The A3 adenosine receptor as a new target for cancer therapy and chemoprotection

Experimental Cell Research

Volumn 269, Issue 2, 2001, Pages 230-236

  Fishman, Pnina ^a,b   Bar Yehuda, Sara ^a,b   Barer, Faina ^a,b   Madi, Lea ^a,b   Multani, Asha S ^c   Pathak, Sen ^c  

^a TEL AVIV UNIVERSITY   (Israel)

^b Can Fite BioPharma Ltd   (Israel)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

A3 adenosine receptor; Bone marrow; G CSF; Melanoma; Neutrophils; Synthetic A3 agonists

Indexed keywords

2 CHLORO N6 (3 IODOBENZYL)ADENOSINE 5' N METHYLURONAMIDE; 6 ETHYL 4 PROPYL 2 PHENYL 3 PYRIDINECARBOXYLIC ACID 5 THIOCARBOXYLIC ACID 5 ETHYL 3 PROPYL ESTER; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; CYCLOPHOSPHAMIDE; GRANULOCYTE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW; BONE MARROW TOXICITY; CANCER INHIBITION; CANCER THERAPY; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; LEUKOCYTE COUNT; LUNG METASTASIS; MELANOMA; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

EID: 0035478429     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5327     Document Type: Article

References (30)

1. Adenosine and other low molecular weight factors released by muscle cells inhibit tumor cell growth: Possible explanation for the rarity of metastases in muscle
2. Adenosine acts as a chemoprotective agent by stimulating G-CSF production: A role for A1&A3 adenosine receptors
3. Structure and function of A1 adenosine receptors
4. Adenosine receptors and beyond: Molecular mechanisms of physiological regulation
5. Adenosine acts as an inhibitor of lymphoma cell growth: A major role for the A3 adenosine receptor
6. Resistance of muscle to tumor metastases: A role for A3 adenosine receptor agonists
7. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining
8. Chromosome banding techniques
9. A modified fluorescence in situ hybridization (FISH) technique
10. A3 adenosine receptors: Protective vs. damaging effects identified using novel agonists and antagonists
11. Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists
12. Functionalized congeners of 1,4-dihydropyridines as antagonist molecular probes for A3 adenosine receptors
13. Activation of the A3 adenosine receptor affects cell cycle progression and cell growth
14. Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists
15. Induction of apoptosis in rat cardiocytes by A3 adenosine receptor activation and its suppression by isoproterenol
16. Effects of adenosine A3 receptor agonists on astrocytes: Induction of cell protection at low and cell death at high concentrations
17. Growth arrest of immortalized human keratinocytes and suppression of telomerase activity by p21WAF1 gene expression
18. Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology
19. Amplification of telomeric DNA directly correlated with metastatic potential of human and murine cancers of various histological origin
20. Telomerase expression in uveal melanoma
21. Progressive increase in telomerase activity from benign melanocytic conditions to malignant melanoma
22. Resistance of muscle to tumor metastases: A role for A3 adenosine receptor agonists
23. Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats
24. The effects of adenosine A3 receptor stimulation on seizures in mice
25. Stimulation of adenosine A3 receptors in cerebral ischemia. Neuronal death, recovery, or both?
26. Synergistic factors for stem cell proliferation: Further studies of the target stem cells and the mechanism of stimulation by interleukin-1, interleukin-6, and granulocyte colony-stimulating factor
27. Interleukin-3 and granulocyte colony-stimulating factor as survival factors in murine hematopoietic stem cells in vitro
28. Adenosine A3 receptor stimulation and cerebral-ischemia
29. Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart
30. Adenosine A3 receptor agonists inhibit murine macrophage tumor necrosis factor-alpha production in vitro and in vivo