Interdomain engineered disulfide bond permitting elucidation of mechanisms of inactivation of coagulation factor Va by activated protein C

Protein Science

Volumn 11, Issue 9, 2002, Pages 2091-2101

  Gale, Andrew J ^a   Xu, Xiao ^a   Pellequer, Jean Luc ^a   Getzoff, Elizabeth D ^a   Griffin, John H ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Activated protein C; Coagulation; Disulfide; Engineered disulfide; Factor Va

Indexed keywords

ACTIVATED PROTEIN C; ANTICOAGULANT AGENT; ARGININE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5 LEIDEN; BLOOD CLOTTING FACTOR 5A; CYSTEINE; GLUTAMINE; MUTANT PROTEIN; PROTHROMBIN; RECOMBINANT PROTEIN; SERINE PROTEINASE; DISULFIDE; PROTEIN C; THROMBIN;

ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CONCENTRATION RESPONSE; DISSOCIATION; DISULFIDE BOND; KINETICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; GENETICS; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

ANTICOAGULANTS; DISULFIDES; FACTOR VA; FACTOR XA; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN C; PROTEIN STRUCTURE, TERTIARY; PROTHROMBIN; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THROMBIN;

EID: 0036707993     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.0210002     Document Type: Article

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