Double-stranded secondary structures on mRNA induce type I interferon (IFN α/β) production and maturation of mRNA-transfected monocyte-derived dendritic cells

Journal of Gene Medicine

Volumn 7, Issue 4, 2005, Pages 452-465

  Ceppi, M ^a,b   Ruggli, N ^a   Tache, V ^a   Gerber, H ^a   McCullough, K C ^a   Summerfield, Artur ^a  

^a INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (Switzerland)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

DC activation; Dendritic cell; Gene therapy; mRNA transfection; Type I interferon

Indexed keywords

ALPHA INTERFERON; B7 ANTIGEN; BETA INTERFERON; CD86 ANTIGEN; DOUBLE STRANDED RNA; GREEN FLUORESCENT PROTEIN; LIPOSOME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; PROTEIN KINASE R; RHODAMINE;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL BASED GENE THERAPY; CELL MATURATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG MECHANISM; FLOW CYTOMETRY; GENE TRANSFER; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; IMMUNOMODULATION; IN VITRO STUDY; MONOCYTE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PREDICTION; PRIORITY JOURNAL; REPORTER GENE; RNA STRUCTURE; RNA TRANSCRIPTION; SWINE; UPREGULATION;

ANIMALS; DENDRITIC CELLS; FLOW CYTOMETRY; INTERFERON-ALPHA; INTERFERON-BETA; MICROSCOPY, CONFOCAL; NUCLEIC ACID CONFORMATION; RNA, MESSENGER; SWINE; TRANSFECTION;

ANIMALIA; SUIDAE;

EID: 17544382774     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jgm.685     Document Type: Article

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