Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders

Biological Psychiatry

Volumn 48, Issue 4, 2000, Pages 319-322

  Bellivier, Frank ^a   Szöke, Andreï ^a   Henry, Chantal ^b   Lacoste, Jérome ^b   Bottos, Corinne ^c   Nosten Bertrand, Marika ^d   Hardy, Patrick ^e   Rouillon, Frederic ^a,d   Launay, Jean Marie ^c   Laplanche, Jean Louis ^c   Leboyer, Marion ^a,d  

^a Hop Henri Mondor Albert C   (France)

^b Serv Psychiat Adulte (Pr M B   (France)

^c Lab de Biochim et Biol Molec   (France)

^d FACULTÉ DE MÉDECINE   (France)

^e Serv Psychiat Adulte (Pr Feline)   (France)

Author keywords

Affective disorder; Candidate symptoms; Serotonin transporter gene; Suicidal behavior

Indexed keywords

SEROTONIN TRANSPORTER;

AFFECTIVE NEUROSIS; ALLELE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC PREDISPOSITION; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; SUICIDAL BEHAVIOR; VIOLENCE;

ADULT; ALLELES; BIPOLAR DISORDER; CARRIER PROTEINS; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE EXPRESSION; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOOD DISORDERS; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SUICIDE; VIOLENCE;

EID: 0342794217     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(00)00891-X     Document Type: Article

References (17)

1. Armitage P., Berry G. Statistical Methods in Medical Research. 1987;Blackwell Scientific, Oxford, UK.
2. Asberg M., Traskman L., Thoren P. 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry. 33:1976;1193-1197.
3. Bellivier F., Henry C., Szoke A., Schurhoff F., Nosten-Bertrand M., Feingold J., et al. Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci Lett. 255:1998;143-146.
4. Brent D.A., Bridge J., Johnson B.A., Connolly J. Suicidal behavior runs in families. A controlled family study of adolescent suicide victims. Arch Gen Psychiatry. 53:1996;1145-1152.
5. Collier D.A., Stober G., Li T., Heils A., Catalano M., Di Bella D., et al. A novel functional polymorphism within the promoter of the serotonin transporter gene Possible role in susceptibility to affective disorders . Mol Psychiatry. 1:1996;453-460.
6. Furlong R.A., Ho L., Walsh C., Rubinsztein J.S., Jain S., Paykel E.S., et al. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet. 81:1998;58-63.
7. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., Lesch K.P. Allelic variation of human serotonin transporter gene expression. J Neurochem. 66:1996;2621-2624.
8. Hoehe M.R., Wendel B., Grunewald I., Chiaroni P., Levy N., Morris-Rosendahl, D, et al. Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. Am J Med Genet. 81:1998;1-3.
9. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 274:1996;1527-1531.
10. Mann J.J. The neurobiology of suicide. Nat Med. 4:1998;25-30.
11. Nurnberger J.J., Blehar M., Kauffmann C., York-Cooler C., Simpson S.G., Harkavy-Friedman J., et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry. 51:1994;849-859.
12. Owens M.J., Nemeroff C.B. Role of serotonin in the pathophysiology of depression Focus on the serotonin transporter . Clin Chem. 40:1994;288-295.
13. Rosenthal N.E., Mazzanti C.M., Barnett R.L., Hardin T.A., Turner E.H., Lam G.K., et al. Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. Mol Psychiatry. 3:1998;175-177.
14. Roy A., Rylander G., Sarchiapone M. Genetic studies of suicidal behavior. Psychiatry Clin North Am. 20:1997;595-611.
15. Roy A., Rylander G., Sarchiapone M. Genetics of suicides. Family studies and molecular genetics. Ann N Y Acad Sci. 836:1997;135-157.
16. Rudnick G., Clark J. From synapse to vesicle The reuptake and storage of biogenic amine neurotransmitters . Biochem Biophys Acta. 1144:1993;249-263.
17. Sham P.C., Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet. 59:1995;97-105.