Bcl-x expression influences keratinocyte cell survival but not terminal differentiation

Cell Growth and Differentiation

Volumn 8, Issue 6, 1997, Pages 619-629

  Pena, John C ^a,b   Fuchs, Elaine ^b   Thompson, Craig B ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; KERATIN; ONCOPROTEIN; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ULTRAVIOLET IRRADIATION; WOUND HEALING;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; BROMODEOXYURIDINE; CELL CULTURE TECHNIQUES; CELL SURVIVAL; EPIDERMIS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; KERATINS; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; WOUND HEALING;

ANIMALIA; MUS MUSCULUS;

EID: 0030971756     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Fuchs, E., and Byrne, C. The epidermis: rising to the surface. Curr. Opin. Genet. Dev., 4: 725-736, 1994.
2. Fuchs, E. Keratins and the skin. Annu. Rev. Cell Dev. Biol., 11: 123-153, 1995.
3. Potten, C. S., and Allen, T. D. The fine structure and cell kinetics of mouse epidermis after wounding. J. Cell Sci., 17: 413-447, 1975.
4. Potten, C. S. Cell replacement in epidermis (keratopoiesis) via discrete units of proliferation. Int. Rev. Cytol., 69: 271-318, 1981.
5. Dover, R., and Potten, C. S. Cell cycle kinetics of cultured human epidermal keratinocytes. J. Invest. Dermatol., 80: 423-429, 1983.
6. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119: 493-501, 1992.
7. Kerr, J. F., Wyllie, A. H., and Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 26: 239-257, 1972.
8. Green, M. R., and Couchman, J. R. Distribution of epidermal growth factor receptors in rat tissues during embryonic skin development, hair formation, and the adult hair growth cycle. J. Invest. Dermatol., 83: 118-123, 1984.
9. McCall, C. A., and Cohen, J. J. Programmed cell death in terminally differentiating keratinocytes: role of endogenous endonuclease. J. Invest. Dermatol., 97: 111-114, 1991.
10. Rice, R. H., and Green, H. Relation of protein synthesis and transglutaminase activity to formation of the cross-linked envelope during terminal differentiation of the cultured human epidermal keratinocyte. J. Cell Biol., 76: 705-711, 1978.
11. Simon, M., and Green, H. Enzymatic cross-linking of involucrin and other proteins by keratinocyte particulates in vitro. Cell, 40: 677-683, 1985.
12. Ananthaswamy, H. N., and Fisher, N. S. Photoreactivation of ultraviolet radiation-induced pyrimidine dinners in neonatal BALB/c mouse skin. Cancer Res., 41: 1829-1833, 1981.
13. Gregg, K., and Mansbridge, J. Epidermal characteristics related to skin cancer susceptibility. J. Invest. Dermatol., 79: 178-182, 1982.
14. Liu, S. C., Meagher, K., and Hanawalt, P. C. Role of solar conditioning in DNA repair response and survival of human epidermal keratinocytes following UV irradiation. J. Invest. Dermatol., 85: 93-97, 1985.
15. Zinkel, S., and Fuchs, E. Skin cancer and transgenic mice. Semin. Cancer Biol., 5: 77-90, 1994.
16. Kraemer, K. H. Sunlight and skin cancer: another link revealed. Proc. Natl. Acad. Sci. USA, 94: 11-14, 1997.
17. Gijbels, M. J., Hogenesch, H., Blauw, B., Roholl, P., and Zurcher, C. Ultrastructure of epidermis of mice with chronic proliferative dermatitis. Ultrastruct. Pathol., 19: 107-111, 1995.
18. Langley, R. G., Walsh, N., Nevill, T., Thomas, L., and Rowden, G. Apoptosis is the mode of keratinocyte death in cutaneous graft-versus-host disease. J. Am. Acad. Dermatol., 35: 187-190, 1996.
19. Paul, C., Wolkenstein, P., Adle, H., Wechsler, J., Garchon, H. J., Revuz, J., and Roujeau, J. C. Apoptosis as a mechanism of keratinocyte death in toxic epidermal necrolysis. Br. J. Dermatol., 134: 710-714, 1996.
20. Marthinuss, J., Lawrence, L., and Seiberg, M. Apoptosis in Pam212, an epidermal keratinocyte cell line: a possible role for bcl-2 in epidermal differentiation. Cell Growth & Differ., 6: 239-250, 1995.
21. Wrone-Smith, T., Johnson, T., Nelson, B., Boise, L. H., Thompson, C. B., Nunez, G., and Nickoloff, B. J. Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo. Am. J. Pathol., 146: 1079-88, 1995.
22. Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science (Washington DC), 267: 1456-1462, 1995.
23. Yang, E., and Korsmeyer, S. J. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood, 88: 386-401, 1996.
24. Boise, L. H., Gonzalez-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nunez, G., and Thompson, C. B. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74: 597-608, 1993.
25. L. J. Biol. Chem., 271: 6306-6312, 1996.
26. Motoyama, N., Wang, F., Roth, K., Sawa, H., Nakayama, K., Hakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., and Loh, D. Y. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science (Washington DC), 267: 1506-1510, 1995.
27. Veis, D. J., Sorenson, C. M., Shutter, J. R., and Korsmeyer, S. J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell, 75: 229-240, 1993.
28. Hockenbery, D. M., Zutter, M., Mickey, W., Nahm, M., and Korsmeyer, S. J. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA, 88: 6961-6965, 1991.
29. Krajewski, S., Krajewska, J., Shabaik, A., Miyashita, T., Wang, H. G., and Reed, J. C. Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am. J. Pathol., 145: 1323-1336, 1994.
30. Lu, Q. L., Poulsom, R., Wong, L., and Hanby, A. M. Bcl-2 expression in adult and embryonic non-haematopoietic tissues. J. Pathol., 169: 431-437, 1993.
31. Krajewski, S., Krajewska, M., and Reed, J. C. Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family. Cancer Res., 56: 2849-2855, 1996.
32. Stenn, K. S., Lawrence, L., Veis, D., Korsmeyer, S., and Seiberg, M. Expression of the bcl-2 proto-oncogene in the cycling adult mouse hair follicle. J. Invest. Dermatol., 103: 107-111, 1994.
33. Rodriquez-Villanueva, J., Colome, M. I., Brisbay, S., and McDonnell, T. J. The expression and localization of bcl-2 protein in normal skin and in non-melanoma skin cancers. Pathol. Res. Pract., 191: 391-398, 1995.
34. Krajewski, S., Krajewska, M., Shabaik, A., Wang, H. G., Irie, S., Fong, L., and Reed, J. C. Immunohistochemical analysis of in vivo patterns of Bcl-x expression. Cancer Res., 54: 5501-5507, 1994.
35. Vassar, R., Rosenberg, M., Ross, S., Tyner, A., and Fuchs, E. Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc. Natl. Acad. Sci. USA, 86: 1563-1567, 1989.
36. Rothberg, S., Nancarrow, G. E., Meydrech, E. F., and Iwanik, M. J. Extracellular stimulation of epidermal DNA synthesis. Cell Tissue Kinet., 9: 439-444, 1976.
37. Bertsch, S., Csontos, K., Schweizer, J., and Marks, F. Effect of mechanical stimulation on cell proliferation in mouse epidermis and on growth regulation by endogenous factors (chalones). Cell Tissue Kinet., 9; 445-457, 1976.
38. Sellheyer, K., Bickenbach, J. R., Rothnagel, J. A., Bundman, D., Longley, M. A., Krieg, T., Roche, N. S., Roberts, A. B., and Roop, D. R. Inhibition of skin development by overexpression of transforming growth factor B1 in the epidermis of transgenic mice. Proc. Natl. Acad. Sci. USA, 90: 5237-5241, 1993.
39. S sensitizes MCF-7 cells to chemotherapy-induced apoptosis. Cancer Res., 55: 2501-2510, 1995.
40. Danno, K., and Horio, T. Sunburn cell: factors involved in its formation. Photochem. Photobiol., 45: 683-690, 1987.
41. Olson, R. L., and Everett, M. A. Epidermal apoptosis: cell deletion by phagocytosis. J. Cutaneous Pathol., 2: 53-57, 1975.
42. Olson, R. L., Gaylor, J., and Everett, M. A. Ultraviolet-induced individual cell keratinization. J. Cutaneous Pathol., 1: 120-125, 1974.
43. L can confer a multidrug resistance phenotype. Blood, 86: 1903-1910, 1995.
44. Guo, L., Degenstein, L., Dowling, J., Yu, Q. C., Wollmann, R., Perman, B., and Fuchs, E. Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell, 81: 233-243, 1995.
45. L. Immunity, 3: 87-98, 1995.
46. Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O., and Korsmeyer, S. J. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell, 67: 879-888, 1991.
47. Lecronique, V., Mignon, A., Fabre, M., Viollet, B., Rouquet, N., Molina, T, Porteu, A., Henrion, A., Bouscary, D., Varlet, P., Joulin, V., and Kahn, A. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat. Med., 2: 80-86, 1996.
48. Polakowska, R. R., and Haake, A. R. Apoptosis: the skin from a new perspective. Cell Death Diff., 1: 19-31, 1994.
49. Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957-967, 1993.
50. Ziegler, A., Jonason, A. S., Leffell, D. J., Simon, J. A., Sharma, H. W., Kimmelman, J., Remington, L., Jacks, T., and Brash, D. E. Sunburn and p53 in the onset of skin cancer. Nature (Lond.), 372: 773-776, 1994.
51. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847-849, 1993.
52. L protects cancer cells from p53-mediated apoptosis. Oncogene, 11: 1389-1394, 1995.
53. L, and Bcl-2 repress a common pathway of cell death. J. Exp. Med., 182: 821-828, 1995.
54. Ko, L. J., and Prives, C. p53: puzzle and paradigm. Genes & Dev., 10: 1054-1072, 1996.
55. L and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage. Genes & Dev., 10: 2621-2631, 1996.
56. Strasser, A., Harris, A. W., Jacks, T., and Cory, S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell, 79: 329-339, 1994.
57. Naik, P., Karrim, J., and Hanahan, D. The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors. Genes & Dev., 10: 2105-2116, 1996.
58. Knighton, D. R., Silver, I. A., M. R. C. V. S., and Hunt, T. K. Regulation of wound-healing angiogenesis: effect of oxygen gradients and inspired oxygen concentration. Surgery (St. Louis), 90: 262-269, 1981.
59. Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., and Giaccia, A. J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (Lond.), 379: 88-91, 1996.
60. Baker, D., Masterson, T., Pace, R., Constable, W., and Wanebo, H. The influence of the surgical wound on local tumor recurrence Surgery (St. Louis), 106: 525-532, 1989.
61. Noel, P. J., Boise, L. H., Green, J. M., and Thompson, C. B. CD28 costimulation prevents cell death during primary T cell activation. J. Immunol., 157: 636-642, 1996.
62. Grillot, D. A. M., Merino, R., Pena, J. C., Fanslow, W. C., Finkelman, F. D., Thompson, C. B., and Nunez, G. bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J. Exp. Med., 183: 381-391, 1996.
63. Odland, G., and Ross, R. Human wound repair. I. Epidermal regeneration. J. Cell Biol., 39: 135-151, 1968.
64. Viziam, C. B., Matoltsy, A. G., and Mescon, H. Epithelialization of small wounds. J. Invest. Dermatol., 43: 499-507, 1964.
65. Ma, A., Pena, J. C., Chang, B., Margosian, E., Davidson, L., Alt, F. W., and Thompson, C. B. Bclx regulates the survival of double-positive thymocytes. Proc. Natl. Acad. Sci. USA, 92: 4763-4767, 1995.
66. Hennings, H., Michael, D., Cheng, C., Steinert, P., Holbrook, K., and Yuspa, S. H. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell, 19: 245-254, 1980.