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Volumn 164, Issue 11, 2000, Pages 6034-6040

Threshold signaling of human Th0 cells in activation and anergy: Modulation of effector function by altered TCR ligand

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ALLERGEN; B7 ANTIGEN; CD3 ANTIGEN; CD86 ANTIGEN; EPITOPE; INTERLEUKIN 10; INTERLEUKIN 5;

EID: 0034123138     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.11.6034     Document Type: Article
Times cited : (15)

References (48)
  • 1
    • 0026708718 scopus 로고
    • Regulation of immunity to parasites by T cells and T cell-derived cytokines
    • Sher, A., and R. L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385.
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 385
    • Sher, A.1    Coffman, R.L.2
  • 2
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12:227.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 227
    • Romagnani, S.1
  • 3
    • 0028361047 scopus 로고
    • Role of cytokines in determining T-lymphocyte function
    • O'Garra, A., and K. Murphy. 1994. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6:458.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 458
    • O'Garra, A.1    Murphy, K.2
  • 4
    • 0025820634 scopus 로고
    • An in vitro model of peptide-mediated immunomodulation of the human T cell response to Dermatophagoides spp. (house dust mite)
    • O'Hehir, R. E., R. Busch, J. B. Rothbard, and J. R. Lamb. 1991. An in vitro model of peptide-mediated immunomodulation of the human T cell response to Dermatophagoides spp. (house dust mite). J. Allergy Clin. Immunol. 87:1120.
    • (1991) J. Allergy Clin. Immunol. , vol.87 , pp. 1120
    • O'Hehir, R.E.1    Busch, R.2    Rothbard, J.B.3    Lamb, J.R.4
  • 8
    • 0026603643 scopus 로고
    • Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: Relationship to tissue eosinophilia
    • Durham, S. R., S. Ying, V. A. Varney, M. R. Jacobson, R. M. Sudderick, I. S. Mackay, A. B. Kay, and Q. A. Hamid. 1992. Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J. Immunol. 148:2390.
    • (1992) J. Immunol. , vol.148 , pp. 2390
    • Durham, S.R.1    Ying, S.2    Varney, V.A.3    Jacobson, M.R.4    Sudderick, R.M.5    Mackay, I.S.6    Kay, A.B.7    Hamid, Q.A.8
  • 9
    • 0028900437 scopus 로고
    • Immunoregulatory properties of IL-13: Its potential role in atopic disease
    • de Vries, J. E., and G. Zurawski. 1995. Immunoregulatory properties of IL-13: its potential role in atopic disease. Int. Arch. Allergy Immunol. 106:175.
    • (1995) Int. Arch. Allergy Immunol. , vol.106 , pp. 175
    • De Vries, J.E.1    Zurawski, G.2
  • 11
    • 0025368379 scopus 로고
    • Comparison of diversity and function of house dust mite-specific T lymphocyte clones from atopic and non-atopic donors
    • Wierenga, E. A., M. Snoek, J. D. Bos, H. M. Jansen, and M. L. Kapsenberg. 1990. Comparison of diversity and function of house dust mite-specific T lymphocyte clones from atopic and non-atopic donors. Eur. J. Immunol. 20:1519.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1519
    • Wierenga, E.A.1    Snoek, M.2    Bos, J.D.3    Jansen, H.M.4    Kapsenberg, M.L.5
  • 12
    • 0029820287 scopus 로고    scopus 로고
    • Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro
    • Akdis, C. A., M. Akdis, T. Blesken, D. Wymann, S. S. Alkan, U. Muller, and K. Blaser. 1996. Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro. J. Clin. Invest. 98:1676.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1676
    • Akdis, C.A.1    Akdis, M.2    Blesken, T.3    Wymann, D.4    Alkan, S.S.5    Muller, U.6    Blaser, K.7
  • 14
    • 0024327899 scopus 로고
    • Clonal expansion versus functional clonal inactivation: A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy
    • Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 445
    • Mueller, D.L.1    Jenkins, M.K.2    Schwartz, R.H.3
  • 15
    • 0021968677 scopus 로고
    • Binding of immunogenic peptides to Ia histocompatibility molecules
    • Babbitt, B. P., P. M. Allen, G. Matsueda, E. Haber, and E. R. Unanue. 1985. Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 317:359.
    • (1985) Nature , vol.317 , pp. 359
    • Babbitt, B.P.1    Allen, P.M.2    Matsueda, G.3    Haber, E.4    Unanue, E.R.5
  • 16
    • 0027174663 scopus 로고
    • Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides
    • Evavold, B. D., J. Sloan-Lancaster, B. L. Hsu, and P. M. Allen. 1993. Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 150:3131.
    • (1993) J. Immunol. , vol.150 , pp. 3131
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Hsu, B.L.3    Allen, P.M.4
  • 17
    • 0026434554 scopus 로고
    • Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
    • Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
    • (1991) Science , vol.252 , pp. 1308
    • Evavold, B.D.1    Allen, P.M.2
  • 18
    • 0027409792 scopus 로고
    • Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling
    • Racioppi, L., F. Ronchese, L. A. Matis, and R. N. Germain. 1993. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J. Exp. Med. 177:1047.
    • (1993) J. Exp. Med. , vol.177 , pp. 1047
    • Racioppi, L.1    Ronchese, F.2    Matis, L.A.3    Germain, R.N.4
  • 20
    • 0030797568 scopus 로고    scopus 로고
    • A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens
    • Nicholson, L. B., A. Murtaza, B. P. Hafler, A. Sette, and V. K. Kuchroo. 1997. A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens. Proc. Natl. Acad. Sci. USA 94:9279.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9279
    • Nicholson, L.B.1    Murtaza, A.2    Hafler, B.P.3    Sette, A.4    Kuchroo, V.K.5
  • 21
    • 0020569052 scopus 로고
    • Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin
    • Lamb, J. R., B. J. Skidmore, N. Green, J. M. Chiller, and M. Feldmann. 1983. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med. 157:1434.
    • (1983) J. Exp. Med. , vol.157 , pp. 1434
    • Lamb, J.R.1    Skidmore, B.J.2    Green, N.3    Chiller, J.M.4    Feldmann, M.5
  • 22
    • 0025223870 scopus 로고
    • Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins
    • O'Hehir, R. E., and J. R. Lamb. 1990. Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins. Proc. Natl. Acad. Sci. USA 87:8884.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 8884
    • O'Hehir, R.E.1    Lamb, J.R.2
  • 23
    • 0027298445 scopus 로고
    • Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
    • Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature 363:156.
    • (1993) Nature , vol.363 , pp. 156
    • Sloan-Lancaster, J.1    Evavold, B.D.2    Allen, P.M.3
  • 24
    • 0028866978 scopus 로고
    • An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
    • Nicholson, L. B., J. M. Greer, R. A. Sobel, M. B. Lees, and V. K. Kuchroo. 1995. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis. Immunity 3:397.
    • (1995) Immunity , vol.3 , pp. 397
    • Nicholson, L.B.1    Greer, J.M.2    Sobel, R.A.3    Lees, M.B.4    Kuchroo, V.K.5
  • 27
    • 0027717415 scopus 로고
    • Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp.: Identification of HLA-DR and -DQ restricted T cell epitopes
    • Verhoef, A., J. A. Higgins, C. J. Thorpe, S. G. E. Marsh, J. D. Hayball, J. R. Lamb, and R. E. O'Hehir. 1993. Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp.: identification of HLA-DR and -DQ restricted T cell epitopes. Int. Immunol. 5:1589.
    • (1993) Int. Immunol. , vol.5 , pp. 1589
    • Verhoef, A.1    Higgins, J.A.2    Thorpe, C.J.3    Marsh, S.G.E.4    Hayball, J.D.5    Lamb, J.R.6    O'Hehir, R.E.7
  • 29
    • 0029037210 scopus 로고
    • Serial triggering of many T-cell receptors by a few peptide-MHC complexes
    • Valitutti, S., S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia. 1995. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375:148.
    • (1995) Nature , vol.375 , pp. 148
    • Valitutti, S.1    Muller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 30
    • 0030047535 scopus 로고    scopus 로고
    • T-cell receptor peptides that inhibit the T-cell response to allergen induce transforming growth factor-β 1 production
    • Hawrylowicz, C. M., E. R. Jarman, L. Guida, R. E. O'Hehir, and J. R. Lamb. 1996. T-cell receptor peptides that inhibit the T-cell response to allergen induce transforming growth factor-β 1 production. J. Allergy Clin. Immunol. 97:707.
    • (1996) J. Allergy Clin. Immunol. , vol.97 , pp. 707
    • Hawrylowicz, C.M.1    Jarman, E.R.2    Guida, L.3    O'Hehir, R.E.4    Lamb, J.R.5
  • 32
    • 0030584803 scopus 로고    scopus 로고
    • Induction of anergy in human T helper 0 cells by stimulation with altered T cell antigen receptor ligands
    • Tsitoura, D. C., W. Holter, A. Cerwenka, C. M. Gelder, and J. R. Lamb. 1996. Induction of anergy in human T helper 0 cells by stimulation with altered T cell antigen receptor ligands. J. Immunol. 156: 2801.
    • (1996) J. Immunol. , vol.156 , pp. 2801
    • Tsitoura, D.C.1    Holter, W.2    Cerwenka, A.3    Gelder, C.M.4    Lamb, J.R.5
  • 33
    • 0027333348 scopus 로고
    • Tickling the TCR: Selective T-cell functions stimulated by altered peplide ligands
    • Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T-cell functions stimulated by altered peplide ligands. Immunol. Today 14:602.
    • (1993) Immunol. Today , vol.14 , pp. 602
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Allen, P.M.3
  • 34
    • 0031045733 scopus 로고    scopus 로고
    • The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells
    • Carballido, J. M., A. Faith, N. Carballido-Perrig, and K. Blaser. 1997. The intensity of T cell receptor engagement determines the cytokine pattern of human allergen-specific T helper cells. Eur. J. Immunol. 27:515.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 515
    • Carballido, J.M.1    Faith, A.2    Carballido-Perrig, N.3    Blaser, K.4
  • 35
    • 0025286210 scopus 로고
    • Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation
    • Harding, C. V., and E. R. Unanue. 1990. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature 346: 574.
    • (1990) Nature , vol.346 , pp. 574
    • Harding, C.V.1    Unanue, E.R.2
  • 36
    • 0031172162 scopus 로고    scopus 로고
    • Serial triggering of TCRs: A basis for the sensitivity and specificity of antigen recognition
    • Valitutti, S., and A. Lanzavecchia. 1997. Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol. Today 18:299.
    • (1997) Immunol. Today , vol.18 , pp. 299
    • Valitutti, S.1    Lanzavecchia, A.2
  • 37
    • 0031935753 scopus 로고    scopus 로고
    • Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: Implications for autoimmunity
    • Nicholson, L. B., H. Waldner, A. M. Carrizosa, A. Sette, M. Collins, and V. K. Kuchroo. 1998. Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity. Proc. Natl. Acad. Sci. USA 95:264.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 264
    • Nicholson, L.B.1    Waldner, H.2    Carrizosa, A.M.3    Sette, A.4    Collins, M.5    Kuchroo, V.K.6
  • 41
    • 0031307386 scopus 로고    scopus 로고
    • Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice
    • Van Parijs, L., M. P. Sethna, A. N. Schweitzer, F. Borriello, A. H. Sharpe, and A. K. Abbas, 1997. Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice. J. Immunol. 159:5336.
    • (1997) J. Immunol. , vol.159 , pp. 5336
    • Van Parijs, L.1    Sethna, M.P.2    Schweitzer, A.N.3    Borriello, F.4    Sharpe, A.H.5    Abbas, A.K.6
  • 43
    • 0028956146 scopus 로고
    • Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand
    • Windhagen, A., C. Scholz, P. Hollsberg, H. Fukaura, A. Sette, and D. A. Hafler. 1995. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 2:373.
    • (1995) Immunity , vol.2 , pp. 373
    • Windhagen, A.1    Scholz, C.2    Hollsberg, P.3    Fukaura, H.4    Sette, A.5    Hafler, D.A.6
  • 44
    • 0030817017 scopus 로고    scopus 로고
    • Regulation of cytokine production by human Th0 cells following stimulation with peptide analogues: Differential expression of TGF-β in activation and anergy
    • Tsitoura, D. C., C. M. Gelder, D. M. Kemeny, and J. R. Lamb. 1997. Regulation of cytokine production by human Th0 cells following stimulation with peptide analogues: differential expression of TGF-β in activation and anergy. Immunology 92:10.
    • (1997) Immunology , vol.92 , pp. 10
    • Tsitoura, D.C.1    Gelder, C.M.2    Kemeny, D.M.3    Lamb, J.R.4
  • 45
    • 0030443348 scopus 로고    scopus 로고
    • Altered TCR ligands affect antigen-presenting cell responses: Up-regulation of IL-12 by an analogue peptide
    • Matsuoka, T., H. Kohrogi, M. Ando, Y. Nishimura, and S. Matsushita. 1996. Altered TCR ligands affect antigen-presenting cell responses: up-regulation of IL-12 by an analogue peptide. J. Immunol. 157:4837.
    • (1996) J. Immunol. , vol.157 , pp. 4837
    • Matsuoka, T.1    Kohrogi, H.2    Ando, M.3    Nishimura, Y.4    Matsushita, S.5
  • 46
    • 0030023918 scopus 로고    scopus 로고
    • Single amino acid substitutions on a Japanese cedar pollen allergen (Cry j 1)-derived peptide induced alterations in human T cell responses and T cell receptor antagonism
    • Ikagawa, S., S. Matsushita, Y. Z. Chen, T. Ishikawa, and Y. Nishimura. 1996. Single amino acid substitutions on a Japanese cedar pollen allergen (Cry j 1)-derived peptide induced alterations in human T cell responses and T cell receptor antagonism. J. Allergy Clin. Immunol. 97:53.
    • (1996) J. Allergy Clin. Immunol. , vol.97 , pp. 53
    • Ikagawa, S.1    Matsushita, S.2    Chen, Y.Z.3    Ishikawa, T.4    Nishimura, Y.5
  • 47
    • 0033083289 scopus 로고    scopus 로고
    • An altered peptide ligand specifically inhibits Th2 cytokine synthesis by abrogating TCR signaling
    • Faith, A., C. A. Akdis, M. Akdis, A. Joss, D. Wymann, and K. Blaser. 1999. An altered peptide ligand specifically inhibits Th2 cytokine synthesis by abrogating TCR signaling. J. Immunol. 162:1836.
    • (1999) J. Immunol. , vol.162 , pp. 1836
    • Faith, A.1    Akdis, C.A.2    Akdis, M.3    Joss, A.4    Wymann, D.5    Blaser, K.6
  • 48
    • 0034650788 scopus 로고    scopus 로고
    • Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma: Amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide
    • Janssen, E. M., A. J. M van Oosterhout, A. J. M. L. van Rensen, W. van Eden, F. P. Nijkamp, and M. H. M. Wauben. 2000. Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma: amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide. J. Immunol. 164:580.
    • (2000) J. Immunol. , vol.164 , pp. 580
    • Janssen, E.M.1    Van Oosterhout, A.J.M.2    Van Rensen, A.J.M.L.3    Van Eden, W.4    Nijkamp, F.P.5    Wauben, M.H.M.6


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