Reduced brain tissue perfusion in TGF-β1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities

Neurobiology of Disease

Volumn 19, Issue 1-2, 2005, Pages 38-46

  Gaertner, Roger F ^a   Wyss Coray, Tony ^b   Von Euw, Dominique ^a   Lesné, Sylvain ^c   Vivien, Denis ^c   Lacombe, Pierre ^a,d  

^a CNRS   (France)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITÉ DE CAEN   (France)

^d INSERM   (France)

Author keywords

Cerebral amyloid angiopathy; Cerebral blood flow; Cerebral glucose utilization; Cytokine; TGF 1 transgenic mice; Thioflavin S

Indexed keywords

AMYLOID BETA PROTEIN; GLUCOSE; THIOFLAVINE; TRANSFORMING GROWTH FACTOR BETA1;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BLOOD FLOW; BLOOD VESSEL; BRAIN BLOOD FLOW; BRAIN TISSUE; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DENSITY; GENE OVEREXPRESSION; GLUCOSE BRAIN LEVEL; HIPPOCAMPUS; LIMBIC CORTEX; MOUSE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; THALAMUS NUCLEUS; TISSUE PERFUSION; TRANSGENIC MOUSE;

EID: 17444432287     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2004.11.008     Document Type: Article

References (49)

1. A.Y. Abramov, L. Canevari, and M.R. Duchen Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase J. Neurosci. 24 2004 565 575
2. N.C. Alonzo, B.T. Hyman, G.W. Rebeck, and S.M. Greenberg Progression of cerebral amyloid angiopathy: accumulation of amyloid-β40 in affected vessels J. Neuropathol. Exp. Neurol. 57 1998 353 359
3. H. Barelli, A. Lebeau, J. Vizzavona, P. Delaere, N. Chevallier, C. Drouot, P. Marambaud, K. Ancolio, J.D. Buxbaum, O. Khorkova, J. Heroux, S. Sahasrabudhe, J. Martinez, J.M. Warter, M. Mohr, and F. Checler Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long Aβ peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases Mol. Med. 3 1997 695 707
4. M.E. Calhoun, P. Burgermeister, A.L. Phinney, M. Stalder, M. Tolnay, K.H. Wiederhold, D. Abramowski, C. Sturchler-Pierrat, B. Sommer, M. Staufenbiel, and M. Jucker Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid Proc. Natl. Acad. Sci. U. S. A. 96 1999 14088 14093
5. C.S. Casley, J.M. Land, M.A. Sharpe, J.B. Clark, M.R. Duchen, and L. Canevari Beta-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons Neurobiol. Dis. 10 2002 258 267
6. R. Christie, M. Yamada, M. Moskowitz, and B. Hyman Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy Am. J. Pathol. 158 2001 1065 1071
7. R. Deane, S. Du Yan, R.K. Submamaryan, B. LaRue, S. Jovanovic, E. Hogg, D. Welch, L. Manness, C. Lin, J. Yu, H. Zhu, J. Ghiso, B. Frangione, A. Stern, A.M. Schmidt, D.L. Armstrong, B. Arnold, B. Liliensiek, P. Nawroth, F. Hofman, M. Kindy, D. Stern, and B. Zlokovic RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain Nat. Med. 7 2003 907 913
8. R.B. DeMattos, K.R. Bales, M. Parsadanian, M.A. O'Dell, E.M. Foss, S.M. Paul, and D.M. Holtzman Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease J. Neurochem. 81 2002 229 236
9. M.M. Esiri, Z. Nagy, M.Z. Smith, L. Barnetson, and A.D. Smith Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease Lancet 354 1999 919 920
10. E. Farkas, and P.G.M. Luiten Cerebral microvascular pathology in aging and Alzheimer's disease Prog. Neurobiol. 64 2001 575 611
11. K.C. Flanders, R.F. Ren, and C.F. Lippa Transforming growth factor-β in neurodegenerative disease Prog. Neurobiol. 54 1998 71 85
12. K.B.J. Franklin, and G. Paxinos The mouse brain in stereotaxic coordinates 1997 Academic Press San Diego
13. K.A. Hossmann The hypoxic brain. Insights from ischemia research Adv. Exp. Med. Biol. 474 1999 155 169
14. A.Y. Hsia, E. Masliah, L. McConlogue, G.Q. Yu, G. Tatsuno, K. Hu, D. Kholodenko, R.C. Malenka, R.A. Nicoll, and L. Mucke Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models Proc. Natl. Acad. Sci. U. S. A. 96 1999 3228 3233
15. C. Iadecola Neurovascular regulation in the normal brain and in Alzheimer's disease Nat. Rev., Neurosci. 5 2004 347 360
16. C. Iadecola, F. Zhang, K. Niwa, C. Eckman, S.K. Turner, E. Fischer, S. Younkin, D.R. Borchelt, K.K. Hsiao, and G.A. Carlson SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein Nat. Neurosci. 2 1999 157 161
17. T.M. Jay, G. Lucignani, A.M. Crane, J. Jehle, and L. Sokoloff Measurement of local cerebral blood flow with [14C]iodoantipyrine in the mouse J. Cereb. Blood Flow Metab. 8 1988 121 129
18. K. Kacem, P. Lacombe, J. Seylaz, and G. Bonvento Structural organization of the perivascular astrocyte endfeet and their relationship with the endothelial glucose transporter: a confocal microscopy study Glia 23 1998 1 10
19. R.N. Kalaria, and C. Ballard Overlap between pathology of Alzheimer disease and vascular dementia Alzheimer Dis. Assoc. Disord. 13 1999 S115 S123
20. J.A. Kleim, R. Bruneau, K. Calder, D. Pocock, P.M. VandenBerg, E. MacDonald, M.H. Monfils, R.J. Sutherland, and K. Nader Functional organization of adult motor cortex is dependent upon continued protein synthesis Neuron 40 2003 167 176
21. M. Koistinaho, M.I. Kettunen, G. Goldsteins, R. Keinänen, A. Salminen, M. Ort, J. Bures, D. Liu, R.A. Kauppinen, L.S. Higgins, and J. Koistinaho β-amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: role of inflammation Proc. Natl. Acad. Sci. U. S. A. 99 2002 1610 1615
22. S. Lesné, F. Docagne, C. Gabriel, G. Liot, D.K. Lahiri, L. Bu'e, L. Plawinski, A. Delacourte, E.T. MacKenzie, A. Buisson, and D. Vivien Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice J. Biol. Chem. 278 2003 18408 18418
23. E. Masliah, M. Alford, M. Mallory, E. Rockenstein, D. Moechars, and F. Van Leuven Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice Exp. Neurol. 163 2000 381 387
24. D. Moechars, I. Dewachter, K. Lorent, D. Reverse, V. Baekelandt, A. Naidu, I. Tesseur, K. Spittaels, C. Van Den Haute, F. Checler, E. Godaux, B. Cordell, and F. Van Leuven Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain J. Biol. Chem. 274 1999 6483 6492
25. K. Niwa, L. Younkin, C. Ebeling, S.K. Turner, D. Westaway, S. Younkin, K.H. Ashe, G.A. Carlson, and C. Iadecola Aβ1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation Proc. Natl. Acad. Sci. U. S. A. 97 2000 9735 9740
26. K. Niwa, K. Kazama, S. Younkin, G.A. Carlson, and C. Iadecola Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein Neurobiol. Dis. 9 2002 61 68
27. D. Paris, J. Humphrey, A. Quadros, N. Patel, R. Crescentini, F. Crawford, and M. Mullan Vasoactive effects of Abeta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammation Neurol. Res. 6 2003 642 651
28. L. Park, J. Anrather, C. Forster, K. Kazama, G.A. Carlson, and C. Iadecola Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex J. Cereb. Blood Flow Metab. 24 2004 334 342
29. L. Pellerin, and P.J. Magistretti Food for thought: challenging the dogmas J. Cereb. Blood Flow Metab. 23 2003 1282 1286
30. E.M. Reiman, R.J. Caselli, K. Chen, G.E. Alexander, D. Bandy, and J. Frost Declining brain activity in cognitively normal apolipoprotein ε4 heterozygotes: a foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease Proc. Natl. Acad. Sci. U. S. A. 98 2001 3334 3339
31. H.L. Scott, D.V. Pow, A.E.G. Tannenberg, and P.R. Dodd Aberrant expression of the glutamate transporter EAAT1 in Alzheimer's disease J. Neurosci. 22 RC206 2002 1 5
32. M. Simard, G. Arcuino, T. Takano, Q.S. Liu, and M. Nedergaard Signaling at the gliovascular interface J. Neurosci. 23 2003 9254 9262
33. J.D. Sipe, and A.S. Cohen Review: history of the amyloid fibril J. Struct. Biol. 130 2000 88 98
34. I. Skoog, R.N. Kalaria, and M.M.B. Breteler Vascular factors and Alzheimer disease Alzheimer Dis. Assoc. Disord. 13 1999 S106 S114
35. G.W. Small, L.M. Ercoli, D.H. Silverman, S.C. Huang, S. Komo, S.Y. Bookheimer, H. Lavretsky, K. Miller, P. Siddarth, N.L. Rasgon, J.C. Mazziotta, S. Saxena, H.M. Wu, M.S. Mega, J.L. Cummings, A.M. Saunders, M.A. Pericak-Vance, A.D. Roses, J.R. Barrio, and M.E. Phelps Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease Proc. Natl. Acad. Sci. U. S. A. 97 2000 6037 6042
36. L. Sokoloff Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose J. Cereb. Blood Flow Metab. 1 1981 7 36
37. T. Thomas, G. Thomas, C. McLendon, T. Sutton, and M. Mullan beta-Amyloid-mediated vasoactivity and vascular endothelial damage Nature 380 1996 168 171
38. J. Van Dorpe, L. Smeijers, I. Dewachter, D. Nuyens, K. Spittaels, C. Van Den Haute, M. Mercken, D. Moechars, I. Laenen, C. Kuiperi, K. Bruynseels, I. Tesseur, R. Loos, H. Vanderstichele, F. Checler, R. Sciot, and F. Van Leuven Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons Am. J. Pathol. 157 2000 1283 1298
39. E. Vaucher, J. Borredon, G. Bonvento, J. Seylaz, and P. Lacombe Autoradiographic evidence for flow-metabolism uncoupling during stimulation of the nucleus basalis of Meynert in the conscious rat J. Cereb. Blood Flow Metab. 17 1997 686 694
40. H.V. Vinters, Z.Z. Wang, and D.L. Secor Brain parenchymal and microvascular amyloid in Alzheimer's disease Brain Pathol. 6 1996 179 195
41. R.O. Weller, A. Massey, T.A. Newman, M. Hutchings, Y.M. Kuo, and A.E. Roher Cerebral amyloid angiopathy-Amyloid β accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease Am. J. Pathol. 153 1998 725 733
42. D.T. Winkler, L. Bondolfi, M.C. Herzig, L. Jann, M.E. Calhoun, K.H. Wiederhold, M. Tolnay, M. Staufenbiel, and M. Jucker Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy J. Neurosci. 21 2001 1619 1627
43. T. Wyss-Coray, E. Masliah, M. Mallory, L. McConlogue, K. Johnson-Wood, C. Lin, and L. Mucke Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease Nature 389 1997 603 606
44. T. Wyss-Coray, C. Lin, D.A. Sanan, L. Mucke, and E. Masliah Chronic overproduction of TGF-β1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice Am. J. Pathol. 156 2000 139 150
45. T. Wyss-Coray, C. Lin, D. Von Euw, E. Masliah, L. Mucke, and P. Lacombe Alzheimer's disease-like cerebrovascular pathology in TGF-β1 transgenic mice and functional metabolic correlates Ann. N. Y. Acad. Sci. 903 2000 317 323
46. T. Wyss-Coray, J.D. Loike, T.C. Brionne, E. Lu, R. Anankov, F. Yan, S.C. Silverstein, and J. Husemann Adult mouse astrocytes degrade amyloid-beta in vitro and in situ Nat. Med. 9 2003 453 457
47. J. Xu, S.W. Chen, G. Ku, S.H. Ahmed, J.M. Xu, H. Chen, and C.Y. Hsu Amyloid-β peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation J. Cereb. Blood Flow Metab. 21 2001 702 710
48. D. Zekry, C. Duyckaerts, R. Moulias, J. Belmin, C. Geoffre, F. Herrmann, and J.J. Hauw Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly Acta Neuropathol. 103 2002 481 487
49. F.Y. Zhang, C. Eckman, S. Younkin, K.K. Hsiao, and C. Iadecola Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein J. Neurosci. 17 1997 7655 7661