Inhibition of GM-CSF Receptor Function by Stable RNA Interference in a NOD/SCID Mouse Hematopoietic Stem Cell Transplantation Model

Oligonucleotides

Volumn 13, Issue 5, 2003, Pages 353-363

  Scherr, Michaela ^a   Battmer, Karin ^a   Dallmann, Iris ^a   Ganser, Arnold ^a   Eder, Matthias ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; DOUBLE STRANDED RNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 3; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 5 RECEPTOR; LENTIVIRUS VECTOR; RNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; GENE CASSETTE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA SYNTHESIS; SCID MOUSE; XENOTRANSPLANTATION;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; DNA PRIMERS; GENE SILENCING; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEMATOPOIETIC STEM CELLS; HUMANS; LENTIVIRUS; MICE; MICE, INBRED NOD; MICE, SCID; MOLECULAR SEQUENCE DATA; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-3; RECEPTORS, INTERLEUKIN-5; RNA, SMALL INTERFERING; STEM CELL TRANSPLANTATION; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

ANIMALIA; LENTIVIRUS;

EID: 1642441675     PISSN: 15454576     EISSN: None     Source Type: Journal    
DOI: 10.1089/154545703322617032     Document Type: Article

References (39)

1. ABBAS-TERKI, T., BLANCO-BOSE, W., DEGLON, N., PRALONG, W., and AEBISCHER, P. (2002). Lentiviral-mediated RNA interference. Hum. Gene Ther. 13, 2197-2201.
2. ASHRAFI, K., CHANG, F.Y., WATTS, J.L., FRASER, A.G., KAMATH, R.S., AHRINGER, J., et al. (2003). Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421, 268-272.
3. (+) progenitor cell-derived macrophages. Mol. Ther. 8, 62-71.
4. BARTON, G.M., and MEDZHITOV, R. (2002). Retroviral delivery of small interfering RNA into primary cells. Proc. Natl. Acad. Sci. USA 99, 14943-14945.
5. BRUMMELKAMP, T.R., BERNARDS, R., and AGAMI, R. (2002). Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2, 243-247.
6. CAPODICI, J., KARIKO, K., and WEISSMAN, D. (2002). Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference. J. Immunol. 169, 5196-5201.
7. CATALANOTTO, C., AZZALIN, G., MACINO, G., and COGONI, C. (2000). Gene silencing in worms and fungi. Nature 404, 245.
8. COBURN, G.A., and CULLEN, B.R. (2002). Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. J. Virol. 76, 9225-9231.
9. DEMAISON, C., PARSLEY, K., BROUNS, G., SCHERR, M., BATTMER, K., KINNON, C., GREZ, M., and THRASHER, A.J. (2002). High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter. Hum. Gene Ther. 13, 803-813.
10. DEVROE, E., and SILVER, P.A. (2002). Retrovirus-delivered siRNA. BMC Biotechnol. 2, 7-15.
11. DICK, J.E., BHATIA, M., GAN, O., KAPP, U., and WANG, J.C. (1997). Assay of human stem cells by repopulation of NOD/SCID mice. Stem Cells 1, 199-203.
12. EDER, M., ERNST, T.J., GANSER, A., JUBINSKY, P.T., INHORN, R., HOELZER, D., and GRIFFIN, J.D. (1994). A low affinity chimeric human alpha/beta-granulocyte-macrophage colony-stimulating factor receptor induces ligand-dependent proliferation in a murine cell line. J. Biol. Chem. 269, 30173-30180.
13. ELBASHIR, S.M., HARBORTH, J., LENDECKEL, W., YALCIN, A., WEBER, K., and TUSCHL, T. (2001). Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498.
14. FIRE, A., XU, S., MONTGOMERY, M.K., KOSTAS, S.A., DRIVER, S.E., and MELLO, C.C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811.
15. FRASER, A.G., KAMATH, R.S., ZIPPERLEN, P., MARTINEZ-CAMPOS, M., SOHRMANN, M., and AHRINGER, J. (2000). Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408, 325-330.
16. GONCZY, P., ECHEVERRI, C., OEGEMA, K., COULSON, A., JONES, S.J., COPLEY, R.R., et al. (2000). Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature 408, 331-336.
17. HAYASHIDA, K., KITAMURA, T., GORMAN, D.M., ARAI, K., YOKOTA, T., and MIYAJIMA, A. (1990). Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): Reconstitution of a high-affinity GM-CSF receptor. Proc. Natl. Acad. Sci. USA 87, 9655-9659.
18. IHLE, J.N. (1995). Cytokine receptor signalling. Nature 377, 591-594.
19. JACQUE, J.M., TRIQUES, K., and STEVENSON, M. (2002). Modulation of HIV-1 replication by RNA interference. Nature 418, 435-438.
20. KAFERT, S., KRAUTER, J., GANSER, A., and EDER, M. (1999a). Differential quantitation of alternatively spliced messenger RNAs using isoform-specific real-time RT-PCR. Anal. Biochem. 269, 210-213.
21. KAFERT, S., LUTHER, S., BOLL, I., WAGNER, K., GANSER, A., and EDER, M. (1999b). Functional analysis of a single chain chimeric alpha/beta-granulocyte-macrophage colony-stimulating factor receptor. Importance of a glutamate residue in the transmembrane region. J. Biol. Chem. 274, 33064-33071.
22. KAMATH, R.S., FRASER, A.G., DONG, Y., POULIN, G., DURBIN, R., GOTTA, M., et al. (2003). Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421, 231-237.
23. KUNATH, T., GISH, G., LICKERT, H., JONES, N., PAWSON, T., and ROSSANT, J. (2003). Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype. Nat. Biotechnol. 21, 559-561.
24. MARTINEZ, L.A., NAGUIBNEVA, I., LEHRMANN, H., VERVISCH, A., TCHENIO, T., LOZANO, G., and HAREL-BELLAN, A. (2002). Synthetic small inhibiting RNAs: Efficient tools to inactivate oncogenic mutations and restore p53 pathways. Proc. Natl. Acad. Sci. USA 99, 14849-14854.
25. McMANUS, M.T., HAINES, B.B., DILLON, C.P., WHITHURST, C.E., VAN PARIJS, L., CHEN, J., and SHARP, P.A. (2002). Small interfering RNA-mediated gene silencing in T lymphocytes. J. Immunol. 169, 5754-5760.
26. METCALF, D. (1989). The molecular control of cell division, differentiation commitment and maturation in hematopoietic cells. Nature 339, 27-30.
27. NGO, H., TSCHUDI, C., GULL, K., and ULLU, E. (1998). Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Proc. Natl. Acad. Sci. USA 95, 14687-14692.
28. PAL-BHADRA, M., BHADRA, U., and BIRCHLER, J.A. (2002). RNAi-related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol. Cell 9, 315-327.
29. QIN, X.F., AN, D.S., CHEN, I.S., and BALTIMORE, D. (2003). Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc. Natl. Acad. Sci. USA 100, 183-188.
30. ROIGNANT, J.Y., CARRE, C., MUGAT, B., SZYMCZAK, D., LEPESANT, J.A., and ANTONIEWSKI, C. (2003). Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila. RNA 9, 299-308.
31. RUBINSON, D.A., DILLON, C.P., KWIATKOWSKI, A.V., SIEVERS, C., YANG, L., KOPINJA, J., ZHANG, M., McMANUS, M.T., GERTLER, F.B., SCOTT, M.L., and VAN PARIJS, L. (2003). A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet. 33, 401-406.
32. + NOD/SCID-repopulating cells. Blood 99, 709-712.
33. SCHERR, M., BATTMER, K., GANSER, A., and EDER, M. (2003a). Modulation of gene expression by lentiviral-mediated delivery of small interfering RNA. Cell Cycle 2, 251-257.
34. SCHERR, M., BATTMER, K., WINKLER, T., HEIDENREICH, O., GANSER, A., and EDER, M. (2003b). Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood 101, 1566-1569.
35. SCHIEDLMEIER, B., KUHLCKE, K., ECKERT, H.G., BAUM, C., ZELLER, W.J., and FRUEHAUF. S. (2000). Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice. Blood 95, 1237-1248.
36. STEWART, S.A., DYKXHOORN, D.M., PALLISER, D., MIZUNO, H., YU, E.Y., AN, D.S., SABATINI, D.M., CHEN, I.S., HAHN, W.C., SHARP, P.A., WEINBERG, R.A., and NOVINA, C.D. (2003). Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9, 493-501.
37. WAGNER, K., KAFERT-KASTING, S., HEIL, G., GANSER, A., and EDER, M. (2001). Inhibition of granulocyte-macrophage colony-stimulating factor receptor function by a splice variant of the common beta-receptor subunit. Blood 98, 2689-2696.
38. WIANNY, F., and ZERNICKA-GOETZ, M. (2000). Specific interference with gene function by double-stranded RNA in early mouse development. Nat. Cell. Biol. 2, 70-75.
39. XIA, H., MAO, Q., PAULSON, H.L., and DAVIDSON, B.L. (2002). siRNA-mediated gene silencing in vitro and in vivo. Nat. Biotechnol. 20, 1006-1010.