Chronic exposure to low levels of antigen in the periphery causes reversible functional impairment correlating with changes in CD5 levels in monoclonal CD8 T cells

Journal of Immunology

Volumn 171, Issue 3, 2003, Pages 1278-1284

  Stamou, Panagiota ^a   De Jersey, James ^a   Carmignac, Danielle ^a   Mamalaki, Clio ^b   Kioussis, Dimitris ^a   Stockinger, Brigitta ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b INSTITUTE OF COMPUTER SCIENCE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CD5 ANTIGEN; CD8 ANTIGEN; GROWTH HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; CHIMERA; CYTOTOXICITY; FLOW CYTOMETRY; GROWTH HORMONE RELEASE; HYPOPHYSIS; IMMUNOLOGICAL TOLERANCE; LONG TERM EXPOSURE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

EID: 0041344452     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.3.1278     Document Type: Article

References (43)

1. Schwartz, R. H. 2002. T cell anergy. Annu. Rev. Immunol.
2. Ohashi, P. S., S. Oehen, K. Buerki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
3. Ksander, B. R., and J. W. Streilein. 1994. Regulation of the immune response within privileged sites. Chem. Immunol. 58:117.
4. Webb, S., C. Morris, and J. Sprent. 1990. Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell 63:1249.
5. Critchfield, J. M., M. K. Racke, J. C. Zuniga-Pflücker, B. Cannella, C. S. Raine, J. Goverman, and M. J. Lenardo. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263:1139.
6. Moskophidis, D., F. Lechner, H. Pircher, and R. M. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362:758.
7. Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445.
8. Ferber, I., G. Schönrich, J. Schenkel, A. L. Mellor, G. J. Hämmerling, and B. Arnold. 1994. Levels of peripheral T cell tolerance induced by different doses of tolerogen. Science 263:674.
9. Schönrich, G., F. Momburg, M. Malissen, A. M. Schmitt-Verhulst, B. Malissen, G. J. Hämmerling, and B. Arnold. 1992. Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen. Int. Immunol. 4:581.
10. Boussiotis, V. A., J. G. Gribben, G. J. Freeman, and L. M. Nadler. 1994. Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Curr. Opin. Immunol. 6:797.
11. + T cells. Eur. J. Immunol. 30:883.
12. Welsh, R. M. 2001. Assessing CD8 T cell number and dysfunction in the presence of antigen. J. Exp. Med. 193:F19.
13. de Jersey, J., D. Carmignac, T. Barthlott, I. Robinson, and B. Stockinger. 2002. Activation of CD8 T cells by antigen expressed in the pituitary gland. J. Immunol. 169:6753.
14. Tarakhovsky, A., S. B. Kanner, J. Hombach, J. A. Ledbetter, W. Muller, N. Killeen, and K. Rajewsky. 1995. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269:535.
15. Mamalaki, C., M. Murdjeva, M. Tolaini, T. Norton, P. Chandler, A. Townsend, E. Simpson, and D. Kioussis. 1995. Tolerance in TCR/cognate antigen double-transgenic mice mediated by imcomplete thymic deletion and peripheral receptor down-regulation. Dev. Immunol. 4:299.
16. De Boer, J., A. Williams, G. Skavdis, N. Harker, M. Coles, M. Tolaini, T. Norton, K. Williams, K. Roderick, A. J. Potocnik, and D. Kioussis. 2003. Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur. J. Immunol. 33:314.
17. Zatz, M. M., and E. M. Lance. 1970. The distribution of chromium 51-labelled lymphoid cells in the mouse: a survey of anatomical compartments. Cell. Immunol. 1:3.
18. Stockinger, B., and B. Hausmann. 1994. Functional recognition of in vivo processed self antigen. Int. Immunol. 6:247.
19. 3H]thymidine incorporation assay. J. Immunol. Methods 170:211.
20. Oehen, S., and K. Brduscha-Riem. 1998. Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division. J. Immunol. 161:5338.
21. Lyons, A. B., and C. R. Parish. 1994. Determination of lymphocyte division by flow cytometry. J. Immunol. Methods 171:131.
22. Matzinger, P. 1991. The JAM test: a simple assay for DNA fragmentation and cell death. J. Immunol. Methods 145:185.
23. Carmignac, D. F., and I. C. Robinson. 1990. Growth hormone (GH) secretion in the dwarf rat: release, clearance and responsiveness to GH-releasing factor and somatostatin. J. Endocrinol. 127:69.
24. Aspinall, R. 1997. Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J. Immunol. 158:3037.
25. Bandeira, A., J. Mengel, O. Burlen-Defranoux, and A. Coutinho. 1991. Proliferative T cell anergyto MIs-1a does not correlate with in vivo tolerance. Int. Immunol. 3:923.
26. Wong, P., G. M. Barton, K. A. Forbush, and A. Y. Rudensky. 2001. Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands. J. Exp. Med. 193:1179.
27. Azzam, H. S., A. Grinberg, K. Lui, H. Shen, E. W. Shores, and P. E. Love. 1998. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188:2301.
28. Smith, K., B. Seddon, M. A. Purbhoo, R. Zamoyska, A. G. Fisher, and M. Merkenschlager. 2001. Sensory adaptation in naive peripheral CD4 T cells. J. Exp. Med. 194:1253.
29. Rocha, B., A. Grandien, and A. A. Freitas. 1995. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181:993.
30. Oehen, S. U., P. S. Ohashi, K. Burki, H. Hengartner, R. M. Zinkernagel, and P. Aichele. 1994. Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels. Cell. Immunol. 158:342.
31. Zajac, A. J., J. N. Blattman, K. Murali-Krishna, D. J. Sourdive, M. Suresh, J. D. Altman, and R. Ahmed. 1998. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188:2205.
32. Hammerling, G. J., G. Schonrich, F. Momburg, N. Auphan, M. Malissen, B. Malissen, A. M. Schmitt-Verhulst, and B. Arnold. 1991. Non-deletional mechanisms of peripheral and central tolerance: studies with transgenic mice with tissue-specific expression of a foreign MHC class I antigen. Immunol. Rev. 122:47.
33. Festenstein, R., M. Tolaini, P. Corbella, C. Mamalaki, J. Parrington, M. Fox, A. Miliou, M. Jones, and D. Kioussis. 1996. Locus control region function and heterochromatin-induced position effect variegation. Science 271:1123.
34. + T lymphocytes on immunizing MIs-1b mice with MIs-1a expressing cells. Nature 339:541.
35. Vezys, V., S. Olson, and L. Lefrancois. 2000. Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction. Immunity 12:505.
36. Rocha, B., and H. von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science 251:1225.
37. + T cells. J. Exp. Med. 186:239.
38. Tham, E. L., P. Shrikant, and M. F. Mescher. 2002. Activation-induced nonresponsiveness: a Th-dependent regulatory checkpoint in the CTL response. J. Immunol. 168:1190.
39. + T cells persist in vivo following induction of peripheral tolerance. J. Immunol. 160:4719.
40. Alferink, J., B. Schittek, G. Schonrich, G. J. Hammerling, and B. Arnold. 1995. Long life span of tolerant T cells and the role of antigen in maintenance of peripheral tolerance. Int. Immunol. 7:331.
41. Barthlott, T., G. Kassiotis, and B. Stockinger. 2003. T cell regulation as a side effect of homeostasis and competition. J. Exp. Med. 197:451.
42. Kassiotis, G., R. Zamoyska, and B. Stockinger. Involvement of avidity for MHC in homeostasis of naive and memory T cells. J. Exp. Med. 197:1007.
43. Hippen, K. L., L. E. Tze, and T. W. Behrens. 2000. CD5 maintains tolerance in anergic B cells. J. Exp. Med. 191:883.