A review of quantitative studies of benzene metabolism

Critical Reviews in Toxicology

Volumn 31, Issue 3, 2001, Pages 285-311

  Lovern, Mark R ^a   Cole, Cammey E ^a   Schlosser, Paul M ^b  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE; CYTOCHROME P450 2E1; EPOXIDE HYDROLASE; OXIDOREDUCTASE;

AEROBIC METABOLISM; BLOOD TOXICITY; BONE MARROW TOXICITY; DOSE RESPONSE; DOSIMETRY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG TISSUE LEVEL; ENZYME ACTIVITY; ENZYME INDUCTION; GLUCURONIDATION; HUMAN; LIVER METABOLISM; LIVER MICROSOME; LIVER PERFUSION; MATHEMATICAL MODEL; NONHUMAN; REVIEW; RISK ASSESSMENT; SIMULATION; SKIN ABSORPTION;

EID: 0034972670     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.1080/20014091111703     Document Type: Review

References (133)

1. Benzene exposure in the United States 1978-1983: An overview
2. Solvents
3. Major sources of exposure to benzene and other volatile organic chemicals
4. Hematotoxicity of inhaled benzene to Sprague-Dawley rats and AKR mice at 300 ppm
5. Alterations in the morphology and functional activity of bone marrow phagocytes following benzene treatment of mice
6. Ascertainment corrected prevalence rate (ACPR) of leukopenia in workers exposed to benzene in small-scale industries calculated with capture-recapture methods
7. Overview of benzene-induced aplastic anaemia
8. Benzene
9. Recent developments in the understanding of benzene toxicity and leukemogenesis
10. Leukemia risk associated with benzene exposure in the pliofilm cohort. I. Mortality update and exposure distribution
11. The mechanism of benzene-induced leukemia: A hypothesis and speculations on the causes of leukemia
12. Benzene and the dose-related incidence of hematologic neoplasms in China
13. A case-control study to investigate the risk of leukaemia associated with exposure to benzene in petroleum marketing and distribution workers in the United Kingdom
14. Benzene: A multipotential carcinogen. Results of long-term biossays performed at the Bologna Institute of Oncology
15. Experimental studies on benzene carcinogenicity at the Bologna Institute of Oncology: Current results and ongoing research
16. 1 mice
17. Loss of p53 in benzene-induced thymic lymphomas in p53+/- mice: Evidence of chromosomal recombination
18. Current concepts of chronic benzene toxicity
19. The toxicity of benzene and its metabolism and molecular pathology in human risk assessment
20. The toxicology of benzene
21. Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression
22. Partial hepatectomy reduces both metabolism and toxicity of benzene
23. Comparison of rat hepatic and pulmonary microsomal metabolism of benzene and the lack of benzene-induced pneumotoxicity and hepatotoxicity
24. 3H-Benzene metabolism in rabbit bone marrow
25. Benzene is metabolized and covalently bound in bone marrow in situ
26. Characterization of the benzene monooxygenase system in rabbit bone marrow
27. Identification and induction of cytochromes P450, P450IIE1 and P450IA1 in rabbit bone marrow
28. 1]benzene
29. 3H] benzene by F344/N rats and B6C3F1 mice
30. 1 mice
31. 14C]benzene by cynomologous monkeys and chimpanzees
32. Quantitative relation of urinary phenol levels to breathzone benzene concentrations: A factory survey
33. Determination of catechol and quinol in the urine of workers exposed to benzene
34. Excretion of 1,2,4,-benzenetriol in the urine of workers exposed to benzene
35. Urinary t,t-muconic acid as an indicator of exposure to benzene
36. Suitability of s-phenyl mercapturic acid and trans-trans-muconic acid as biomarkers for exposure to low concentrations of benzene
37. Identification of benzene oxide as a product of benzene metabolism by mouse, rat and human liver microsomes
38. Measurement of benzene oxide in the blood of rats following administration of benzene
39. Toxicokinetics
40. Identification of ethanol-inducible P450 isozyme 3a (P450IIE1) as a benzene and phenol hydroxylase
41. Monoclonal antibody-directed characterization of benzene, ethoxyresorufin and pentoxyresorufin metabolism in rat liver microsomes
42. Benzene metabolism by reconstituted cytochromes P450 2B1 and 2E1 and its modulation by cytochrome b5, microsomal epoxide hydrolase, and glutathione transferases: Evidence for an important role of microsomal epoxide hydrolase in the formation of hydroquinone
43. Benzene metabolism by human liver microsomes in relation to cytochrome P450 2E1 activity
44. Microsomal hydroxylation of specifically deuterated monosubstituted benzenes. Evidence for direct aromatic hydroxylation
45. Role of the arene-oxide system in the metabolism of aromatic substrates: In vitro conversion of benzene oxide to a premercapturic acid and dihydrodiol
46. Formation of muconaldehyde, an open-ring metabolite of benzene, in mouse liver microsomes: An additional pathway for toxic metabolites
47. Detection and identification of sulfhydryl conjugates of p-benzoquinone in microsomal incubations of benzene and phenol
48. Identification of N-acetyl-S-(2,5-di-hydroxyphenyl)-L-cysteine as a urinary metabolite of benzene, phenol, and hydroquinone
49. Identification of multi-S-substituted conjugates of hydroquinone by HPLC-coulometric electrode array analysis and mass spectroscopy
50. Peroxidase-dependent metabolism of benzene's phenolic metabolites and its potential role in benzene toxicity and carcinogenicity
51. Metabolic basis of benzene toxicity
52. Genotoxicity of two metabolites of benzene: Phenol and hydroquinone show strong synergistic effects in vivo
53. Synergistic action of benzene metabolite hydroquinone on myelopoietic stimulating activity of granulocyte/macrophage colony-stimulating in vitro
54. Benzene and its phenolic metabolites produce oxidative DNA damage in HL-60 cell in vitro and in the bone marrow in vivo
55. Inhibition of lymphocyte transformation and microtubule assembly by quinone metabolites of benzene: Evidence for a common mechanism
56. Topoisomerase inhibition by phenolic metabolites: A potential mechanism for benzene's clastogenic effects
57. Mechanistics studies on benzene toxicity: Formation of DNA-protein crosslinks induced by benzene in mice and muconaldehyde in HL-60 cells
58. Studies on guanine adducts excreted in rat urine after benzene exposure
59. 13C6]benzene
60. Biological markers of exposure to benzene: S-phenylcysteine in albumin
61. 609C→T mutation and rapid fractional excretion of chlorzoxazone
62. Recent advances in the metabolism and toxicity of benzene
63. Carcinogenic effects of benzene: An update
64. Benzene toxicity, carcinogenesis, and epidemiology
65. 14C]benzene administered orally or by inhalation in rats and mice
66. Subchronic inhalation toxicity of glucuronidation in rats and mice
67. A perspective on benzene leukemogenesis
68. Dose-, route-, and sex-dependent urinary excretion of phenol metabolites in B6C3F1 mice
69. Effect of sex, strain, age and route of exposure in benzene-induced sister chromatid exchange (SCE) in murine bone marrow
70. Modifications in the myeloclastogenic effect of benzene in mice with toluene, phenobarbital, 3-methylcholanthrene, Aroclor 1254 and SKF-525A
71. Induction of micronuclei by benzene in B6C3F1 mice: Retrospective analysis of peripheral blood smears from the NTP carcinogenesis bioassay
72. The effect of exposure regimen and duration on benzene-induced bone marrow damage in mice. I. Sex comparison in DBA/2 mice
73. Effect of phenobarbitol pretreatment on benzene biotransformation in the rat. II. 9000 g supernatant and isolated perfused liver versus living rat
74. Dose-dependent metabolism of benzene in hamsters, rats, and mice
75. Biological monitoring of occupational exposure to low levels of benzene
76. Measurement of the urinary benzene metabolite trans,trans-muconic acid for benzene exposure in humans
77. Urinary excretion of phenol, catechol, hydroquinone, and muconic acid by workers occupationally exposed to benzene
78. Use of a mathematical model of rodent in vitro metabolism to predict human in vitro metabolism data
79. Pharmacokinetic interaction between benzene metabolites, phenol and hydroquinone, in B6D3F1 mice
80. 1 mice
81. Effect of ethanol and phenobarbital administration on the metabolism and toxicity of benzene
82. Enhanced metabolism of volatile hydrocarbons in rat liver following food deprivation, restricted carbohydrate intake and administration of ethanol, phenobarbital, polychlorinated biphenyl and 3-methylcholanthrene: A comparative study
83. Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes
84. Effects of enzyme induction on microsomal benzene metabolism
85. Differences in rates of benzene metabolism correlate with observed genotoxicity
86. A comparative study on the effects of benzene, toluene and xylene on their in vitro metabolism and drug-metabolizing enzymes in rat liver
87. Exposure to various benzene derivatives differentially induces cytochromes P450 2B1 and 2E1 in rat liver
88. Influence of gender and acetone pretreatment of benzene metabolism in mice exposed by nose-only inhalation
89. Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: Ethanol, imidazole, trichloroethylene, pyrazole, and isoniazid
90. Effect of exposure to four organic solvents on hepatic cytochrome P450 isozymes in rat
91. Effect of repeated benzene inhalation exposures on benzene metabolism, binding to hemoglobin, and induction of micronuclei
92. Repeated oral benzene exposure alters enzymes involved in benzene metabolism
93. Guide to occupational exposure values-1996
94. Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: A putative probe of CYP2E1 activity
95. Risk assessment: Toxicity from chemical exposure resulting from enhanced expression of CYP2E1
96. Human cytochrome P450 2E1 (CYP2E1): From genotype to phenotype
97. A genetic polymorphism in the regulatory sequences of human CYP2E1: Association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake
98. In vitro conjugation of benzene metabolites by human liver: Potential influence of interindividual variability on benzene toxicity
99. Metabolism of benzene in rat hepatocytes. Influence of inducers on phenol glucuronidation
100. Mutual metabolic suppression between benzene and toluene in man
101. Evaluation of the interaction of benzene and toluene on the urinary excretion of t,t-muconic acid in rats
102. Co-exposure to gasoline vapor decreases benzene metabolism in Fischer-344 rats
103. Comparison of the metabolism of benzene and its metabolite phenol in rat liver microsomes
104. Benzene and phenol metabolism by mouse and rat liver microsomes
105. Metabolism of benzene in human liver microsomes: Individual variations in relation to CYP2E1 expression
106. Acetominophen and phenol: Substrates for both a thermostable and thermolabile form of human platelet phenol sulfotransferase
107. Thermolabile and thermostable human platelet phenol sulfotransferase. Substrate specificity and physical separation
108. Cytochromes P450 in benzene metabolism and involvement of their metabolites and reactive oxygen species in toxicity
109. Inhibition of p-nitrophenol hydroxylase in rat liver microsomes by small aromatic and heterocyclic molecules
110. Cytochrome P450 destruction and radical scavenging by benzene and its metabolites
111. Benzene metabolism in rodent hepatocytes: Role of sulphate conjugation
112. Benzene metabolism in the isolated perfused mouse liver
113. 14C] phenol in the isolated perfused mouse liver
114. Mechanistic considerations in benzene physiological model development
115. Metabolism of benzene and trans-trans-muconaldehyde in the isolated perfused rat liver
116. Absence of detectable P450 2E1 in bone marrow of B6C3F1 mice: Relevance to butadiene-induced bone marrow toxicity
117. CYP2E1-dependent benzene toxicity: The role of extrahepatic benzene metabolism
118. A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity
119. A physiological model for simulation of benzene metabolism by rats and mice
120. Pharmacokinetics of benzene
121. Mechanism of benzene carcinogenesis: Application of a physiological model of benzene pharmacokinetics and metabolism
122. Comparison of three physiologically based pharmacokinetic models of benzene disposition
123. Modeling benzene pharmacokinetics across three sets of animal data: Parametric sensitivity and risk implications
124. An analysis of exposure rate effects for benzene using a physiologically based pharmacokinetic model
125. Age-related changes in benzene disposition in male C57BL/6N mice described by a physiologically based pharmacokinetic model
126. Population toxicokinetics of benzene
127. In vitro-based and In vivo-based simulations of benzene uptake and metabolism in rats
128. A pharmacokinetic study of occupational and environmental exposure with regard to gender
129. Penetration of benzene through human skin
130. Effect of environmental conditions on the penetration of benzene through human skin
131. The in vitro permeability of human skin to benzene, ethylene glycol, formaldehyde, and n-hexane
132. Structure and validation of a pharmacokinetic model for benzene
133. Benzene disposition in the rat after exposure by inhalation