Identification of functionally important amino acid residues within the C2-domain of human factor V using alanine-scanning mutagenesis

Biochemistry

Volumn 39, Issue 8, 2000, Pages 1951-1958

  Kim, Suhng Wook ^a   Quinn Allen, Mary Ann ^a   Camp, J Terese ^a   Macedo Ribeiro, Sandra ^b   Fuentes Prior, Pablo ^b   Bode, Wolfram ^b   Kane, William H ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; ARGININE; ASPARTIC ACID; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING INHIBITOR; EPITOPE; GLUTAMIC ACID; MONOCLONAL ANTIBODY; MUTANT PROTEIN; PHOSPHATIDYLSERINE; POLYCLONAL ANTIBODY;

ANTIGEN RECOGNITION; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; MEMBRANE BINDING; MOLECULAR INTERACTION; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

ALANINE; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FACTOR V; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLSERINES; PHOSPHOLIPIDS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; THROMBOPLASTIN;

EID: 0001252591     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992256r     Document Type: Article

References (38)

1. Kane, W. H., and Davie, E. W. (1988) Blood 71, 539-555.
2. Mann, K. G., Nesheim, M. E., Church, W. R., Haley, P., and Krishnaswamy, S. (1990) Blood 76, 1-16.
3. Kane, W. H., and Davie, E. W. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 6800-6804.
4. Kane, W. H., Ichinose, A., Hagen, F. S., and Davie, E. W. (1987) Biochemistry 26, 6508-6514.
5. Jenny, R. J., Pittman, D. D., Toole, J. J., Kriz, R. W., Aldape, R. A., Hewick, R. M., Kaufman, R. J., and Mann, K. G. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 4846-4850.
6. Dahlbäck, B. (1980) J. Clin. Invest. 66, 583-591.
7. Kane, W. H., and Majerus, P. W. (1981) J. Biol. Chem. 256, 1002-1007.
8. Thorelli, E., Kaufman, R. J., and Dahlbäck, B. (1997) Eur. J. Biochem. 247, 12-20.
9. Takahashi, N., Ortel, T. L., and Putnam, F. W. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 390-394.
10. Church, W. R., Jernigan, R. L., Toole, J., Hewick, R. M., Knopf, J., Knutson, G. J., Nesheim, M. E., Mann, K. G., and Fass, D. N. (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 6934-6937.
11. Zaitseva, I., Zaisev, V., Card, G., Moshkov, K., Bax, B., Ralph, A., and Lindley, P. (1996) J. Biol. Inorg. Chem. 1, 15-23.
12. Villoutreix, B. O., and Dahlbäck, B. (1998) Protein Sci. 7, 1317-1325.
13. Pemberton, S., Lindley, P., Zaitsev, V., Card, G., Tuddenham, E. G. D., and Kemball-Cook, G. (1997) Blood 89, 2413-2421.
14. Baumgartner, S., Hofmann, K., Chiquet-Ehrismann, R., and Bucher, P. (1998) Protein Sci. 7, 1626-1631.
15. Ortel, T. L., Devore-Carter, D., Quinn-Allen, M. A., and Kane, W. H. (1992) J. Biol. Chem. 267, 4189-4198.
16. Ortel, T. L., Quinn-Allen, M. A., Charles, L. A., Devore-Carter, D., and Kane, W. H. (1992) J. Clin. Invest. 90, 2340-2347.
17. Ortel, T. L., Quinn-Allen, M. A., Keller, F. G., Peterson, J. A., Larocca, D., and Kane, W. H. (1994) J. Biol. Chem. 269, 15898-15905.
18. Villoutreix, B. O., Bucher, P., Hoffman, K., Baumgartner, S., and Dahlbäck, B. (1998) J. Mol. Model. 4, 268-275.
19. Pellequer, J. L., Gale, A. J., Griffin, J. H., and Getzoff, E. D. (1998) Blood Cells, Mol Dis. 24, 448-461.
20. Macedo-Ribeiro, S., Bode, W., Huber, R., Quinn-Allen, M. A., Ortel, T. L., Kim, S. W., Bourenkov, G. P., Bartunik, H. D., Stubbs, M. J., Kane, W. H., and Fuentes-Prior, P. (1999) Nature 402, 434-439.
21. Kane, W. H., Devore-Carter, D., and Ortel, T. L. (1990) Biochemistry 29, 6762-6768.
22. Wells, J. A. (1991) Methods Enzymol. 202, 390-411.
23. Davies, D. R. and Cohen, G. H. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 7-12.
24. Goldberg, M. E. (1991) Trends Biochem. Sci. 16, 358-362.
25. Ito, N., Phillips, S. E., Yadav, K. D., and Knowles, P. F. (1994) J. Mol. Biol. 238, 794-814.
26. Kemball-Cook, G., and Tuddenham, E. G. (1999) Nucleic Acids Res. 25, 128-132.
27. Pipe, S. W., and Kaufman, R. J. (1996) J. Biol. Chem. 271, 25671-25676.
28. Ito, N., Keen, J. N., Knowles, P. F., McPherson, M. J., Phillips, S. E., Stevens, C., and Yadav, K. D. (1990) Biochem. Soc. Trans. 18, 931-932.
29. Coots, M. C., Muhleman, A. F., and Glueck, H. I. (1978) Am. J. Hematol. 4, 193-206.
30. Novotny, J., Handschumacher, M., Haber, E., Bruccoleri, R. E., Carlson, W. B., Fanning, D. W., Smith, J. A., and Rose, G. D. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 226-230.
31. Ortel, T. L., Moore, K. D., Quinn-Allen, M. A., Okamura, T., Sinclair, A. J., Lazarchick, J., Govindan, R., Carmagnol, F., and Kane, W. H. (1998) Blood 91, 4188-4196.
32. Campos, B., Mo, Y. D., Mealy, T. R., Li, C. W., Swairjo, M. A., Balch, C., Head, J. F., Retzinger, G., Dedman, J. R., and Seaton, B. A. (1998) Biochemistry 37, 8004-8010.
33. Gilbert, G. E., and Baleja, J. D. (1995) Biochemistry 34, 3022-3031.
34. Veeraraghavan, S., Baleja, J. D., and Gilbert, G. E. (1998) Biochem. J. 332 (Pt 2), 549-555.
35. Pratt, K. P., Shen, B. W., Takeshima, K., Davie, E. W., Fujikawa, K., and Stoddard, B. L. (1999) Nature 402, 439-442.
36. Kim, S. W., Ortel, T. L., Quinn-Allen, M., Yoo, L., Worfolk, L., Zhai, X., Lentz, B. R., and Kane, W. H. (1999) Biochemistry 38, 11448-11454.
37. Rosing, J., Bakker, H. M., Thomassen, M. C. L. G. D., Hemker, H. C., and Tans, G. (1993) J. Biol. Chem. 268, 21130-21136.
38. Koppaka, V., Talbot, W. F., Zhai, X., and Lentz, B. R. (1997) Biophys. J. 73, 2638-2652.