Recent findings on the genetic basis of bipolar disorder

Psychiatric Clinics of North America

Volumn 28, Issue 2, 2005, Pages 481-498

  Payne, Jennifer L ^a   Potash, James B ^a   DePaulo Jr , J Raymond ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; SEROTONIN TRANSPORTER;

ALZHEIMER DISEASE; ANXIETY DISORDER; BIPOLAR DISORDER; BIPOLAR II DISORDER; CLINICAL TRIAL; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST; DISEASE ASSOCIATION; DISEASE COURSE; ENVIRONMENTAL FACTOR; EVOKED RESPONSE; FOLLOW UP; GENE INTERACTION; GENE LOCUS; GENE MUTATION; GENETIC HETEROGENEITY; GENETIC IDENTIFICATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEALTH CARE; HUMAN; MEDICAL PRACTICE; MEDICAL TECHNOLOGY; MENTAL DISEASE; META ANALYSIS; MOLECULAR BIOLOGY; MONOZYGOTIC TWINS; MOOD DISORDER; NEUROPHARMACOLOGY; PANIC; PATHOGENICITY; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROBABILITY; PSYCHOSIS; REVIEW; SCHIZOPHRENIA; STATISTICAL ANALYSIS; STRESS;

EID: 17044404967     PISSN: 0193953X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psc.2005.01.003     Document Type: Review

References (131)

1. F.K. Goodwin, and K.R. Jamison Manic-depressive illness 1990 Oxford University Press New York p. 938
2. N. Craddock, and I. Jones Genetics of bipolar disorder J Med Genet 36 1999 585 594
3. J.B. Potash, and J.R. DePaulo Jr. Searching high and low: a review of the genetics of bipolar disorder Bipolar Disord 2 2000 8 26
4. J.W. Smoller, and C.T. Finn Family, twin and adoption studies of bipolar disorder Am J Med Genet 123C 2003 48 58
5. D. Botstein, R.L. White, and M. Skolnick Construction of a genetic linkage map in man using restriction fragment length polymorphisms Am J Hum Genet 32 1980 314 331
6. J.L. Weber, and P.E. May Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction Am J Hum Genet 44 1989 388 396
7. T.G. Schulze, and F.J. McMahon Genetic linkage and association studies in bipolar affective disorder: a time for optimism Am J Hum Genet 123C 2003 36 47
8. E. Lander, and L. Kruglyak Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results Nat Genet 11 1995 241 247
9. J.C. Venter, M.D. Adams, and E.W. Myers The sequence of the human genome Science 291 2001 1304 1351
10. H. Coon, S. Jensen, and M. Hoff A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance Am J Hum Genet 52 6 1993 1234 1249
11. S. Cichon, J. Schumacher, and D.J. Muller A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 18q Hum Mol Genet 10 25 2001 2933 2944
12. D. Avramopoulos, V.L. Willour, and P.P. Zandi Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis Mol Psychiatry 9 2004 191 196
13. G. Turecki, P. Grof, and E. Grof Mapping susceptibility genes for bipolar disorder: a pharmacogenetic approach based on excellent response to lithium Mol Psychiatry 6 5 2001 570 578
14. M. Maziade, M.A. Roy, and E. Rouillard A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes Mol Psychiatry 6 6 2001 684 693
15. R.E. Straub, T. Lehner, and Y. Luo A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3 Nat Genet 8 1994 291 296
16. J. Liu, S.H. Juo, and J.D. Terwilliger A follow-up linkage study supports evidence for a bipolar affective disorder locus on chromosome 21q22 Am J Med Genet 105 2 2001 189 194
17. J.R. Kelsoe, M.A. Spence, and E. Loetscher A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22 Proc Natl Acad Sci U S A 98 2 2001 585 590
18. D.H. Blackwood, L. He, and S.W. Morris A locus for bipolar affective disorder on chromosome 4p Nat Genet 12 1996 427 430
19. L.J. Adams, P.B. Mitchell, and S.L. Fielder A susceptibility locus for bipolar affective disorder on chromosome 4q35 Am J Hum Genet 62 1998 1084 1091
20. M.G. McInnis, D.M. Dick, and V.L. Willour Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health Genetics Initiative bipolar pedigrees Biol Psychiatry 54 2003 1265 1273
21. J. Morissette, A. Villeneuve, and L. Bordeleau Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to a locus of major effect on chromosome 12q23-q24 Am J Med Genet 88 1999 567 587
22. Shink E, Morissette J, Sherrington R, Barden N. A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12. Mol Psychiatry 2004 Oct 19; [Epub ahead of print].
23. S.D. Detera-Wadleigh, and J.A. Badner A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2 Proc Natl Acad Sci U S A 96 1999 5604 5609
24. C. Liu, J.A. Badner, and S.L. Christian Fine mapping supports previous linkage evidence for a bipolar disorder susceptibility locus on 13q32 Am J Med Genet 105 2001 375 380
25. H.J. Edenberg, T. Foroud, and M. Conneally Initial genomic scan of the NIMH Genetics Initiative bipolar pedigrees: chromosomes 3, 5, 15, 16, 17 and 22 Am J Med Genet 74 1997 238 246
26. W.H. Berrettini, T.N. Ferraro, and L.R. Goldin Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene Proc Natl Acad Sci U S A 91 1994 5918 5921
27. S.G. Schwab, J. Hallmayer, and B. Lerer Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis Am J Hum Genet 63 1998 1139 1152
28. O.C. Stine, J. Xu, and R. Koskela Evidence for linkage of bipolar disorder to chromosome 18 with parent-of-origin effect Am J Hum Genet 57 1995 1384 1394
29. F.J. McMahon, P.J. Hopkins, and J. Xu Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series Am J Hum Genet 61 1997 1397 1404
30. P. Bennett, R. Segurado, and I. Jones The Wellcome trust UK-Iris bipolar affective disorder sibling-pair genome screen: first stage report Mol Psychiatry 7 2002 189 200
31. Pekkarinen P, Terwilliger J, Bredbacka PE, et al. Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree. Genome Res 1995;5:105-15.
32. O.C. Stine, F.J. McMahon, and L. Chen Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: chromosomes 2,11,13,14, and X Am J Med Genet 74 1997 263 269
33. J.A. Badner, and E.S. Gershon Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia Mol Psychiatry 7 4 2002 405 411
34. R. Sequardo, S.D. Detera-Wadleigh, and D.F. Levinson Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder Am J Hum Genet 73 2003 49 62
35. J.R. DePaulo Genetics of bipolar disorder: where do we stand? Am J Psychiatry 161 2004 595 597
36. W. Berrettini Genetics of major mood disorders Psychiatry 1 2 2004 38 48
37. J.R. Burke, and A.D. Roses Genetics of Alzheimer's disease Int J Neurol 25 1991 41 51
38. A. Goate, M.C. Chartier-Harlin, and M. Mullan Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease Nature 349 1991 704 706
39. E.R. Martin, W.K. Scott, and M.A. Nance Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease JAMA 286 2001 2245 2250
40. S. Prathikanti, and F.J. McMahon Genome scans for susceptibility genes in bipolar affective disorder Ann Med 33 2001 257 262
41. A. Bertelsen, B. Harvald, and M. Hauge A Danish twin study of manic depressive disorders Br J Psychiatry 130 1977 330 351
42. E.S. Gershon, J. Hamovit, and J.J. Guroff A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands Arch Gen Psychiatry 39 1982 1157 1167
43. L.E. Adler, E. Pachtman, and R.D. Franks Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia Biol Psychiatry 17 1982 639 654
44. J.M. Gorman, R.R. Goetz, and D. Dillon Sodium d-lactate infusion of panic disorder patients Neuropsychopharmacology 3 1990 181 189
45. N. Risch, and K. Merikangas The future of genetic studies of complex human diseases Science 273 1996 1516 1517
46. N. Risch Searching for genes in complex diseases: lessons from systemic lupus erythematosus J Clin Invest 105 2000 1503 1506
47. I. Chumakov, M. Blumenfeld, and O. Guerassimenko Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia Proc Natl Acad Sci U S A 99 21 2002 13675 13680
48. E. Hattori, C. Liu, and J.A. Badner Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series Am J Hum Genet 72 5 2003 1131 1140
49. Y.S. Chen, N. Akula, and S.D. Detera-Wadleigh Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33 Mol Psychiatry 9 2004 87 92
50. J. Schumacher, R. Abon Jamra, and J. Frudenberg Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder Mol Psychiatry 9 2004 203 207
51. R.M. Lindsay, S.J. Wiegrand, and C.A. Altar Neurotrophic factors: from molecule to man Trends Neurosci 17 1994 182 190
52. G.R. Lewin, and Y.A. Barde Physiology of neurotrophins Annu Rev Neurosci 19 1996 289 317
53. L.A. Mamounas, M.E. Blue, and J.A. Siuciak Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in the mouse brain J Neurosci 15 1995 7929 7939
54. R.S. Duman, G.R. Heninger, and E.J. Nestler A molecular and cellular theory of depression Arch Gen Psychiatry 54 1997 597 606
55. C.A. Altar Neurotrophins and depression Trends Pharmacol Sci 20 1999 59 61
56. R.C. Shelton Cellular mechanisms in the vulnerability to depression response to antidepressants Psychiatr Clin North Am 23 2000 713 729
57. F. Karege, G. Perret, and G. Bondolfi Decreased serum brain-derived neurotrophic factor levels in major depressed patients Psychiatry Res 109 2002 143 148
58. P. Sklar, S.B. Gabriel, and M.G. McInnis Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neurotrophic factor Mol Psychiatry 7 6 2002 579 593
59. M. Neves-Pereira, E. Mundo, and P. Muglia The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study Am J Hum Genet 71 3 2002 651 655
60. S. Sen, R.M. Nesse, and S.F. Stoltenberg A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression Neuropsychopharmacology 28 2 2003 397 401
61. C.J. Hong, S.J. Huo, and F.C. Yen Association study of a brain-derived neurotrophic factor genetic polymorphism and mood disorders, age of onset and suicidal behavior Neuopsychobiology 48 2003 186 189
62. K. Nakata, H. Ujike, and A. Sakai Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder Neurosci Lett 337 1 2003 17 20
63. H. Kunugi, Y. Iijima, and M. Tatsumi No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study Biol Psychiatry 56 2004 376 378
64. D.A. Collier, M.J. Arranz, and P. Sham The serotonin transporter is a potential susceptibility factor for bipolar affective disorder Neuroreport 7 10 1996 1675 1679
65. D.A. Collier, G. Stober, and T. Li A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders Mol Psychiatry 1 6 1996 453 460
66. S. Battersby, A.D. Ogilvie, and C.A. Smith Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder Psychiatr Genet 6 4 1996 177 181
67. M. Rees, N. Norton, and I. Jones Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT) Mol Psychiatry 2 5 1997 398 402
68. L. Oruc, G.R. Verheyen, and I. Furac Association analysis of the 5-HT2C receptor and 5-HT transporter genes in bipolar disorder Am J Med Genet 74 5 1997 504 506
69. H. Kunugi, M. Hattori, and T. Kato Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder Mol Psychiatry 2 6 1997 457 462
70. F. Bellivier, C. Henry, and A. Szoke Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression Neurosci Lett 255 3 1998 143 146
71. J.B. Vincent, M. Masellis, and J. Lawrence Genetic association analysis of serotonin system genes in bipolar affective disorder Am J Psychiatry 156 1 1999 136 138
72. R.A. Furlong, L. Ho, and C. Walsh Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders Am J Med Genet 81 1 1998 58 63
73. L.E. Esterling, T. Yoshikawa, and G. Turner Serotonin transporter (5-HTT) gene and bipolar affective disorder Am J Med Genet 81 1 1998 37 40
74. M.R. Hoehe, B. Wendel, and I. Grunewald Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders Am J Med Genet 81 1 1998 1 3
75. J.R. Mendes de Oliveira, P.A. Otto, and H. Vallada Analysis of a novel functional polymorphism within the promoter region of the serotonin transporter gene (5-HTT) in Brazilian patients affected by bipolar disorder and schizophrenia Am J Med Genet 81 3 1998 225 227
76. B. Gutierrez, M.J. Arranz, and D.A. Collier Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population Biol Psychiatry 43 11 1998 843 847
77. G. Kirov, M. Rees, and I. Jones Bipolar disorder and the serotonin transporter gene: a family-based association study Psychol Med 29 5 1999 1249 1254
78. W. Liu, N. Gu, and G. Feng Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese Pharmacogenetics 9 4 1999 491 495
79. A. Bocchetta, M.P. Piccardi, and M.A. Palmas Family-based association study between bipolar disorder and DRD2, DRD4, DAT, and SERT in Sardinia Am J Med Genet 88 5 1999 522 526
80. L. Mynett-Johnson, C. Kealey, and E. Claffey Multimarker haplotypes within the serotonin transporter gene suggest evidence of an association with bipolar disorder Am J Med Genet 96 6 2000 845 849
81. Q. Saleem, S. Ganesh, and M. Vijaykumar Association analysis of 5HT transporter gene in bipolar disorder in the Indian population Am J Med Genet 96 2 2000 170 172
82. E. Mundo, M. Walker, and H. Tims Lack of linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and bipolar disorder Am J Med Genet 96 3 2000 379 383
83. J. Ospina-Duque, and C. Duque An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia Neurosci Lett 292 3 2000 199 202
84. A. Serretti, S. Cristina, and R. Lilli Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders Am J Med Genet 114 4 2002 361 369
85. A. Rotondo, C. Mazzanti, and L. Dell'Osso Catechol O-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder Am J Psychiatry 159 1 2002 23 29
86. A. Dimitrova, L. Georgieva, and I. Nikolov Major psychiatric disorders and the serotonin transporter gene (SLC6A4): family-based association studies Psychiatr Genet 12 3 2002 137 141
87. N. Craddock, S. Dave, and J. Greening Association studies of bipolar disorder Bipolar Disord 3 6 2001 284 298
88. F. Bellivier, A. Szoke, and C. Henry Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders Biol Psychiatry 48 4 2000 319 322
89. P. Courtet, P. Baud, and M. Abbar Association between violent suicidal behavior and the low activity allele of the serotonin transporter gene Mol Psychiatry 6 3 2001 338 341
90. B. Bondy, A. Erfurth, and S. de Jonge Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide Mol Psychiatry 5 2 2000 193 195
91. D. Rujescu, I. Giegling, and T. Sato A polymorphism in the promoter of the serotonin transporter gene is not associated with suicidal behavior Psychiatr Genet 11 3 2001 169 172
92. A. MacKenzie, and J. Quinn A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo Proc Natl Acad Sci U S A 96 26 1999 15251 15255
93. L.C. Lim, J. Powell, and P. Sham Evidence for a genetic association between alleles of monoamine oxidase A gene and bipolar affective disorder Am J Med Genet 60 4 1995 325 331
94. Y. Kawada, M. Hattori, and X.Y. Dai Possible association between monoamine oxidase A gene and bipolar affective disorder Am J Hum Genet 56 1 1995 335 336
95. N. Craddock, J. Daniels, and E. Roberts No evidence for allelic association between bipolar disorder and monoamine oxidase A gene polymorphisms Am J Med Genet 60 4 1995 322 324
96. M.M. Nothen, K. Eggermann, and M. Albus Association analysis of the monoamine oxidase A gene in bipolar affective disorder by using family-based internal controls Am J Hum Genet 57 4 1995 975 978
97. D.C. Rubinsztein, J. Leggo, and S. Goodburn Genetic association between monoamine oxidase A microsatellite and RFLP alleles and bipolar affective disorder: analysis and meta-analysis Hum Mol Genet 5 6 1996 779 782
98. T. Muramatsu, S. Matsushita, and S. Kanba Monoamine oxidase genes polymorphisms and mood disorder Am J Med Genet 74 5 1997 494 496
99. A. Parsian, and R.D. Todd Genetic association between monoamine oxidase and manic-depressive illness: comparison of relative risk and haplotype relative risk data Am J Med Genet 74 5 1997 475 479
100. G. Turecki, P. Grof, and P. Cavazzoni MAOA: association and linkage studies with lithium responsive bipolar disorder Psychiatr Genet 9 1 1999 13 16
101. H. Kunugi, S. Ishida, and T. Kato A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders Mol Psychiatry 4 4 1999 393 395
102. R.A. Furlong, L. Ho, and J.S. Rubinsztein Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter Am J Med Genet 88 4 1999 398 406
103. G. Kirov, N. Norton, and I. Jones A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder Int J Neuropsychopharmcol 2 4 1999 293 298
104. M. Preisig, F. Bellivier, and B.T. Fenton Association between bipolar disorder and monoamine oxidase A gene polymorphisms: results of a multicenter study Am J Psychiatry 157 6 2000 948 955
105. Y.V. Syagailo, G. Stober, and M. Grassle Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders Am J Med Genet 105 2 2001 168 171
106. Biomed European Bipolar Collaborative Group No association between bipolar disorder and alleles at a functional polymorphism in the COMT gene Br J Psychiatry 170 1997 526 528
107. T. Li, H. Vallada, and D. Curtis Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and allelic association of the low activity allele with bipolar affective disorder Pharmacogenetics 7 5 1997 349 353
108. B. Gutierrez, J. Bertranpetit, and R. Guillamat Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder Am J Psychiatry 154 1 1997 113 115
109. H. Kunugi, H.P. Vallada, and F. Hoda No evidence for an association of affective disorders with high- or low-activity allele of catechol-O- methyltransferase gene Biol Psychiatry 42 4 1997 282 285
110. H.M. Lachman, J. Kelsoe, and L. Moreno Lack of association of catechol-O-methyltransferase (COMT) functional polymorphism in bipolar affective disorder Psychiatr Genet 7 1 1997 13 17
111. L.A. Mynett-Johnson, V.E. Murphy, and E. Claffey Preliminary evidence of an association between bipolar disorder in females and the catechol-O- methyltransferase gene Psychiatr Genet 8 4 1998 221 225
112. D.F. Papolos, S. Veit, and G.L. Faedda Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele Mol Psychiatry 3 4 1998 346 349
113. K. Ohara, M. Nagai, and Y. Suzuki Low activity allele of catechol-O-methyltransferase gene and Japanese unipolar depression Neuroreport 9 7 1998 1305 1308
114. G. Kirov, K.C. Murphy, and M.J. Arranz Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder Mol Psychiatry 3 4 1998 342 345
115. G. Kirov, I. Jones, and F. McCandless Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5 Mol Psychiatry 4 6 1999 558 565
116. B. Geller, and E.H. Cook Jr. Ultradian rapid cycling in prepubertal and early adolescent bipolarity is not in transmission disequilibrium with Val/Met COMT alleles Biol Psychiatry 47 7 2000 605 609
117. A. Rotondo, C. Mazzanti, and L. Dell'Osso Catechol O-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder Am J Psychiatry 159 1 2002 23 29
118. J.B. Potash, V.L. Willour, and Y.F. Chiu The familial aggregation of psychotic symptoms in bipolar disorder pedigrees Am J Psychiatry 158 8 2001 1258 1264
119. J.B. Potash, Y.F. Chiu, and D.F. MacKinnon Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees Am J Med Genet 116 2003 90 97
120. J.B. Potash, P.P. Zandi, and V.L. Willour Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder Am J Psychiatry 160 4 2003 680 686
121. W.H. Berrettini Are schizophrenic and bipolar disorders related? A review of family and molecular studies Biol Psychiatry 48 6 2000 531 538
122. E.S. Gershon, J. Hamovit, and J.J. Guroff A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands Arch Gen Psychiatry 39 10 1982 1157 1167
123. N.C. Andreasen, J. Rice, and J. Endicott Familial rates of affective disorder. A report from the national Institute of Mental Health Collaborative Study Arch Gen Psychiatry 44 1988 461 469
124. R. Heun, and W. Maier Bipolar II disorders in six first-degree relatives Biol Psychiatry 34 1993 274 276
125. T.G. Schulze, Y.S. Chen, and J.A. Badner Additional, physically ordered markers increase linkage signal for bipolar disorder on chromosome 18q22 Biol Psychiatry 53 3 2003 239 243
126. D.F. MacKinnon, F.J. McMahon, and S.G. Simpson Panic disorder with familial bipolar disorder Biol Psychiatry 42 1997 90 95
127. D.F. MacKinnon, P.P. Zandi, and J. Cooper Comorbid bipolar disorder and panic disorder in families with a high prevalence of bipolar disorder Am J Psychiatry 159 2002 30 35
128. D.F. MacKinnon, J. Xu, and F.J. McMahon Bipolar disorder and panic disorder in families: an analysis of chromosome 18 data Am J Psychiatry 155 1998 829 831
129. P. Grof, A. Duffy, and P. Cavazzoni Is response to prophylactic lithium a familial trait? J Clin Psychiatry 63 10 2002 942 947
130. A. Caspi, K. Sugden, and T.E. Moffitt Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 2003 386 389
131. K.P. Lesch Animal models of anxiety R. Plomin J.C. DeFries I.W. Craig Behavioral genetics in the postgenomics era 2003 American Psychiatric Association Washington (DC) 389 424