Chemotherapy-induced O6-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer

Cancer Research

Volumn 62, Issue 11, 2002, Pages 3070-3076

  Liu, Lili ^a   Schwartz, Stuart ^a   Davis, Brian M ^a   Gerson, Stanton L ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O BENZYLGUANINE; ASPARAGINE; CARMUSTINE; GLUTAMIC ACID; LYSINE; TEMOZOLOMIDE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; COLON CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG RESISTANCE; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; IC 50; METHYLATION; MISMATCH NEGATIVITY; MISMATCH REPAIR; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; WESTERN BLOTTING;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BASE PAIR MISMATCH; CARMUSTINE; CARRIER PROTEINS; CHO CELLS; COLONIC NEOPLASMS; CRICETINAE; DNA REPAIR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; GENES, P53; GUANINE; HUMANS; MUTAGENESIS; MUTATION; NEOPLASM PROTEINS; NUCLEAR PROTEINS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0036606370     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Regulation and expression of the adaptive response to alkylating agents
2. 6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
3. 6-alkylguanine-DNA alkyltransferase
4. 6-alkylguanine-DNA alkyltransferase, a target for the modulation of drug resistance
5. Inhibition of a specific DNA repair system and nitrosourea cytotoxicity
6. 6-alkylguanine-DNA alkyltransferase by streptozotocin in vivo
7. 6-alkylguanine-DNA alkyltransferase mediated carmustine resistance using streptozotocin: Phase I clinical trial
8. 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
9. 6-benzylguanine analogous on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents
10. 6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumor cells
11. 6-alkylguanine-DNA alkyltransferase
12. Formation of the cross-link I-[N3-deoxycytidyl],2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N-bis(2-chloroethyl)-1 nitrosourea
13. 6-benzylguanine and its effect on the sensitivity of a human glioma tumor to methyl CCNU
14. 6-benzylguanine on the sensitivity of human tumor xenografts to BCNU and on DNA interstrand cross-link formation
15. 6-benzylguanine and BCNU in human colon cancer xenografts completely resistant to BCNU alone
16. Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiform
17. 6-benzylguanine on the sensitivity of human colon tumor xenografts to BCNU
18. 6-Benzylguanine and its role in chemotherapy
19. A clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair
20. 6-benzylguanine
21. 6 benzylguanine
22. Engineering human DNA alkyltransferase for gene therapy using random sequence mutagenesis
23. 6-benzylguanine (BG)
24. Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide by not to 1,3-bis(2 chloroethyl)nitrosourea
25. 6-alkylguanine-DNA AGT activity based on cellular DNA content in human, rat and mouse tissues
26. Detection of aneuploidy and aneuploidy-inducing agents in human lymphocytes using fluorescence in situ hybridization with chromosome-specific DNA probes
27. 6-methylguanine-DNA methyltransferase gene
28. 6-benzylguanine using a transgenic model
29. 6-benzylguanine in human brain tumor cells
30. Molecular mechanisms of DNA mismatch repair
31. The role of DNA mismatch repair in drug resistance
32. Mutator phenotypes in human colorectal carcinoma cell lines
33. Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer
34. DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines
35. Accumulation of multiple mutations in tumor suppressor genes during colorectal tumorigenesis in HNPCC patients
36. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
37. 6-alkylguanine-DNA alkyltransferase
38. 6-alkylguanine-DNA alkyltransferase
39. 6-methylguanine-DNA methyltransferase activity revealed by saturation mutagenesis with negative and positive screening
40. 6-methylguanine-DNA methyltransferase from E. coli
41. 6-methylguanine-DNA methyltransferase activity: Analyses of three residues at or near the methyl acceptor site
42. 6-alkylguanine
43. 6-alkylguanine DNA alkyltransferase
44. Novel human DNA alkyltransferases obtained by random substitution and genetic selection in bacteria
45. Active and alkylated human AGT structures: A novel zinc site, inhibitor and extrahelical base binding
46. 6-benzylguanine
47. 6-alkylguanine by alkyltransferases