Inhibition of PARS attenuates endotoxin-induced dysfunction of pulmonary vasorelaxation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 277, Issue 4 21-4, 1999, Pages

  Pulido, Edward J ^a   Shames, Brian D ^a   Selzman, Craig H ^a   Barton, Hazel A ^a   Banerjee, Anirban ^a   Bensard, Denis D ^b   McIntyre Jr , Robert C ^a,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

3 aminobenzamide; Myeloperoxidase; Nicotinamide; Poly(ADP ribose) synthase; Pulmonary artery

Indexed keywords

3 AMINOBENZAMIDE; MYELOPEROXIDASE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG BLOOD VESSEL; LUNG INJURY; PHOSPHATE METABOLISM; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0032734399     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.277.4.l769     Document Type: Article

References (42)

1. Andreoli, S. P. Mechanisms of endothelial cell ATP depletion after oxidant injury. Pediatr. Res. 25: 97-101, 1989.
2. Banasik, M., H. Komura, M. Shimoyama, and K. Ueda. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J. Biol. Chem. 267: 1569-1575, 1992.
3. Barmann, T. E. Enzyme Handbook. New York: Springer-Verlag, 1969, vol. I, p. 234-236.
4. Beckman, J. S., T. W. Beckman, J. Chen, P. A. Marshall, and B. A. Freeman. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87: 1620-1624, 1990.
5. Beckman, J. S., and W. H. Koppenol. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am. J. Physiol. 271 (Cell Physiol. 40): C1424-C1437, 1996.
6. Chabot, F., J. A. Mitchell, G. J. Quinlan, and T. W. Evans. Characterization of the vasodilator properties of peroxynitrite on rat pulmonary artery: role of poly (adenosine 5′-diphosphoribose) synthase. Br. J. Pharmacol. 121: 485-490, 1997.
7. Chang, S. W., C. O. Feddersen, P. M. Henson, and N. F. Voelkel. Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats. J. Clin. Invest. 79: 1498-1509, 1987.
8. Cuzzocrea, S., A. P. Caputi, and B. Zingarelli. Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy. Immunology 93: 96-101, 1998.
9. Fullerton, D. A., R. C. McIntyre, A. R. Hahn, J. Agrafojo, K. Koike, X. Meng, A. Banerjee, and A. H. Harken. Dysfunction of cGMP-mediated pulmonary vasorelaxation in endotoxin-induced acute lung injury. Am. J. Physiol. 268 (Lung Cell. Mol. Physiol. 12): L1029-L1035, 1995.
10. Hauschildt, S., P. Scheipers, W. G. Bessler, and A. Mulsch. Induction of nitric oxide synthase in L929 cells by tumournecrosis factor alpha is prevented by inhibitors of poly(ADP-ribose) polymerase. Biochem. J. 288: 255-260, 1992.
11. Heller, B., Z. Q. Wang, E. F. Wagner, J. Radons, A. Burkle, K. Fehsel, V. Burkart, and H. Kolb. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells. J. Biol. Chem. 270: 11176-11180, 1995.
12. Ischiropoulos, H., L. Zhu, and J. S. Beckman. Peroxynitrite formation from macrophage-derived nitric oxide. Arch. Biochem. Biophys. 298: 446-451, 1992.
13. Kilbourn, R. G., and O. W. Griffith. Overproduction of nitric oxide in cytokine-mediated and septic shock. J. Natl. Cancer Inst. 84:827-831, 1992.
14. Kirkland, J. B. Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymerase. Biochim. Biophys. Acta 1092: 319-325, 1991.
15. Kooy, N. W., J. A. Royall, Y. Z. Ye, D. R. Kelly, and J. S. Beckman. Evidence for in vivo peroxynitrite production in human acute lung injury. Am. J. Respir. Crit. Care Med. 151: 1250-1254, 1995.
16. Kurrek, M. M., W. M. Zapol, A. Holzmann, G. Filippov, M. Winkler, and K. D. Bloch. In vivo lipopolysaccharide pretreatment inhibits cGMP release from the isolated-perfused rat lung. Am. J. Physiol. 269 (Lung Cell. Mol. Physiol. 13): L618-L624, 1995.
17. Lefer, D. J., R. Scalia, B. Campbell, T. Nossuli, R. Hayward, M. Salamon, J. Grayson, and A. M. Lefer. Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats. J. Clin. Invest. 99: 684-691, 1997.
18. McIntyre, R. C., Jr., B. Sheridan, J. Agrafojo, and D. A. Fullerton. Endotoxin differentially impairs cyclic guanosine monophosphate-mediated relaxation in the pulmonary and systemic circulations. Crit. Care Med. 25: 318-323, 1997.
19. Meisterernst, M., G. Stelzer, and R. G. Roeder. Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitro. Proc. Natl. Acad. Sci. USA 94: 2261-2265, 1997.
20. Rodman, D. M., J. Mallet, and I. F. McMurtry. Difference in effect of inhibitors of energy metabolism on endothelium-dependent relaxation of rat pulmonary artery and aorta. Am. J. Respir. Cell Mol. Biol. 4: 237-242, 1991.
21. Roitt, I. The inhibition of carbohydrate metabolism in ascites-tumour cells by ethylenimines. Biochem. J. 63: 300-307, 1956.
22. Said, S. I., H. I. Berisha, and H. Pakbaz. Excitotoxicity in the lung: N-methyl-D-aspartate-induced, nitric oxide-dependent pulmonary edema is attenuated by vasoactive intestinal peptide and by inhibitors of poly(ADP-ribose) polymerase. Proc. Natl. Acad. Sci. USA 93: 4688-4692, 1996.
23. Schraufstatter, I. U., D. B. Hinshaw, P. A. Hyslop, R. G. Spragg, and C. G. Cochrane. Oxidant injury of cells: DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J. Clin. Invest. 77: 1312-1320, 1986.
24. Sheridan, B. C., R. C. McIntyre, J. Agrafojo, D. R. Meldrum, X. Meng, and D. A. Fullerton. Neutrophil depletion attenuates endotoxin-induced dysfunction of cGMP-mediated pulmonary vasorelaxation. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L820-L828, 1996.
25. Spath, J. A. J., P. J. Sloane, M. H. Gee, and K. H. Albertine. Loss of endothelium-dependent vasodilation in the pulmonary vessels of sheep after prolonged endotoxin. J. Appl. Physiol. 76: 361-369, 1994.
26. Szabo, A., A. L. Salzman, and C. Szabo. Poly (ADP-ribose) synthetase activation mediates pulmonary microvascular and intestinal mucosal dysfunction in endotoxin shock. Life Sci. 63: 2133-2139, 1998.
27. Szabo, C., S. Cuzzocrea, B. Zingarelli, M. O'Connor, and A. L. Salzman. Endothelial dysfunction in a rat model of endotoxic shock: importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite. J. Clin. Invest. 100: 723-735, 1997.
28. Szabo, C., and V. L. Dawson. Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol. Sci. 19: 287-298, 1998.
29. Szabo, C., L. H. Lim, S. Cuzzocrea, S. J. Getting, B. Zingarelli, R. J. Flower, A. L. Salzman, and M. Perretti. Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects. J. Exp. Med. 186: 1041-1049, 1997.
30. Szabo, C., C. Saunders, M. O'Connor, and A. L. Salzman. Peroxynitrite causes energy depletion and increases permeability via activation of poly (ADP-ribose) synthetase in pulmonary epithelial cells. Am. J. Respir. Cell Mol. Biol. 16: 105-109, 1997.
31. Szabo, C., B. Zingarelli, M. O'Connor, and A. L. Salzman. DNA strand breakage, activation of poly(ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc. Natl. Acad. Sci. USA 93: 1753-1758, 1996.
32. Szabo, C., B. Zingarelli, and A. L. Salzman. Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ. Res. 78: 1051-1063, 1996.
33. Thiemermann, C., J. Bowes, F. P. Myint, and J. R. Vane. Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc. Natl. Acad. Sci. USA 94: 679-683, 1997.
34. Wizemann, T. M., C. R. Gardner, J. D. Laskin, S. S. Quinones, S. K. Durham, N. L. Goller, S. T. Ohnishi, and D. L. Laskin. Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia. J. Leukoc. Biol. 56: 759-768, 1994.
35. Wizemann, T. M., and D. L. Laskin. Enhanced phagocytosis, chemotaxis, and production of reactive oxygen intermediates by interstitial lung macrophages following acute endotoxemia. Am. J. Respir. Cell Mol. Biol. 11: 358-365, 1994.
36. Wray, G. M., C. J. Hinds, and C. Thiemermann. Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin. Shock 10: 13-19, 1998.
37. Wu, M., K. A. Pritchard, P. M. Kaminski, R. P. Fayngersh, T. H. Hintze, and M. S. Wolin. Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H2108-H2113, 1994.
38. Zingarelli, B., S. Cuzzocrea, Z. Zsengeller, A. L. Salzman, and C. Szabo. Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Cardiovasc. Res. 36: 205-215, 1997.
39. Zingarelli, B., B. J. Day, J. D. Crapo, A. L. Salzman, and C. Szabo. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br. J. Pharmacol. 120: 259-267, 1997.
40. Zingarelli, B., M. O'Connor, H. Wong, A. L. Salzman, and C. Szabo. Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depeletion in macrophages stimulated with bacterial lipopolysaccharide. J. Immunol. 156: 350-358, 1996.
41. Zingarelli, B., A. L. Salzman, and C. Szabo. Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: potential involvement of polyADP ribosyl synthetase. Shock 5: 258-264, 1996.
42. Zingarelli, B., A. L. Salzman, and C. Szabo. Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ. Res. 83: 85-94, 1998.