The origin of FOXP3-expressing CD4+ regulatory T cells: Thymus or periphery

Journal of Clinical Investigation

Volumn 112, Issue 9, 2003, Pages 1310-1312

  Sakaguchi, Shimon ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; REPRESSOR PROTEIN;

AUTOIMMUNE DISEASE; FOXP3 GENE; GENE; GENE CONTROL; GENE EXPRESSION; GENETIC MARKER; HUMAN; IMMUNOLOGICAL TOLERANCE; INFLAMMATION; LYMPHOCYTE FUNCTION; LYMPHOPOIESIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYMUS; X CHROMOSOME LINKED DISORDER; X LINKED IMMUNE DYSREGULATION POLYENDOCRINOPATHY ENTEROPATHY SYNDROME;

AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; RECEPTORS, INTERLEUKIN-2; THYMUS GLAND;

EID: 0346095412     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200320274     Document Type: Review

References (21)

1. Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell. 101:455-458.
2. Shevach, E.M. 2000. Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 18:423-449.
3. Maloy, K.J., and Powrie, F. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2:816-822.
4. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., and Toda, M. 1995. Immunologic tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1151-1164.
5. + suppressor T cells. J. Exp. Med. 193:F41-F46.
6. Gambineri, E., Torgerson, T.R., and Ochs, H.D. 2003. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr. Opin. Rheumatol. 15:430-435.
7. Brunkow, M.E., et al. 2001. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27:68-73.
8. Chatila, T.A., et al. 2000. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J. Clin. Invest. 106:R75-R81.
9. Wildin, R.S., et al. 2001. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 27:18-20.
10. Bennett, C.L., et al. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27:20-21.
11. Hori, S., Nomura, T., and Sakaguchi, S. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:1057-1061.
12. + regulatory T cells. Nat. Immunol. 4:330-336.
13. + T regulatory cells. Nat. Immunol. 4:337-342.
14. - T cells. J. Clin. Invest. 112:1437-1443. doi:10.1172/JCI200319441.
15. +CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167:188-195.
16. Apostolou, I., Sarukhan, A., Klein, L., and von Boehmer, H. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756-763.
17. Annacker, O., Burlen-Defranoux, O., Pimenta-Araujo, R., Cumano, A., and Bandeira, A. 2000. Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment. J. Immunol. 164:3573-3580.
18. + suppressor T cells in vivo. Nat. Immunol. 3:33-41.
19. - subpopulations. J. Immunol. 165:3105-3110.
20. + T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 196:1335-1346.
21. O'Garra, A., and Vieira, P., et al. 2003. Twenty-first century Foxp3. Nat. Immunol. 4:304-306.