Suppression of apoptosis by Bcl-2 to enhance benzene metabolites- induced oxidative DNA damage and mutagenesis: A possible mechanism of carcinogenesis

Molecular Pharmacology

Volumn 55, Issue 5, 1999, Pages 894-901

  Kuo, Min Liang ^a   Shiah, Shine Gwo ^a   Wang, Chau Jong ^c   Chuang, Shuang En ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BENZOQUINONE; 8 HYDROXYDEOXYGUANOSINE; BENZENE DERIVATIVE; HYDROQUINONE; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL SURVIVAL; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA DAMAGE; DNA REPAIR; GENE FREQUENCY; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RECEPTOR UPREGULATION; REGULATORY MECHANISM;

APOPTOSIS; BENZOQUINONES; DNA DAMAGE; DNA REPAIR; HL-60 CELLS; HUMANS; HYDROQUINONES; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTAGENESIS; MUTAGENS; MUTATION; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 0032952349     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Aksoy M (1989) Hematotoxicity and carcinogenicity of benzene. Environ Health Perspect 82:193-197.
2. 2 protein expression in breast cancer in relation to established prognostic factor and other clinic pathological variables. Ann Oncol 61:1005-1010.
3. Cherbonnel-Lasserre C and Dosanjh MK (1997) Suppression of apoptosis by overexpression of Bcl-2 or Bcl-xL promotes survival and mutagenesis after oxidative damage. Biochimie (Paris) 79:613-617.
4. Cherbonnel-Lasserre C, Gauny S and Kronenberg A (1996) Suppression of apoptosis by Bcl-2 or Bcl-XL promotes susceptibility to mutagenesis. Oncogene 13:1489-1497.
5. Dean BJ (1985) Recent finding on the genetic toxicology of benzene, toluene, xylenes and phenols. Mutat Res 154:153-181.
6. Elder DJE, Hague A, Hicks DJ and Paraskeua C (1996) Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lives: Enhanced apoptosis in carcinoma and in vitro transformed adenoma relative to adenoma cell lives. Cancer Res 56:2273-2276.
7. Gupta RC (1984) Nonrandom binding of carcinogen N-hydro-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo. Proc Natl Acad Sci USA 81:6943-6947.
8. Hall P, Coates PJ, Ansari B and Hopwood D (1994) Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis. J Cell Sci 107: 3569-3577.
9. Hanada M, Aime-Sampe C, Sato T and Reed JC (1995) Structure-function analysis of Bcl-2 protein. Identification of conserved domain important for homodimerization with Bcl-2 and heterodimerization with Bax. J Biol Chem 270:11962-11965.
10. Hiraku Y and Kawaniski S (1996) Oxidative DNA damage and apoptosis induced by benzene metabolites. Cancer Res 56:5172-5178.
11. 2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241-251.
12. 2 protein in the adenoma-carcinoma sequence of colorectal neoplasia. J Pathol 79:10-14.
13. Kolachana P, Subrahmanyam VV, Meyer KB, Zhary L and Smith MT (1993) Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo. Cancer Res 53:1023-1026.
14. 2 initiates a new category of oncogenes: Regulation of cell death. Blood 80:879-886.
15. Kuo ML, Chen CW, Jee SW, Chang SE and Cheng AL (1997) Transforming growth factor β1 attenuates ceramide-induced CPP32/Yama activation and apoptosis in human leukemic HL60 cell. Biochem J 327:663-667.
16. Kuo ML, Huang TS and Lin JK (1996) Curcumin, an antioxidant and anti-tumor promoters, induces apoptosis in human leukemia cells. Biochim Biophys Acta 1317:95-100.
17. 2. Cancer Res 57:150-1653.
18. Matsuba L, Kodama T, Takao M, Yasui A, Yamamoto K and Asano M (1997) Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/ apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res 57:2151-2156.
19. McDonnel TJ and Korsmeyer SJ (1991) Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature (London) 349:254-256.
20. + human bone marrow progenitor cells. Mol Pharmacol 50:610-615.
21. 2 and the regulation of programmed cell death. J Cell Biol 124:1-6.
22. Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science (Wash) 267:1456-1462.
23. Tice R, Costa D and Drew R (1980) Cytogenetic effects of inhaled benzene on murine bone marrow: Induction of sister chromatid exchanges, chromosomal aberrations and cell proliferation inhibition in DBA/2 mice. Proc Natl Acad Sci USA 77:2148-2155.
24. Tsujimoto Y and Croce C (1986) Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci USA 83:5214-5218.
25. Ubezio P and Civoli F (1994) Flow cytometric detection of hydrogen peroxide production induced by doxorubicin in cancer cells. Free Radical Biol Med 16:509-516.
26. Vaux DL (1993) Towards an understanding of the molecular mechanism of a physiological cell death. Proc Natl Acad Sci USA 90:786-789.
27. Ward JB Jr, Ammenbenser MM, Ramanjam VM, Morrison DL, Whorton EB JY and Legator MS (1992) The mutagenic effects of low level sub-acute inhalation exposure to benzene in CD-1 mice. Mutat Res 288:49-57.
28. Wright SC, Zhang J and Lamck JW (1994) Inhibition of apoptosis as a mechanism of tumor promotion. FASEB J 8:654-660.
29. Yandell DM, Dryja TP and Little JB (1990) Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells. Mutat Res 229-89-102.
30. Yang J, Lin X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP and Wang X (1997) Prevention of apoptosis by Bcl2: Release of cytochrome c from mitochondria blocked. Science (Wash) 275:1129-1132.
31. Yardley-Jones A, Anderson D, Lovell DP and Jenkrison PC (1990) Analysis of chromosomal aberrations in workers exposed to low level benzene. Br J Induct Med 47:48-51.
32. Yardley-Jones A, Anderson D and Porke DV (1991) The toxicity of benzene and its metabolism and molecular pathology in human risk assessment. Br J Ind Med 48:437-444.
33. Yin DX and Schimke PT (1996) Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment. Proc Natl Acad Sci USA 93:3394-3398.