The hypoxic brain: Insights from ischemia research

Advances in Experimental Medicine and Biology

Volumn 474, Issue , 2000, Pages 155-169

  Hossmann, K A ^a  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

Delayed neuronal death; Endoplasmic reticulum; Ischemia; Penumbra; Protein synthesis; Selective vulnerability; Threshold concept

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE; ADENOSINE TRIPHOSPHATE; DOPAMINE; GENE PRODUCT; GLYCINE; MESSENGER RNA; NEUROTRANSMITTER; SEROTONIN;

ALTITUDE; ANIMAL MODEL; BRAIN BLOOD FLOW; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN OXYGEN CONSUMPTION; CAUDATE NUCLEUS; CONFERENCE PAPER; ENDOPLASMIC RETICULUM; ENERGY METABOLISM; HIPPOCAMPUS; NERVE CELL NECROSIS; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; THALAMUS NUCLEUS;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; HUMANS; HYPOXIA, BRAIN; REGIONAL BLOOD FLOW;

ANIMALIA;

EID: 0034465081     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (89)

1. Arachidonic acid metabolism in ischemic neuronal damage
2. 31P NMR spectroscopy
3. + at critical levels of brain ischemia
4. + at critical levels of brain ischemia
5. Thresholds in cerebral ischemia - The ischemic penumbra
6. Diffusion nuclear magnetic resonance imaging in experimental stroke. Correlation with cerebral metabolites
7. Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression - Effect on blood flow, tissue oxygenation, and electroencephalogram
8. Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic-resonance microscopy
9. Extracellular potassium activity, evoked potential and tissue blood flow. Relationships during progressive ischaemia in baboon cerebral cortex
10. Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon
11. Can diffusion-weighted magnetic-resonance-imaging detect critical cerebral blood-flow thresholds and energy failure during cerebral-ischemia?
12. Glutamate neurotoxicity in cortical cell culture is calcium dependent
13. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death
14. Global brain ischemia and reperfusion: Modifications in eukaryotic initiation factors associated with inhibition of translation initiation
15. Protein synthesis in the hippocampal slice: Transient inhibition by glutamate and lasting inhibition by ischemia
16. Relation of neuronal endoplasmic reticulum calcium homeostasis to ribosomal aggregation and protein synthesis - Implications for stress-induced suppression of protein synthesis
17. Very delayed infarction after mild focal cerebral ischemia: A role for apoptosis?
18. Cerebral ischemia: Pharmacological bases of drug therapy
19. Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation
20. Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia
21. Regulation of cerebral circulation
22. Extracellular pH, potassium, and calcium activities in progressive ischaemia of rat cortex
23. Changes in extracellular calcium activity in cerebral ischaemia
24. Differential expression of c-fos and hsp72 mRNA in focal cerebral ischemia of mice
25. Cortical neuronal function during ischemia. Effects of occlusion of one middle cerebral artery on single-unit activity in cats
26. Functional recovery of cortical neurons as related to degree and duration of ischemia
27. Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: The relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances
28. Viability thresholds and the penumbra of focal ischemia
29. Reperfusion of the brain after global ischemia - Hemodynamic disturbances
30. Glutamate-mediated injury in focal cerebral ischemia - The excitotoxin hypothesis revised
31. Disturbances of cerebral protein synthesis and ischemic cell death
32. Periinfarct depolarizations
33. Diffusion and perfusion MR imaging of cerebral ischemia
34. Recovery of integrative central nervous function after one hour global cerebro-circulatory arrest in normothermic cat
35. Experimental brain infarcts in cats. I. Pathophysiological observations
36. Morphometric evaluation of post-ischemic capillary perfusion in selectively vulnerable areas of gerbil brain
37. 2+ of N-methyl-D-aspartate-activated channels
38. Thresholds of focal cerebral ischemia in awake monkeys
39. Neuroprotective effects of glutamate antagonists and extracellular acidity
40. CBF thresholds for mRNA and protein synthesis after focal ischemia and the effect of MK-801
41. Delayed neuronal death in the gerbil hippocampus following ischemia
42. 31P NMR-spectroscopy and laser-Doppler flowmetry of rat brain during global-ischemia and reperfusion
43. Relationship between diffusion-weighted magnetic resonance MR images, cerebral blood flow and energy state in experimental brain infarction
44. Altered gene expression in brain ischemia
45. Evaluation of monoaminergic neurotransmitters in the rat striatum during varied global cerebral ischemia
46. Suppression of protein synthesis in the reperfused brain
47. Calcium-related damage in ischemia
48. Ischemic penumbra and neuronal death: Comments on the therapeutic window in acute stroke with particular reference to thrombolytic therapy
49. Apoptosis and protein expression after focal cerebral ischemia in rat
50. Kappa receptor agonist (Ci-977) inhibits glutamate release in the focal ischaemic penumbra
51. DNA damage consistent with apoptosis in transient focal ischaemic neocortex
52. Gene expression induced by cerebral ischemia - An apoptotic perspective
53. The stress gene response in brain
54. Flow thresholds for extracellular purine catabolite elevation in cat focal ischemia
55. Elevation of neuroactive substances in the cortex of cats during prolonged focal ischemia
56. Cortical impedance and extracellular volume changes following middle cerebral artery occlusion in cats
57. Brain tissue osmolality after middle cerebral artery occlusion in cats
58. Flow and neuronal density in tissue surrounding chronic infarction
59. Correlation between periinfarct dc shifts and ischemic neuronal damage in rat
60. Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion in rat
61. Regional cerebral blood flow thresholds during cerebral ischemia
62. Early detection of regional cerebral ischemia in cats: Comparison of diffusion- and T2-weighted MRI and spectroscopy
63. Upregulation of c-myc gene expression following focal ischemia in the rat brain
64. 23Na nuclear magnetic resonance spectroscopy
65. Regulation of heat shock genes by ischemia
66. Brain tissue concentrations of ATP, phosphocreatine, lactate, and tissue pH in relation to reduced cerebral blood flow following experimental acute middle cerebral artery occlusion
67. Extracellular neuroactive amino-acids in the rat striatum during ischemia - Comparison between penumbral conditions and ischemia with sustained anoxic depolarization
68. Disturbances of calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic cell damage
69. Effects of transient cerebral ischemia on hsp40 mRNA levels in rat brain
70. Threshold relationship between cerebral blood-flow, glucose-utilization, and energy metabolites during development of stroke in gerbils
71. Glutamate antagonists in therapy of stroke
72. Temporal profile of neuronal damage in a model of transient forebrain ischemia
73. Experimental brain infarcts in cats. II. Ischemic brain edema
74. Correlation of continuous electroencephalograms with cerebral blood flow measurements during carotid endarterectomy
75. Differences in ischemia-induced accumulation of amino acids in the cat cortex
76. Ischemic flow threshold for extracellular glutamate increase in cat cortex
77. Mechanisms of secondary brain injury
78. Zur pathogenese örtlich elektiver gehirnveränderungen
79. The effects of 5-minute ischemia in mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus
80. The concepts of thresholds of ischaemia in relation to brain structure and function
81. Changes in amino acid neurotransmitters and cerebral blood flow in the ischemic penumbral region following middle cerebral artery occlusion in the rat - Correlation with histopathology
82. Effect of hyperthermia on glutamate release in ischemic penumbra after middle cerebral artery occlusion in rats
83. 14C)iodoantipyrine autoradiography following middle cerebral artery occlusion
84. Recovery of the subhuman primate after deep cerebral hypothermia and prolonged ischaemia
85. (14C)leucine incorporation into brain proteins in gerbils after transient ischemia: Relationship to selective vulnerability of hippocampus
86. In situ hybridization of mRNA expression for IP3 receptor and IP3-3-kinase in rat brain after transient focal cerebral ischemia