DNA topoisomerases as targets for the anticancer drug TAS-103: Primary cellular target and DNA cleavage enhancement

Biochemistry

Volumn 38, Issue 47, 1999, Pages 15573-15579

  Byl, Jo Ann Wilson ^a   Fortune, John M ^a   Burden, D Andrew ^a   Nitiss, John L ^b   Utsugi, Teruhiro ^c   Yamada, Yuji ^c   Osheroff, Neil ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 [2 (DIMETHYLAMINO)ETHYLAMINO] 3 HYDROXY 7H INDENO[2,1 C]QUINOLIN 7 ONE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DNA CLEAVAGE; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; PRIORITY JOURNAL;

AMINOQUINOLINES; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA, FUNGAL; DNA-BINDING PROTEINS; ETOPOSIDE; HUMANS; HYDROLYSIS; INDENES; ISOENZYMES; PLASMIDS; SACCHAROMYCES CEREVISIAE;

MAMMALIA;

EID: 0033598737     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991791o     Document Type: Article

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