Quinolone action against human topoisomerase IIα: Stimulation of enzyme-mediated double-stranded DNA cleavage

Biochemistry

Volumn 42, Issue 12, 2003, Pages 3393-3398

  Bromberg, Kenneth D ^a   Burgin, Alex B ^b   Osheroff, Neil ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DECODE GENETICS   (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DRUG PRODUCTS; ENZYMES;

QUINOLONE ACTION;

DNA;

CP 115953; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; ELLIPTICINE; ETOPOSIDE; GENISTEIN; OLIGONUCLEOTIDE; QUINOLONE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; DNA CLEAVAGE; DNA STRAND BREAKAGE; DNA STRUCTURE; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; ANTI-INFECTIVE AGENTS; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; DNA; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ETOPOSIDE; FLUOROQUINOLONES; HUMANS; KINETICS; MODELS, BIOLOGICAL; OLIGODEOXYRIBONUCLEOTIDES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0344405682     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi027383t     Document Type: Article

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