Characterization by liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry of two coupled oxidative-conjugative metabolic pathways for 7-ethoxycoumarin in human liver microsomes treated with alamethicin

Drug Metabolism and Disposition

Volumn 30, Issue 3, 2002, Pages 270-275

  Fisher, Michael B ^a,b   Jackson, David ^a   Kaerner, Andreas ^a   Wrighton, Steven A ^a   Borel, Anthony G ^a  

^a ELI LILLY AND COMPANY   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHOXYCOUMARIN; ALAMETHICIN; CYTOCHROME P450; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ARTICLE; CATALYSIS; ENZYME LOCALIZATION; ENZYME METABOLISM; ENZYME SUBSTRATE; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; LIVER SLICE; MICROSOME MEMBRANE; MULTIGENE FAMILY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; XENOBIOTIC METABOLISM;

7-ALKOXYCOUMARIN O-DEALKYLASE; ALAMETHICIN; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; COUMARINS; GLUCURONOSYLTRANSFERASE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER; NADP; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 0036179380     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.3.270     Document Type: Article

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