domain of vitamin K-dependent protein S determining specificity of the activated protein C cofactor function
-
He X, Shen L, Villoutreix BO, Dahlbäck B. Amino acid residues in thrombin-sensitive region and first epidermal growth factor domain of vitamin K-dependent protein S determining specificity of the activated protein C cofactor function. J Biol Chem 1998; 273: 27449-58.
-
(1998)
J Biol Chem
, vol.273
, pp. 27449-27458
-
-
He, X.1
Shen, L.2
Villoutreix, B.O.3
Dahlbäck, B.4
-
51
-
-
0032145758
-
Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module
-
Hackeng TM, Dawson PE, Kent SB, Griffin JH. Chemical synthesis of human protein S thrombin-sensitive module and first epidermal growth factor module. Biopolymers 1998; 46: 53-63.
-
(1998)
Biopolymers
, vol.46
, pp. 53-63
-
-
Hackeng, T.M.1
Dawson, P.E.2
Kent, S.B.3
Griffin, J.H.4
-
52
-
-
84858768011
-
Deletion or replacement of the second EGF-like domain of protein S results in loss of APC cofactor activity
-
Mille-Baker B, Rezende SM, Simmonds RE, Lane DA, Laffan MA. Deletion or replacement of the second EGF-like domain of protein S results in loss of APC cofactor activity. Blood 2002; 10: 10.
-
(2002)
Blood
, vol.10
, pp. 10
-
-
Mille-Baker, B.1
Rezende, S.M.2
Simmonds, R.E.3
Lane, D.A.4
Laffan, M.A.5
-
53
-
-
0033854083
-
The second laminin G-type domain of protein S is indispensable for expression of full cofactor activity in activated protein C-catalysed inactivation of factor Va and factor VIIIa
-
Evenäs P, Garcia de Frutos P, Nicolaes GA, Dahlbäck B. The second laminin G-type domain of protein S is indispensable for expression of full cofactor activity in activated protein C-catalysed inactivation of factor Va and factor VIIIa. Thromb Haemost 2000; 84: 271-7.
-
(2000)
Thromb Haemost
, vol.84
, pp. 271-277
-
-
Evenäs, P.1
Garcia de Frutos, P.2
Nicolaes, G.A.3
Dahlbäck, B.4
-
54
-
-
0030951464
-
Binding site for C4b-binding protein in vitamin K-dependent protein S fully contained in carboxy-terminal laminin-G-type repeats. A study using recombinant factor IX-protein S chimeras and surface plasmon resonance
-
He X, Shen L, Malmborg AC, Smith KJ, Dahlbäck B, Linse S. Binding site for C4b-binding protein in vitamin K-dependent protein S fully contained in carboxy-terminal laminin-G-type repeats. A study using recombinant factor IX-protein S chimeras and surface plasmon resonance. Biochemistry 1997; 36: 3745-54.
-
(1997)
Biochemistry
, vol.36
, pp. 3745-3754
-
-
He, X.1
Shen, L.2
Malmborg, A.C.3
Smith, K.J.4
Dahlbäck, B.5
Linse, S.6
-
55
-
-
0033573154
-
Both G-type domains of protein S are required for the high-affinity interaction with C4b-binding protein
-
Evenäs P, Garcia De Frutos P, Linse S, Dahlbäck B. Both G-type domains of protein S are required for the high-affinity interaction with C4b-binding protein. Eur J Biochem 1999; 266: 935-42.
-
(1999)
Eur J Biochem
, vol.266
, pp. 935-942
-
-
Evenäs, P.1
Garcia De Frutos, P.2
Linse, S.3
Dahlbäck, B.4
-
56
-
-
0000952390
-
The C4b-binding protein-protein S interaction is hydrophobic in nature
-
Blom AM, Covell DG, Wallqvist A, Dahlbäck B, Villoutreix BO. The C4b-binding protein-protein S interaction is hydrophobic in nature. Biochim Biophys Acta 1998; 1388: 181-9.
-
(1998)
Biochim Biophys Acta
, vol.1388
, pp. 181-189
-
-
Blom, A.M.1
Covell, D.G.2
Wallqvist, A.3
Dahlbäck, B.4
Villoutreix, B.O.5
-
57
-
-
0035830943
-
Localization of a hydrophobic binding site for anticoagulant protein S on the beta-chain of complement regulator C4b-binding protein
-
Webb JH, Villoutreix BO, Dahlbäck B, Blom AM. Localization of a hydrophobic binding site for anticoagulant protein S on the beta-chain of complement regulator C4b-binding protein. J Biol Chem 2001; 276: 4330-7.
-
(2001)
J Biol Chem
, vol.276
, pp. 4330-4337
-
-
Webb, J.H.1
Villoutreix, B.O.2
Dahlbäck, B.3
Blom, A.M.4
-
58
-
-
0024459550
-
Characterization of a synthetic peptide that inhibits the interaction between protein S and C4b-binding protein
-
Walker FJ. Characterization of a synthetic peptide that inhibits the interaction between protein S and C4b-binding protein. J Biol Chem 1989; 264: 17645-8.
-
(1989)
J Biol Chem
, vol.264
, pp. 17645-17648
-
-
Walker, F.J.1
-
59
-
-
0032104787
-
Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein
-
Discussion 13
-
Fernandez JA, Griffin JH, Chang GT, Stam J, Reitsma PH, Bertina RM, Bouma BN. Involvement of amino acid residues 423-429 of human protein S in binding to C4b-binding protein. Blood Cells Mol Dis 1998; 24: 101-12, Discussion 13.
-
(1998)
Blood Cells Mol Dis
, vol.24
, pp. 101-112
-
-
Fernandez, J.A.1
Griffin, J.H.2
Chang, G.T.3
Stam, J.4
Reitsma, P.H.5
Bertina, R.M.6
Bouma, B.N.7
-
60
-
-
0030947233
-
A region of vitamin Kdependent protein S that binds to C4b binding protein (C4 BP) identified using bacteriophage peptide display libraries
-
Linse S, Härdig Y, Schultz DA, Dahlbäck B. A region of vitamin Kdependent protein S that binds to C4b binding protein (C4 BP) identified using bacteriophage peptide display libraries. J Biol Chem 1997; 272: 14658-65.
-
(1997)
J Biol Chem
, vol.272
, pp. 14658-14665
-
-
Linse, S.1
Härdig, Y.2
Schultz, D.A.3
Dahlbäck, B.4
-
61
-
-
0037177873
-
Structural requirements of anticoagulant protein S for its binding to the complement regulator C4b-binding protein
-
Giri TK, Linse S, Garcia de Frutos P, Yamazaki T, Villoutreix BO, Dahlbäck B. Structural requirements of anticoagulant protein S for its binding to the complement regulator C4b-binding protein. J Biol Chem 2002; 277: 15099-106.
-
(2002)
J Biol Chem
, vol.277
, pp. 15099-15106
-
-
Giri, T.K.1
Linse, S.2
Garcia de Frutos, P.3
Yamazaki, T.4
Villoutreix, B.O.5
Dahlbäck, B.6
-
62
-
-
0035342451
-
Threedimensional model of the SHBG-like region of anticoagulant protein S. new structure-function insights
-
Villoutreix BO, Dahlbäck B, Borgel D, Gandrille S, Muller YA. Threedimensional model of the SHBG-like region of anticoagulant protein S. new structure-function insights. Proteins 2001; 43: 203-16.
-
(2001)
Proteins
, vol.43
, pp. 203-216
-
-
Villoutreix, B.O.1
Dahlbäck, B.2
Borgel, D.3
Gandrille, S.4
Muller, Y.A.5
-
63
-
-
0037113999
-
Crystal Structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor Tyrosine kinase activation by laminin G-like domains
-
Sasaki T, Knyazev PG, Cheburkin Y, Gohring W, Tisi D, Ullrich A, Timpl R, Hohenester E. Crystal Structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor Tyrosine kinase activation by laminin G-like domains. J Biol Chem 2002; 277: 44164-70.
-
(2002)
J Biol Chem
, vol.277
, pp. 44164-44170
-
-
Sasaki, T.1
Knyazev, P.G.2
Cheburkin, Y.3
Gohring, W.4
Tisi, D.5
Ullrich, A.6
Timpl, R.7
Hohenester, E.8
-
64
-
-
0033024329
-
The complement regulator C4b-binding protein analyzed by molecular modeling, bioinformatics and computer-aided experimental design
-
Villoutreix BO, Blom AM, Webb J, Dahlbäck B. The complement regulator C4b-binding protein analyzed by molecular modeling, bioinformatics and computer-aided experimental design. Immunopharmacology 1999; 42: 121-34.
-
(1999)
Immunopharmacology
, vol.42
, pp. 121-134
-
-
Villoutreix, B.O.1
Blom, A.M.2
Webb, J.3
Dahlbäck, B.4
-
65
-
-
0345215157
-
Structural investigation of C4b-binding protein by molecular modeling: localization of putative binding sites
-
Villoutreix BO, Härdig Y, Wallqvist A, Covell DG, Garcia de Frutos P, Dahlbäck B. Structural investigation of C4b-binding protein by molecular modeling: localization of putative binding sites. Proteins 1998; 31: 391-405.
-
(1998)
Proteins
, vol.31
, pp. 391-405
-
-
Villoutreix, B.O.1
Härdig, Y.2
Wallqvist, A.3
Covell, D.G.4
Garcia de Frutos, P.5
Dahlbäck, B.6
-
66
-
-
0029808210
-
The amino-terminal module of the C4b-binding protein beta-chain contains the protein S-binding site
-
Härdig Y, Dahlbäck B. The amino-terminal module of the C4b-binding protein beta-chain contains the protein S-binding site. J Biol Chem 1996; 271: 20861-7.
-
(1996)
J Biol Chem
, vol.271
, pp. 20861-20867
-
-
Härdig, Y.1
Dahlbäck, B.2
-
67
-
-
0037221375
-
Role of CCP2 of the C4b-binding protein b-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies
-
Webb JH, Villoutreix BO, Dahlbäck B, Blom AM. Role of CCP2 of the C4b-binding protein b-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies. Eur J Biochem 2003; 270: 93-100.
-
(2003)
Eur J Biochem
, vol.270
, pp. 93-100
-
-
Webb, J.H.1
Villoutreix, B.O.2
Dahlbäck, B.3
Blom, A.M.4
-
68
-
-
0033382422
-
C4 BP b-chain SCR-2 specifically contributes to the interaction of protein S with C4 BP b-chain SCR-1
-
van de Poel RHL, Meijers JCM, Dahlbäck B, Bouma BN. C4 BP b-chain SCR-2 specifically contributes to the interaction of protein S with C4 BP b-chain SCR-1. Blood Cell Molecules Dis 1999; 25: 279-86.
-
(1999)
Blood Cell Molecules Dis
, vol.25
, pp. 279-286
-
-
van de Poel, R.H.L.1
Meijers, J.C.M.2
Dahlbäck, B.3
Bouma, B.N.4
-
69
-
-
0036721697
-
Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells
-
Webb JH, Blom AM, Dahlbäck B. Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells. J Immunol 2002; 169: 2580-6.
-
(2002)
J Immunol
, vol.169
, pp. 2580-2586
-
-
Webb, J.H.1
Blom, A.M.2
Dahlbäck, B.3
-
70
-
-
0029833850
-
Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va
-
Heeb MJ, Kojima Y, Hackeng TM, Griffin JH. Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va. Protein Sci 1996; 5: 1883-9.
-
(1996)
Protein Sci
, vol.5
, pp. 1883-1889
-
-
Heeb, M.J.1
Kojima, Y.2
Hackeng, T.M.3
Griffin, J.H.4
-
71
-
-
0032511045
-
Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va
-
Kojima Y, Heeb MJ, Gale AJ, Hackeng TM, Griffin JH. Binding site for blood coagulation factor Xa involving residues 311-325 in factor Va. J Biol Chem 1998; 273: 14900-5.
-
(1998)
J Biol Chem
, vol.273
, pp. 14900-14905
-
-
Kojima, Y.1
Heeb, M.J.2
Gale, A.J.3
Hackeng, T.M.4
Griffin, J.H.5
-
72
-
-
0034623962
-
Directed glycosylation of human coagulation factor X at residue 333. Insight into factor Va-dependent prothrombin catalysis
-
Cook BC, Rudolph AE, Kurumbail RG, Porche-Sorbet R, Miletich JP. Directed glycosylation of human coagulation factor X at residue 333. Insight into factor Va-dependent prothrombin catalysis. J Biol Chem 2000; 275: 38774-9.
-
(2000)
J Biol Chem
, vol.275
, pp. 38774-38779
-
-
Cook, B.C.1
Rudolph, A.E.2
Kurumbail, R.G.3
Porche-Sorbet, R.4
Miletich, J.P.5
-
74
-
-
0037159218
-
Identification of a binding site for blood coagulation factor Xa on the heavy chain of factor Va: amino acid residues 323-331 of factor V represent an interactive site for activated factor X
-
Kalafatis M, Beck DO. Identification of a binding site for blood coagulation factor Xa on the heavy chain of factor Va: amino acid residues 323-331 of factor V represent an interactive site for activated factor X. Biochemistry 2002; 41: 12715-28.
-
(2002)
Biochemistry
, vol.41
, pp. 12715-12728
-
-
Kalafatis, M.1
Beck, D.O.2
-
75
-
-
0347997285
-
Defining the factor Xa-binding site on factor Va by site-directed glycosylation
-
Steen M, Villoutreix BO, Norstrom EA, Yamazaki T, Dahlbäck B. Defining the factor Xa-binding site on factor Va by site-directed glycosylation. J Biol Chem 2002; 277: 50022-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 50022-50029
-
-
Steen, M.1
Villoutreix, B.O.2
Norstrom, E.A.3
Yamazaki, T.4
Dahlbäck, B.5
-
76
-
-
0037064117
-
Thrombin-mediated proteolysis of factor V resulting in Gradual B-domain release and exposure of the factor Xa-binding site
-
Steen M, Dahlbäck B. Thrombin-mediated proteolysis of factor V resulting in Gradual B-domain release and exposure of the factor Xa-binding site. J Biol Chem 2002; 277: 38424-30.
-
(2002)
J Biol Chem
, vol.277
, pp. 38424-38430
-
-
Steen, M.1
Dahlbäck, B.2
-
77
-
-
0035844226
-
Factor IXa: factor VIIIa interaction: helix 330-338 of factor IXa interacts with residues 558-565 and spatially adjacent regions of the A2 subunit of factor VIIIa
-
Bajaj SP, Schmidt AE, Mathur A, Padmanabhan K, Zhong D, Mastri M, Fay PJ. Factor IXa: factor VIIIa interaction: helix 330-338 of factor IXa interacts with residues 558-565 and spatially adjacent regions of the A2 subunit of factor VIIIa. J Biol Chem 2001; 276: 16302-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 16302-16309
-
-
Bajaj, S.P.1
Schmidt, A.E.2
Mathur, A.3
Padmanabhan, K.4
Zhong, D.5
Mastri, M.6
Fay, P.J.7
-
78
-
-
0032722436
-
Factor VIII-factor IX interactions: molecular sites involved in enzyme-cofactor complex assembly
-
Mertens K, Celie PH, Kolkman JA, Lenting PJ. Factor VIII-factor IX interactions: molecular sites involved in enzyme-cofactor complex assembly. Thromb Haemost 1999; 82: 209-17.
-
(1999)
Thromb Haemost
, vol.82
, pp. 209-217
-
-
Mertens, K.1
Celie, P.H.2
Kolkman, J.A.3
Lenting, P.J.4
-
79
-
-
0037036401
-
The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain
-
Celie PH, Van Stempvoort G, Fribourg C, Schurgers LJ, Lenting PJ, Mertens K. The connecting segment between both epidermal growth factor-like domains in blood coagulation factor IX contributes to stimulation by factor VIIIa and its isolated A2 domain. J Biol Chem 2002; 277: 20214-20.
-
(2002)
J Biol Chem
, vol.277
, pp. 20214-20220
-
-
Celie, P.H.1
Van Stempvoort, G.2
Fribourg, C.3
Schurgers, L.J.4
Lenting, P.J.5
Mertens, K.6
-
80
-
-
0037144428
-
The Nterminal epidermal growth factor-like domain of coagulation factor IX. Probing its functions in the activation of factor IX and factor X with a monoclonal antibody
-
Persson KE, Villoutreix BO, Thämlitz AM, Knobe KE, Stenflo J. The Nterminal epidermal growth factor-like domain of coagulation factor IX. Probing its functions in the activation of factor IX and factor X with a monoclonal antibody. J Biol Chem 2002; 277: 35616-24.
-
(2002)
J Biol Chem
, vol.277
, pp. 35616-35624
-
-
Persson, K.E.1
Villoutreix, B.O.2
Thämlitz, A.M.3
Knobe, K.E.4
Stenflo, J.5
-
81
-
-
0030468098
-
The 2.8 A crystal structure of Gla-domainless activated protein C
-
Mather T, Oganessyan V, Hof P, Huber R, Foundling S, Esmon C, Bode W. The 2.8 A crystal structure of Gla-domainless activated protein C. Embo J 1996; 15: 6822-31.
-
(1996)
Embo J
, vol.15
, pp. 6822-6831
-
-
Mather, T.1
Oganessyan, V.2
Hof, P.3
Huber, R.4
Foundling, S.5
Esmon, C.6
Bode, W.7
-
82
-
-
0035144327
-
Screening the molecular surface of human anticoagulant protein C. a search for interaction sites
-
Villoutreix BO, Covell DG, Blom AM, Wallqvist A, Friedrich U, Dahlbäck B. Screening the molecular surface of human anticoagulant protein C. a search for interaction sites. J Comput Aided Mol Des 2001; 15: 13-27.
-
(2001)
J Comput Aided Mol Des
, vol.15
, pp. 13-27
-
-
Villoutreix, B.O.1
Covell, D.G.2
Blom, A.M.3
Wallqvist, A.4
Friedrich, U.5
Dahlbäck, B.6
-
83
-
-
0032773568
-
Involvement of Lys 62 (217) and Lys 63 (218): of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor
-
Shen L, Villoutreix BO, Dahlbäck B. Involvement of Lys 62 (217) and Lys, 1999; 63 (218): of human anticoagulant protein C in heparin stimulation of inhibition by the protein C inhibitor. Thromb Haemost; 82: 72-9.
-
(1999)
Thromb Haemost
, vol.82
, pp. 72-79
-
-
Shen, L.1
Villoutreix, B.O.2
Dahlbäck, B.3
-
84
-
-
0037076527
-
Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C
-
Yang L, Manithody C, Rezaie AR. Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C. Biochemistry 2002; 41: 6149-57.
-
(2002)
Biochemistry
, vol.41
, pp. 6149-6157
-
-
Yang, L.1
Manithody, C.2
Rezaie, A.R.3
-
85
-
-
0037047277
-
Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C
-
Gale AJ, Tsavaler A, Griffin JH. Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C. J Biol Chem 2002; 277: 28836-40.
-
(2002)
J Biol Chem
, vol.277
, pp. 28836-28840
-
-
Gale, A.J.1
Tsavaler, A.2
Griffin, J.H.3
-
86
-
-
0032716327
-
Structural prediction and analysis of endothelial cell protein C/activated protein C receptor
-
Villoutreix BO, Blom AM, Dahlbäck B. Structural prediction and analysis of endothelial cell protein C/activated protein C receptor. Protein Eng 1999; 12: 833-40.
-
(1999)
Protein Eng
, vol.12
, pp. 833-840
-
-
Villoutreix, B.O.1
Blom, A.M.2
Dahlbäck, B.3
-
87
-
-
0029874551
-
Protein fold recognition using sequencederived predictions
-
Fischer D, Eisenberg D. Protein fold recognition using sequencederived predictions. Protein Sci 1996; 5: 947-55.
-
(1996)
Protein Sci
, vol.5
, pp. 947-955
-
-
Fischer, D.1
Eisenberg, D.2
-
88
-
-
0031137254
-
A theoretical model for the Gla-TSR-EGF-1 region of the anticoagulant cofactor protein S. from biostructural pathology to species-specific cofactor activity
-
Villoutreix BO, Teleman O, Dahlbäck B. A theoretical model for the Gla-TSR-EGF-1 region of the anticoagulant cofactor protein S. from biostructural pathology to species-specific cofactor activity. J Comput Aided Mol Des 1997; 11: 293-304.
-
(1997)
J Comput Aided Mol Des
, vol.11
, pp. 293-304
-
-
Villoutreix, B.O.1
Teleman, O.2
Dahlbäck, B.3
-
89
-
-
0031743385
-
Topological studies of the amino terminal modules of vitamin Kdependent protein S using monoclonal antibody epitope mapping and molecular modeling
-
Giri TK, Villoutreix BO, Wallqvist A, Dahlbäck B, de Frutos PG. Topological studies of the amino terminal modules of vitamin Kdependent protein S using monoclonal antibody epitope mapping and molecular modeling. Thromb Haemost 1998; 80: 798-804.
-
(1998)
Thromb Haemost
, vol.80
, pp. 798-804
-
-
Giri, T.K.1
Villoutreix, B.O.2
Wallqvist, A.3
Dahlbäck, B.4
de Frutos, P.G.5
|