Progression of cerebral amyloid angiopathy: Accumulation of amyloid- β40 in affected vessels

Journal of Neuropathology and Experimental Neurology

Volumn 57, Issue 4, 1998, Pages 353-359

  Alonzo, Norma C ^a   Hyman, Bradley T ^a   Rebeck, G William ^a   Greenberg, Steven M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Aging; Amyloid; Apolipoprotein E; Hemorrhage; Stroke

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E4;

AGED; AMYLOIDOSIS; ARTICLE; BLOOD VESSEL RUPTURE; CEREBROVASCULAR DISEASE; CONFOCAL MICROSCOPY; DISEASE ASSOCIATION; DISEASE SEVERITY; DOSE RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS;

EID: 0031942889     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199804000-00008     Document Type: Article

References (46)

1. Vinters HV. Cerebral amyloid angiopathy. A critical review. Stroke 1987;18:311-24
2. Kase CS. Cerebral amyloid angiopathy. In: Kase CS, Caplan LR, ed. Intracerebral hemorrhage. Boston: Butterworth-Heinemann 1994:179-200
3. Vonsattel JP, Myers RH, Hedley-Whyte ET, Ropper AH, Bird ED, Richardson EP. Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study. Ann Neurol 1991;30:637-49
4. Iwamoto N, Ishihara T, Ito H, Uchino F. Morphological evaluation of amyloid-laden arteries in leptomeninges, cortices and subcortices in cerebral amyloid angiopathy with subcortical hemorrhage. Acta Neuropathol 1993;86:418-21
5. Maggio JE, Mantyh PW. Brain amyloid - A physicochemical perspective. Brain Pathology 1996;6:147-62
6. Jarrett JT, Berger EP, Lansbury PT. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease. Biochem 1993;32:4693-97
7. Motter R, Vigo-Pelfrey C, Kholodenko D, et al. Reduction of betaamyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol 1995;38:643-48
8. Graff-Radford NR, Eckman C, Younkin S. Amyloid B protein in plasma of Alzheimer's disease patients and controls. Neurology 1996;46:A161
9. Kosaka T, Imagawa M, Seki K, et al. The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta42(43). Neurology 1997;48:741-45
10. Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is A beta 42(43). Neuron 1994;13:45-53
11. Murphy GMJ, Forno LS, Higgins L, Scardina JM, Eng LE Cordell B. Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders. Am J Pathol 1994;144:1082-88
12. Gravina SA, Ho LB, Eckman CB, et al. Amyloid beta protein (a-beta) in Alzheimers disease brain - Biochemical and immunocytochemical analysis with antibodies specific for forms ending at a-beta-40 or a-beta-42(43). J Biol Chem 1995;270:7013-16
13. Iwatsubo T, Mann DM, Odaka A, Suzuki N, Ihara Y. Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome. Ann Neurol 1995;37:294-99
14. Mann DM, Iwatsubo T. Diffuse plaques in the cerebellum and corpus striatum in Down's syndrome contain amyloid beta protein (A beta) only in the form of A beta 42(43). Neurodegeneration 1996;5:115-20
15. Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-72
16. Schmechel DE, Saunders AM, Strittmatter WJ, et al. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 1993;90:9649-53
17. Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron 1993;11:575-80
18. Polvikoski T, Sulkava R, Haltia M, et al. Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein. N Engl J Med 1995;333:1242-47
19. Gearing M, Mori H, Mirra SS. Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease. Ann Neurol 1996;39:395-99
20. Mann DM, Iwatsubo T, Pickering-Brown SM, Owen F, Saido TC, Perry RH. Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele. Neurosci Lett 1997;221:81-84
21. Ishii K, Tamaoka A, Mizusawa H, et al. Abeta 1-40 but not Abeta 1-42 levels in cortex correlate with apolipoprotein E epsilon4 allele dosage in sporadic Alzheimer's disease. Brain Res 1997;748:250-52
22. Verbeek MM, Eikelenboom P, de Waal RM. Differences between the pathogenesis of senile plaques and congophilic angiopathy in Alzheimer disease. J Neuropathol Exp Neurol 1997;56:751-61
23. Mak K, Yang F, Vinters HV, Frautschy SA, Cole GM. Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum. Brain Res 1994;667:138-42
24. Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid β-peptides and APO E in Down syndrome. Implications for initial events in amyloid plaque formation. Neurobiol Disease 1996;3:16-32
25. Castano EM, Prelli F, Soto C, et al. The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease. J Biol Chem 1996;271:32185-91
26. Mann DM, Iwatsubo T, Ihara Y, et al. Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. Am J Pathol 1996;148:1257-66
27. Suzuki N, Cheung TT, Cai XD, et al. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 1994;264:1336-40
28. Greenberg SM, Rebeck GW, Vonsattel JPV, Gomez-Isla T, Hyman BT. Apolipoprotein E e4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol 1995;38:254-59
29. Premkumar DR, Cohen DL, Hedera P, Friedland RR, Kalaria RN. Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol 1996;148:2083-95
30. Olichney JM, Hansen LA, Galasko D, et al. The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant. Neurology 1996;47:190-96
31. Nicoll JA, Burnett C, Love S, et al. High frequency of apolipoprotein E epsilon 2 allele in hemorrhage due to cerebral amyloid angiopathy. Ann Neurol 1997;41:716-21
32. Greenberg SM, Vonsattel J-PG, Segal AZ, et al. Association of apolipoprotein E e2 and vasculopathy in cerebral amyloid angiopathy. Neurology 1998. Forthcoming.
33. Vonsattel J-PG, Aizawa H, Ge P, et al. An improved approach to prepare human brains for research. J Neuropathol Exp Neurol 1995;54:42-56
34. Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991;41:479-86
35. Gomez-Isla T, Wasco W, Pettingell WP, et al. A novel presenilin-1 mutation: Increased beta-amyloid and neurofibrillary changes. Ann Neurol 1997;41:809-13
36. Cuzick J. A Wilcoxon-type test for trend. Stat Med 1985;4:87-90
37. Surbek B. L'angiopathie dyshorique (Morel) de l'ecorce cerebrale. Acta Neuropathol 1961;1:168-97
38. Kalaria RN, Premkumar DR, Pax AB, Cohen DL, Lieberburg I. Production and increased detection of amyloid beta protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in alzheimers disease. Molecular Brain Research 1996;35:58-68
39. Shinkai Y, Yoshimura M, Ito Y, et al. Amyloid β-proteins 1-40 and 1-42(43) in the soluble fraction of extra- and intracranial blood vessels. Ann Neurol 1995;38:421-28
40. Esler WP, Stimson ER, Ghilardi JR, et al. In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics. Biochem 1996;35:749-57
41. Vinters HV, Secor DL, Read SL, et al. Microvasculature in brain biopsy specimens from patients with Alzheimer's disease: An immunohistochemical and ultrastructural study. Ultrastruc Pathol 1994;18:333-48
42. Prior R, Durso D, Frank R, Prikulis I, Pavlakovic G. Loss of vessel wall viability in cerebral amyloid angiopathy. Neuroreport 1996;7:562-64
43. Mandybur TI. Cerebral amyloid angiopathy: The vascular pathology and complications. J Neuropathol Exp Neurol 1986;45:79-90
44. Maeda A, Yamada M, Itoh Y, Otomo E, Hayakawa M, Miyatake T. Computer-assisted three-dimensional image analysis of cerebral amyloid angiopathy. Stroke 1993;24:1857-64
45. Yamada M, Itoh Y, Shintaku M, et al. Immune reactions associated with cerebral amyloid angiopathy. Stroke 1996;27:1155-62
46. Maat-Schieman ML, van Duinen SG, Rozemuller AJ, Haan J, Roos RA. Association of vascular amyloid beta and cells of the mononuclear phagocyte system in hereditary cerebral hemorrhage with amyloidosis (Dutch) and Alzheimer disease. J Neuropathol Exp Neurol 1997;56:273-84