Probing the activation of protein C by the thrombin-thrombomodulin complex using structural analysis, site-directed mutagenesis, and computer modeling

Proteins: Structure, Function and Genetics

Volumn 35, Issue 2, 1999, Pages 218-234

  Knobe, Karin E ^a   Berntsdotter, Ann ^a   Shen, Lei ^a   Morser, John ^b   Dahlbäck, Björn ^a   Villoutreix, Bruno O ^a  

^a LUND UNIVERSITY   (Sweden)

^b BAYER AG   (Germany)

Author keywords

Activation rate; Protein C; Protein modeling; Thrombin; Thrombomodulin

Indexed keywords

MUTANT PROTEIN; PROTEIN C; RECOMBINANT PROTEIN; THROMBIN; THROMBOMODULIN;

ARTICLE; COMPUTER MODEL; KINETICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

CELL LINE; COMPUTER SIMULATION; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN C; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; THROMBIN; THROMBOMODULIN;

EID: 0033135017     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19990501)35:2<218::AID-PROT8>3.0.CO;2-2     Document Type: Article

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