Transcutaneous immunization with cholera toxin B subunit adjuvant suppresses IgE antibody responses via selective induction of Thl immune responses

Journal of Immunology

Volumn 170, Issue 3, 2003, Pages 1586-1592

  Anjuère, Fabienne ^a   George Chandy, Annie ^b   Audant, Florence ^a   Rousseau, Déborah ^a   Holmgren, Jan ^b   Czerkinsky, Cecil ^a  

^a INSERM   (France)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; CHOLERA TOXIN A SUBUNIT; CHOLERA TOXIN B SUBUNIT; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOLOGICAL ADJUVANT; OVALBUMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DERMIS; DRUG EFFECT; DRUG MECHANISM; EPIDERMIS; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 0037309156     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.3.1586     Document Type: Article

References (31)

1. Elson, C., and W. Ealding. 1984. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen. J. Immunol. 133:2892.
2. Holmgren, J., N. Lycke, and C. Czerkinsky. 1973. Cholera toxin and cholera toxin B subunit as oral-mucosal adjuvant and antigen vector systems. Vaccine 11:1179.
3. Lycke, N., and J. Holmgren. 1986. Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens. Immunology 59:301.
4. Glenn, G. M., M. Rao, G. R. Matyas, and C. R. Alving. 1998. Skin immunization made possible by cholera toxin. Nature 391:851.
5. Glenn, G. M., T. Scharton-Kersten, R. Vassell, G. R. Matyas, and C. R. Alving. 1999. Transcutaneous immunization with bacterial ADP-ribosylating exotoxins as antigen and adjuvant. Infect. Immun. 67:1100.
6. Glenn, G. M., D. N. Taylor, X. Li, S. Frankel, A. Montemarano. and C. R. Alving. 2000. Transcutaneous immunization: a human vaccine delivery strategy using a patch. Nat. Med. 6:1403.
7. Hammond, S. A., D. Walwender, C. R. Alving, and G. M. Glenn. 2001. Transcutaneous immunization: T cell responses and boosting of existing immunity. Vaccine 19:2701.
8. Tamura, S., Y. Shoji, K. Hasiguchi, C. Aizawa, and T. Kurata. 1994. Effects of cholera toxin adjuvant on IgE antibody response to orally or nasally administered ovalbumin. Vaccine 12:1238.
9. Snider, D. P., J. S. Marshall, M. H. Perdue and H. Liang. 1994. Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin. J. Immunol. 153:647.
10. Hodge, L. M., M. Marinaro, H. P. Jones, J. R. McGhee, H. Kiyono, and J. W. Simecka. 2001. Immunoglobulin A (IgA) responses and IgE-associated inflammation along the respiratory tract after mucosal but not systemic immunization. Infect. Immun. 69:2328.
11. Qadri, F., M. Asaduzzaman, C. Wemeras, G. Mohi, M. J. Albert, M. Abdus Salam, R. B. Sack, M. Jertbom, J. R. McGhee, D. A. Sacks, and J. Holmgren. 2000. Enterotoxin-specific immunoglobulin E responses in humans after infection or vaccination with diarrhea-causing enteropathogens. Infect. Immun. 68:6077.
12. Spergel, J. M., E. Mizoguchi, J. P. Brewer, T. R. Martin, A. K. Bhan, and R. S. Geha. 1998. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J. Clin. Invest. 101:1614.
13. Wang, L. F., J. Y. Lin, K. H. Hsieh, and R. H. Lin. 1996. Epicutaneous exposure of protein antigen induces a predominant Th2-like response with high IgE production in mice. J. Immunol. 156:4079.
14. Holmgren, J. 1981. Actions of cholera toxin and the prevention and treatment of cholera. Nature 292:413.
15. Czerkinsky, C., F. Anjuère, J. R. McGhee, A. George-Chandy, J. Holmgren, M. P. Kieny, K. Fujiyashi, J. F. Mestecky, V. Pierrefite-Carle, C. Rask, and J. B. Sun. 1999. Mucosal immunity and tolerance: relevance to vaccine development. Immunol. Rev. 170:197.
16. Sun, J. B., J. Holmgren, and C. Czerkinsky. 1994. Cholera toxin B subunit: an efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance. Proc. Natl. Acad. Sci. USA 91:10795.
17. Mougneau, E., F. Altare, A. E. Wakil, S. Zheng, T. Coppola, Z. E. Wang, R. Waldmann, R. M. Locksley, and N. Glaichenhaus. 1995. Expression cloning of a protective Leishmania antigen. Science 268:563.
18. Lebens, M., S. Johansson, J. Osek, M. Lindblad, and J. Holmgren. 1993. Large-scale production of Vibrio cholerae toxin B subunit for use in oral vaccines. Biotechnology 11:1574.
19. Rask, C., J. Holmgren, M. Frednksson M. Linblad, I. Nordström, J.-B. Sun, and C. Czerkinsky. 2000. Prolonged oral treatment with low doses of allergen conjugated to cholera toxin B subunit suppresses immunoglobulin E antibody responses in sensitized mice: Clin. Exp. Allergy 30:1024.
20. Svennerholm, A. M., and J. Holmgren. 1978. Identification of Escherichia coli heat-labile enterotoxin by means of a ganglioside immunosorbant assay (GM1-ELISA) procedure. Curr. Microbiol. 1:19.
21. Ovary, Z. 1964. Passive cutaneous anaphylaxis. In immunological Methods, J. F. Ackroyd, ed. Blackwell Scientific, p. 259.
22. Anjuère, F., and C. Ardavin. 2001. Isolation of mouse thymic dendritic cells. In Methods in Molecular Medicine: Dendritic Cell Protocols, Vol. 64. S. P. Robinson and A. J. Stagg, eds. Humana Press, Tolowa, p. 23.
23. Anjuère, F., P. Martín, I. Ferrero, M. Lopez Fraga, G. Martinez del Hoyo, N. Wright, and C. Ardavin. 1999. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes and skin of the mouse. Blood 93:590.
24. Anjuère, F., G. Martinez del Hoyo, P. Martin, and C. Ardavin. 2000. Langerhans cells develop from a lymphoid-committed precursor. Blood 96:1633.
25. Nithiuthai, S., and J. R. Allen. 1984. Effects of ultraviolet irradiation on epidermal Langerhans cells in guinea-pigs. Immunology 51:143.
26. Becksteadt, J. M. 1994. A simple technique for preservation of fixation-sensitive antigens in paraffin-embedded tissues. J. Histochem. Cytochem. 42:1127.
27. Holmgren, J., and L. Lindholm. 1976. Cholera toxin, ganglioside receptors and the immune response. Immunol. Commun. 5:737.
28. Lycke, N., T. Tsuij, and J. Holmgren. 1992. The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity. Eur. J. Immunol. 22:2277.
29. Freeman, G. J., V. A. Boussiotis, A. Anumanthan, G. M. Bernstein, X.-Y. Ke, P. D. Rennert, G. S. Gray, J. G. Gribben, and L. M. Nadler. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523.
30. Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
31. Schweitzer, A. N., F. Borriello, R. C. Wong, A. K. Abbas, and A. H. Sharpe. 1997. Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86. J. Immunol. 158:2713.